Details of the Target

General Information of Target

Target ID LDTP12619
Target Name Midasin (MDN1)
Gene Name MDN1
Gene ID 23195
Synonyms
KIAA0301; Midasin; Dynein-related AAA-ATPase MDN1; MIDAS-containing protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAENSKQFWKRSAKLPGSIQPVYGAQHPPLDPRLTKNFIKERSKVNTVPLKNKKASSFH
EFARNTSDAWDIGDDEEEDFSSPSFQTLNSKVALATAAQVLENHSKLRVKPERSQSTTSD
VPANYKVIKSSSDAQLSRNSSDTCLRNPLHKQQSLPLRPIIPLVARISDQNASGAPPMTV
REKTRLEKFRQLLSSQNTDLDELRKCSWPGVPREVRPITWRLLSGYLPANTERRKLTLQR
KREEYFGFIEQYYDSRNEEHHQDTYRQIHIDIPRTNPLIPLFQQPLVQEIFERILFIWAI
RHPASGYVQGINDLVTPFFVVFLSEYVEEDVENFDVTNLSQDMLRSIEADSFWCMSKLLD
GIQDNYTFAQPGIQKKVKALEELVSRIDEQVHNHFRRYEVEYLQFAFRWMNNLLMRELPL
RCTIRLWDTYQSEPEGFSHFHLYVCAAFLIKWRKEILDEEDFQGLLMLLQNLPTIHWGNE
EIGLLLAEAYRLKYMFADAPNHYRR
Target Bioclass
Other
Family
Midasin family
Subcellular location
Nucleus, nucleolus
Function
Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits. Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus. At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm. Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex. This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation.
Uniprot ID
Q9NU22
Ensemble ID
ENST00000369393.8
HGNC ID
HGNC:18302
ChEMBL ID
CHEMBL4105779

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.97  LDD0402  [1]
A-EBA
 Probe Info  		3.95  LDD0215  [2]
TH211
 Probe Info  		Y5445(7.57); Y1292(5.89)  LDD0257  [3]
Probe 1
 Probe Info  		Y4543(10,236.47); Y5158(18.23)  LDD3495  [4]
BTD
 Probe Info  		C1332(1.34)  LDD2090  [5]
AHL-Pu-1
 Probe Info  		C2030(3.79); C4517(2.22); C449(2.28); C4409(2.17)  LDD0168  [6]
DBIA
 Probe Info  		C1394(1.19); C4041(1.15); C1332(1.15); C1011(1.10)  LDD0078  [7]
ATP probe
 Probe Info  		K3250(0.00); K2796(0.00); K2797(0.00); K478(0.00)  LDD0199  [8]
N1
 Probe Info  		S3271(0.00); S3272(0.00)  LDD0245  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1839(0.00); C554(0.00); C3195(0.00); C1545(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C882(0.00); C1011(0.00)  LDD0032  [11]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [12]
Lodoacetamide azide
 Probe Info  		C1839(0.00); C4517(0.00); C1394(0.00); C3195(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [13]
TFBX
 Probe Info  		C5328(0.00); C309(0.00); C979(0.00); C271(0.00)  LDD0027  [13]
WYneN
 Probe Info  		N.A.  LDD0021  [14]
ENE
 Probe Info  		C2158(0.00); C3985(0.00)  LDD0006  [14]
IPM
 Probe Info  		C2784(0.00); C3308(0.00); C3195(0.00); C1332(0.00)  LDD0005  [14]
NHS
 Probe Info  		N.A.  LDD0010  [14]
STPyne
 Probe Info  		K1683(0.00); K1768(0.00); K2825(0.00)  LDD0009  [14]
VSF
 Probe Info  		C1332(0.00); C3308(0.00); C57(0.00); C3985(0.00)  LDD0007  [14]
YN-1
 Probe Info  		N.A.  LDD0447  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		C4517(0.00); C1011(0.00); C271(0.00); C3308(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		C979(0.00); C4517(0.00)  LDD0219  [17]
Methacrolein
 Probe Info  		C4517(0.00); C1867(0.00); C3512(0.00); C4192(0.00)  LDD0218  [17]
W1
 Probe Info  		C979(0.00); C1545(0.00); C1867(0.00); C1394(0.00)  LDD0236  [18]
AOyne
 Probe Info  		10.00  LDD0443  [19]
NAIA_5
 Probe Info  		C579(0.00); C3460(0.00); C1545(0.00)  LDD2223  [20]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C431
 Probe Info  		14.62  LDD2086  [21]
STS-2
 Probe Info  		N.A.  LDD0139  [22]
VE-P
 Probe Info  		N.A.  LDD0396  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1598(0.81)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1598(0.87); C3985(0.59)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C2030(3.79); C4517(2.22); C449(2.28); C4409(2.17)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C4517(3.60); C449(2.26); C3308(2.23); C271(3.78)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C4041(1.47); C1011(1.08); C1236(0.94); C1243(0.94)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C1011(1.17); C1236(0.86); C1243(0.86); C1332(0.92)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C1011(0.97); C1236(0.76); C1243(0.76); C1332(1.19)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C1011(1.05); C1236(0.65); C1243(0.65); C1332(1.23)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C1011(1.01); C1236(0.72); C1243(0.72); C1332(1.12)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C1011(1.21); C1236(0.56); C1243(0.56); C1332(1.34)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C1011(1.05); C1236(0.65); C1243(0.65); C1332(1.02)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C1011(1.07); C1236(0.63); C1243(0.63); C1332(1.22)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C1011(1.10); C1236(0.63); C1243(0.63); C1332(1.27)