Details of the Target

General Information of Target

Target ID LDTP10525
Target Name Ribosomal protein uL16-like (RPL10L)
Gene Name RPL10L
Gene ID 140801
Synonyms
Ribosomal protein uL16-like; 60S ribosomal protein L10-like; Large ribosomal subunit protein uL16-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARALVQLWAICMLRVALATVYFQEEFLDGEHWRNRWLQSTNDSRFGHFRLSSGKFYGHK
EKDKGLQTTQNGRFYAISARFKPFSNKGKTLVIQYTVKHEQKMDCGGGYIKVFPADIDQK
NLNGKSQYYIMFGPDICGFDIKKVHVILHFKNKYHENKKLIRCKVDGFTHLYTLILRPDL
SYDVKIDGQSIESGSIEYDWNLTSLKKETSPAESKDWEQTKDNKAQDWEKHFLDASTSKQ
SDWNGDLDGDWPAPMLQKPPYQDGLKPEGIHKDVWLHRKMKNTDYLTQYDLSEFENIGAI
GLELWQVRSGTIFDNFLITDDEEYADNFGKATWGETKGPEREMDAIQAKEEMKKAREEEE
EELLSGKINRHEHYFNQFHRRNEL
Target Bioclass
Other
Family
Universal ribosomal protein uL16 family
Subcellular location
Cytoplasm
Function
Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I. Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome. It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm.
Uniprot ID
Q96L21
Ensemble ID
ENST00000298283.5
HGNC ID
HGNC:17976

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C105(4.19)  LDD1699  [1]
AZ-9
 Probe Info  		D109(10.00)  LDD2209  [2]
IPM
 Probe Info  		N.A.  LDD0241  [3]
DBIA
 Probe Info  		C195(3.49)  LDD3312  [4]
AHL-Pu-1
 Probe Info  		C105(2.11)  LDD0168  [5]
ATP probe
 Probe Info  		N.A.  LDD0035  [6]
OSF
 Probe Info  		N.A.  LDD0029  [7]
VSF
 Probe Info  		N.A.  LDD0007  [8]
Acrolein
 Probe Info  		H147(0.00); C195(0.00); C105(0.00); H95(0.00)  LDD0217  [9]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [9]
Crotonaldehyde
 Probe Info  		H147(0.00); H92(0.00); H95(0.00); C195(0.00)  LDD0219  [9]
Methacrolein
 Probe Info  		C195(0.00); H95(0.00); C105(0.00)  LDD0218  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C195(0.67); C105(0.62)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C195(0.87); C105(0.83)  LDD2112  [1]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C195(1.29); C105(0.63)  LDD2095  [1]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C195(0.82); C105(0.83)  LDD2130  [1]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C195(0.83); C105(1.10)  LDD2117  [1]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C195(1.05); C105(1.34)  LDD2152  [1]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C195(0.85); C105(0.55)  LDD2132  [1]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C195(1.33); C105(0.74)  LDD2131  [1]
 LDCM0025  4SU-RNA HEK-293T C105(2.11)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA DM93 C105(2.38)  LDD0171  [5]
 LDCM0545  Acetamide MDA-MB-231 C195(0.61); C105(0.49)  LDD2138  [1]
 LDCM0520  AKOS000195272 MDA-MB-231 C195(0.75); C105(0.79)  LDD2113  [1]
 LDCM0498  BS-3668 MDA-MB-231 C195(0.88); C105(0.55)  LDD2091  [1]
 LDCM0108  Chloroacetamide HeLa H147(0.00); H92(0.00); K42(0.00); H95(0.00)  LDD0222  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C105(2.02); C195(1.52)  LDD1702  [1]
 LDCM0107  IAA HeLa H92(0.00); H147(0.00); H95(0.00); H130(0.00)  LDD0221  [9]
 LDCM0022  KB02 22RV1 C195(2.58)  LDD2243  [4]
 LDCM0023  KB03 MDA-MB-231 C195(5.60); C105(4.05)  LDD1701  [1]
 LDCM0024  KB05 HMCB C195(3.49)  LDD3312  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C195(0.73); C105(1.03)  LDD2102  [1]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C195(0.79); C105(0.63)  LDD2121  [1]
 LDCM0109  NEM HeLa H147(0.00); H92(0.00); H130(0.00); H95(0.00)  LDD0223  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C195(0.64); C105(0.81)  LDD2089  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C195(0.88)  LDD2092  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C195(0.81); C105(1.09)  LDD2093  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C195(1.00); C105(1.26)  LDD2094  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C105(0.20)  LDD2096  [1]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C195(1.01); C105(0.88)  LDD2097  [1]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C195(0.72); C105(0.71)  LDD2098  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C195(0.87); C105(0.94)  LDD2099  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C195(0.87); C105(0.77)  LDD2100  [1]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C195(0.96); C105(0.93)  LDD2101  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C195(0.71); C105(0.78)  LDD2104  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C195(1.13); C105(1.33)  LDD2105  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C195(0.80); C105(0.86)  LDD2106  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C195(0.94); C105(1.08)  LDD2107  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C195(0.61); C105(0.53)  LDD2108  [1]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C195(0.81); C105(0.80)  LDD2109  [1]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C195(0.92); C105(3.61)  LDD2110  [1]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C195(0.73); C105(1.10)  LDD2111  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C195(0.75); C105(1.04)  LDD2114  [1]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C195(0.69); C105(0.59)  LDD2115  [1]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C195(1.64); C105(2.08)  LDD2119  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C195(0.81); C105(0.77)  LDD2120  [1]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C105(0.11)  LDD2122  [1]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C195(0.70); C105(0.94)  LDD2125  [1]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C195(0.78); C105(1.14)  LDD2127  [1]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C105(0.78)  LDD2128  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C195(0.80); C105(1.09)  LDD2129  [1]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C195(0.63)  LDD2133  [1]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C105(0.50)  LDD2134  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C195(0.80); C105(1.12)  LDD2135  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C195(1.05); C105(1.20)  LDD2136  [1]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C195(0.82); C105(0.98)  LDD2137  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C105(1.43); C195(0.89)  LDD1700  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C195(0.71); C105(0.75)  LDD2140  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C195(0.69); C105(0.53)  LDD2141  [1]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C195(0.95); C105(0.75)  LDD2143  [1]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C195(1.85); C105(2.23)  LDD2144  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C105(6.40)  LDD2145  [1]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C195(1.53); C105(1.45)  LDD2147  [1]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C195(0.47); C105(0.50)  LDD2148  [1]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C195(1.60); C105(1.31)  LDD2153  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(S)-3-phenyllactic Acid . DB02494
Anisomycin . DB07374
Puromycin . DB08437

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
7 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.