Details of the Target

General Information of Target

Target ID LDTP11862
Target Name Polyadenylate-binding protein 3 (PABPC3)
Gene Name PABPC3
Gene ID 5042
Synonyms
PABP3; PABPL3; Polyadenylate-binding protein 3; PABP-3; Poly(A)-binding protein 3; Testis-specific poly(A)-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMQESGTETKSNGSAIQNGSGGSNHLLECGGLREGRSNGETPAVDIGAADLAHAQQQQQQ
ALQVARQLLLQQQQQQQVSGLKSPKRNDKQPALQVPVSVAMMTPQVITPQQMQQILQQQV
LSPQQLQVLLQQQQALMLQQQQLQEFYKKQQEQLQLQLLQQQHAGKQPKEQQQVATQQLA
FQQQLLQMQQLQQQHLLSLQRQGLLTIQPGQPALPLQPLAQGMIPTELQQLWKEVTSAHT
AEETTGNNHSSLDLTTTCVSSSAPSKTSLIMNPHASTNGQLSVHTPKRESLSHEEHPHSH
PLYGHGVCKWPGCEAVCEDFQSFLKHLNSEHALDDRSTAQCRVQMQVVQQLELQLAKDKE
RLQAMMTHLHVKSTEPKAAPQPLNLVSSVTLSKSASEASPQSLPHTPTTPTAPLTPVTQG
PSVITTTSMHTVGPIRRRYSDKYNVPISSADIAQNQEFYKNAEVRPPFTYASLIRQAILE
SPEKQLTLNEIYNWFTRMFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVE
FQKRRPQKISGNPSLIKNMQSSHAYCTPLNAALQASMAENSIPLYTTASMGNPTLGNLAS
AIREELNGAMEHTNSNESDSSPGRSPMQAVHPVHVKEEPLDPEEAEGPLSLVTTANHSPD
FDHDRDYEDEPVNEDME
Target Bioclass
Other
Family
Polyadenylate-binding protein type-1 family
Subcellular location
Cytoplasm
Function Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.
Uniprot ID
Q9H361
Ensemble ID
ENST00000281589.5
HGNC ID
HGNC:8556

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		E239(10.00)  LDD2208  [1]
DBIA
 Probe Info  		C132(1.07)  LDD3310  [2]
BTD
 Probe Info  		C132(2.33)  LDD2119  [3]
AHL-Pu-1
 Probe Info  		C339(2.44)  LDD0169  [4]
HHS-475
 Probe Info  		Y508(0.94); Y364(0.96)  LDD0264  [5]
HHS-465
 Probe Info  		Y508(6.94)  LDD2237  [6]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [7]
OSF
 Probe Info  		N.A.  LDD0029  [8]
Acrolein
 Probe Info  		H612(0.00); C339(0.00); C132(0.00)  LDD0217  [9]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [9]
Crotonaldehyde
 Probe Info  		C339(0.00); C132(0.00)  LDD0219  [9]
Methacrolein
 Probe Info  		C339(0.00); C132(0.00)  LDD0218  [9]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		7.85  LDD0475  [10]
FFF probe3
 Probe Info  		6.59  LDD0464  [10]
STS-1
 Probe Info  		N.A.  LDD0136  [11]
STS-2
 Probe Info  		N.A.  LDD0138  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C132(0.77)  LDD2130  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C132(0.57)  LDD2132  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C339(2.44)  LDD0169  [4]
 LDCM0108  Chloroacetamide HeLa H612(0.00); C339(0.00); C132(0.00)  LDD0222  [9]
 LDCM0116  HHS-0101 DM93 Y508(0.94); Y364(0.96)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y364(0.83); Y508(0.87)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y508(0.76); Y364(0.82)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y364(0.86); Y508(0.87)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y364(0.75); Y508(0.86)  LDD0268  [5]
 LDCM0107  IAA HeLa C339(0.00); H612(0.00)  LDD0221  [9]
 LDCM0022  KB02 22RV1 C132(1.22)  LDD2243  [2]
 LDCM0023  KB03 22RV1 C132(1.30)  LDD2660  [2]
 LDCM0024  KB05 COLO792 C132(1.07)  LDD3310  [2]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C132(0.59)  LDD2121  [3]
 LDCM0109  NEM HeLa H612(0.00); C339(0.00); H569(0.00)  LDD0223  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C132(2.33)  LDD2119  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C132(0.25)  LDD2124  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C132(1.32)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C132(0.97)  LDD2140  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C132(3.53)  LDD2144  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Terminal nucleotidyltransferase 5D (TENT5D) TENT family Q8NEK8
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Wolframin (WFS1) . O76024

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
11 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.