Details of the Target

General Information of Target

Target ID LDTP13862
Target Name GDP-fucose protein O-fucosyltransferase 2 (POFUT2)
Gene Name POFUT2
Gene ID 23275
Synonyms
C21orf80; FUT13; KIAA0958; GDP-fucose protein O-fucosyltransferase 2; EC 2.4.1.221; Peptide-O-fucosyltransferase 2; O-FucT-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLF
EQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVN
GAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGE
TNLKTHVAVPETALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPE
SLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISE
AVISTILKYTWQAEEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVT
VEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFR
ECSINGMKYQEINGRLVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPENETE
LIKEHDLFFKAVSLCHTVQISNVQTDCTGDGPWQSNLAPSQLEYYASSPDEKALVEAAAR
IGIVFIGNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESS
ILPKCIGGEIEKTRIHVDEFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEK
LAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSC
GHFHRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLF
MEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMG
KEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYC
LFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKT
FLYWTILGFSHAFIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALE
THFWTWINHLVTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMV
VTCLFLDIIKKVFDRHLHPTSTEKAQLTETNAGIKCLDSMCCFPEGEAACASVGRMLERV
IGRCSPTHISRSWSASDPFYTNDRSILTLSTMDSSTC
Target Bioclass
Enzyme
Family
Glycosyltransferase 68 family
Subcellular location
Endoplasmic reticulum
Function
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively. O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm.
Uniprot ID
Q9Y2G5
Ensemble ID
ENST00000331343.11
HGNC ID
HGNC:14683

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K321(1.12)  LDD0277  [1]
DBIA
 Probe Info  		C419(1.71)  LDD3314  [2]
BTD
 Probe Info  		C419(0.98)  LDD2099  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C419(0.00); C412(0.00)  LDD0036  [5]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		10.13  LDD1725  [6]
C313
 Probe Info  		12.13  LDD1980  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C419(1.05); C412(1.06); C161(0.69)  LDD1507  [7]
 LDCM0215  AC10 PaTu 8988t C412(0.63)  LDD1094  [8]
 LDCM0226  AC11 PaTu 8988t C412(0.40)  LDD1105  [8]
 LDCM0230  AC113 PaTu 8988t C412(1.27)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C412(0.98)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C412(0.94)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C412(1.08)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C412(1.11)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C412(1.09)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C412(0.81)  LDD1115  [8]
 LDCM0237  AC12 PaTu 8988t C412(0.69)  LDD1116  [8]
 LDCM0238  AC120 PaTu 8988t C412(0.72)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C412(0.54)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C412(1.03)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C412(0.95)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C412(0.61)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C412(0.87)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C412(1.16)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C412(0.81)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C412(1.35)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C412(0.90)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C412(1.11)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C412(0.94)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C412(1.10)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C412(0.52)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C412(0.61)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C412(0.63)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C412(0.62)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C412(0.62)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C412(1.00)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C412(0.91)  LDD1137  [8]
 LDCM0259  AC14 PaTu 8988t C412(0.49)  LDD1138  [8]
 LDCM0260  AC140 PaTu 8988t C412(1.04)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C412(1.38)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C412(0.92)  LDD1141  [8]
 LDCM0263  AC143 PaTu 8988t C412(0.89)  LDD1142  [8]
 LDCM0264  AC144 PaTu 8988t C412(1.09)  LDD1143  [8]
 LDCM0265  AC145 PaTu 8988t C412(0.79)  LDD1144  [8]
 LDCM0266  AC146 PaTu 8988t C412(1.05)  LDD1145  [8]
 LDCM0267  AC147 PaTu 8988t C412(0.77)  LDD1146  [8]
 LDCM0268  AC148 PaTu 8988t C412(0.74)  LDD1147  [8]
