Details of the Target

General Information of Target

Target ID LDTP03970
Target Name Signal transducer and activator of transcription 6 (STAT6)
Gene Name STAT6
Gene ID 6778
Synonyms
Signal transducer and activator of transcription 6; IL-4 Stat
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDT
VQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMP
FHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALA
MLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQ
EVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLR
FLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALF
KNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDN
NAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQK
IFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIG
FISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIR
SLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPE
LQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQE
PHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAF
PQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMD
LRANPSW
Target Type
Literature-reported
Target Bioclass
Transcription factor
Family
Transcription factor STAT family
Subcellular location
Cytoplasm
Function Carries out a dual signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
TTD ID
T20585
Uniprot ID
P42226
DrugMap ID
TTWOE1T
Ensemble ID
ENST00000300134.8
HGNC ID
HGNC:11368
ChEMBL ID
CHEMBL5401

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L551R DBIA    Probe Info 
DU145 Insertion: p.Q281PfsTer92 .
HCT116 Insertion: p.Q281PfsTer92 .
JURKAT Deletion: p.Q281RfsTer3 .
LS180 SNV: p.L761F .
MCC26 Substitution: p.A291T .
MOLT4 SNV: p.Q101Ter; p.A321V IA-alkyne    Probe Info 
NCIH1993 SNV: p.E112D .
OVCAR8 Insertion: p.S728QfsTer10 .
SNU1 SNV: p.V110D DBIA    Probe Info 
SUPT1 Deletion: p.L469CfsTer69 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K107(1.67); K288(2.60)  LDD0277  [1]
THZ1-DTB
 Probe Info  		C356(1.05)  LDD0460  [2]
HHS-475
 Probe Info  		Y641(0.64)  LDD0264  [3]
DBIA
 Probe Info  		C272(0.79)  LDD0533  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C228(0.00); C272(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C228(0.00); C452(0.00); C272(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C228(0.00); C452(0.00); C272(0.00)  LDD0037  [5]
TFBX
 Probe Info  		C452(0.00); C272(0.00)  LDD0148  [6]
AOyne
 Probe Info  		9.20  LDD0443  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C452(1.03)  LDD1507  [8]
 LDCM0215  AC10 HEK-293T C452(0.98)  LDD1508  [8]
 LDCM0216  AC100 HCT 116 C272(0.79)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C272(0.82)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C272(0.78)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C272(0.79)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C272(0.77)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C272(0.74)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C272(0.72)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C272(1.03)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C272(0.84)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C272(0.84)  LDD0542  [4]
 LDCM0227  AC110 HCT 116 C272(0.93)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C272(0.96)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C272(0.96)  LDD0546  [4]
 LDCM0237  AC12 HEK-293T C452(0.96)  LDD1510  [8]
 LDCM0246  AC128 HCT 116 C272(1.24)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C272(1.01)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C272(0.94)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C272(1.08)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C272(1.11)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C272(1.03)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C272(1.09)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C272(1.07)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C272(1.10)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C272(1.02)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C272(1.30)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C272(1.15)  LDD0575  [4]
 LDCM0260  AC140 HCT 116 C272(1.22)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C272(1.26)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C272(1.06)  LDD0579  [4]
 LDCM0270  AC15 HEK-293T C452(0.88)  LDD1513  [8]
 LDCM0276  AC17 HEK-293T C452(0.92)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C452(0.90)  LDD1516  [8]
 LDCM0279  AC2 HEK-293T C452(0.97)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C452(0.93)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C384(1.75)  LDD1520  [8]
 LDCM0283  AC23 HEK-293T C452(0.88)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C452(0.86)  LDD1523  [8]
 LDCM0285  AC25 HEK-293T C452(0.91)  LDD1524  [8]
 LDCM0286  AC26 HEK-293T C452(1.02)  LDD1525  [8]
 LDCM0288  AC28 HEK-293T C452(1.03)  LDD1527  [8]
 LDCM0289  AC29 HEK-293T C384(1.73)  LDD1528  [8]
 LDCM0292  AC31 HEK-293T C452(0.94)  LDD1531  [8]
 LDCM0293  AC32 HEK-293T C452(0.84)  LDD1532  [8]
 LDCM0294  AC33 HEK-293T C452(0.94)  LDD1533  [8]
 LDCM0295  AC34 HEK-293T C452(0.96)  LDD1534  [8]
 LDCM0297  AC36 HEK-293T C452(1.06)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C384(1.26)  LDD1537  [8]
 LDCM0300  AC39 HEK-293T C452(0.95)  LDD1539  [8]
 LDCM0301  AC4 HEK-293T C452(1.02)  LDD1540  [8]
 LDCM0302  AC40 HEK-293T C452(0.94)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C452(0.90)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C452(1.04)  LDD1543  [8]
 LDCM0306  AC44 HEK-293T C452(0.98)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C384(1.74)  LDD1546  [8]
 LDCM0308  AC46 HCT 116 C272(0.91)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C272(0.83)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C272(0.88)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C272(1.10)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C384(2.98)  LDD1551  [8]
