Details of the Target

General Information of Target

Target ID LDTP05422
Target Name Copper-transporting ATPase 1 (ATP7A)
Gene Name ATP7A
Gene ID 538
Synonyms
MC1; MNK; Copper-transporting ATPase 1; EC 7.2.2.8; Copper pump 1; Menkes disease-associated protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDPSMGVNSVTISVEGMTCNSCVWTIEQQIGKVNGVHHIKVSLEEKNATIIYDPKLQTPK
TLQEAIDDMGFDAVIHNPDPLPVLTDTLFLTVTASLTLPWDHIQSTLLKTKGVTDIKIYP
QKRTVAVTIIPSIVNANQIKELVPELSLDTGTLEKKSGACEDHSMAQAGEVVLKMKVEGM
TCHSCTSTIEGKIGKLQGVQRIKVSLDNQEATIVYQPHLISVEEMKKQIEAMGFPAFVKK
QPKYLKLGAIDVERLKNTPVKSSEGSQQRSPSYTNDSTATFIIDGMHCKSCVSNIESTLS
ALQYVSSIVVSLENRSAIVKYNASSVTPESLRKAIEAVSPGLYRVSITSEVESTSNSPSS
SSLQKIPLNVVSQPLTQETVINIDGMTCNSCVQSIEGVISKKPGVKSIRVSLANSNGTVE
YDPLLTSPETLRGAIEDMGFDATLSDTNEPLVVIAQPSSEMPLLTSTNEFYTKGMTPVQD
KEEGKNSSKCYIQVTGMTCASCVANIERNLRREEGIYSILVALMAGKAEVRYNPAVIQPP
MIAEFIRELGFGATVIENADEGDGVLELVVRGMTCASCVHKIESSLTKHRGILYCSVALA
TNKAHIKYDPEIIGPRDIIHTIESLGFEASLVKKDRSASHLDHKREIRQWRRSFLVSLFF
CIPVMGLMIYMMVMDHHFATLHHNQNMSKEEMINLHSSMFLERQILPGLSVMNLLSFLLC
VPVQFFGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLIILLVAMYERAKVNPITF
FDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLDSDNILLSEEQVDVE
LVQRGDIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSL
LICATHVGADTTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVFVSIATLLVWIVIG
FLNFEIVETYFPGYNRSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGA
QNGILIKGGEPLEMAHKVKVVVFDKTGTITHGTPVVNQVKVLTESNRISHHKILAIVGTA
ESNSEHPLGTAITKYCKQELDTETLGTCIDFQVVPGCGISCKVTNIEGLLHKNNWNIEDN
NIKNASLVQIDASNEQSSTSSSMIIDAQISNALNAQQYKVLIGNREWMIRNGLVINNDVN
DFMTEHERKGRTAVLVAVDDELCGLIAIADTVKPEAELAIHILKSMGLEVVLMTGDNSKT
ARSIASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGT
GTDVAIEAADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFMPI
GLVLQPWMGSAAMAASSVSVVLSSLFLKLYRKPTYESYELPARSQIGQKSPSEISVHVGI
DDTSRNSPKLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPDKHSLLVGDFREDDDTAL
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type IB subfamily
Subcellular location
Cytoplasm, cytosol; Endoplasmic reticulum; Golgi apparatus, trans-Golgi network membrane
Function
ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis. Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway. Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions. May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3. In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis.
Uniprot ID
Q04656
Ensemble ID
ENST00000341514.11
HGNC ID
HGNC:869

