Details of the Target

General Information of Target

Target ID LDTP06006
Target Name Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)
Gene Name IDI1
Gene ID 3422
Synonyms
Isopentenyl-diphosphate Delta-isomerase 1; EC 5.3.3.2; Isopentenyl pyrophosphate isomerase 1; IPP isomerase 1; IPPI1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEINTNHLDKQQVQLLAEMCILIDENDNKIGAETKKNCHLNENIEKGLLHRAFSVFLFN
TENKLLLQQRSDAKITFPGCFTNTCCSHPLSNPAELEESDALGVRRAAQRRLKAELGIPL
EEVPPEEINYLTRIHYKAQSDGIWGEHEIDYILLVRKNVTLNPDPNEIKSYCYVSKEELK
ELLKKAASGEIKITPWFKIIAATFLFKWWDNLNHLNQFVDHEKIYRM
Target Bioclass
Enzyme
Family
IPP isomerase type 1 family
Subcellular location
Peroxisome
Function Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Uniprot ID
Q13907
Ensemble ID
ENST00000381344.8
HGNC ID
HGNC:5387

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.35  LDD0402  [1]
A-EBA
 Probe Info  		3.72  LDD0215  [2]
TH211
 Probe Info  		Y171(5.28)  LDD0260  [3]
STPyne
 Probe Info  		K37(4.85)  LDD0277  [4]
IPM
 Probe Info  		C39(0.00); C172(0.00)  LDD0241  [5]
Probe 1
 Probe Info  		Y130(12.93); Y171(11.16); Y173(35.62)  LDD3495  [6]
THZ1-DTB
 Probe Info  		C80(1.04)  LDD0460  [7]
BTD
 Probe Info  		C39(1.03)  LDD1700  [8]
Jackson_14
 Probe Info  		2.17  LDD0123  [9]
AHL-Pu-1
 Probe Info  		C172(2.19)  LDD0168  [10]
HHS-475
 Probe Info  		Y171(0.69)  LDD0264  [11]
DBIA
 Probe Info  		C172(0.99)  LDD1492  [12]
5E-2FA
 Probe Info  		H8(0.00); H214(0.00)  LDD2235  [13]
ATP probe
 Probe Info  		K36(0.00); K37(0.00); K223(0.00)  LDD0199  [14]
4-Iodoacetamidophenylacetylene
 Probe Info  		C39(0.00); C172(0.00)  LDD0038  [15]
IA-alkyne
 Probe Info  		C85(0.00); C86(0.00); C80(0.00); C39(0.00)  LDD0036  [15]
IPIAA_L
 Probe Info  		C39(0.00); C80(0.00); C172(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C39(0.00); C172(0.00); C85(0.00); C86(0.00)  LDD0037  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [18]
Acrolein
 Probe Info  		C39(0.00); C172(0.00); H88(0.00)  LDD0217  [19]
Methacrolein
 Probe Info  		C172(0.00); C39(0.00); K37(0.00)  LDD0218  [19]
W1
 Probe Info  		N.A.  LDD0236  [5]
AOyne
 Probe Info  		14.50  LDD0443  [20]
NAIA_5
 Probe Info  		C39(0.00); C172(0.00); C21(0.00)  LDD2223  [21]
TER-AC
 Probe Info  		N.A.  LDD0426  [22]
HHS-465
 Probe Info  		Y171(0.00); K37(0.00)  LDD2240  [23]
HHS-482
 Probe Info  		Y171(2.42)  LDD2239  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C39(0.99); C172(1.35)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C39(0.90); C172(1.39)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C39(0.76)  LDD2103  [8]
 LDCM0025  4SU-RNA HEK-293T C172(2.19)  LDD0168  [10]
 LDCM0215  AC10 HEK-293T C172(1.01)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C172(1.06)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C172(1.17)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C172(1.14)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C172(1.27); C85(1.20)  LDD1513  [12]
 LDCM0277  AC18 HEK-293T C172(1.06)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C172(1.03)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C172(1.05)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C172(1.21)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C86(0.97)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C172(1.14)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C172(1.40); C85(1.19)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C172(1.24); C85(1.02)  LDD1523  [12]
 LDCM0286  AC26 HEK-293T C172(0.87)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C172(0.93)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C172(1.08)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C86(0.74)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C172(0.87)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C172(0.91)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C172(1.05); C85(1.15)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C172(1.17); C85(1.06)  LDD1532  [12]
 LDCM0295  AC34 HEK-293T C172(1.29)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C172(1.23)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C172(1.47)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C86(0.91)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C172(1.34)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C172(1.50); C85(1.20)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C172(0.94)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C172(1.16); C85(0.95)  LDD1541  [12]
 LDCM0304  AC42 HEK-293T C172(0.94)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C172(1.15)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C172(1.30)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C86(0.92)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C172(1.18)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C172(1.40); C85(1.10)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C172(1.31); C85(1.11)  LDD1549  [12]
 LDCM0312  AC5 HEK-293T C86(1.40)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C172(1.06)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C172(1.11)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C172(1.36)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C86(1.01)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C172(1.30)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C172(1.39); C85(1.21)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C172(1.29); C85(0.91)  LDD1558  [12]
 LDCM0321  AC58 HEK-293T C172(1.12)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C172(1.19)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C172(0.86)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C172(1.24)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C86(0.83)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C172(1.17)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C172(1.41); C85(1.16)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C172(1.25); C85(1.05)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C172(0.98); C85(0.89)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C172(0.77); C85(0.87)  LDD1569  [12]
