Details of the Target

General Information of Target

Target ID LDTP00114
Target Name Putative annexin A2-like protein (ANXA2P2)
Gene Name ANXA2P2
Synonyms
ANX2L2; ANX2P2; LPC2B; Putative annexin A2-like protein; Annexin A2 pseudogene 2; Lipocortin II pseudogene
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSTVHEILCKLSLEGDHSTPPSAYGSVKAYTNFDAERDALNIETAIKTKGVDEVTIVNIV
TNRDNAQRQDIVFSYQRRTKKELASALKSALSGHLETVILGLLKTPAQYDASELKASMKG
LGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRA
EDGSVIDYELIDQDAQDLYDAGVKRKGTDVPKWISIMTERSVPHLQKVFDRYKSYSPYDM
LESIRKEVKGDLENAFLNLVQRIQNKPLYFADQLYDSMKGKGTRDKVLIRIMVSRSEVDM
LKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
Target Bioclass
Other
Family
Annexin family
Subcellular location
Secreted, extracellular space, extracellular matrix, basement membrane
Function
Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response.
Uniprot ID
A6NMY6
HGNC ID
HGNC:539
ChEMBL ID
CHEMBL4295633

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AZ-9
 Probe Info  		D322(0.97); D34(0.98); E36(0.98); E219(0.96)  LDD2208  [1]
OPA-S-S-alkyne
 Probe Info  		K212(1.42); K28(1.99); K119(2.12); K157(4.25)  LDD3494  [2]
DBIA
 Probe Info  		C353(4.39); C151(6.91)  LDD3312  [3]
THZ1-DTB
 Probe Info  		C133(1.10)  LDD0460  [4]
HHS-475
 Probe Info  		Y316(0.74); Y317(0.81); Y24(0.86); Y235(1.01)  LDD0264  [5]
IA-alkyne
 Probe Info  		C9(0.59)  LDD2206  [6]
HHS-465
 Probe Info  		Y238(10.00); Y24(1.56); Y30(10.00); Y317(5.56)  LDD2237  [7]
5E-2FA
 Probe Info  		H17(0.00); H94(0.00); H5(0.00)  LDD2235  [8]
m-APA
 Probe Info  		H17(0.00); H94(0.00); H5(0.00)  LDD2231  [8]
JW-RF-010
 Probe Info  		C9(0.00); C133(0.00)  LDD0026  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
NPM
 Probe Info  		N.A.  LDD0016  [10]
PPMS
 Probe Info  		N.A.  LDD0008  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Ox-W18
 Probe Info  		N.A.  LDD2175  [12]
NAIA_5
 Probe Info  		C335(0.00); C133(0.00); C9(0.00)  LDD2223  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0116  HHS-0101 DM93 Y316(0.74); Y317(0.81); Y24(0.86); Y235(1.01)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y316(0.58); Y317(0.68); Y24(0.73); Y30(1.31)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y317(0.70); Y316(0.70); Y235(0.76); Y24(0.80)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y316(0.68); Y317(0.69); Y24(0.73); Y30(0.89)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y316(0.45); Y317(0.60); Y24(0.64); Y30(0.73)  LDD0268  [5]
 LDCM0022  KB02 42-MG-BA C353(1.85); C151(2.74)  LDD2244  [3]
 LDCM0023  KB03 42-MG-BA C353(1.58); C151(2.63)  LDD2661  [3]
 LDCM0024  KB05 HMCB C353(4.39); C151(6.91)  LDD3312  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C9(0.59)  LDD2206  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C9(0.71)  LDD2207  [6]
 LDCM0021  THZ1 HeLa S3 C133(1.10)  LDD0460  [4]

References

1 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264