Details of the Target

General Information of Target

Target ID LDTP10279
Target Name Dysbindin (DTNBP1)
Gene Name DTNBP1
Gene ID 84062
Synonyms
BLOC1S8; Dysbindin; Biogenesis of lysosome-related organelles complex 1 subunit 8; BLOC-1 subunit 8; Dysbindin-1; Dystrobrevin-binding protein 1; Hermansky-Pudlak syndrome 7 protein; HPS7 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSESSSFLKGVMLGSIFCALITMLGHIRIGHGNRMHHHEHHHLQAPNKEDILKISEDER
MELSKSFRVYCIILVKPKDVSLWAAVKETWTKHCDKAEFFSSENVKVFESINMDTNDMWL
MMRKAYKYAFDKYRDQYNWFFLARPTTFAIIENLKYFLLKKDPSQPFYLGHTIKSGDLEY
VGMEGGIVLSVESMKRLNSLLNIPEKCPEQGGMIWKISEDKQLAVCLKYAGVFAENAEDA
DGKDVFNTKSVGLSIKEAMTYHPNQVVEGCCSDMAVTFNGLTPNQMHVMMYGVYRLRAFG
HIFNDALVFLPPNGSDND
Target Bioclass
Other
Family
Dysbindin family
Subcellular location
Cytoplasm
Function
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.
Uniprot ID
Q96EV8
Ensemble ID
ENST00000338950.9
HGNC ID
HGNC:17328

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CMK Substitution: p.P105L DBIA    Probe Info 
DU145 SNV: p.Q151L DBIA    Probe Info 
HT115 SNV: p.K91N DBIA    Probe Info 
MFE319 Deletion: p.N161IfsTer13 DBIA    Probe Info 
NB1 SNV: p.K191N DBIA    Probe Info 
NCIH1975 SNV: p.M150I DBIA    Probe Info 
RL SNV: p.V181G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C302(0.69)  LDD1700  [2]
AHL-Pu-1
 Probe Info  		C302(2.79)  LDD0168  [3]
DBIA
 Probe Info  		C302(0.94)  LDD0531  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
ENE
 Probe Info  		N.A.  LDD0006  [9]
IPM
 Probe Info  		N.A.  LDD0005  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
NAIA_5
 Probe Info  		C69(0.00); C302(0.00); C147(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C431
 Probe Info  		14.32  LDD2086  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C302(1.32)  LDD2152  [2]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C302(0.45)  LDD2103  [2]
 LDCM0025  4SU-RNA HEK-293T C302(2.79)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C302(11.04)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C302(0.94)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C302(1.32)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C302(1.13)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C302(1.07)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C302(1.04)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C302(1.16)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C302(0.75)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C302(0.91)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C302(0.97)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C302(0.83)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C302(0.93)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C302(0.80)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C302(1.27)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C302(0.95)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C302(0.94)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C302(1.22)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C302(1.00)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C302(1.04)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C302(1.01)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C302(1.00)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C302(1.01)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C302(0.97)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C302(0.92)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C302(1.13)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C302(1.00)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C302(0.91)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C302(1.11)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C302(0.96)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C302(0.89)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C302(0.94)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C302(0.96)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C302(1.16)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C302(0.70)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C302(0.66)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C302(0.78)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C302(0.79)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C302(0.77)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C302(0.73)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C302(0.89)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C302(0.86)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C302(0.75)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C302(0.81)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C302(1.16)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C302(1.11)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C302(1.40)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C302(1.42)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C302(1.17)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C302(0.90)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C302(1.01)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C302(1.23)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C302(0.90)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C302(1.08)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C302(1.00)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C302(1.17)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C302(1.33)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C302(1.33)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C302(1.34)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C302(1.17)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C302(1.04)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C302(1.45)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C302(1.00)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C302(1.71)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C302(0.84)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C302(1.02)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C302(0.84)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C302(0.93)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C302(0.92)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C302(0.87)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C302(1.11)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C302(1.08)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C302(1.12)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C302(1.10)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C302(0.81)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C302(1.08)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C302(1.08)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C302(0.99)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C302(1.22)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C302(1.14)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C302(0.88)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C302(1.10)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C302(1.04)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C302(1.11)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C302(1.21)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C302(1.39)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C302(0.90)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C302(0.90)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C302(0.84)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C302(0.74)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C302(0.73)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C302(0.80)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C302(1.03)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C302(0.90)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C302(0.79)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C302(0.88)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C302(0.84)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C302(1.22)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C302(1.52)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C302(1.45)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C302(1.14)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C302(1.53)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