 LDCM0545  Acetamide MDA-MB-231 C39(0.30)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C39(0.71)  LDD2113  [8]
 LDCM0248  AKOS034007472 HEK-293T C86(1.18)  LDD1511  [12]
 LDCM0275  AKOS034007705 HEK-293T C172(1.10); C85(1.00)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 13.86  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C39(0.00); C172(0.00)  LDD0222  [19]
 LDCM0367  CL1 HEK-293T C172(1.01)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C172(0.88)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C86(1.07)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C172(1.18)  LDD1574  [12]
 LDCM0372  CL103 HEK-293T C172(1.24); C86(1.13)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C86(0.97)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C172(1.23)  LDD1578  [12]
 LDCM0376  CL107 HEK-293T C172(1.15); C86(1.15)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C86(0.97)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C172(0.96)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C172(1.27); C85(1.16)  LDD1583  [12]
 LDCM0381  CL111 HEK-293T C172(1.12); C86(1.06)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C86(0.94)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C172(1.41)  LDD1587  [12]
 LDCM0385  CL115 HEK-293T C172(1.09); C86(0.94)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C86(0.96)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C172(1.50)  LDD1591  [12]
 LDCM0389  CL119 HEK-293T C172(0.94); C86(1.04)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C172(1.20); C85(0.92)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C86(1.03)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C172(1.40)  LDD1596  [12]
 LDCM0394  CL123 HEK-293T C172(1.19); C86(1.03)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C86(1.11)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C172(1.12)  LDD1600  [12]
 LDCM0398  CL127 HEK-293T C172(1.19); C86(0.98)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C86(0.99)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C172(1.09)  LDD1604  [12]
 LDCM0402  CL15 HEK-293T C172(1.19); C86(1.26)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C86(0.87)  LDD1607  [12]
 LDCM0405  CL18 HEK-293T C172(1.14)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C172(1.19)  LDD1610  [12]
 LDCM0408  CL20 HEK-293T C172(1.45)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C86(0.99)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C172(1.18)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C172(1.51); C85(1.26)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C172(1.34); C85(0.87)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C172(1.72)  LDD1617  [12]
 LDCM0415  CL27 HEK-293T C172(1.21); C86(1.05)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C86(0.86)  LDD1620  [12]
 LDCM0418  CL3 HEK-293T C172(0.95); C86(0.94)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C172(1.13)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C172(1.03)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C172(1.39)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C86(0.87)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C172(1.28)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C172(1.50); C85(1.27)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C172(1.33); C85(1.02)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C172(1.44)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C172(1.30); C86(1.17)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C86(0.92)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C86(1.11)  LDD1634  [12]
 LDCM0432  CL42 HEK-293T C172(1.09)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C172(1.06)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C172(1.25)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C86(0.88)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C172(1.15)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C172(1.39); C85(1.16)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C172(1.36); C85(1.07)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C172(1.19)  LDD1643  [12]
 LDCM0443  CL52 HEK-293T C86(1.16)  LDD1646  [12]
 LDCM0445  CL54 HEK-293T C172(1.25)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C172(1.29)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C172(1.48)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C86(1.09)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C172(1.25)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C172(1.55); C85(1.34)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C172(0.90)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C172(1.66); C85(1.02)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C172(1.27)  LDD1656  [12]
 LDCM0455  CL63 HEK-293T C172(1.22); C86(1.14)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C86(1.09)  LDD1659  [12]
 LDCM0458  CL66 HEK-293T C172(1.26)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C172(1.10)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C172(1.45)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C86(1.16)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C172(1.16)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C172(1.31)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C172(1.38); C85(1.21)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C172(1.54); C85(1.25)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C172(0.98)  LDD1669  [12]
 LDCM0469  CL76 HEK-293T C86(1.03)  LDD1672  [12]
