Details of the Target

General Information of Target

Target ID LDTP11540
Target Name Crooked neck-like protein 1 (CRNKL1)
Gene Name CRNKL1
Gene ID 51340
Synonyms
CRN; Crooked neck-like protein 1; Crooked neck homolog; hCrn
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MKEEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPP
TLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFL
DNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPET
LLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE
KRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREK
AKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL
RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE
KKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEG
GEE
Target Bioclass
Other
Family
Crooked-neck family
Subcellular location
Nucleus
Function Involved in pre-mRNA splicing process. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Uniprot ID
Q9BZJ0
Ensemble ID
ENST00000377340.6
HGNC ID
HGNC:15762

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y223(5.34)  LDD0257  [1]
STPyne
 Probe Info  		K388(10.00); K445(9.19); K823(5.56)  LDD0277  [2]
Probe 1
 Probe Info  		Y223(11.97); Y273(29.20); Y514(9.27); Y663(8.28)  LDD3495  [3]
BTD
 Probe Info  		C603(0.33)  LDD2091  [4]
AHL-Pu-1
 Probe Info  		C745(11.14)  LDD0168  [5]
HHS-475
 Probe Info  		Y223(0.94)  LDD0264  [6]
HHS-465
 Probe Info  		Y223(4.30)  LDD2237  [7]
Acrolein
 Probe Info  		N.A.  LDD0226  [8]
DBIA
 Probe Info  		C640(0.64)  LDD0531  [9]
ATP probe
 Probe Info  		K602(0.00); K605(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C640(0.00); C745(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C640(0.00); C745(0.00)  LDD0036  [11]
Lodoacetamide azide
 Probe Info  		C640(0.00); C745(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD0147  [12]
OSF
 Probe Info  		N.A.  LDD0029  [13]
SF
 Probe Info  		Y391(0.00); Y223(0.00)  LDD0028  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
NAIA_5
 Probe Info  		C640(0.00); C745(0.00)  LDD2223  [15]
HHS-482
 Probe Info  		Y223(0.92)  LDD2239  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C277
 Probe Info  		9.85  LDD1947  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C625(1.19)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C625(1.74)  LDD2152  [4]
 LDCM0025  4SU-RNA HEK-293T C745(11.14)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C745(2.59)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C640(0.64)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C640(0.66)  LDD0532  [9]
 LDCM0216  AC100 PaTu 8988t C640(0.49)  LDD1095  [9]
 LDCM0217  AC101 PaTu 8988t C640(0.57)  LDD1096  [9]
 LDCM0218  AC102 PaTu 8988t C640(0.63)  LDD1097  [9]
 LDCM0219  AC103 PaTu 8988t C640(0.65)  LDD1098  [9]
 LDCM0220  AC104 PaTu 8988t C640(0.56)  LDD1099  [9]
 LDCM0221  AC105 PaTu 8988t C640(0.56)  LDD1100  [9]
 LDCM0222  AC106 PaTu 8988t C640(0.46)  LDD1101  [9]
 LDCM0223  AC107 PaTu 8988t C640(0.70)  LDD1102  [9]
 LDCM0224  AC108 PaTu 8988t C640(0.47)  LDD1103  [9]
 LDCM0225  AC109 PaTu 8988t C640(0.46)  LDD1104  [9]
 LDCM0226  AC11 HCT 116 C640(0.68)  LDD0543  [9]
 LDCM0227  AC110 PaTu 8988t C640(0.47)  LDD1106  [9]
 LDCM0228  AC111 PaTu 8988t C640(0.47)  LDD1107  [9]
 LDCM0229  AC112 PaTu 8988t C640(0.56)  LDD1108  [9]
 LDCM0230  AC113 PaTu 8988t C640(1.19)  LDD1109  [9]
 LDCM0231  AC114 PaTu 8988t C640(1.40)  LDD1110  [9]
 LDCM0232  AC115 PaTu 8988t C640(0.95)  LDD1111  [9]
 LDCM0233  AC116 PaTu 8988t C640(0.94)  LDD1112  [9]
 LDCM0234  AC117 PaTu 8988t C640(1.11)  LDD1113  [9]
 LDCM0235  AC118 PaTu 8988t C640(0.95)  LDD1114  [9]
 LDCM0236  AC119 PaTu 8988t C640(1.15)  LDD1115  [9]
 LDCM0237  AC12 HCT 116 C640(0.80)  LDD0554  [9]
 LDCM0238  AC120 PaTu 8988t C640(1.51)  LDD1117  [9]
 LDCM0239  AC121 PaTu 8988t C640(1.30)  LDD1118  [9]
 LDCM0240  AC122 PaTu 8988t C640(1.32)  LDD1119  [9]
 LDCM0241  AC123 PaTu 8988t C640(1.16)  LDD1120  [9]
 LDCM0242  AC124 PaTu 8988t C640(1.25)  LDD1121  [9]
 LDCM0243  AC125 PaTu 8988t C640(0.74)  LDD1122  [9]
 LDCM0244  AC126 PaTu 8988t C640(0.94)  LDD1123  [9]
 LDCM0245  AC127 PaTu 8988t C640(1.15)  LDD1124  [9]
 LDCM0246  AC128 PaTu 8988t C640(0.89)  LDD1125  [9]
 LDCM0247  AC129 PaTu 8988t C640(0.82)  LDD1126  [9]
 LDCM0249  AC130 PaTu 8988t C640(0.91)  LDD1128  [9]
 LDCM0250  AC131 PaTu 8988t C640(0.87)  LDD1129  [9]
 LDCM0251  AC132 PaTu 8988t C640(0.90)  LDD1130  [9]
 LDCM0252  AC133 PaTu 8988t C640(0.85)  LDD1131  [9]
 LDCM0253  AC134 PaTu 8988t C640(0.90)  LDD1132  [9]
 LDCM0254  AC135 PaTu 8988t C640(0.84)  LDD1133  [9]
 LDCM0255  AC136 PaTu 8988t C640(0.87)  LDD1134  [9]
 LDCM0256  AC137 PaTu 8988t C640(0.90)  LDD1135  [9]
 LDCM0257  AC138 PaTu 8988t C640(0.85)  LDD1136  [9]
 LDCM0258  AC139 PaTu 8988t C640(0.93)  LDD1137  [9]
 LDCM0259  AC14 HCT 116 C640(0.76)  LDD0576  [9]
 LDCM0260  AC140 PaTu 8988t C640(0.76)  LDD1139  [9]
 LDCM0261  AC141 PaTu 8988t C640(0.79)  LDD1140  [9]
 LDCM0262  AC142 PaTu 8988t C640(0.79)  LDD1141  [9]