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C1011(1.07); C1236(0.58); C1243(0.58); C1332(1.20)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C1011(0.89); C1236(0.85); C1243(0.76); C1332(1.27)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C1011(0.86); C1236(0.75); C1243(0.78); C1332(1.08)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C1011(1.16); C1236(0.81); C1243(0.81); C1332(1.36)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C1011(0.88); C1236(0.72); C1243(0.72); C1332(1.22)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C1011(0.93); C1236(0.72); C1243(0.77); C1332(1.25)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C1011(1.08); C1236(0.55); C1243(0.56); C1332(1.29)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C1011(0.87); C1122(0.89); C1236(0.91); C1243(0.91)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C1011(1.07); C1122(0.81); C1236(0.87); C1243(0.85)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C1011(1.04); C1122(0.71); C1236(0.77); C1243(0.76)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C1011(1.02); C1122(0.81); C1236(0.76); C1243(0.74)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C1011(1.16); C1122(0.81); C1236(0.85); C1243(0.84)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C1011(1.14); C1122(0.91); C1236(0.94); C1243(0.93)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C1011(1.05); C1122(0.81); C1236(0.85); C1243(0.81)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C1011(0.94); C1236(0.95); C1243(0.95); C1332(0.96)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C1011(1.07); C1122(1.24); C1236(0.80); C1243(0.80)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C1011(1.29); C1122(0.79); C1236(1.02); C1243(1.00)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C1011(1.07); C1122(0.84); C1236(0.94); C1243(0.98)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C1011(1.95); C1122(0.95); C1236(1.05); C1243(0.99)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C1011(1.10); C1122(0.69); C1236(1.04); C1243(1.03)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C1011(0.93); C1122(0.88); C1236(0.99); C1243(1.04)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C1011(1.05); C1122(0.63); C1236(0.91); C1243(0.92)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C1011(1.16); C1122(0.67); C1236(0.91); C1243(0.89)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C1011(1.28); C1122(0.87); C1236(1.31); C1243(1.31)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C1011(0.88); C1122(0.67); C1236(1.36); C1243(1.36)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C1011(1.09); C1122(0.68); C1236(1.07); C1243(1.07)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C1011(0.96); C1122(0.67); C1236(1.12); C1243(1.12)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C1011(1.07); C1122(0.60); C1236(1.16); C1243(1.16)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C1011(1.14); C1122(0.82); C1236(1.11); C1243(1.11)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C1011(1.24); C1122(0.72); C1236(0.98); C1243(0.98)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C1011(1.13); C1122(0.91); C1236(1.07); C1243(1.07)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C1011(1.22); C1122(0.82); C1236(0.95); C1243(0.95)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C1011(1.15); C1122(0.87); C1236(1.27); C1243(1.27)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C1011(1.32); C1122(0.64); C1236(1.05); C1243(1.05)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C1011(1.16); C1122(0.74); C1236(1.12); C1243(1.12)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C1011(1.07); C1236(0.86); C1243(0.86); C1332(0.99)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C1011(1.36); C1122(0.64); C1236(1.13); C1243(1.13)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C1011(1.36); C1122(0.81); C1236(1.05); C1243(1.05)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C1011(1.01); C1122(1.03); C1236(1.23); C1243(1.23)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C4345(0.61); C4371(0.61); C4068(0.65); C172(0.73)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C882(0.55); C172(0.61); C1545(0.67); C4345(0.75)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C449(0.65); C882(0.65); C172(0.70); C4192(0.84)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C882(0.63); C172(0.64); C4345(0.68); C4371(0.68)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C882(0.56); C4345(0.60); C4371(0.60); C172(0.61)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C3263(0.44); C882(0.55); C1545(0.72); C172(0.73)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C882(0.56); C3263(0.