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.E145Q .
AGS SNV: p.E1064D .
AN3CA Insertion: p.L566FfsTer16 .
CCK81 SNV: p.A522V .
HCC1395 SNV: p.D870H .
HCT15 SNV: p.L593P .
HEC1 SNV: p.E223D .
HEC1B SNV: p.E223D .
Ishikawa (Heraklio) 02 ER SNV: p.H799Q .
LS123 SNV: p.I133L .
MCC13 SNV: p.R1349K
Substitution: p.G1315K		 .
MCC26 SNV: p.E224K .
MOLM16 SNV: p.V252E .
NCIH1299 SNV: p.V1251F .
NCIH1993 SNV: p.D635A .
OCUM1 SNV: p.G572Ter .
OPM2 SNV: p.S1417I .
OZ SNV: p.L1222V .
RL952 SNV: p.R636Q .
SW1271 SNV: p.K109N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.60  LDD0318  [1]
STPyne
 Probe Info  		K1471(7.14)  LDD0277  [2]
DBIA
 Probe Info  		C241(2.85)  LDD3410  [3]
AHL-Pu-1
 Probe Info  		C160(4.56)  LDD0171  [4]
ATP probe
 Probe Info  		K1282(0.00); K1285(0.00); K156(0.00)  LDD0199  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [7]
IPM
 Probe Info  		C391(0.00); C160(0.00)  LDD2156  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C186
 Probe Info  		12.82  LDD1864  [10]
C201
 Probe Info  		27.67  LDD1877  [10]
C310
 Probe Info  		12.91  LDD1977  [10]
C390
 Probe Info  		20.68  LDD2049  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C388(4.79)  LDD0172  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C160(4.56)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C903(1.02)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C160(1.05); C903(1.03)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C160(1.04)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C903(1.10); C595(1.09)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C160(0.99); C903(1.16); C288(1.04)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C160(1.01); C903(1.10)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C903(1.25)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C160(0.99); C903(1.00)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C160(0.91)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C160(1.06); C903(1.21)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C903(0.95); C595(1.18)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C160(0.97); C288(1.14)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C160(0.96); C903(0.96); C288(1.01)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C160(0.99); C903(1.07)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C160(0.95)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C903(1.14)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C160(0.96); C903(1.04)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C160(1.00)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C903(1.01); C595(0.94)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C160(0.95); C288(0.92)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C160(0.97)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C160(0.95); C903(1.02); C288(1.02)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C160(1.08); C903(1.19)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C160(1.01)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C903(1.03)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C160(1.07); C903(0.92)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C160(1.04)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C903(1.10); C595(1.10)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C160(1.01); C288(1.02)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C160(0.94); C903(1.02); C288(1.00)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C160(1.11); C903(1.16)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C903(1.07); C595(1.10)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C160(1.03)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C903(1.01)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C160(1.19); C903(0.99)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C160(1.13)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C903(1.19); C595(1.03)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C160(1.04); C288(0.93)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C160(1.00); C903(1.09); C288(1.12)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C160(0.96); C903(0.99)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C160(1.05)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C903(1.13)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C160(1.05); C288(0.99)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C160(1.17); C903(1.13)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C160(1.02)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C903(1.04); C595(1.14)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C160(1.00); C288(1.00)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C160(1.00); C903(1.03); C288(1.04)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C160(0.99); C903(1.07)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C160(1.00)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C903(1.17)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C160(0.98); C903(1.02)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C160(0.96)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C160(1.09); C903(1.04); C288(1.07)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C903(1.10); C595(1.05)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C160(0.96); C288(0.99)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C160(1.04); C903(1.00); C288(1.04)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C160(1.02); C903(1.02)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C160(0.97)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C160(1.07); C903(1.15)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C160(0.99)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C160(0.96); C288(1.29)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C903(1.18)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C160(1.04)  LDD1514  [11]
 LDCM0367  CL1 HEK-293T C160(1.07); C903(1.12); C288(1.03)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C160(1.15); C903(0.91); C288(1.05)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C160(1.00)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C160(0.99); C903(1.11); C288(1.07)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C160(0.99)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C160(0.95); C903(1.14)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C160(1.06)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C160(1.03); C903(0.92); C288(1.05)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C160(0.92)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C160(1.11); C903(1.14)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C160(1.02)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C160(0.96); C903(1.06); C288(0.97)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C160(1.32); C903(1.07)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C160(0.91)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C160(1.05); C903(1.08)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C160(1.04)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C160(1.02); C903(1.15); C288(1.10)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C160(1.04)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C160(1.04); C903(1.07)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C160(1.03)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C160(1.05); C903(1.06); C288(0.98)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C160(0.93)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C160(1.12); C903(1.20)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C160(1.15)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C160(1.11)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C160(1.00); C903(1.05); C288(0.98)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C160(0.88)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