Details of the Target

General Information of Target

Target ID LDTP03611
Target Name 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH)
Gene Name HIBADH
Gene ID 11112
Synonyms
3-hydroxyisobutyrate dehydrogenase, mitochondrial; HIBADH; EC 1.1.1.31
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASLRLLGAASGLRYWSRRLRPAAGSFAAVCSRSVASKTPVGFIGLGNMGNPMAKNLMK
HGYPLIIYDVFPDACKEFQDAGEQVVSSPADVAEKADRIITMLPTSINAIEAYSGANGIL
KKVKKGSLLIDSSTIDPAVSKELAKEVEKMGAVFMDAPVSGGVGAARSGNLTFMVGGVED
EFAAAQELLGCMGSNVVYCGAVGTGQAAKICNNMLLAISMIGTAEAMNLGIRLGLDPKLL
AKILNMSSGRCWSSDTYNPVPGVMDGVPSANNYQGGFGTTLMAKDLGLAQDSATSTKSPI
LLGSLAHQIYRMMCAKGYSKKDFSSVFQFLREEETF
Target Bioclass
Enzyme
Family
HIBADH-related family, 3-hydroxyisobutyrate dehydrogenase subfamily
Subcellular location
Mitochondrion
Uniprot ID
P31937
Ensemble ID
ENST00000265395.7
HGNC ID
HGNC:4907
ChEMBL ID
CHEMBL4523215

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
STPyne
 Probe Info  		K141(7.20); K297(6.04)  LDD0277  [2]
DBIA
 Probe Info  		C75(1.12)  LDD3310  [3]
THZ1-DTB
 Probe Info  		C199(0.91)  LDD0460  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C75(0.00); C211(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C75(0.00); C211(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C75(0.00); C211(0.00)  LDD0037  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [7]
1c-yne
 Probe Info  		K297(0.00); K125(0.00); K321(0.00)  LDD0228  [8]
1d-yne
 Probe Info  		K149(0.00); K145(0.00); K141(0.00)  LDD0357  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
W1
 Probe Info  		N.A.  LDD0236  [10]
MPP-AC
 Probe Info  		N.A.  LDD0428  [11]
NAIA_5
 Probe Info  		C75(0.00); C211(0.00)  LDD2223  [12]
TER-AC
 Probe Info  		N.A.  LDD0426  [11]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		9.51  LDD1838  [13]
FFF probe13
 Probe Info  		12.12  LDD0475  [14]
FFF probe2
 Probe Info  		7.72  LDD0463  [14]
FFF probe3
 Probe Info  		5.02  LDD0465  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]
DA-2
 Probe Info  		N.A.  LDD0072  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C75(1.06)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C75(1.08); C251(1.10); C211(1.07)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C75(1.04); C251(0.94); C211(1.06)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C75(1.04); C251(0.96); C211(0.98)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C75(1.06); C251(0.91); C211(1.01)  LDD1512  [17]
 LDCM0263  AC143 PaTu 8988t C251(1.17)  LDD1142  [18]
 LDCM0264  AC144 PaTu 8988t C251(0.97)  LDD1143  [18]
 LDCM0265  AC145 PaTu 8988t C251(1.18)  LDD1144  [18]
 LDCM0266  AC146 PaTu 8988t C251(0.97)  LDD1145  [18]
 LDCM0267  AC147 PaTu 8988t C251(0.95)  LDD1146  [18]
 LDCM0268  AC148 PaTu 8988t C251(1.15)  LDD1147  [18]
 LDCM0269  AC149 PaTu 8988t C251(1.20)  LDD1148  [18]
 LDCM0270  AC15 HEK-293T C75(0.99); C251(0.98); C211(0.94)  LDD1513  [17]
 LDCM0271  AC150 PaTu 8988t C251(1.22)  LDD1150  [18]
 LDCM0272  AC151 PaTu 8988t C251(1.26)  LDD1151  [18]
 LDCM0273  AC152 PaTu 8988t C251(1.26)  LDD1152  [18]
 LDCM0274  AC153 PaTu 8988t C251(1.24)  LDD1153  [18]
 LDCM0621  AC154 PaTu 8988t C251(1.48)  LDD2166  [18]
 LDCM0622  AC155 PaTu 8988t C251(1.10)  LDD2167  [18]
 LDCM0623  AC156 PaTu 8988t C251(1.06)  LDD2168  [18]
 LDCM0624  AC157 PaTu 8988t C251(0.96)  LDD2169  [18]
 LDCM0276  AC17 PaTu 8988t C251(1.07)  LDD1155  [18]
 LDCM0277  AC18 PaTu 8988t C251(1.16)  LDD1156  [18]
 LDCM0278  AC19 PaTu 8988t C251(1.11)  LDD1157  [18]
 LDCM0279  AC2 HEK-293T C75(1.05); C251(1.04); C211(1.13)  LDD1518  [17]
 LDCM0280  AC20 PaTu 8988t C251(1.30)  LDD1159  [18]
 LDCM0281  AC21 PaTu 8988t C251(1.13)  LDD1160  [18]
 LDCM0282  AC22 PaTu 8988t C251(1.23)  LDD1161  [18]
 LDCM0283  AC23 PaTu 8988t C251(1.31)  LDD1162  [18]
 LDCM0284  AC24 PaTu 8988t C251(1.24)  LDD1163  [18]
 LDCM0285  AC25 PaTu 8988t C251(1.00)  LDD1164  [18]