58); C449(0.61); C1545(0.71)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C4345(0.70); C3308(0.70); C449(0.73); C4371(0.73)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C882(0.68); C172(0.74); C4345(0.84); C4371(0.84)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C882(0.71); C991(0.74); C172(0.76); C4345(0.80)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C882(0.56); C449(0.60); C172(0.69); C1545(0.79)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C3263(0.52); C882(0.54); C1545(0.74); C1236(0.79)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C1011(1.15); C1236(1.21); C1243(1.16); C1332(1.03)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C1011(1.09); C1236(1.01); C1243(1.01); C1332(1.10)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C1011(1.05); C1236(0.94); C1243(0.89); C1332(1.08)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C1011(0.96); C1236(1.03); C1243(1.03); C1332(1.00)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C3818(0.68); C2954(0.86); C4068(0.88); C4604(0.88)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C2247(0.68); C3818(0.69); C1236(0.78); C1243(0.78)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C2247(0.57); C3070(0.82); C1236(0.83); C1243(0.83)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C3985(0.66); C4345(0.79); C4371(0.79); C3308(0.85)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C2247(0.55); C57(0.85); C3985(0.86); C4604(0.87)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C2247(0.56); C3818(0.70); C2954(0.80); C271(0.90)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C2247(0.44); C3985(0.80); C271(0.90); C57(0.91)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C2247(0.61); C3818(0.76); C3070(0.80); C3985(0.85)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C2247(0.55); C449(0.81); C3818(0.81); C3985(0.83)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C4604(0.66); C4345(0.67); C4371(0.67); C2954(0.69)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C4345(0.60); C4371(0.60); C4604(0.63); C1236(0.77)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C4345(0.56); C4371(0.56); C1236(0.72); C1243(0.72)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C4604(0.38); C4345(0.59); C4371(0.59); C1236(0.69)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C4345(0.68); C4371(0.68); C1236(0.70); C1243(0.70)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C3985(0.67); C4345(0.80); C4371(0.80); C3308(0.83)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C1236(0.67); C1243(0.67); C4345(0.70); C4371(0.70)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C4345(0.56); C4371(0.56); C4604(0.61); C1236(0.75)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C4345(0.52); C4371(0.52); C4604(0.55); C1236(0.56)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C4345(0.48); C4371(0.48); C1236(0.59); C1243(0.59)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C2954(0.50); C1236(0.58); C1243(0.58); C4345(0.59)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C1867(0.74); C271(0.80); C1011(0.84); C43(0.85)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C4345(0.67); C4371(0.67); C271(0.78); C2954(0.81)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C1867(0.72); C43(0.74); C4345(0.77); C4371(0.77)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C4345(0.74); C4371(0.74); C3985(0.82); C1867(0.83)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C1867(0.60); C4345(0.65); C4371(0.65); C882(0.81)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C4345(0.73); C4371(0.73); C3308(0.82); C4068(0.83)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C1867(0.46); C3985(0.96); C882(0.96); C1236(0.97)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C4345(0.69); C4371(0.69); C755(0.83); C3985(0.85)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C4345(0.70); C4371(0.70); C3985(0.82); C755(0.82)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C4345(0.73); C4371(0.73); C3985(0.78); C1867(0.87)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C4345(0.67); C4371(0.67); C449(0.84); C1867(0.85)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C1867(0.68); C755(0.72); C4345(0.73); C4371(0.73)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C755(0.55); C3069(0.71); C3070(0.71); C3985(0.88)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C755(0.60); C3069(0.70); C3070(0.70); C3985(0.86)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C755(0.68); C3069(0.80); C3070(0.80); C4192(0.81)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C755(0.62); C3985(0.65); C309(0.79); C882(0.86)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