Details of the Target

General Information of Target

Target ID LDTP09542
Target Name 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5)
Gene Name ABHD5
Gene ID 51099
Synonyms
NCIE2; 1-acylglycerol-3-phosphate O-acyltransferase ABHD5; EC 2.3.1.51; Abhydrolase domain-containing protein 5; Lipid droplet-binding protein CGI-58
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAEEEEVDSADTGERSGWLTGWLPTWCPTSISHLKEAEEKMLKCVPCTYKKEPVRISNG
NKIWTLKFSHNISNKTPLVLLHGFGGGLGLWALNFGDLCTNRPVYAFDLLGFGRSSRPRF
DSDAEEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWG
FPERPDLADQDRPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMF
EDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGKMHPDIPVSVIFGARSCI
DGNSGTSIQSLRPHSYVKTIAILGAGHYVYADQPEEFNQKVKEICDTVD
Target Bioclass
Enzyme
Family
Peptidase S33 family, ABHD4/ABHD5 subfamily
Subcellular location
Cytoplasm
Function
Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.
Uniprot ID
Q8WTS1
Ensemble ID
ENST00000644371.2
HGNC ID
HGNC:21396

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [1]
DBIA
 Probe Info  		C140(0.95)  LDD0531  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0025  [4]
Compound 11
 Probe Info  		N.A.  LDD2213  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C100
 Probe Info  		5.35  LDD1789  [8]
A-DA
 Probe Info  		20.00  LDD0143  [9]
AEA-DA
 Probe Info  		15.76  LDD0333  [10]
OEA-DA
 Probe Info  		20.00  LDD0046  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C140(0.95)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C140(1.18)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C140(0.87)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C140(0.98)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C140(1.09)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C140(0.89)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C140(0.96)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C140(0.96)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C140(0.97)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C140(0.93)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C140(0.89)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C140(0.86)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C140(1.17)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C140(1.15)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C140(1.03)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C140(1.02)  LDD0546  [2]
 LDCM0230  AC113 HCT 116 C140(0.92); C45(0.93); C48(0.93)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C140(0.84); C45(0.91); C48(0.91)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C140(1.02); C45(0.96); C48(0.96)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C140(1.08); C45(0.89); C48(0.89)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C140(1.02); C45(0.89); C48(0.89)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C140(0.94); C45(0.85); C48(0.85)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C140(0.96); C45(1.07); C48(1.07)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C140(0.92)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C140(0.85); C45(0.98); C48(0.98)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C140(0.83); C45(0.99); C48(0.99)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C140(0.87); C45(0.95); C48(0.95)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C140(0.81); C45(0.94); C48(0.94)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C140(0.92); C45(0.80); C48(0.80)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C140(0.95); C45(0.99); C48(0.99)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C140(0.94); C45(0.95); C48(0.95)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C140(0.87); C45(0.90); C48(0.90)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C140(1.16)  LDD0576  [2]
 LDCM0263  AC143 HCT 116 C140(1.05); C45(1.09); C48(1.09)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C45(1.05); C48(1.05); C140(1.29)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C45(1.07); C48(1.07); C140(1.15)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C45(0.94); C48(0.94); C140(1.18)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C45(1.02); C48(1.02); C140(1.20)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C45(0.87); C48(0.87); C140(1.69)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C45(0.99); C48(0.99); C140(1.40)  LDD0586  [2]
 LDCM0270  AC15 HCT 116 C140(1.08)  LDD0587  [2]
 LDCM0271  AC150 HCT 116 C45(0.94); C48(0.94); C140(1.06)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C140(1.09); C45(1.27); C48(1.27)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C45(1.18); C48(1.18); C140(1.26)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C45(0.79); C48(0.79); C140(1.73)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C140(1.17); C45(1.02); C48(1.02)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C140(1.25); C45(1.11); C48(1.11)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C140(1.09); C45(1.12); C48(1.12)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C140(1.11); C45(0.96); C48(0.96)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C140(1.11)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C140(1.03)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C140(1.09)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C140(1.04)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C140(0.99)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C140(1.04)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C140(1.08)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C140(1.00)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C140(1.00)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C140(0.94)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C140(1.05)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C140(1.08)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C140(0.99)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C140(1.11)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C140(1.05)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C140(1.06)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C140(1.02)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C140(1.03)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C140(0.90)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C140(0.99)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C140(0.83)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C140(0.91)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C140(0.95)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C140(0.98)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C140(1.00)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C140(1.05)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C140(0.97)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C140(0.95)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C140(0.99)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C140(0.99)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C140(0.98)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C140(1.03)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C140(0.83)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C140(0.95)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C140(1.00)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C140(1.07)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C140(1.10)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C140(1.02)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C140(0.81)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C140(0.98)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C140(0.97)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C140(0.98)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C140(1.07)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C140(1.05)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C45(0.45); C48(0.45); C140(1.27)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C45(0.39); C48(0.39); C140(1.24)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C45(0.50); C48(0.50); C140(1.41)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C140(1.27)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C45(0.34); C48(0.34); C140(1.32)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C45(0.24); C48(0.24); C140(1.25)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C45(0.36); C48(0.36); C140(1.44)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C45(0.43); C48(0.43); C140(1.21)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C45(0.39); C48(0.39); C140(1.49)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C45(0.44); C48(0.44); C140(1.67)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C45(0.49); C48(0.49); C140(1.57)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C45(0.23); C48(0.23); C140(1.72)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C45(0.51); C48(0.51); C140(0.89)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C45(0.36); C48(0.36); C140(0.77)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C140(1.09)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C45(0.42); C48(0.42); C140(0.91)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C45(0.64); C48(0.64); C140(0.88)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C45(0.50); C48(0.50); C140(1.00)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C45(0.23); C48(0.23); C140(0.98)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C45(0.22); C48(0.22); C140(0.93)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C45(0.22); C48(0.22); C140(0.99)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C45(0.46); C48(0.46); C140(0.97)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C45(0.57); C48(0.57); C140(0.90)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C45(0.37); C48(0.37); C140(0.97)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C45(0.67); C48(0.67); C140(0.93)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C140(1.01)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C45(0.55); C48(0.55); C140(0.89)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C45(0.70); C48(0.70); C140(0.93)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C45(0.26); C48(0.26); C140(0.95)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C45(0.50); C48(0.50)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C45(0.49); C48(0.49)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C45(0.63); C48(0.63)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C45(1.03); C48(1.03)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C45(0.85); C48(0.85)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C45(1.13); C48(1.13)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C45(0.71); C48(0.71)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C45(1.66); C48(1.66)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C45(0.55); C48(0.55)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C45(0.66); C48(0.66)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C45(0.95); C48(0.95)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C45(0.70); C48(0.70)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C45(0.57); C48(0.57)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C45(0.62); C48(0.62)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C45(0.83); C48(0.83)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C140(1.07)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C140(0.92)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C140(0.98)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C140(1.10)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C140(1.36)  LDD0592  [2]