 LDCM0263  AC143 HCT 116 C640(0.72)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C640(0.49)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C640(0.56)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C640(0.55)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C640(0.54)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C640(0.59)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C640(0.57)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C640(0.67)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C640(0.71)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C640(0.62)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C640(0.53)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C640(0.54)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C640(0.52)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C640(0.53)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C640(0.78)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C640(0.81)  LDD2161  [9]
 LDCM0276  AC17 PaTu 8988t C640(1.03)  LDD1155  [9]
 LDCM0277  AC18 PaTu 8988t C640(0.75)  LDD1156  [9]
 LDCM0278  AC19 PaTu 8988t C640(0.97)  LDD1157  [9]
 LDCM0279  AC2 HCT 116 C640(0.77)  LDD0596  [9]
 LDCM0280  AC20 PaTu 8988t C640(0.78)  LDD1159  [9]
 LDCM0281  AC21 PaTu 8988t C640(0.92)  LDD1160  [9]
 LDCM0282  AC22 PaTu 8988t C640(0.72)  LDD1161  [9]
 LDCM0283  AC23 PaTu 8988t C640(0.67)  LDD1162  [9]
 LDCM0284  AC24 PaTu 8988t C640(0.72)  LDD1163  [9]
 LDCM0285  AC25 PaTu 8988t C640(1.17)  LDD1164  [9]
 LDCM0286  AC26 PaTu 8988t C640(0.91)  LDD1165  [9]
 LDCM0287  AC27 PaTu 8988t C640(0.90)  LDD1166  [9]
 LDCM0288  AC28 PaTu 8988t C640(0.75)  LDD1167  [9]
 LDCM0289  AC29 PaTu 8988t C640(0.76)  LDD1168  [9]
 LDCM0290  AC3 HCT 116 C640(0.70)  LDD0607  [9]
 LDCM0291  AC30 PaTu 8988t C640(0.88)  LDD1170  [9]
 LDCM0292  AC31 PaTu 8988t C640(1.02)  LDD1171  [9]
 LDCM0293  AC32 PaTu 8988t C640(0.82)  LDD1172  [9]
 LDCM0294  AC33 PaTu 8988t C640(0.81)  LDD1173  [9]
 LDCM0295  AC34 PaTu 8988t C640(0.80)  LDD1174  [9]
 LDCM0296  AC35 HCT 116 C640(1.19)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C640(1.04)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C640(0.91)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C640(1.05)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C640(1.10)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C640(0.61)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C640(1.03)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C640(1.02)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C640(1.04)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C640(1.03)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C640(1.05)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C640(1.04)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C640(1.47)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C640(2.69)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C640(1.84)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C640(1.18)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C640(0.64)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C640(1.75)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C640(3.63)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C640(0.96)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C640(1.55)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C640(1.50)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C640(1.74)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C640(1.94)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C640(0.54)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C640(0.52)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C640(0.57)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C640(0.62)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C640(0.56)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C640(0.58)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C640(0.53)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C640(0.56)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C640(0.57)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C640(0.68)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C640(0.63)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C640(0.58)  LDD0648  [9]
 LDCM0332  AC68 PaTu 8988t C640(1.33)  LDD1211  [9]
 LDCM0333  AC69 PaTu 8988t C640(0.99)  LDD1212  [9]
 LDCM0334  AC7 HCT 116 C640(0.75)  LDD0651  [9]
 LDCM0335  AC70 PaTu 8988t C640(0.98)  LDD1214  [9]
 LDCM0336  AC71 PaTu 8988t C640(1.29)  LDD1215  [9]
 LDCM0337  AC72 PaTu 8988t C640(1.64)  LDD1216  [9]
 LDCM0338  AC73 PaTu 8988t C640(1.51)  LDD1217  [9]
 LDCM0339  AC74 PaTu 8988t C640(1.24)  LDD1218  [9]
 LDCM0340  AC75 PaTu 8988t C640(1.08)  LDD1219  [9]
 LDCM0341  AC76 PaTu 8988t C640(1.05)  LDD1220  [9]
 LDCM0342  AC77 PaTu 8988t C640(1.50)  LDD1221  [9]
 LDCM0343  AC78 PaTu 8988t C640(1.32)  LDD1222  [9]
 LDCM0344  AC79 PaTu 8988t C640(1.42)  LDD1223  [9]
 LDCM0345  AC8 HCT 116 C640(0.69)  LDD0662  [9]
 LDCM0346  AC80 PaTu 8988t C640(1.46)  LDD1225  [9]
 LDCM0347  AC81 PaTu 8988t C640(1.41)  LDD1226  [9]
 LDCM0348  AC82 PaTu 8988t C640(1.39)  LDD1227  [9]
 LDCM0349  AC83 PaTu 8988t C640(1.06)  LDD1228  [9]