C4345(0.70); C4371(0.70); C3308(0.80); C3985(0.86)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C3985(0.56); C755(0.64); C3069(0.79); C3070(0.79)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C3985(0.57); C755(0.80); C95(0.82); C2890(0.86)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C755(0.60); C3985(0.63); C1011(0.80); C95(0.81)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C3985(0.55); C755(0.60); C3069(0.78); C3070(0.78)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C3985(0.59); C755(0.73); C3069(0.78); C3070(0.78)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C3985(0.66); C95(0.81); C755(0.88); C3308(0.91)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C3985(0.57); C755(0.64); C882(0.93); C95(0.98)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C1400(0.66); C1545(0.73); C1236(0.80); C1243(0.80)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C1400(0.73); C1236(0.77); C1243(0.77); C1545(0.77)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C1400(0.59); C1545(0.69); C1236(0.74); C1243(0.74)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C4371(0.68); C4345(0.72); C1236(0.75); C1243(0.75)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C1400(0.60); C4068(0.70); C882(0.72); C1236(0.81)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C1400(0.75); C882(0.77); C1545(0.77); C3985(0.82)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C882(0.68); C1545(0.78); C1236(0.80); C1243(0.80)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C4068(0.63); C882(0.66); C1400(0.68); C1236(0.84)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C4068(0.62); C1400(0.70); C1545(0.71); C882(0.74)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C1400(0.80); C2890(0.83); C1545(0.86); C1236(0.86)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C1400(0.78); C2890(0.83); C1545(0.85); C1236(0.87)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C1400(0.71); C882(0.72); C1545(0.79); C3069(0.81)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C1011(0.79); C2890(0.80); C3818(0.81); C449(0.82)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C4409(0.76); C57(0.76); C449(0.77); C1011(0.77)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C4371(0.63); C4345(0.64); C882(0.77); C755(0.84)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C755(0.68); C1545(0.81); C882(0.81); C4604(0.87)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C1011(0.67); C4409(0.71); C1358(0.85); C2890(0.85)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C4409(0.87); C2890(0.87); C1545(0.87); C755(0.88)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C3985(0.85); C4409(0.94); C1011(0.94); C755(0.97)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C1011(0.69); C4409(0.78); C57(0.83); C2890(0.84)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C3985(0.79); C2890(0.88); C57(0.92); C4409(0.93)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C1011(0.66); C4409(0.71); C755(0.78); C3985(0.87)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C3985(0.64); C449(0.75); C2890(0.78); C755(0.80)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C3985(0.67); C1011(0.68); C4409(0.83); C2890(0.83)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C3985(0.66); C57(0.84); C755(0.86); C4409(0.88)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C4371(0.69); C882(0.70); C1545(0.73); C4345(0.76)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C1011(0.69); C3985(0.76); C4409(0.77); C755(0.79)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C172(0.34); C612(0.72); C3985(0.72); C4409(0.75)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C1011(0.69); C3985(0.72); C4409(0.81); C2890(0.91)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C1236(0.68); C1243(0.68); C1545(0.83); C4517(0.84)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C1236(0.65); C1243(0.65); C755(0.71); C3818(0.81)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C1236(0.70); C1243(0.70); C4259(0.74); C755(0.75)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C1236(0.69); C1243(0.69); C95(0.83); C1545(0.85)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C1867(0.59); C755(0.79); C309(0.81); C3263(0.81)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C1867(0.54); C755(0.77); C4259(0.83); C1236(0.85)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C1867(0.65); C1236(0.68); C1243(0.68); C755(0.75)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C1867(0.67); C3985(0.82); C755(0.83); C95(0.88)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C3818(0.70); C1236(0.71); C1243(0.71); C755(0.82)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