 LDCM0286  AC26 PaTu 8988t C251(1.13)  LDD1165  [18]
 LDCM0287  AC27 PaTu 8988t C251(1.32)  LDD1166  [18]
 LDCM0288  AC28 PaTu 8988t C251(1.49)  LDD1167  [18]
 LDCM0289  AC29 PaTu 8988t C251(1.13)  LDD1168  [18]
 LDCM0290  AC3 HEK-293T C75(1.12); C251(0.98); C211(0.95)  LDD1529  [17]
 LDCM0291  AC30 PaTu 8988t C251(1.22)  LDD1170  [18]
 LDCM0292  AC31 PaTu 8988t C251(1.37)  LDD1171  [18]
 LDCM0293  AC32 PaTu 8988t C251(1.21)  LDD1172  [18]
 LDCM0294  AC33 PaTu 8988t C251(1.49)  LDD1173  [18]
 LDCM0295  AC34 PaTu 8988t C251(1.22)  LDD1174  [18]
 LDCM0296  AC35 PaTu 8988t C251(1.29)  LDD1175  [18]
 LDCM0297  AC36 PaTu 8988t C251(1.45)  LDD1176  [18]
 LDCM0298  AC37 PaTu 8988t C251(1.13)  LDD1177  [18]
 LDCM0299  AC38 PaTu 8988t C251(1.52)  LDD1178  [18]
 LDCM0300  AC39 PaTu 8988t C251(1.58)  LDD1179  [18]
 LDCM0301  AC4 HEK-293T C75(1.08); C251(1.02); C211(1.17)  LDD1540  [17]
 LDCM0302  AC40 PaTu 8988t C251(1.52)  LDD1181  [18]
 LDCM0303  AC41 PaTu 8988t C251(1.28)  LDD1182  [18]
 LDCM0304  AC42 PaTu 8988t C251(1.26)  LDD1183  [18]
 LDCM0305  AC43 PaTu 8988t C251(1.04)  LDD1184  [18]
 LDCM0306  AC44 PaTu 8988t C251(1.22)  LDD1185  [18]
 LDCM0307  AC45 PaTu 8988t C251(1.26)  LDD1186  [18]
 LDCM0308  AC46 PaTu 8988t C251(1.21)  LDD1187  [18]
 LDCM0309  AC47 PaTu 8988t C251(1.07)  LDD1188  [18]
 LDCM0310  AC48 PaTu 8988t C251(1.50)  LDD1189  [18]
 LDCM0311  AC49 PaTu 8988t C251(1.08)  LDD1190  [18]
 LDCM0312  AC5 HEK-293T C75(1.14); C251(1.01); C211(1.17)  LDD1551  [17]
 LDCM0313  AC50 PaTu 8988t C251(1.28)  LDD1192  [18]
 LDCM0314  AC51 PaTu 8988t C251(1.20)  LDD1193  [18]
 LDCM0315  AC52 PaTu 8988t C251(1.39)  LDD1194  [18]
 LDCM0316  AC53 PaTu 8988t C251(1.41)  LDD1195  [18]
 LDCM0317  AC54 PaTu 8988t C251(1.56)  LDD1196  [18]
 LDCM0318  AC55 PaTu 8988t C251(1.42)  LDD1197  [18]
 LDCM0319  AC56 PaTu 8988t C251(0.89)  LDD1198  [18]
 LDCM0320  AC57 HEK-293T C75(1.02)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C75(1.09); C251(0.94); C211(1.04)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C75(1.14); C251(0.94); C211(0.97)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C75(1.03); C251(0.95); C211(1.01)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C75(0.98); C251(1.06); C211(1.09)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C75(1.02); C251(0.98); C211(1.12)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C75(1.08); C251(0.84); C211(1.17)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C75(1.05); C251(1.02); C211(1.06)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C75(1.00); C251(0.99)  LDD1567  [17]
 LDCM0332  AC68 PaTu 8988t C251(0.83)  LDD1211  [18]
 LDCM0333  AC69 PaTu 8988t C251(1.22)  LDD1212  [18]
 LDCM0334  AC7 HEK-293T C75(0.97); C251(1.07); C211(0.81)  LDD1568  [17]
 LDCM0335  AC70 PaTu 8988t C251(0.71)  LDD1214  [18]
 LDCM0336  AC71 PaTu 8988t C251(1.13)  LDD1215  [18]
 LDCM0337  AC72 PaTu 8988t C251(0.93)  LDD1216  [18]
 LDCM0338  AC73 PaTu 8988t C251(0.67)  LDD1217  [18]
 LDCM0339  AC74 PaTu 8988t C251(1.06)  LDD1218  [18]
 LDCM0340  AC75 PaTu 8988t C251(1.00)  LDD1219  [18]
 LDCM0341  AC76 PaTu 8988t C251(0.71)  LDD1220  [18]
 LDCM0342  AC77 PaTu 8988t C251(1.19)  LDD1221  [18]
 LDCM0343  AC78 PaTu 8988t C251(1.13)  LDD1222  [18]
 LDCM0344  AC79 PaTu 8988t C251(0.86)  LDD1223  [18]
 LDCM0345  AC8 HEK-293T C75(1.08); C251(1.03)  LDD1569  [17]
 LDCM0346  AC80 PaTu 8988t C251(1.20)  LDD1225  [18]
 LDCM0347  AC81 PaTu 8988t C251(0.91)  LDD1226  [18]
 LDCM0348  AC82 PaTu 8988t C251(1.04)  LDD1227  [18]
 LDCM0248  AKOS034007472 HEK-293T C75(1.00); C251(1.09); C211(1.06)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C75(0.90)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C75(0.98); C251(1.14)  LDD1514  [17]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [9]
