Details of the Target

General Information of Target

Target ID LDTP01508
Target Name Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)
Gene Name AKR7A3
Gene ID 22977
Synonyms
AFAR2; Aflatoxin B1 aldehyde reductase member 3; EC 1.-.-.-; AFB1 aldehyde reductase 2; AFB1-AR 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRQLSRARPATVLGAMEMGRRMDAPTSAAVTRAFLERGHTEIDTAFVYSEGQSETILGG
LGLRLGGSDCRVKIDTKAIPLFGNSLKPDSLRFQLETSLKRLQCPRVDLFYLHMPDHSTP
VEETLRACHQLHQEGKFVELGLSNYAAWEVAEICTLCKSNGWILPTVYQGMYNAITRQVE
TELFPCLRHFGLRFYAFNPLAGGLLTGKYKYEDKNGKQPVGRFFGNTWAEMYRNRYWKEH
HFEGIALVEKALQAAYGASAPSMTSATLRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLA
AAEEGPLEPAVVDAFNQAWHLVTHECPNYFR
Target Bioclass
Enzyme
Family
Aldo/keto reductase family, Aldo/keto reductase 2 subfamily
Subcellular location
Cytoplasm
Function
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen.
Uniprot ID
O95154
Ensemble ID
ENST00000361640.5
HGNC ID
HGNC:390

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C214(0.93)  LDD3310  [1]
THZ1-DTB
 Probe Info  		C186(1.06)  LDD0460  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C70(1.42)  LDD2243  [1]
 LDCM0023  KB03 22RV1 C70(1.78)  LDD2660  [1]
 LDCM0024  KB05 COLO792 C214(0.93)  LDD3310  [1]
 LDCM0021  THZ1 HeLa S3 C186(1.06)  LDD0460  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aflatoxin B1 aldehyde reductase member 2 (AKR7A2) Aldo/keto reductase family O43488
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3) Aldo/keto reductase family O95154
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.