 LDCM0269  AC149 PaTu 8988t C412(0.73)  LDD1148  [8]
 LDCM0270  AC15 PaTu 8988t C412(0.59)  LDD1149  [8]
 LDCM0271  AC150 PaTu 8988t C412(0.69)  LDD1150  [8]
 LDCM0272  AC151 PaTu 8988t C412(0.40)  LDD1151  [8]
 LDCM0273  AC152 PaTu 8988t C412(0.74)  LDD1152  [8]
 LDCM0274  AC153 PaTu 8988t C412(0.43)  LDD1153  [8]
 LDCM0621  AC154 PaTu 8988t C412(0.42)  LDD2166  [8]
 LDCM0622  AC155 PaTu 8988t C412(0.52)  LDD2167  [8]
 LDCM0623  AC156 PaTu 8988t C412(1.00)  LDD2168  [8]
 LDCM0624  AC157 PaTu 8988t C412(0.52)  LDD2169  [8]
 LDCM0276  AC17 HEK-293T C419(0.91); C412(1.01); C161(0.84)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C419(1.15); C161(1.14)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C419(1.16); C412(1.13); C161(1.12)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C419(0.99); C161(1.03)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C419(1.00); C412(0.95)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C419(1.07)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C419(1.00); C161(0.97)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C419(0.94)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C419(1.01); C412(0.96)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C412(0.94)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C412(1.03)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C412(1.25)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C412(1.17)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C412(1.22)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C419(1.06); C412(0.96); C161(0.75)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C412(1.23)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C412(1.18)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C412(0.97)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C412(1.25)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C412(0.87)  LDD0893  [8]
 LDCM0296  AC35 HEK-293T C419(1.02); C412(1.01); C161(0.83)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C419(1.03); C412(1.05)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C419(1.03)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C419(1.09); C161(1.09)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C419(0.94)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C419(0.98); C412(1.01)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C419(1.01); C412(0.96)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C419(1.06); C412(1.19); C161(0.85)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C419(1.18); C161(1.04)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C419(1.06); C412(0.98); C161(0.88)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C419(1.05); C412(1.05)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C419(1.17)  LDD1546  [7]
 LDCM0308  AC46 PaTu 8988t C412(0.79)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C412(0.59)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C412(0.64)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C412(0.63)  LDD1190  [8]
 LDCM0312  AC5 HEK-293T C419(1.12)  LDD1551  [7]
 LDCM0313  AC50 PaTu 8988t C412(0.52)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C412(0.17)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C412(0.74)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C412(0.44)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C412(0.44)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C412(0.79)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C412(0.52)  LDD1198  [8]
 LDCM0320  AC57 HEK-293T C419(1.00); C412(1.10); C161(0.95)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C419(1.02); C161(1.07)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C419(0.98); C412(0.99); C161(0.93)  LDD1561  [7]
 LDCM0323  AC6 PaTu 8988t C412(0.89)  LDD1202  [8]
 LDCM0324  AC60 HEK-293T C419(0.98); C412(1.06)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C419(0.97)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C419(1.12); C161(1.04)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C419(0.89)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C419(1.08); C412(0.94)  LDD1567  [7]
 LDCM0332  AC68 HEK-293T C412(1.11)  LDD0930  [8]
 LDCM0333  AC69 HEK-293T C412(1.22)  LDD0931  [8]
 LDCM0334  AC7 PaTu 8988t C412(0.78)  LDD1213  [8]
 LDCM0335  AC70 HEK-293T C412(1.30)  LDD0933  [8]
 LDCM0336  AC71 HEK-293T C412(1.20)  LDD0934  [8]
 LDCM0337  AC72 HEK-293T C412(1.21)  LDD0935  [8]
 LDCM0338  AC73 HEK-293T C412(1.25)  LDD0936  [8]
 LDCM0339  AC74 HEK-293T C412(1.84)  LDD0937  [8]
 LDCM0340  AC75 HEK-293T C412(1.43)  LDD0938  [8]
 LDCM0341  AC76 HEK-293T C412(1.23)  LDD0939  [8]
 LDCM0342  AC77 HEK-293T C412(1.21)  LDD0940  [8]
