Details of the Target

General Information of Target

Target ID LDTP04676
Target Name Mesencephalic astrocyte-derived neurotrophic factor (MANF)
Gene Name MANF
Gene ID 7873
Synonyms
ARMET; ARP; Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; Protein ARMET
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MRRMWATQGLAVALALSVLPGSRALRPGDCEVCISYLGRFYQDLKDRDVTFSPATIENEL
IKFCREARGKENRLCYYIGATDDAATKIINEVSKPLAHHIPVEKICEKLKKKDSQICELK
YDKQIDLSTVDLKKLRVKELKKILDDWGETCKGCAEKSDYIRKINELMPKYAPKAASART
DL
Target Type
Literature-reported
Target Bioclass
Other
Family
ARMET family
Subcellular location
Secreted
Function
Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
TTD ID
T62415
Uniprot ID
P55145
DrugMap ID
TT56RYE
Ensemble ID
ENST00000528157.7
HGNC ID
HGNC:15461

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y160(20.00); Y76(14.87)  LDD0260  [1]
C-Sul
 Probe Info  		27.26  LDD0066  [2]
ONAyne
 Probe Info  		K157(7.18); K45(4.43)  LDD0274  [3]
OPA-S-S-alkyne
 Probe Info  		K45(4.01)  LDD3494  [4]
m-APA
 Probe Info  		13.34  LDD0403  [5]
HHS-475
 Probe Info  		Y76(0.76)  LDD0264  [6]
DBIA
 Probe Info  		C117(1.18)  LDD0532  [7]
ATP probe
 Probe Info  		K94(0.00); K104(0.00); K108(0.00)  LDD0199  [8]
IA-alkyne
 Probe Info  		C75(0.00); C151(0.00)  LDD0032  [9]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
BTD
 Probe Info  		N.A.  LDD0004  [11]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [12]
IPM
 Probe Info  		C117(0.00); C30(0.00)  LDD2156  [13]
NHS
 Probe Info  		N.A.  LDD0010  [11]
OSF
 Probe Info  		H99(0.00); H98(0.00)  LDD0029  [14]
STPyne
 Probe Info  		K94(0.00); K123(0.00)  LDD0009  [11]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
Acrolein
 Probe Info  		H99(0.00); H98(0.00)  LDD0217  [16]
AOyne
 Probe Info  		15.00  LDD0443  [17]
NAIA_5
 Probe Info  		C64(0.00); C117(0.00); C154(0.00); C151(0.00)  LDD2223  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C151(0.94)  LDD1507  [19]
 LDCM0215  AC10 HCT 116 C117(1.18)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C117(0.99)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C117(1.28)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C117(1.12)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C117(1.57)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C117(0.98)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C117(0.98)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C117(1.11)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C117(1.06)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C117(1.26)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C117(1.14)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C117(1.09)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C117(1.64)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C117(1.22)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C117(1.44)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C117(0.83)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C117(1.28)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C117(1.30)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C117(1.14)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C117(0.86)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C117(1.09)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C117(1.13)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C117(1.03)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C117(1.13)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C117(0.84)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C117(0.90)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C117(0.88)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C117(0.82)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C117(1.00)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C117(1.28)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C117(1.21)  LDD0562  [7]
 LDCM0259  AC14 HCT 116 C117(1.15)  LDD0576  [7]
 LDCM0270  AC15 HCT 116 C117(1.27)  LDD0587  [7]
 LDCM0276  AC17 HCT 116 C117(0.99)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C117(0.91)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C117(0.96)  LDD0595  [7]
 LDCM0279  AC2 HEK-293T C151(0.97)  LDD1518  [19]