C160(0.94); C903(1.05)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C160(1.00)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C160(0.94); C903(1.40); C288(1.15)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C160(0.97)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C160(1.02); C903(1.00)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C160(1.05)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C160(1.28); C903(1.07); C288(1.14)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C160(0.92)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C160(1.17); C903(0.85)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C160(1.08)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C903(1.00)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C160(1.06); C903(1.13)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C160(1.21)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C160(1.07)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C903(1.14); C595(1.03)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C160(1.14); C288(1.01)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C160(1.17); C903(1.37); C288(1.07)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C160(1.35); C903(1.04)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C160(1.17)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C160(1.01); C903(1.10); C288(0.94)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C160(1.03)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C160(0.99); C903(1.30)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C160(1.02)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C903(1.19)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C160(1.16); C903(1.06)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C160(0.99); C903(0.95)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C160(1.04)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C903(1.08); C595(1.07)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C160(1.09); C288(0.97)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C160(1.12); C903(1.13); C288(0.97)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C160(1.41); C903(0.89)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C160(1.09)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C160(0.95); C903(1.10); C288(1.00)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C160(1.08); C903(1.12)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C160(1.11)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C160(0.96)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C903(1.03)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C160(1.09); C903(1.13)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C160(1.10)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C903(1.02); C595(1.07)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C160(1.27); C288(1.01)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C160(1.10); C903(1.05); C288(1.06)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C160(1.25); C903(1.08)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C160(1.19)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C160(0.97); C903(1.20); C288(0.94)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C903(1.18)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C160(0.95)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C160(1.03)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C903(0.95)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C160(1.14); C903(0.99)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C160(1.17)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C903(1.08); C595(1.04)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C160(1.12); C288(1.09)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C160(1.12); C903(1.10); C288(1.13)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C160(1.30); C903(1.20)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C160(1.09); C903(1.01)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C160(1.15)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C160(0.98); C903(1.16); C288(0.99)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C160(0.99)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C160(1.00); C903(0.98)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C160(0.99)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C903(1.13)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C160(1.09); C903(1.21)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C160(1.13)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C903(1.12); C595(1.07)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C160(1.13); C288(0.86)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C160(1.23)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C160(1.11); C903(1.09); C288(1.05)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C160(1.34); C903(1.12)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C160(1.08)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C160(0.97); C903(1.03); C288(1.02)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C160(0.98)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C160(1.03)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C903(1.17)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C160(1.06); C903(1.03)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C160(1.07)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C903(0.82); C595(0.84)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C903(1.09); C595(1.01)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C160(1.16); C288(1.05)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C160(1.07); C903(1.08); C288(0.98)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C160(1.20); C903(1.04)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C160(1.11)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C160(1.01); C903(1.44); C288(1.25)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C160(0.99)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C160(1.00); C903(1.31)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C160(1.02)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C903(1.41)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C160(1.24); C288(1.01)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C160(1.10); C903(1.07)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C160(1.15)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C903(1.09); C595(1.06)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C160(1.04); C288(1.03)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C160(1.15); C903(1.24); C288(1.05)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C160(1.18); C903(0.91)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C160(1.04)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C160(1.04); C903(1.10); C288(0.87)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C160(1.02)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C160(1.02); C903(0.99)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C160(1.04); C903(1.13)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C160(1.01); C903(1.01)  LDD1671  [11]
 LDCM0427  Fragment51 HEK-293T C160(0.94)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C288(1.07); C575(0.89); C578(0.89)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C288(0.90); C575(0.93); C578(0.93)  LDD1497  [11]
 LDCM0024  KB05 RPMI-7951 C241(2.85)  LDD3410  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dopamine beta-hydroxylase (DBH) Copper type II ascorbate-dependent monooxygenase family P09172
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
PDZ domain-containing protein 11 (PDZD11) . Q5EBL8

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Cisplatin Small molecular drug DB00515
Copper . DB09130

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402