 LDCM0471  CL78 HEK-293T C172(0.93)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C172(0.95)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C172(0.93)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C172(1.02)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C86(1.10)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C172(0.97)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C172(1.16); C85(1.36)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C172(1.08); C85(0.91)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C172(1.68)  LDD1682  [12]
 LDCM0481  CL87 HEK-293T C172(1.13); C86(1.17)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C86(0.97)  LDD1685  [12]
 LDCM0484  CL9 HEK-293T C86(0.93)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C172(1.38)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C172(1.25)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C172(1.55)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C86(0.97)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C172(1.27)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C172(1.30); C85(1.37)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C172(1.29); C85(1.12)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C172(1.02)  LDD1695  [12]
 LDCM0494  CL99 HEK-293T C172(0.94); C86(0.99)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C172(1.17); C86(1.35)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C172(1.31)  LDD1702  [8]
 LDCM0625  F8 Ramos C39(1.06); C172(0.83)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C39(1.06); C172(0.91)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C39(8.35); C172(0.53)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C39(1.02); C172(0.76)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C39(2.39); C172(0.79)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C39(0.89); C172(0.87)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C39(0.96); C172(0.58)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C39(1.43); C172(1.39)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C39(1.04); C172(1.43)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C39(3.06); C172(1.19)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C39(0.61)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C39(1.23); C172(1.16)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C39(0.84); C172(1.11)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C39(0.87); C172(0.63)  LDD2201  [25]
 LDCM0468  Fragment33 HEK-293T C172(0.88); C86(0.90)  LDD1671  [12]
 LDCM0596  Fragment38 Ramos C39(1.29); C172(1.48)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C39(0.98); C172(0.77)  LDD2184  [25]
 LDCM0610  Fragment52 Ramos C39(1.60); C172(0.79)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C39(0.85); C172(0.82)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C39(1.06); C172(0.82)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C39(0.75); C172(0.61)  LDD2188  [25]
 LDCM0116  HHS-0101 DM93 Y171(0.69)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y171(0.52)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y171(0.54)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y171(0.61)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y171(0.77)  LDD0268  [11]
 LDCM0107  IAA HeLa N.A.  LDD0221  [19]
 LDCM0022  KB02 HEK-293T C172(0.99)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C172(1.08)  LDD1497  [12]
 LDCM0024  KB05 HEK-293T C172(0.79)  LDD1502  [12]
 LDCM0109  NEM HeLa N.A.  LDD0223  [19]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C39(0.60)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C39(0.99)  LDD2094  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C39(1.06)  LDD2097  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C39(0.87)  LDD2099  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C39(0.67)  LDD2101  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C39(0.99)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C39(0.52); C172(0.63)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C39(0.82)  LDD2111  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C39(0.46)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C39(0.89)  LDD2116  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C39(0.74)  LDD2120  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C39(0.70)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C39(0.95)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C39(1.11)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C39(0.76)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C39(0.55)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C39(0.91); C172(0.53)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C172(1.78)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C39(0.98); C172(1.00)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C39(0.88); C172(1.15)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C39(1.03)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C39(0.68)  LDD2140  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C39(1.01)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C39(2.47)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C39(0.54)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C39(1.80)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C39(0.48); C172(0.48)  LDD2148  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C39(0.18)  LDD2150  [8]
 LDCM0131  RA190 MM1.R C172(1.35)  LDD0304  [26]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.17  LDD0123  [9]
 LDCM0021  THZ1 HeLa S3 C80(1.04)  LDD0460  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dimethylallyl Diphosphate Small molecular drug DB01785

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
24 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.