 LDCM0367  CL1 HEK-293T C75(1.00); C251(1.20); C211(0.90)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C75(0.93); C251(1.23); C211(0.94)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C75(0.99); C251(1.20)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C75(1.04); C251(1.03); C211(1.12)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C75(1.02); C251(1.20); C211(0.86)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C75(0.92); C251(0.74)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C75(1.03); C251(1.12)  LDD1577  [17]
 LDCM0374  CL105 PaTu 8988t C251(1.16)  LDD1253  [18]
 LDCM0375  CL106 PaTu 8988t C251(1.06)  LDD1254  [18]
 LDCM0376  CL107 PaTu 8988t C251(1.20)  LDD1255  [18]
 LDCM0377  CL108 PaTu 8988t C251(1.14)  LDD1256  [18]
 LDCM0378  CL109 PaTu 8988t C251(1.34)  LDD1257  [18]
 LDCM0379  CL11 HEK-293T C75(0.99); C251(1.04); C211(1.08)  LDD1583  [17]
 LDCM0380  CL110 PaTu 8988t C251(1.30)  LDD1259  [18]
 LDCM0381  CL111 PaTu 8988t C251(1.35)  LDD1260  [18]
 LDCM0382  CL112 PaTu 8988t C251(1.14)  LDD1261  [18]
 LDCM0383  CL113 PaTu 8988t C251(1.04)  LDD1262  [18]
 LDCM0384  CL114 PaTu 8988t C251(1.25)  LDD1263  [18]
 LDCM0385  CL115 PaTu 8988t C251(1.24)  LDD1264  [18]
 LDCM0386  CL116 PaTu 8988t C251(1.63)  LDD1265  [18]
 LDCM0387  CL117 PaTu 8988t C251(1.16)  LDD1266  [18]
 LDCM0388  CL118 PaTu 8988t C251(1.33)  LDD1267  [18]
 LDCM0389  CL119 PaTu 8988t C251(1.28)  LDD1268  [18]
 LDCM0390  CL12 HEK-293T C75(0.93); C251(0.87)  LDD1594  [17]
 LDCM0391  CL120 PaTu 8988t C251(1.35)  LDD1270  [18]
 LDCM0392  CL121 PaTu 8988t C251(1.36)  LDD1271  [18]
 LDCM0393  CL122 PaTu 8988t C251(0.84)  LDD1272  [18]
 LDCM0394  CL123 PaTu 8988t C251(1.21)  LDD1273  [18]
 LDCM0395  CL124 PaTu 8988t C251(1.54)  LDD1274  [18]
 LDCM0396  CL125 HEK-293T C75(1.05); C251(1.10); C211(1.00)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C75(1.10); C251(1.02); C211(1.02)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C75(0.94); C251(1.09)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C75(1.06); C251(1.20)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C75(0.96); C251(1.12); C211(0.88)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C75(1.13); C251(0.98); C211(0.84)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C75(0.90); C251(1.56)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C75(0.94); C251(1.25)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C75(0.84)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C75(1.17); C251(1.12); C211(1.02)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C75(0.98); C251(1.04); C211(1.23)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C75(1.11); C251(1.08); C211(0.90)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C75(1.02); C251(1.00); C211(1.20)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C75(0.97); C251(1.22); C211(1.14)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C75(1.08); C251(0.96); C211(1.02)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C75(0.99); C251(0.99); C211(1.06)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C75(0.93); C251(1.03)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C75(0.92); C251(1.17); C211(1.11)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C75(1.05); C251(1.06); C211(0.80)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C75(1.08); C251(1.00)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C75(1.05); C251(1.23)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C75(1.07)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C75(0.99); C251(1.27)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C75(1.09); C251(1.05); C211(0.93)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C75(1.13); C251(1.02); C211(1.15)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C75(0.96); C251(1.18); C211(1.12)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C75(0.96); C251(1.38); C211(1.02)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C75(1.11); C251(1.09); C211(0.94)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