 LDCM0083  Avasimibe A-549 20.00  LDD0143  [9]
 LDCM0367  CL1 HCT 116 C140(0.96)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C140(1.06)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C140(1.02)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C140(1.26)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C140(0.97)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C140(1.05)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C140(1.05)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C140(1.00)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C140(1.04)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C140(1.11)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C140(1.08)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C140(1.19)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C140(0.94)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C140(1.15)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C140(1.18)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C140(0.95)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C140(0.94)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C140(0.92)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C140(1.02)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C140(0.98)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C140(1.02)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C140(1.03)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C140(0.99)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C140(1.06)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C140(0.96)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C140(1.24)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C140(1.00)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C140(0.96)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C140(1.07)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C140(1.13); C45(1.20); C48(1.20)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C45(0.98); C48(0.98); C140(1.09)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C45(0.57); C48(0.57); C140(1.05)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C45(0.68); C48(0.68); C140(1.35)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C140(1.03)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C140(1.21)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C140(0.89)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C140(0.94)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C140(0.92)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C140(1.01)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C140(1.03)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C140(0.91)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C140(1.12)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C140(1.14)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C140(1.58)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C140(1.05)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C140(1.23)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C140(1.19)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C140(1.03)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C140(1.10)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C140(1.06)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C140(1.16)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C140(0.87)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C140(0.96)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C140(0.88)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C140(0.89)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C140(0.93)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C140(0.97)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C140(1.08)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C140(0.92)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C140(1.05)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C140(0.91)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C140(0.92)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C140(0.87)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C140(0.98)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C140(0.92)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C140(0.97)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C140(1.02)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C140(1.00)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C140(0.88)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C140(0.92)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C140(1.04)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C140(1.05)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C140(0.96)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C140(0.92)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C140(0.92)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C140(0.98)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C140(0.98)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C140(0.90)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C140(0.84)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C140(0.91)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C140(0.94)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C140(0.97)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C140(0.90)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C140(1.02)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C140(0.98)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C140(1.19)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C140(1.00)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C140(1.24)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C140(1.38)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C140(1.12)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C140(1.31)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C140(1.23)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C140(0.95)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C140(1.04)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C140(1.11)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C140(1.00)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C140(1.08)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C140(1.08)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C140(1.10)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C140(1.19)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C140(1.02)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C140(0.86)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C140(0.97)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C140(1.15)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C140(0.90)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C140(1.02)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C140(1.05)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C140(1.09)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C140(1.12)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C140(1.23)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C140(1.01)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C140(0.95)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C140(1.09)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C140(1.13)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C140(1.26)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C140(1.03)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C140(0.79)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C140(0.99)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C140(0.91)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C140(0.93)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C140(0.94)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C140(0.90)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C140(1.04)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C140(1.08)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C140(1.04)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C140(1.03)  LDD0811  [2]
 LDCM0468  Fragment33 HCT 116 C140(1.15)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C140(0.75)  LDD0744  [2]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [1]
 LDCM0022  KB02 HEK-293T C140(1.10)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C140(1.04)  LDD1497  [11]
 LDCM0024  KB05 HMCB C140(1.18)  LDD3312  [12]
 LDCM0084  Ro 48-8071 A-549 7.03  LDD0145  [9]
 LDCM0136  SR-4559 HEK-293T 6.47  LDD0329  [10]
 LDCM0137  SR-4995 HEK-293T 8.58  LDD0331  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Inactive glycosyltransferase 25 family member 3 (CERCAM) Glycosyltransferase 25 family Q5T4B2
Glutamate decarboxylase 2 (GAD2) Group II decarboxylase family Q05329
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
H(+)/Cl(-) exchange transporter 4 (CLCN4) Chloride channel family P51793
Endophilin-B1 (SH3GLB1) Endophilin family Q9Y371
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Perilipin-2 (PLIN2) Perilipin family Q99541
Perilipin-3 (PLIN3) Perilipin family O60664
Perilipin-5 (PLIN5) Perilipin family Q00G26
Putative ribosome-binding factor A, mitochondrial (RBFA) RbfA family Q8N0V3
Mitochondrial dynamics protein MIEF1 (MIEF1) SMCR7 family Q9NQG6
Tumor protein D54 (TPD52L2) TPD52 family O43399
Zinc finger CCHC domain-containing protein 12 (ZCCHC12) ZCCHC12 family Q6PEW1
AP-4 complex accessory subunit RUSC1 (RUSC1) . Q9BVN2

References

1 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
10 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840