Details of the Target

General Information of Target

Target ID LDTP17347
Target Name Eukaryotic translation initiation factor 5A-1-like (EIF5AL1)
Gene Name EIF5AL1
Gene ID 143244
Synonyms
Eukaryotic translation initiation factor 5A-1-like; eIF-5A-1-like; eIF-5A1-like; Eukaryotic initiation factor 5A isoform 1-like
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMAENNLKMLKIQQCVVANKLPRNRPYVCNICFKHFETPSKLARHYLIHTGQKPFECDVC
HKTFRQLVHLERHQLTHSLPFKCSICQRHFKNLKTFVKHQQLHNETYQNNVKQVRRLLEA
KQEKSMYGVYNTFTTEERWALHPCSKSDPMYSMKRRKNIHACTICGKMFPSQSKLDRHVL
IHTGQRPFKCVLCTKSFRQSTHLKIHQLTHSEERPFQCCFCQKGFKIQSKLLKHKQIHTR
NKAFRALLLKKRRTESRPLPNKLNANQGGFENGEIGESEENNPLDVHSIYIVPFQCPKCE
KCFESEQILNEHSCFAARSGKIPSRFKRSYNYKTIVKKILAKLKRARSKKLDNFQSEKKV
FKKSFLRNCDLISGEQSSEQTQRTFVGSLGKHGTYKTIGNRKKKTLTLPFSWQNMGKNLK
GILTTENILSIDNSVNKKDLSICGSSGEEFFNNCEVLQCGFSVPRENIRTRHKICPCDKC
EKVFPSISKLKRHYLIHTGQRPFGCNICGKSFRQSAHLKRHEQTHNEKSPYASLCQVEFG
NFNNLSNHSGNNVNYNASQQCQAPGVQKYEVSESDQMSGVKAESQDFIPGSTGQPCLPNV
LLESEQSNPFCSYSEHQEKNDVFLYRCSVCAKSFRSPSKLERHYLIHAGQKPFECSVCGK
TFRQAPHWKRHQLTHFKERPQGKVVALDSVM
Target Bioclass
Transporter and channel
Family
EIF-5A family
Subcellular location
Cytoplasm
Function
Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step. Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity.
Uniprot ID
Q6IS14
Ensemble ID
ENST00000520547.4
HGNC ID
HGNC:17419

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K68(8.64); K85(15.01); K150(20.00); K126(20.00)  LDD2217  [2]
AZ-9
 Probe Info  		E116(1.10); D118(1.13); R113(1.06)  LDD2208  [3]
DBIA
 Probe Info  		C159(0.86)  LDD3310  [4]
BTD
 Probe Info  		C73(0.51)  LDD2096  [5]
AHL-Pu-1
 Probe Info  		C129(2.01)  LDD0169  [6]
HHS-475
 Probe Info  		Y69(0.89); Y127(20.00)  LDD0264  [7]
HHS-465
 Probe Info  		Y69(10.00)  LDD2237  [8]
IA-alkyne
 Probe Info  		C73(0.00); C22(0.00)  LDD0163  [9]
IPM
 Probe Info  		N.A.  LDD0025  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
OSF
 Probe Info  		N.A.  LDD0029  [12]
PPMS
 Probe Info  		N.A.  LDD0008  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
AOyne
 Probe Info  		15.00  LDD0443  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C73(0.78)  LDD2103  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C73(0.49)  LDD2132  [5]
 LDCM0025  4SU-RNA DM93 C129(2.15)  LDD0170  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C129(2.01)  LDD0169  [6]
 LDCM0214  AC1 HEK-293T C73(0.94); C129(0.97)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C73(1.01); C129(1.09)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C73(0.92); C129(1.02)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C73(1.03); C129(1.01)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C73(1.05); C129(1.02)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C73(1.01); C129(1.02)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C73(1.02); C129(0.97)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C73(0.94); C129(1.02)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C73(0.79); C129(0.82)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C73(1.13); C129(1.08)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C73(1.03); C129(0.99)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C73(0.98); C129(0.98)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C73(1.05); C129(1.10)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C73(1.09); C129(1.05)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C73(1.09); C129(1.06)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C73(0.97); C129(0.94)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C73(1.04); C129(0.99)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C73(0.97); C129(0.98)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C73(1.02); C129(0.98)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C73(1.07); C129(1.03)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C73(0.92); C129(1.01)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C73(1.07); C129(0.97)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C73(1.05); C129(0.98)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C73(1.07); C129(1.08)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C73(1.00); C129(1.03)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C73(1.07); C129(1.02)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C73(0.99); C129(1.03)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C73(1.07); C129(0.99)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C73(1.12); C129(1.13)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C73(1.08); C129(1.07)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C73(1.01); C129(1.00)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C73(0.96); C129(0.96)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C73(1.01); C129(1.13)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C73(0.95); C129(1.01)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C73(0.97); C129(1.01)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C73(0.95); C129(1.02)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C73(0.94); C129(0.99)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C73(1.00); C129(1.02)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C73(1.00); C129(1.05)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C73(0.97); C129(1.02)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C73(1.05); C129(1.11)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C73(0.97); C129(1.03)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C73(0.96); C129(1.12)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C73(1.00); C129(1.05)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C73(1.04); C129(1.05)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C73(0.96); C129(0.99)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C73(1.02); C129(1.03)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C73(1.01); C129(1.01)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C73(0.94); C129(1.08)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C73(0.96); C129(1.08)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C73(0.90); C129(0.98)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C73(1.00); C129(1.05)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C73(0.93); C129(1.04)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C73(0.99); C129(0.98)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C73(0.97); C129(1.00)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C73(0.86); C129(1.03)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C73(0.90); C129(1.01)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C73(0.96); C129(1.02)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C73(0.96); C129(1.06)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C73(1.06); C129(1.03)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C73(1.08); C129(1.06)  LDD1569  [14]