 LDCM0350  AC84 PaTu 8988t C640(1.03)  LDD1229  [9]
 LDCM0351  AC85 PaTu 8988t C640(1.12)  LDD1230  [9]
 LDCM0352  AC86 PaTu 8988t C640(1.04)  LDD1231  [9]
 LDCM0353  AC87 PaTu 8988t C640(1.18)  LDD1232  [9]
 LDCM0354  AC88 PaTu 8988t C640(1.14)  LDD1233  [9]
 LDCM0355  AC89 PaTu 8988t C640(1.07)  LDD1234  [9]
 LDCM0357  AC90 PaTu 8988t C640(1.26)  LDD1236  [9]
 LDCM0358  AC91 PaTu 8988t C640(1.18)  LDD1237  [9]
 LDCM0359  AC92 PaTu 8988t C640(1.03)  LDD1238  [9]
 LDCM0360  AC93 PaTu 8988t C640(1.40)  LDD1239  [9]
 LDCM0361  AC94 PaTu 8988t C640(1.03)  LDD1240  [9]
 LDCM0362  AC95 PaTu 8988t C640(1.02)  LDD1241  [9]
 LDCM0363  AC96 PaTu 8988t C640(1.67)  LDD1242  [9]
 LDCM0364  AC97 PaTu 8988t C640(1.20)  LDD1243  [9]
 LDCM0365  AC98 PaTu 8988t C640(0.62)  LDD1244  [9]
 LDCM0366  AC99 PaTu 8988t C640(0.55)  LDD1245  [9]
 LDCM0545  Acetamide MDA-MB-231 C603(0.32)  LDD2138  [4]
 LDCM0248  AKOS034007472 HCT 116 C640(0.91)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C640(0.68)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C640(0.59)  LDD0592  [9]
 LDCM0498  BS-3668 MDA-MB-231 C603(0.33)  LDD2091  [4]
 LDCM0632  CL-Sc Hep-G2 C745(0.26)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C640(1.17)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C640(0.74)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C640(0.59)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C640(0.64)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C640(0.81)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C640(0.79)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C640(0.81)  LDD0690  [9]
 LDCM0374  CL105 PaTu 8988t C640(0.83)  LDD1253  [9]
 LDCM0375  CL106 PaTu 8988t C640(0.87)  LDD1254  [9]
 LDCM0376  CL107 PaTu 8988t C640(1.06)  LDD1255  [9]
 LDCM0377  CL108 PaTu 8988t C640(0.84)  LDD1256  [9]
 LDCM0378  CL109 PaTu 8988t C640(0.73)  LDD1257  [9]
 LDCM0379  CL11 HCT 116 C640(0.79)  LDD0696  [9]
 LDCM0380  CL110 PaTu 8988t C640(0.83)  LDD1259  [9]
 LDCM0381  CL111 PaTu 8988t C640(0.69)  LDD1260  [9]
 LDCM0382  CL112 PaTu 8988t C640(0.96)  LDD1261  [9]
 LDCM0383  CL113 PaTu 8988t C640(0.85)  LDD1262  [9]
 LDCM0384  CL114 PaTu 8988t C640(0.75)  LDD1263  [9]
 LDCM0385  CL115 PaTu 8988t C640(0.92)  LDD1264  [9]
 LDCM0386  CL116 PaTu 8988t C640(1.34)  LDD1265  [9]
 LDCM0387  CL117 HCT 116 C640(1.03)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C640(1.00)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C640(1.05)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C640(0.86)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C640(1.10)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C640(1.65)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C640(1.07)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C640(1.18)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C640(1.14)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C640(0.83)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C640(0.67)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C640(0.67)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C640(0.53)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C640(0.79)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C640(0.93)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C640(0.82)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C640(0.75)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C640(0.50)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C640(0.67)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C640(0.73)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C640(1.10)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C640(0.63)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C640(0.60)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C640(0.73)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C640(0.65)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C640(0.64)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C640(0.62)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C640(0.67)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C640(0.71)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C640(0.62)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C640(0.67)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C640(0.96)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C640(0.74)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C640(0.71)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C640(0.82)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C640(0.65)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C640(0.60)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C640(0.59)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C640(0.60)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C640(0.57)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C640(0.61)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C640(0.88)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C640(0.67)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C640(0.60)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