C75(1.11); C251(0.96); C211(1.06)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C75(0.96); C251(1.05)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C75(0.99); C251(1.22); C211(1.23)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C75(0.92); C251(1.11)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C75(0.90); C251(1.18)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C75(0.94); C251(1.05)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C75(1.03)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C75(1.13); C251(1.02); C211(1.16)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C75(1.17); C251(0.97); C211(1.11)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C75(1.09); C251(0.97); C211(1.07)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C75(0.92); C251(1.29); C211(1.19)  LDD1639  [17]
 LDCM0436  CL46 PaTu 8988t C251(1.22)  LDD1315  [18]
 LDCM0437  CL47 PaTu 8988t C251(1.21)  LDD1316  [18]
 LDCM0438  CL48 PaTu 8988t C251(0.93)  LDD1317  [18]
 LDCM0439  CL49 PaTu 8988t C251(1.47)  LDD1318  [18]
 LDCM0440  CL5 HEK-293T C75(1.00)  LDD1644  [17]
 LDCM0441  CL50 PaTu 8988t C251(1.29)  LDD1320  [18]
 LDCM0442  CL51 PaTu 8988t C251(1.32)  LDD1321  [18]
 LDCM0443  CL52 PaTu 8988t C251(1.26)  LDD1322  [18]
 LDCM0444  CL53 PaTu 8988t C251(1.22)  LDD1323  [18]
 LDCM0445  CL54 PaTu 8988t C251(0.84)  LDD1324  [18]
 LDCM0446  CL55 PaTu 8988t C251(1.46)  LDD1325  [18]
 LDCM0447  CL56 PaTu 8988t C251(1.08)  LDD1326  [18]
 LDCM0448  CL57 PaTu 8988t C251(1.24)  LDD1327  [18]
 LDCM0449  CL58 PaTu 8988t C251(1.20)  LDD1328  [18]
 LDCM0450  CL59 PaTu 8988t C251(1.47)  LDD1329  [18]
 LDCM0451  CL6 HEK-293T C75(1.04); C251(1.31); C211(1.22)  LDD1654  [17]
 LDCM0452  CL60 PaTu 8988t C251(1.08)  LDD1331  [18]
 LDCM0453  CL61 HEK-293T C75(1.00); C251(1.07); C211(0.81)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C75(1.12); C251(1.07); C211(0.87)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C75(0.98); C251(1.11)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C75(0.88); C251(1.40)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C75(0.96)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C75(1.06); C251(0.97); C211(1.18)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C75(1.14); C251(1.01); C211(0.98)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C75(1.07); C251(1.07); C211(1.01)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C75(0.94); C251(1.20); C211(1.38)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C75(1.10); C251(1.16); C211(1.18)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C75(1.02); C251(0.88); C211(0.99)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C75(0.97); C251(0.96); C211(1.25)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C75(0.87); C251(1.02)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C75(0.98); C251(1.11); C211(1.07)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C75(1.07); C251(1.02); C211(0.99)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C75(1.01); C251(1.18)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C75(0.87)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C75(1.12); C251(0.99); C211(1.07)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C75(1.06); C251(1.08); C211(0.94)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C75(0.91); C251(1.26); C211(1.17)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C75(1.12); C251(0.98); C211(1.19)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C75(0.99); C251(1.11); C211(1.13)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C75(1.14); C251(0.97); C211(0.98)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C75(1.09); C251(1.06); C211(1.27)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C75(0.98); C251(1.11)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C75(1.08); C251(1.11); C211(0.85)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