 LDCM0545  Acetamide MDA-MB-231 C73(0.65)  LDD2138  [5]
 LDCM0248  AKOS034007472 HEK-293T C73(1.00); C129(1.08)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C73(0.94); C129(1.05)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C73(1.01); C129(1.08)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 13.18  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C73(0.98); C129(0.99)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C73(0.88); C129(0.91)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C73(0.93); C129(1.01)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C73(0.91); C129(0.99)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C73(0.87); C129(0.91)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C73(1.02); C129(1.06)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C73(0.88); C129(1.02)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C73(0.99); C129(0.97)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C73(0.98); C129(0.94)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C73(0.99); C129(1.08)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C73(0.96); C129(0.99)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C73(1.00); C129(0.96)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C73(1.00); C129(0.97)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C73(0.92); C129(0.88)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C73(1.02); C129(0.97)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C73(0.91); C129(0.96)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C73(1.03); C129(1.07)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C73(0.92); C129(0.88)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C73(1.06); C129(1.00)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C73(0.92); C129(1.01)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C73(0.92); C129(1.04)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C73(0.94); C129(1.00)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C73(1.03); C129(1.02)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C73(1.07); C129(1.02)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C73(0.94); C129(1.05)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C73(0.89); C129(1.03)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C73(0.89); C129(0.98)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C73(0.89); C129(0.93)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C73(0.83); C129(0.95)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C73(0.74); C129(1.08)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C73(0.76); C129(0.97)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C73(0.89); C129(1.02)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C73(0.80); C129(1.00)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C73(0.80); C129(0.96)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C73(1.04); C129(1.04)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C73(0.88); C129(0.93)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C73(0.97); C129(1.05)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C73(0.85); C129(0.89)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C73(1.07); C129(1.11)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C73(0.92); C129(1.09)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C73(0.97); C129(1.00)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C73(1.12); C129(1.02)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C73(1.04); C129(0.96)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C73(0.92); C129(1.05)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C73(1.04); C129(1.06)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C73(1.04); C129(1.09)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C73(0.83); C129(0.97)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C73(1.04); C129(1.03)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C73(1.07); C129(1.06)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C73(0.95); C129(0.98)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C73(1.02); C129(1.06)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C73(0.99); C129(1.07)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C73(1.08); C129(1.10)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C73(0.92); C129(0.94)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C73(1.06); C129(0.99)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C73(0.90); C129(0.87)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C73(0.93); C129(1.01)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C73(1.07); C129(0.99)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C73(1.08); C129(1.09)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C73(0.90); C129(1.00)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C73(1.08); C129(0.99)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C73(0.85); C129(1.01)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C73(1.05); C129(1.03)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C73(0.98); C129(0.93)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C73(0.99); C129(1.05)