C640(0.62)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C640(0.61)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C640(0.59)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C640(0.59)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C640(1.32)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C640(1.01)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C640(1.20)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C640(0.94)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C640(0.92)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C640(1.00)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C640(1.09)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C640(1.03)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C640(0.96)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C640(1.11)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C640(1.03)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C640(0.91)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C640(0.95)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C640(1.10)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C640(1.04)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C640(0.84)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C640(0.95)  LDD0769  [9]
 LDCM0453  CL61 PaTu 8988t C640(0.98)  LDD1332  [9]
 LDCM0454  CL62 PaTu 8988t C640(0.35)  LDD1333  [9]
 LDCM0455  CL63 PaTu 8988t C640(0.73)  LDD1334  [9]
 LDCM0456  CL64 PaTu 8988t C640(0.76)  LDD1335  [9]
 LDCM0457  CL65 PaTu 8988t C640(0.67)  LDD1336  [9]
 LDCM0458  CL66 PaTu 8988t C640(0.38)  LDD1337  [9]
 LDCM0459  CL67 PaTu 8988t C640(0.57)  LDD1338  [9]
 LDCM0460  CL68 PaTu 8988t C640(0.68)  LDD1339  [9]
 LDCM0461  CL69 PaTu 8988t C640(0.38)  LDD1340  [9]
 LDCM0462  CL7 HCT 116 C640(0.92)  LDD0779  [9]
 LDCM0463  CL70 PaTu 8988t C640(0.64)  LDD1342  [9]
 LDCM0464  CL71 PaTu 8988t C640(0.59)  LDD1343  [9]
 LDCM0465  CL72 PaTu 8988t C640(0.57)  LDD1344  [9]
 LDCM0466  CL73 PaTu 8988t C640(0.55)  LDD1345  [9]
 LDCM0467  CL74 PaTu 8988t C640(0.86)  LDD1346  [9]
 LDCM0469  CL76 HCT 116 C640(0.69)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C640(0.77)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C640(0.59)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C640(0.74)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C640(0.79)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C640(0.79)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C640(0.72)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C640(0.71)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C640(0.70)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C640(0.61)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C640(0.94)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C640(0.76)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C640(0.65)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C640(0.81)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C640(0.81)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C640(0.84)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C640(1.16)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C640(0.73)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C640(0.83)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C640(0.73)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C640(0.59)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C640(0.55)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C640(0.62)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C640(0.59)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C640(0.58)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C640(0.55)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C640(0.97)  LDD1698  [17]
 LDCM0468  Fragment33 PaTu 8988t C640(0.70)  LDD1347  [9]
 LDCM0427  Fragment51 HCT 116 C640(0.58)  LDD0744  [9]
 LDCM0116  HHS-0101 DM93 Y223(0.94)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y223(0.66)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y223(1.14)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y223(1.42)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y223(1.00)  LDD0268  [6]
 LDCM0022  KB02 HEK-293T C640(1.02)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C640(1.03)  LDD1497  [17]
 LDCM0024  KB05 HMCB C640(4.97)  LDD3312  [18]
 LDCM0109  NEM HeLa N.A.  LDD0226  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C603(0.64)  LDD2099  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C603(0.57)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C625(1.40); C603(0.62)  LDD2111  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C603(0.54)  LDD2124  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C625(1.41)  LDD2129  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C603(0.98)  LDD2136  [4]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C603(1.05)  LDD2137  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C603(0.46)  LDD2140  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 12 (CCDC12) . Q8WUD4

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840