Details of the Target
General Information of Target
| Target ID | LDTP02172 | |||||
|---|---|---|---|---|---|---|
| Target Name | Histone H2B type 1-J (H2BC11) | |||||
| Gene Name | H2BC11 | |||||
| Gene ID | 8970 | |||||
| Synonyms |
H2BFR; HIST1H2BJ; Histone H2B type 1-J; Histone H2B.1; Histone H2B.r; H2B/r |
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| 3D Structure | ||||||
| Sequence |
MPEPAKSAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKQVHPDTGISSKAM
GIMNSFVNDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVT KYTSAK |
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| Target Bioclass |
Other
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| Family |
Histone H2B family
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| Subcellular location |
Nucleus
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| Function |
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.; Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
Probe 1 Probe Info |
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Y43(19.08) | LDD3495 | [1] | |
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HHS-475 Probe Info |
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Y84(1.13) | LDD0264 | [2] | |
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HHS-465 Probe Info |
 |
Y84(2.95) | LDD2237 | [3] | |
|
OSF Probe Info |
 |
Y84(0.00); H83(0.00); H110(0.00) | LDD0029 | [4] | |
Competitor(s) Related to This Target
The Interaction Atlas With This Target
References