C1236(0.71); C1243(0.71); C95(0.76); C3818(0.78)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C755(0.73); C1236(0.74); C1243(0.74); C95(0.74)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C3818(0.60); C755(0.65); C1867(0.71); C4259(0.73)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1867(0.55); C3818(0.74); C3985(0.77); C755(0.83)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C1867(0.68); C3818(0.71); C95(0.77); C1236(0.79)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C1236(0.58); C1243(0.58); C755(0.62); C3818(0.67)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C4345(0.50); C4371(0.50); C1236(0.59); C1243(0.59)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C4345(0.69); C4371(0.69); C1236(0.76); C1243(0.76)  LDD0683  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C1598(0.70)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C1011(1.01); C1236(1.00); C1243(1.00); C1332(1.00)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C4371(0.58); C4345(0.60); C882(0.70); C3308(0.78)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C1236(0.67); C1243(0.67); C755(0.67); C4371(0.73)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C1394(1.19); C4041(1.15); C1332(1.15); C1011(1.10)  LDD0078  [7]
 LDCM0102  BDHI 8 Jurkat C57(23.74)  LDD0204  [24]
 LDCM0108  Chloroacetamide HeLa C882(0.00); C1011(0.00); C4259(0.00); C1867(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C3308(1.41); C309(0.32)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C4604(0.68); C3069(0.75); C3070(0.75); C43(0.80)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C4604(0.63); C1236(0.84); C1243(0.84); C3069(0.85)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C3985(0.66); C1236(0.81); C1243(0.81); C4345(0.81)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C4371(0.62); C4345(0.64); C882(0.64); C1236(0.73)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C4371(0.60); C4345(0.66); C882(0.76); C3308(0.79)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C882(0.70); C3308(0.74); C3069(0.76); C4371(0.80)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C882(0.69); C3308(0.74); C449(0.76); C1236(0.79)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C2247(0.53); C3818(0.74); C1236(0.81); C1243(0.81)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C2247(0.61); C1545(0.88); C4259(0.89); C1236(0.91)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C2247(0.49); C1236(0.77); C1243(0.77); C1545(0.78)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C2247(0.52); C1236(0.77); C1243(0.77); C1545(0.85)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C2247(0.53); C1236(0.77); C1243(0.77); C1545(0.84)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C3985(0.78); C755(0.83); C1236(0.86); C1243(0.86)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C4259(0.77); C1236(0.83); C1243(0.83); C1545(0.87)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C2247(0.61); C4259(0.76); C3818(0.81); C57(0.82)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C4345(0.55); C4371(0.55); C4604(0.69); C1236(0.74)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C4345(0.53); C4371(0.53); C1236(0.57); C1243(0.57)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C4345(0.67); C4371(0.67); C882(0.72); C1236(0.75)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C4345(0.63); C4371(0.63); C1236(0.66); C1243(0.66)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C4345(0.46); C4371(0.46); C2954(0.72); C4604(0.74)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C1867(0.45); C4345(0.88); C4371(0.88); C755(0.93)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C4345(0.70); C4371(0.70); C1867(0.71); C755(0.79)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C3985(0.78); C882(0.86); C1122(0.91); C1236(0.93)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C3069(0.80); C3070(0.80); C755(0.81); C3985(0.82)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C1867(0.74); C4345(0.77); C4371(0.77); C3985(0.79)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C43(0.42); C4371(0.58); C979(0.72); C4192(0.73)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C3985(0.66); C755(0.81); C309(0.87); C95(0.87)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C755(0.57); C3985(0.80); C882(0.84); C3069(0.88)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C3985(0.54); C755(0.68); C3069(0.74); C3070(0.74)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C4068(0.52); C3818(0.88); C1545(0.89); C3985(0.90)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C1400(0.74); C882(0.80); C4068(0.81); C1545(0.84)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