 LDCM0343  AC78 HEK-293T C412(1.17)  LDD0941  [8]
 LDCM0344  AC79 HEK-293T C412(1.20)  LDD0942  [8]
 LDCM0345  AC8 PaTu 8988t C412(0.85)  LDD1224  [8]
 LDCM0346  AC80 HEK-293T C412(1.44)  LDD0944  [8]
 LDCM0347  AC81 HEK-293T C412(1.31)  LDD0945  [8]
 LDCM0348  AC82 HEK-293T C412(1.83)  LDD0946  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C412(0.48)  LDD1127  [8]
 LDCM0356  AKOS034007680 PaTu 8988t C412(0.78)  LDD1235  [8]
 LDCM0275  AKOS034007705 PaTu 8988t C412(0.63)  LDD1154  [8]
 LDCM0367  CL1 PaTu 8988t C412(0.88)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C412(0.47)  LDD1247  [8]
 LDCM0369  CL100 HEK-293T C419(0.93); C412(1.07); C161(0.93)  LDD1573  [7]
 LDCM0370  CL101 PaTu 8988t C412(0.73)  LDD1249  [8]
 LDCM0371  CL102 PaTu 8988t C412(0.65)  LDD1250  [8]
 LDCM0372  CL103 PaTu 8988t C412(0.43)  LDD1251  [8]
 LDCM0373  CL104 PaTu 8988t C412(0.73)  LDD1252  [8]
 LDCM0374  CL105 HEK-293T C419(0.96)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C419(0.92); C412(1.03); C161(0.96)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C412(1.22)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C419(1.02); C412(0.89); C161(0.98)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C419(1.03)  LDD1582  [7]
 LDCM0379  CL11 PaTu 8988t C412(0.84)  LDD1258  [8]
 LDCM0380  CL110 HEK-293T C419(0.84); C412(1.13); C161(1.62)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C412(1.08)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C412(1.12)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C412(0.94)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C412(1.32)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C412(1.07)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C412(1.22)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C419(0.98)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C419(1.12); C412(1.27); C161(0.93)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C412(1.07)  LDD1593  [7]
 LDCM0390  CL12 PaTu 8988t C412(0.78)  LDD1269  [8]
 LDCM0391  CL120 HEK-293T C419(1.01); C412(0.97); C161(1.02)  LDD1595  [7]
 LDCM0392  CL121 PaTu 8988t C412(0.82)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C412(0.78)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C412(0.68)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C412(0.57)  LDD1274  [8]
 LDCM0396  CL125 HEK-293T C419(0.91)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C419(0.97); C412(1.11); C161(0.91)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C412(1.17)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C419(0.94); C412(0.93); C161(1.06)  LDD1603  [7]
 LDCM0400  CL13 PaTu 8988t C412(0.43)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C412(0.38)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C412(0.64)  LDD1281  [8]
 LDCM0403  CL16 PaTu 8988t C412(0.84)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C412(0.76)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C412(0.54)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C412(0.50)  LDD1285  [8]
 LDCM0407  CL2 PaTu 8988t C412(0.70)  LDD1286  [8]
 LDCM0408  CL20 PaTu 8988t C412(0.58)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C412(0.51)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C412(0.47)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C412(0.62)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C412(1.09)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C412(0.90)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C412(0.49)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C412(0.68)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C412(0.56)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C412(0.56)  LDD1296  [8]
 LDCM0418  CL3 PaTu 8988t C412(1.00)  LDD1297  [8]
 LDCM0419  CL30 PaTu 8988t C412(0.95)  LDD1298  [8]
 LDCM0420  CL31 HEK-293T C419(0.91); C412(1.11); C161(0.96)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C419(1.06); C412(1.19)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C419(1.19)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C419(1.07); C161(1.21)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C419(0.93)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C419(0.96); C412(1.03)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C419(0.92)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C412(1.07)  LDD1632  [7]
 LDCM0429  CL4 PaTu 8988t C412(0.96)  LDD1308  [8]
 LDCM0430  CL40 HEK-293T C419(0.94); C412(1.04); C161(1.09)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C419(0.85); C412(1.09); C161(0.78)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C419(1.17); C161(1.07)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C419(0.97); C412(1.17); C161(1.13)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C419(1.05); C412(1.14)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C419(1.16)  LDD1639  [7]