 LDCM0280  AC20 HCT 116 C117(0.91)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C117(0.88)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C117(0.87)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C117(0.80)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C117(0.86)  LDD0601  [7]
 LDCM0285  AC25 HEK-293T C151(0.86)  LDD1524  [19]
 LDCM0286  AC26 HEK-293T C151(1.03)  LDD1525  [19]
 LDCM0287  AC27 HEK-293T C151(0.94)  LDD1526  [19]
 LDCM0288  AC28 HEK-293T C151(0.91)  LDD1527  [19]
 LDCM0289  AC29 HEK-293T C151(0.99)  LDD1528  [19]
 LDCM0290  AC3 HEK-293T C151(0.93)  LDD1529  [19]
 LDCM0291  AC30 HEK-293T C151(0.90)  LDD1530  [19]
 LDCM0292  AC31 HEK-293T C151(0.92); C117(1.00)  LDD1531  [19]
 LDCM0293  AC32 HEK-293T C151(0.95)  LDD1532  [19]
 LDCM0294  AC33 HEK-293T C151(0.81)  LDD1533  [19]
 LDCM0295  AC34 HEK-293T C151(0.88)  LDD1534  [19]
 LDCM0296  AC35 HEK-293T C75(0.98)  LDD0894  [7]
 LDCM0297  AC36 HEK-293T C75(0.95)  LDD0895  [7]
 LDCM0298  AC37 HEK-293T C75(0.98)  LDD0896  [7]
 LDCM0299  AC38 HEK-293T C75(0.94)  LDD0897  [7]
 LDCM0300  AC39 HEK-293T C75(1.04)  LDD0898  [7]
 LDCM0301  AC4 HEK-293T C151(0.92)  LDD1540  [19]
 LDCM0302  AC40 HEK-293T C75(0.88)  LDD0900  [7]
 LDCM0303  AC41 HEK-293T C75(0.92)  LDD0901  [7]
 LDCM0304  AC42 HEK-293T C75(0.87)  LDD0902  [7]
 LDCM0305  AC43 HEK-293T C75(0.85)  LDD0903  [7]
 LDCM0306  AC44 HEK-293T C75(0.79)  LDD0904  [7]
 LDCM0307  AC45 HEK-293T C75(0.91)  LDD0905  [7]
 LDCM0308  AC46 HCT 116 C117(0.90)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C117(0.86)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C117(0.85)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C117(1.02)  LDD0628  [7]
 LDCM0312  AC5 HEK-293T C151(0.95)  LDD1551  [19]
 LDCM0313  AC50 HCT 116 C117(0.92)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C117(0.90)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C117(0.90)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C117(0.93)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C117(0.85)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C117(0.99)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C117(0.88)  LDD0636  [7]
 LDCM0320  AC57 HEK-293T C151(0.77)  LDD1559  [19]
 LDCM0321  AC58 HEK-293T C151(0.89)  LDD1560  [19]
 LDCM0322  AC59 HEK-293T C151(0.90)  LDD1561  [19]
 LDCM0323  AC6 HCT 116 C117(1.09)  LDD0640  [7]
 LDCM0324  AC60 HEK-293T C151(0.83)  LDD1563  [19]
 LDCM0325  AC61 HEK-293T C151(0.87)  LDD1564  [19]
 LDCM0326  AC62 HEK-293T C151(0.87)  LDD1565  [19]
 LDCM0327  AC63 HEK-293T C151(0.86); C117(0.99)  LDD1566  [19]
 LDCM0328  AC64 HEK-293T C151(0.90)  LDD1567  [19]
 LDCM0332  AC68 HCT 116 C117(0.75)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C117(0.84)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C117(1.26)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C117(0.97)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C117(0.74)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C117(1.11)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C117(0.89)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C117(0.70)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C117(1.09)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C117(0.72)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C117(1.10)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C117(0.79)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C117(1.01)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C117(1.21)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C117(0.68)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C117(0.86)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C117(1.08)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C117(1.31)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C117(1.20)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C117(0.86)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C117(1.12)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C117(0.95)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C117(0.99)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C117(1.09)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C117(1.16)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C117(1.25)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C117(1.50)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C117(1.05)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C117(1.24)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C117(1.21)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C117(1.13)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C117(1.20)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C117(1.06)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C117(1.41)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C117(1.02)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C117(1.20)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C117(1.24)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 13.34  LDD0403  [5]