C4068(0.70); C755(0.80); C1400(0.82); C1545(0.83)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C1400(0.57); C1545(0.71); C1236(0.75); C1243(0.75)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C3985(0.74); C2890(0.80); C1236(0.80); C1243(0.80)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C4604(0.70); C612(0.74); C3985(0.83); C1236(0.85)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C4604(0.76); C4345(0.81); C4371(0.81); C3069(0.83)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C4345(0.70); C4371(0.70); C3263(0.73); C4517(0.74)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C4345(0.62); C4371(0.62); C4604(0.69); C3263(0.73)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C4345(0.60); C4371(0.60); C4604(0.61); C882(0.63)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C3263(0.71); C882(0.73); C4345(0.75); C4371(0.75)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C3069(0.65); C3070(0.65); C612(0.79); C4068(0.81)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C1236(0.63); C1243(0.63); C4345(0.65); C4371(0.65)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C4604(0.62); C882(0.72); C1545(0.73); C4068(0.73)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C882(0.84); C1545(0.85); C1236(0.90); C1243(0.90)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C1236(0.68); C1243(0.68); C1545(0.70); C882(0.73)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C882(0.61); C4345(0.74); C4371(0.74); C1545(0.77)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C1011(1.11); C1236(0.82); C1243(0.82); C1332(1.35)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C1011(1.06); C1236(0.78); C1243(0.78); C1332(1.12)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C1011(1.03); C1236(0.72); C1243(0.72); C1332(1.00)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C1011(1.17); C1236(0.74); C1243(0.74); C1332(1.22)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C1011(1.15); C1236(0.69); C1243(0.69); C1332(1.14)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C4041(1.04); C1011(0.98); C1236(0.94); C1243(0.94)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C1011(1.00); C1236(0.91); C1243(0.91); C1332(1.03)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C1011(0.98); C1236(0.90); C1243(0.90); C1332(1.26)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C1011(1.27); C1236(0.81); C1243(0.81); C1332(1.35)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C1011(1.48); C1236(0.83); C1243(0.83); C1332(1.53)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C1011(1.05); C1236(0.76); C1243(0.76); C1332(1.52)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C1011(0.92); C1236(0.69); C1243(0.69); C1332(1.37)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C1011(1.06); C1236(0.77); C1243(0.77); C1332(1.40)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C1011(1.01); C1236(0.80); C1243(0.80); C1332(1.52)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C1011(1.04); C1236(0.82); C1243(0.82); C1332(1.71)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C4041(1.16); C1011(1.27); C1236(0.88); C1243(0.88)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C1011(1.07); C1236(0.75); C1243(0.75); C1332(1.62)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C1011(1.16); C1236(0.74); C1243(0.74); C1332(1.40)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C1011(1.08); C1236(0.93); C1243(0.93); C1332(2.07)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C1011(0.97); C1236(0.80); C1243(0.80); C1332(1.42)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C1011(0.87); C1236(0.86); C1243(0.86); C1332(1.50)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C1011(0.86); C1236(0.85); C1243(0.85); C1332(1.70)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C4041(0.73); C1011(0.76); C1122(1.06); C1236(0.96)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C4041(0.87); C1011(0.78); C1122(1.06); C1236(0.97)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C4041(1.18); C1011(0.81); C1122(1.14); C1236(1.12)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C4041(1.00); C1011(0.81); C1122(1.26); C1236(0.97)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C4041(0.99); C1011(0.85); C1236(0.83); C1243(0.83)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C4041(0.87); C1011(0.74); C1122(1.12); C1236(1.07)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C4041(0.88); C1011(0.70); C1122(0.89); C1236(1.07)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C4041(0.72); C1011(0.90); C1122(1.21); C1236(0.86)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C4041(0.95); C1011(0.89); C1122(1.44); C