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C73(1.12); C129(1.05)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C73(1.05); C129(0.93)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C73(1.00); C129(0.96)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C73(1.00); C129(1.01)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C73(1.09); C129(0.95)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C73(1.07); C129(1.08)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C73(0.89); C129(1.08)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C73(0.85); C129(0.99)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C73(0.92); C129(0.97)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C73(0.94); C129(1.04)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C73(0.87); C129(0.92)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C73(0.86); C129(0.97)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C73(0.95); C129(1.05)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C73(1.13); C129(0.97)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C73(1.01); C129(0.97)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C73(0.95); C129(0.98)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C73(0.99); C129(1.00)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C73(0.87); C129(0.93)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C73(1.10); C129(1.08)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C73(0.91); C129(1.06)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C73(1.06); C129(1.02)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C73(1.04); C129(1.08)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C73(0.92); C129(0.93)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C73(1.01); C129(1.07)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C73(1.00); C129(1.08)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C73(1.04); C129(1.03)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C73(1.07); C129(0.97)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C73(0.98); C129(1.08)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C73(0.87); C129(0.99)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C73(0.97); C129(1.09)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C73(0.97); C129(0.98)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C73(1.02); C129(1.09)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C73(0.88); C129(1.02)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C73(0.97); C129(0.99)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C73(0.88); C129(1.02)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C73(0.84); C129(0.91)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C73(1.03); C129(1.08)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C73(1.00); C129(1.04)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C73(0.75); C129(0.73)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C73(1.07); C129(1.06)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C73(1.05); C129(1.04)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C73(1.03); C129(1.04)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C73(1.00); C129(1.03)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C73(0.97); C129(0.97)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C73(0.75); C129(1.07)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C73(0.70); C129(1.06)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C73(0.85); C129(1.10)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C73(0.76); C129(1.06)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C73(0.80); C129(1.08)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C73(1.01); C129(0.99)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C73(0.71); C129(0.82)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C73(0.80); C129(1.10)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C73(0.86); C129(0.95)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C73(0.90); C129(1.01)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C73(0.88); C129(1.01)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C73(0.79); C129(0.86)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C73(0.70); C129(0.98)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C73(0.88); C129(0.96)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C73(0.93); C129(0.93)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C73(1.01); C129(1.00)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C73(1.10); C129(1.06)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C73(0.74)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C73(1.01); C129(1.03)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C73(1.01); C129(1.02)  LDD1631  [14]
 LDCM0116  HHS-0101 DM93 Y69(0.89); Y127(20.00)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y69(0.71); Y127(20.00)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y69(0.68)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y69(0.77)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y69(0.97); Y127(20.00)  LDD0268  [7]
 LDCM0022  KB02 HEK-293T C73(1.00); C129(1.01)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C73(0.93); C129(1.03)  LDD1497  [14]
 LDCM0024  KB05 COLO792 C159(0.86)  LDD3310  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C73(0.51)  LDD2096  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C73(1.23)  LDD2105  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C73(0.89)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C73(0.90)  LDD2118  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C73(0.79)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C73(0.68)  LDD2122  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C73(0.83)  LDD2124  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C73(0.94)  LDD2126  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C73(0.71)  LDD2128  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C73(0.63)  LDD2150  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402