C302(0.85)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C302(1.35)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C302(1.33)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C302(1.03)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C302(1.38)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C302(1.49)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C302(1.89)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C302(3.38)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C302(0.80)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C302(0.93)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C302(0.94)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C302(1.30)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C302(1.03)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C302(0.82)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C302(0.78)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C302(0.67)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C302(0.70)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C302(0.69)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C302(0.63)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C302(0.65)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C302(1.09)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C302(1.24)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C302(1.28)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C302(1.14)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C302(1.15)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C302(1.18)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C302(1.51)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C302(1.57)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C302(1.73)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C302(1.37)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C302(1.46)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C302(1.15)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C302(1.04)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C302(1.36)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C302(1.30)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C302(1.10)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C302(1.83)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C302(1.20)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C302(1.17)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C302(1.27)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C302(1.08)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C302(1.09)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C302(1.29)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C302(1.16)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C302(1.17)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C302(1.11)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C302(1.43)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C302(1.41)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C302(1.22)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C302(1.39)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C302(1.07)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C302(1.62)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C302(1.47)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C302(1.28)  LDD0683  [4]
 LDCM0545  Acetamide MDA-MB-231 C302(0.32)  LDD2138  [2]
 LDCM0248  AKOS034007472 HCT 116 C302(0.99)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C302(1.05)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C302(2.01)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 10.28  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C302(1.16)  LDD2171  [4]
 LDCM0498  BS-3668 MDA-MB-231 C302(0.34)  LDD2091  [2]
 LDCM0632  CL-Sc Hep-G2 C147(1.97); C302(0.71); C302(0.55)  LDD2227  [7]
 LDCM0367  CL1 HCT 116 C302(1.09)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C302(0.79)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C302(0.88)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C302(1.21)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C302(1.18)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C302(1.25)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C302(1.11)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C302(0.96)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C302(0.97)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C302(1.09)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C302(0.86)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C302(1.10)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C302(0.77)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C302(1.09)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C302(1.04)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C302(0.83)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C302(1.41)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C302(1.07)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C302(1.15)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C302(1.00)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C302(1.21)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C302(0.96)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C302(0.81)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C302(0.93)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C302(0.98)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C302(1.02)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C302(1.09)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C302(1.43)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C302(1.59)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C302(1.25)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C302(0.87)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C302(1.19)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C302(0.93)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C302(0.84)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C302(0.84)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C302(0.79)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C302(0.82)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C302(0.92)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C302(1.06)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C302(1.04)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C302(1.14)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C302(1.01)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C302(1.52)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C302(1.55)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C302(0.75)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C302(1.12)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C302(1.00)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C302(1.02)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C302(0.86)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C302(1.09)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C302(1.03)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C302(0.84)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C302(0.85)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C302(1.03)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C302(0.99)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C302(1.07)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C302(1.24)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C302(1.28)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C302(1.25)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C302(1.22)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C302(1.12)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C302(0.91)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C302(1.33)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C302(0.97)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C302(1.59)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C302(1.32)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C302(1.18)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C302(1.41)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C302(0.95)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C302(1.09)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C302