1236(0.97)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C4041(0.66); C1011(0.71); C1122(1.12); C1236(0.96)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C4041(0.78); C1011(0.64); C1122(1.19); C1236(1.03)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C4041(0.81); C1011(0.78); C1122(1.25); C1236(0.97)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C4041(0.98); C1011(0.75); C1122(1.23); C1236(0.94)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C4041(0.83); C1011(0.85); C1122(1.01); C1236(1.02)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C4041(1.29); C1011(0.74); C1122(1.04); C1236(1.04)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C4041(1.24); C1011(0.98); C1236(0.88); C1243(0.88)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C4041(0.98); C1011(0.74); C1122(0.87); C1236(0.97)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C4041(1.21); C1011(1.08); C1236(0.74); C1243(0.74)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C4041(1.23); C1011(1.18); C1236(0.75); C1243(0.75)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C4041(1.32); C1011(1.24); C1236(0.64); C1243(0.64)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C4041(2.16); C1011(1.31); C1236(0.65); C1243(0.65)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C4041(1.37); C1011(1.18); C1236(0.83); C1243(0.83)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C4041(2.15); C1011(1.62); C1236(0.68); C1243(0.68)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C4041(1.47); C1011(1.50); C1236(0.71); C1243(0.71)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C4041(1.68); C1011(1.30); C1236(0.69); C1243(0.69)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C4041(1.28); C1011(1.14); C1236(0.71); C1243(0.71)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C4041(1.48); C1011(0.86); C1236(0.86); C1243(0.86)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C4041(1.23); C1011(1.17); C1236(0.77); C1243(0.77)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C4041(1.51); C1011(1.32); C1236(0.70); C1243(0.70)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C4041(1.09); C1011(1.17); C1236(0.71); C1243(0.71)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C4041(1.76); C1011(1.27); C1236(0.67); C1243(0.67)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C4041(1.46); C1011(1.29); C1236(0.67); C1243(0.67)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C4041(1.18); C1011(1.14); C1236(0.99); C1243(0.99)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C4041(1.40); C1011(1.08); C1236(0.94); C1243(0.94)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C4041(1.23); C1011(1.08); C1236(0.84); C1243(0.84)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C4041(1.72); C1011(1.36); C1236(0.75); C1243(0.75)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C4041(3.10); C1011(1.22); C1236(0.85); C1243(0.85)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C4041(1.06); C1011(1.18); C1236(0.96); C1243(0.96)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C4041(1.35); C1011(1.15); C1236(0.86); C1243(0.86)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C4041(1.98); C1011(1.46); C1236(0.86); C1243(0.86)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C4041(1.98); C1011(1.38); C1236(0.82); C1243(0.82)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C4041(2.39); C1011(1.78); C1236(0.97); C1243(0.97)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C4041(1.44); C1011(1.20); C1236(0.80); C1243(0.80)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C4041(1.25); C1011(1.02); C1236(0.90); C1243(0.90)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C4041(1.57); C1011(1.12); C1236(0.78); C1243(0.78)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C4041(1.74); C1011(1.33); C1236(0.78); C1243(0.78)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C4041(3.20); C1011(1.96); C1236(1.05); C1243(1.05)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C4041(1.48); C1011(0.99); C1236(0.71); C1243(0.71)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C4041(2.75); C1011(1.10); C1236(1.13); C1243(1.13)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C4041(2.04); C1011(1.15); C1236(1.05); C1243(1.05)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C4041(2.44); C1011(1.05); C1236(1.08); C1243(1.08)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C4041(2.33); C1011(0.98); C1236(1.12); C1243(1.12)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C4041(2.52); C1011(1.11); C1236(0.85); C1243(0.85)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C4041(3.26); C1011(1.17); C1236(0.99); C1243(0.99)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C4041(2.36); C1011(1.04); C1236(0.90); C1243(0.90)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C4041(2.09); C1011(1.16); C1236(0.92); C1243(0.92)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C4041(2.54); C1011(1.26); C1236(0.78); C1243(0.78)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C4041(2.26); C1011(1.16); C1236(0.82); C1243(0.82)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C979(0.60)  LDD2228  [20]