 LDCM0436  CL46 PaTu 8988t C412(1.01)  LDD1315  [8]
 LDCM0437  CL47 PaTu 8988t C412(1.15)  LDD1316  [8]
 LDCM0438  CL48 PaTu 8988t C412(0.83)  LDD1317  [8]
 LDCM0439  CL49 PaTu 8988t C412(1.00)  LDD1318  [8]
 LDCM0440  CL5 PaTu 8988t C412(0.48)  LDD1319  [8]
 LDCM0441  CL50 PaTu 8988t C412(0.95)  LDD1320  [8]
 LDCM0442  CL51 PaTu 8988t C412(1.13)  LDD1321  [8]
 LDCM0443  CL52 PaTu 8988t C412(1.00)  LDD1322  [8]
 LDCM0444  CL53 PaTu 8988t C412(1.11)  LDD1323  [8]
 LDCM0445  CL54 PaTu 8988t C412(0.96)  LDD1324  [8]
 LDCM0446  CL55 PaTu 8988t C412(0.92)  LDD1325  [8]
 LDCM0447  CL56 PaTu 8988t C412(0.91)  LDD1326  [8]
 LDCM0448  CL57 PaTu 8988t C412(0.95)  LDD1327  [8]
 LDCM0449  CL58 PaTu 8988t C412(0.95)  LDD1328  [8]
 LDCM0450  CL59 PaTu 8988t C412(0.94)  LDD1329  [8]
 LDCM0451  CL6 PaTu 8988t C412(0.52)  LDD1330  [8]
 LDCM0452  CL60 PaTu 8988t C412(0.77)  LDD1331  [8]
 LDCM0453  CL61 HEK-293T C412(1.05)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C412(1.10)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C412(0.98)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C412(0.91)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C412(1.14)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C412(0.99)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C412(0.96)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C412(1.16)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C412(1.05)  LDD1059  [8]
 LDCM0462  CL7 PaTu 8988t C412(0.42)  LDD1341  [8]
 LDCM0463  CL70 HEK-293T C412(1.09)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C412(1.14)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C412(1.11)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C412(1.29)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C412(1.95)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C412(0.83)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C412(0.90)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C412(0.77)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C412(1.06)  LDD1070  [8]
 LDCM0473  CL8 PaTu 8988t C412(0.58)  LDD1352  [8]
 LDCM0474  CL80 HEK-293T C412(0.87)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C412(1.01)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C412(1.35)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C412(1.50)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C412(0.85)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C412(0.91)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C412(1.09)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C412(1.17)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C412(1.18)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C412(1.08)  LDD1081  [8]
 LDCM0484  CL9 PaTu 8988t C412(0.41)  LDD1363  [8]
 LDCM0485  CL90 HEK-293T C412(0.88)  LDD1083  [8]
 LDCM0486  CL91 HEK-293T C419(1.02); C412(1.11); C161(0.84)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C419(0.97); C412(0.94)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C419(1.04)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C419(1.18); C161(1.27)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C419(0.90)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C419(1.05); C412(1.03)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C419(1.12)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C419(0.95); C412(1.21); C161(1.17)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C412(1.00)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C412(1.17)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C412(1.60)  LDD1066  [8]
 LDCM0427  Fragment51 HEK-293T C419(0.94); C412(1.15); C161(0.91)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C412(1.11); C161(0.85)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C412(1.09); C161(1.13)  LDD1497  [7]
 LDCM0024  KB05 IGR37 C419(1.71)  LDD3314  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C419(0.98)  LDD2099  [3]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C419(0.93)  LDD2101  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C419(1.35)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C419(1.22)  LDD2109  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C419(0.67)  LDD2134  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C419(1.04)  LDD2137  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C419(0.61)  LDD2143  [3]

References

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Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.