 LDCM0020  ARS-1620 HCC44 C117(1.12); C75(1.01)  LDD2171  [7]
 LDCM0108  Chloroacetamide HeLa H98(0.00); C117(0.00); H99(0.00); C151(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C75(0.80)  LDD0965  [7]
 LDCM0368  CL10 HEK-293T C75(0.88)  LDD0966  [7]
 LDCM0369  CL100 HEK-293T C151(0.91); C117(0.96)  LDD1573  [19]
 LDCM0370  CL101 HCT 116 C117(1.16)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C117(0.94)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C117(1.01)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C117(1.13)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C117(0.92)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C117(0.88)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C117(0.91)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C117(1.06)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C117(0.90)  LDD0695  [7]
 LDCM0379  CL11 HEK-293T C75(1.08)  LDD0977  [7]
 LDCM0380  CL110 HCT 116 C117(0.92)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C117(0.85)  LDD0698  [7]
 LDCM0382  CL112 HEK-293T C151(0.89); C117(1.01)  LDD1586  [19]
 LDCM0383  CL113 HEK-293T C151(0.89)  LDD1587  [19]
 LDCM0384  CL114 HEK-293T C151(1.00); C117(0.94)  LDD1588  [19]
 LDCM0385  CL115 HEK-293T C151(0.96)  LDD1589  [19]
 LDCM0386  CL116 HEK-293T C151(0.90); C117(1.14)  LDD1590  [19]
 LDCM0387  CL117 HEK-293T C75(0.97)  LDD0985  [7]
 LDCM0388  CL118 HEK-293T C75(1.11)  LDD0986  [7]
 LDCM0389  CL119 HEK-293T C75(0.90)  LDD0987  [7]
 LDCM0390  CL12 HEK-293T C75(1.06)  LDD0988  [7]
 LDCM0391  CL120 HEK-293T C75(1.08)  LDD0989  [7]
 LDCM0392  CL121 HCT 116 C117(0.98)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C117(0.86)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C117(0.83)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C117(0.91)  LDD0712  [7]
 LDCM0396  CL125 HEK-293T C151(0.84)  LDD1600  [19]
 LDCM0397  CL126 HEK-293T C151(0.98); C117(0.97)  LDD1601  [19]
 LDCM0398  CL127 HEK-293T C151(0.88)  LDD1602  [19]
 LDCM0399  CL128 HEK-293T C151(0.83); C117(1.01)  LDD1603  [19]
 LDCM0400  CL13 HEK-293T C75(1.02)  LDD0998  [7]
 LDCM0401  CL14 HEK-293T C75(1.03)  LDD0999  [7]
 LDCM0402  CL15 HEK-293T C75(0.74)  LDD1000  [7]
 LDCM0403  CL16 HCT 116 C117(1.02)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C117(0.86)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C117(1.07)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C117(1.07)  LDD0723  [7]
 LDCM0407  CL2 HEK-293T C75(1.50)  LDD1005  [7]
 LDCM0408  CL20 HCT 116 C117(1.09)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C117(0.95)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C117(1.01)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C117(1.04)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C117(1.07)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C117(0.94)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C117(1.06)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C117(0.99)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C117(1.08)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C117(1.12)  LDD0734  [7]
 LDCM0418  CL3 HEK-293T C75(1.13)  LDD1016  [7]
 LDCM0419  CL30 HCT 116 C117(1.08)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C117(1.03)  LDD0737  [7]
 LDCM0421  CL32 HEK-293T C75(0.96)  LDD1019  [7]
 LDCM0422  CL33 HEK-293T C75(0.97)  LDD1020  [7]
 LDCM0423  CL34 HEK-293T C75(1.12)  LDD1021  [7]
 LDCM0424  CL35 HEK-293T C75(0.88)  LDD1022  [7]
 LDCM0425  CL36 HEK-293T C75(1.03)  LDD1023  [7]
 LDCM0426  CL37 HEK-293T C75(0.98)  LDD1024  [7]
 LDCM0428  CL39 HEK-293T C75(0.98)  LDD1026  [7]
 LDCM0429  CL4 HEK-293T C75(1.30)  LDD1027  [7]
 LDCM0430  CL40 HEK-293T C75(0.95)  LDD1028  [7]
 LDCM0431  CL41 HEK-293T C75(0.92)  LDD1029  [7]
 LDCM0432  CL42 HEK-293T C75(1.05)  LDD1030  [7]