 LDCM0495  E2913 HEK-293T C521(1.09); C979(0.87); C95(0.84); C1567(0.92)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C3512(10.30); C3308(7.57); C2030(6.03); C3985(5.91)  LDD1702  [5]
 LDCM0625  F8 Ramos C95(0.78); C1332(1.08); C2816(0.90); C882(1.14)  LDD2187  [26]
 LDCM0573  Fragment11 Ramos C95(2.21); C2816(3.20); C4259(2.89); C1394(0.50)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C4259(0.70)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C2816(0.59); C4259(0.49); C1394(0.79)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C1332(1.56); C882(2.04); C1394(1.28)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C4259(0.63)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C95(1.45); C1332(1.34); C2816(0.72); C4259(0.57)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C1332(0.88); C4259(1.03); C1394(1.01)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C95(0.92); C2816(0.63); C4259(0.91)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C95(1.07); C1332(1.13); C2816(1.26); C4259(0.69)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C95(1.27); C1332(1.50); C2816(0.78); C4259(0.74)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C95(1.08); C1332(0.70); C2816(0.88); C4259(1.14)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C2816(1.70); C4259(0.55)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C4041(1.62); C1011(1.23); C1236(0.68); C1243(0.68)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C95(1.50); C1332(0.83); C2816(0.62); C4259(0.84)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C1332(1.21); C1394(1.64)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C1011(1.00); C1236(0.86); C1243(0.86); C1332(1.64)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C2816(0.46); C4259(0.67); C1394(0.42)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C1332(0.63); C2816(0.58); C4259(0.98); C1394(0.89)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C2816(1.76); C4259(0.74); C882(1.23); C1394(1.11)  LDD2186  [26]
 LDCM0022  KB02 HCT 116 C1358(8.65); C2890(1.95); C2954(5.88); C57(2.71)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C1358(10.34); C2890(12.05); C2954(20.00); C57(6.55)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C1358(8.71); C2890(8.11); C2954(3.49); C57(2.81)  LDD0082  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1332(1.34)  LDD2090  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1598(0.72)  LDD2093  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1598(0.77)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1598(1.53); C3985(0.48); C2192(1.16); C1332(0.84)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C1598(0.42)  LDD2101  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C3985(1.07)  LDD2104  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1598(0.88); C1332(0.52); C2030(1.40)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1598(0.89); C2192(0.49)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1598(0.98); C2192(1.12)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1332(0.85)  LDD2114  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1598(0.20)  LDD2115  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1598(0.62); C2192(0.76)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1567(1.09)  LDD2127  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1598(0.35)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1598(0.86)  LDD2134  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1567(1.36)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C2192(0.65); C1332(1.17)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C2192(0.65)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1598(1.26); C1567(1.13)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1598(1.03); C1567(2.37); C1332(0.58)  LDD2146  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C979(0.22)  LDD2207  [27]
 LDCM0021  THZ1 HCT 116 C1867(1.96); C309(1.01); C979(1.15); C3308(0.93)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proline-, glutamic acid- and leucine-rich protein 1 (PELP1) RIX1/PELP1 family Q8IZL8

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
24 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.