C75(1.10); C251(1.13); C211(0.82)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C75(0.93); C251(1.07)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C75(1.09); C251(1.09)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C75(1.10)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C75(0.96); C251(1.24); C211(1.11)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C75(0.97); C251(1.19); C211(0.97)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C75(1.16); C251(1.05); C211(1.13)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C75(0.97); C251(1.06); C211(1.17)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C75(1.03); C251(1.24); C211(1.39)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C75(1.06); C251(1.03); C211(0.93)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C75(0.84); C251(1.20); C211(0.68)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C75(0.99); C251(1.06)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C75(0.93); C251(1.09); C211(0.93)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C75(1.02); C251(1.20); C211(0.79)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C75(0.94); C251(1.16)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C75(0.90); C251(1.10)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C75(0.98); C251(1.12)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C75(0.91); C251(1.01); C211(0.89)  LDD1631  [17]
 LDCM0107  IAA HeLa H307(0.00); H61(0.00)  LDD0221  [9]
 LDCM0022  KB02 HEK-293T C75(0.95); C251(0.86)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C75(1.00); C251(1.13)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C75(1.12)  LDD3310  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [9]
 LDCM0021  THZ1 HeLa S3 C199(0.91)  LDD0460  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phosphatidate cytidylyltransferase 2 (CDS2) CDS family O95674
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11) Complex I NDUFB11 subunit family Q9NX14
Endoplasmic reticulum metallopeptidase 1 (ERMP1) Peptidase M28 family Q7Z2K6
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
UbiA prenyltransferase domain-containing protein 1 (UBIAD1) UbiA prenyltransferase family Q9Y5Z9
Transporter and channel
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysosome membrane protein 2 (SCARB2) CD36 family Q14108
Protein cornichon homolog 2 (CNIH2) Cornichon family Q6PI25
Myelin and lymphocyte protein (MAL) MAL family P21145
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Transferrin receptor protein 1 (TFRC) Peptidase M28 family P02786
Cardiac phospholamban (PLN) Phospholamban family P26678
PRA1 family protein 2 (PRAF2) PRA1 family O60831
Vesicle-associated membrane protein 2 (VAMP2) Synaptobrevin family P63027
Transmembrane 6 superfamily member 2 (TM6SF2) TM6SF family Q9BZW4
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Phospholipid transfer protein C2CD2L (C2CD2L) . O14523
Transmembrane protein 60 (TMEM60) . Q9H2L4
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7) Chemokine-like factor family Q96FZ5
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycodelin (PAEP) Lipocalin family P09466
Ephrin-A5 (EFNA5) Ephrin family P52803
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Vesicle transport protein SFT2B (SFT2D2) SFT2 family O95562
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Vesicle-trafficking protein SEC22b (SEC22B) Synaptobrevin family O75396
Receptor-transporting protein 2 (RTP2) TMEM7 family Q5QGT7
Zinc finger protein-like 1 (ZFPL1) ZFPL1 family O95159
Asialoglycoprotein receptor 1 (ASGR1) . P07306
C-type lectin domain family 2 member A (CLEC2A) . Q6UVW9
Protein SNORC (SNORC) . Q6UX34
Transmembrane protein 222 (TMEM222) . Q9H0R3

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
11 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
14 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.