(1.02)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C302(0.93)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C302(0.70)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C302(0.96)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C302(1.00)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C302(1.24)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C302(1.03)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C302(1.17)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C302(1.21)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C302(1.17)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C302(1.06)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C302(1.14)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C302(1.03)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C302(0.80)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C302(1.04)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C302(0.92)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C302(0.98)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C302(1.07)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C302(1.05)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C302(0.91)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C302(1.26)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C302(1.09)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C302(0.90)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C302(0.91)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C302(0.71)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C302(1.10)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C302(0.95)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C302(1.04)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C302(1.22)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C302(1.07)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C302(0.97)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C302(1.11)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C302(1.21)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C302(0.90)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C302(0.87)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C302(0.98)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C302(1.00)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C302(0.87)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C302(1.09)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C302(1.21)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C302(1.24)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C302(1.15)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C302(1.03)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C302(1.03)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C302(1.01)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C302(0.99)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C302(1.10)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C302(0.96)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C302(0.90)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C302(0.80)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C302(0.74)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C302(0.83)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C302(0.83)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C302(0.95)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C302(0.93)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C302(0.92)  LDD0811  [4]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C302(1.18)  LDD1702  [2]
 LDCM0625  F8 Ramos C302(1.67); C147(0.85)  LDD2187  [13]
 LDCM0572  Fragment10 Ramos C302(1.24)  LDD2189  [13]
 LDCM0573  Fragment11 Ramos C302(0.53); C147(1.05)  LDD2190  [13]
 LDCM0574  Fragment12 Ramos C302(0.65)  LDD2191  [13]
 LDCM0575  Fragment13 Ramos C302(1.02)  LDD2192  [13]
 LDCM0576  Fragment14 Ramos C302(0.68); C147(0.71)  LDD2193  [13]
 LDCM0579  Fragment20 Ramos C302(0.63)  LDD2194  [13]
 LDCM0580  Fragment21 Ramos C302(0.86)  LDD2195  [13]
 LDCM0582  Fragment23 Ramos C302(1.50)  LDD2196  [13]
 LDCM0578  Fragment27 Ramos C302(1.41)  LDD2197  [13]
 LDCM0586  Fragment28 Ramos C302(0.71); C147(0.95)  LDD2198  [13]
 LDCM0588  Fragment30 Ramos C302(1.89)  LDD2199  [13]
 LDCM0589  Fragment31 Ramos C302(1.04)  LDD2200  [13]
 LDCM0590  Fragment32 Ramos C302(1.37)  LDD2201  [13]
 LDCM0468  Fragment33 HCT 116 C302(1.02)  LDD0785  [4]
 LDCM0596  Fragment38 Ramos C302(0.94)  LDD2203  [13]
 LDCM0566  Fragment4 Ramos C302(0.83); C147(0.98)  LDD2184  [13]
 LDCM0427  Fragment51 HCT 116 C302(1.56)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C302(1.63)  LDD2204  [13]
 LDCM0614  Fragment56 Ramos C302(1.67)  LDD2205  [13]
 LDCM0569  Fragment7 Ramos C302(0.79); C147(1.09)  LDD2186  [13]
 LDCM0571  Fragment9 Ramos C302(1.02)  LDD2188  [13]
 LDCM0022  KB02 HEK-293T C302(0.94)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C302(0.95)  LDD1497  [14]
 LDCM0024  KB05 G361 C302(1.21)  LDD3311  [15]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C302(0.58)  LDD2121  [2]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C302(0.56)  LDD2089  [2]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C302(0.96)  LDD2090  [2]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C302(0.85)  LDD2092  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C302(0.84)  LDD2093  [2]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C302(1.03)  LDD2094  [2]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C302(0.96)  LDD2096  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C302(0.83)  LDD2098  [2]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C302(1.41)  LDD2105  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C302(0.78)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C302(0.66)  LDD2111  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C302(1.05)  LDD2116  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C302(0.99)  LDD2118  [2]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C302(1.06)  LDD2120  [2]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C302(0.98)  LDD2122  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C302(1.04)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C302(0.46)  LDD2125  [2]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C302(0.88)  LDD2128  [2]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C302(0.53)  LDD2135  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C302(1.07)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C302(0.91)  LDD2137  [2]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C302(0.69)  LDD1700  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C302(0.67)  LDD2141  [2]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C302(1.11)  LDD2143  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C302(0.77)  LDD2146  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C302(1.20)  LDD2149  [2]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C302(1.47)  LDD2151  [2]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C302(1.29)  LDD2153  [2]
 LDCM0628  OTUB2-COV-1 HEK-293T C147(1.35)  LDD2207  [16]
 LDCM0021  THZ1 HCT 116 C302(1.16)  LDD2173  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dystrobrevin beta (DTNB) Dystrophin family O60941
Very long chain fatty acid elongase 7 (ELOVL7) ELO family A1L3X0
X-ray repair cross-complementing protein 5 (XRCC5) Ku80 family P13010
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (SSC5D) . A1L4H1
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
SNARE-associated protein Snapin (SNAPIN) SNAPIN family O95295
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5) BLOC1S5 family Q8TDH9
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) BLOC1S6 family Q9UL45
Protein BRICK1 (BRK1) BRK1 family Q8WUW1
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Protein Mis18-beta (OIP5) Mis18 family O43482
Shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL) SHFL family Q9NUL5
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Coiled-coil domain-containing protein 153 (CCDC153) UPF0610 family Q494R4
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
KAT8 regulatory NSL complex subunit 1 (KANSL1) . Q7Z3B3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
16 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.