 LDCM0433  CL43 HEK-293T C75(1.07)  LDD1031  [7]
 LDCM0434  CL44 HEK-293T C75(0.85)  LDD1032  [7]
 LDCM0435  CL45 HEK-293T C75(0.93)  LDD1033  [7]
 LDCM0436  CL46 HEK-293T C151(1.06)  LDD1640  [19]
 LDCM0437  CL47 HEK-293T C151(0.99); C117(1.00)  LDD1641  [19]
 LDCM0438  CL48 HEK-293T C151(1.10)  LDD1642  [19]
 LDCM0439  CL49 HEK-293T C151(1.04)  LDD1643  [19]
 LDCM0440  CL5 HEK-293T C75(1.32)  LDD1038  [7]
 LDCM0441  CL50 HEK-293T C151(0.96); C117(1.03)  LDD1645  [19]
 LDCM0443  CL52 HEK-293T C151(0.95); C117(1.13)  LDD1646  [19]
 LDCM0444  CL53 HEK-293T C151(1.01)  LDD1647  [19]
 LDCM0445  CL54 HEK-293T C151(1.12)  LDD1648  [19]
 LDCM0446  CL55 HEK-293T C151(0.99)  LDD1649  [19]
 LDCM0447  CL56 HEK-293T C151(0.99)  LDD1650  [19]
 LDCM0448  CL57 HEK-293T C151(1.50)  LDD1651  [19]
 LDCM0449  CL58 HEK-293T C151(1.24)  LDD1652  [19]
 LDCM0450  CL59 HEK-293T C151(1.04); C117(1.54)  LDD1653  [19]
 LDCM0451  CL6 HEK-293T C75(1.06)  LDD1049  [7]
 LDCM0452  CL60 HEK-293T C151(1.07)  LDD1655  [19]
 LDCM0453  CL61 HEK-293T C151(0.85)  LDD1656  [19]
 LDCM0454  CL62 HEK-293T C151(0.92); C117(1.01)  LDD1657  [19]
 LDCM0455  CL63 HEK-293T C151(0.93)  LDD1658  [19]
 LDCM0456  CL64 HEK-293T C151(0.96); C117(0.94)  LDD1659  [19]
 LDCM0457  CL65 HEK-293T C151(0.84)  LDD1660  [19]
 LDCM0458  CL66 HEK-293T C151(0.98)  LDD1661  [19]
 LDCM0459  CL67 HEK-293T C151(0.97)  LDD1662  [19]
 LDCM0460  CL68 HEK-293T C151(1.15)  LDD1663  [19]
 LDCM0461  CL69 HEK-293T C151(1.37)  LDD1664  [19]
 LDCM0462  CL7 HEK-293T C75(0.97)  LDD1060  [7]
 LDCM0463  CL70 HEK-293T C151(1.04)  LDD1666  [19]
 LDCM0464  CL71 HEK-293T C151(1.01); C117(1.37)  LDD1667  [19]
 LDCM0465  CL72 HEK-293T C151(1.05)  LDD1668  [19]
 LDCM0466  CL73 HEK-293T C151(0.92)  LDD1669  [19]
 LDCM0467  CL74 HEK-293T C151(0.89); C117(1.08)  LDD1670  [19]
 LDCM0469  CL76 HEK-293T C75(1.72)  LDD1067  [7]
 LDCM0470  CL77 HEK-293T C75(1.81)  LDD1068  [7]
 LDCM0471  CL78 HEK-293T C75(2.06)  LDD1069  [7]
 LDCM0472  CL79 HEK-293T C75(1.45)  LDD1070  [7]
 LDCM0473  CL8 HEK-293T C75(1.20)  LDD1071  [7]
 LDCM0474  CL80 HEK-293T C75(1.81)  LDD1072  [7]
 LDCM0475  CL81 HEK-293T C75(1.70)  LDD1073  [7]
 LDCM0476  CL82 HEK-293T C75(1.85)  LDD1074  [7]
 LDCM0477  CL83 HEK-293T C75(1.64)  LDD1075  [7]
 LDCM0478  CL84 HEK-293T C75(1.41)  LDD1076  [7]
 LDCM0479  CL85 HEK-293T C75(2.05)  LDD1077  [7]
 LDCM0480  CL86 HEK-293T C75(1.90)  LDD1078  [7]
 LDCM0481  CL87 HEK-293T C75(2.16)  LDD1079  [7]
 LDCM0482  CL88 HEK-293T C75(2.30)  LDD1080  [7]
 LDCM0483  CL89 HEK-293T C75(1.97)  LDD1081  [7]
 LDCM0484  CL9 HEK-293T C75(1.14)  LDD1082  [7]
 LDCM0485  CL90 HEK-293T C75(1.51)  LDD1083  [7]
 LDCM0486  CL91 HEK-293T C151(1.00)  LDD1689  [19]
 LDCM0487  CL92 HEK-293T C151(1.31)  LDD1690  [19]
 LDCM0488  CL93 HEK-293T C151(1.57)  LDD1691  [19]
 LDCM0489  CL94 HEK-293T C151(1.05)  LDD1692  [19]
 LDCM0490  CL95 HEK-293T C151(0.92); C117(1.11)  LDD1693  [19]
 LDCM0491  CL96 HEK-293T C151(1.03)  LDD1694  [19]
 LDCM0492  CL97 HEK-293T C151(1.08)  LDD1695  [19]
 LDCM0493  CL98 HEK-293T C151(1.08); C117(1.01)  LDD1696  [19]
 LDCM0494  CL99 HEK-293T C151(0.94)  LDD1697  [19]
 LDCM0495  E2913 HEK-293T C151(0.95)  LDD1698  [19]
 LDCM0468  Fragment33 HEK-293T C151(1.00)  LDD1671  [19]
 LDCM0427  Fragment51 HEK-293T C75(0.95)  LDD1025  [7]
 LDCM0116  HHS-0101 DM93 Y76(0.76)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y76(0.66)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y76(0.92)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y76(0.77)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y76(0.27)  LDD0268  [6]
 LDCM0107  IAA HeLa H98(0.00); H99(0.00); C33(0.00)  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C151(0.85)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C151(0.72)  LDD1497  [19]
 LDCM0024  KB05 SNU-245 C22(1.53)  LDD3440  [20]
 LDCM0109  NEM HeLa H98(0.00); H99(0.00)  LDD0223  [16]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C117(0.83); C33(0.70)  LDD2120  [21]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C117(0.96)  LDD2128  [21]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C117(1.04); C33(0.77)  LDD2143  [21]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C117(3.19)  LDD2147  [21]
 LDCM0021  THZ1 HCT 116 C117(1.12); C75(1.01)  LDD2173  [7]

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761