 LDCM0313  AC50 HCT 116 C272(0.97)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C272(0.98)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C272(0.97)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C272(0.87)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C272(1.00)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C272(0.94)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C272(0.99)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C272(0.89)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C272(0.98)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C272(0.96)  LDD0639  [4]
 LDCM0324  AC60 HCT 116 C272(0.86)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C272(0.98)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C272(0.82)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C272(0.91)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C272(1.01)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C272(0.89)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C272(0.96)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C272(0.92)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C272(0.99)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C272(1.13)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C452(0.84)  LDD1568  [8]
 LDCM0335  AC70 HCT 116 C272(0.84)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C272(1.01)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C272(1.16)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C272(1.18)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C272(1.19)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C272(1.27)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C272(1.15)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C272(1.07)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C272(0.93)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C272(1.12)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C452(0.97)  LDD1569  [8]
 LDCM0346  AC80 HCT 116 C272(1.16)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C272(0.90)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C272(1.02)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C272(0.96)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C272(0.96)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C272(0.82)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C272(0.88)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C272(0.88)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C272(0.85)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C272(0.88)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C272(0.85)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C272(1.04)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C272(0.92)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C272(0.90)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C272(0.95)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C272(0.86)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C272(0.94)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C272(0.93)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C272(0.75)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C272(0.74)  LDD0683  [4]
 LDCM0248  AKOS034007472 HEK-293T C384(1.62)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C452(0.92)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C452(0.89)  LDD1514  [8]
 LDCM0367  CL1 HCT 116 C272(1.05)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C272(1.12)  LDD0685  [4]
 LDCM0369  CL100 HEK-293T C452(0.96)  LDD1573  [8]
 LDCM0370  CL101 HEK-293T C384(1.82)  LDD1574  [8]
 LDCM0373  CL104 HEK-293T C452(1.03)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C384(1.32)  LDD1578  [8]
 LDCM0377  CL108 HEK-293T C452(0.84)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C384(1.44)  LDD1582  [8]
 LDCM0379  CL11 HCT 116 C272(1.19)  LDD0696  [4]
 LDCM0382  CL112 HEK-293T C452(0.97)  LDD1586  [8]
 LDCM0383  CL113 HEK-293T C384(1.66)  LDD1587  [8]
 LDCM0386  CL116 HEK-293T C452(0.93)  LDD1590  [8]
 LDCM0387  CL117 HEK-293T C384(1.75)  LDD1591  [8]
 LDCM0390  CL12 HCT 116 C272(1.30)  LDD0707  [4]
 LDCM0391  CL120 HEK-293T C452(0.98)  LDD1595  [8]
 LDCM0392  CL121 HCT 116 C272(0.94)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C272(0.92)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C272(0.81)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C272(0.91)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C272(0.95)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C272(0.93)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C272(0.83)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C272(0.94)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C272(1.10)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C272(1.11)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C272(1.06)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C272(0.95)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C272(1.12)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C272(0.88)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C272(0.98)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C272(1.02)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C272(1.08)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C272(1.33)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C272(1.37)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C272(1.02)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C272(1.10)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C272(1.06)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C272(0.99)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C272(0.92)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C272(1.08)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C272(1.00)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C272(1.07)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C272(0.89)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C272(1.00)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C272(0.96)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C272(1.03)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C272(1.25)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C272(1.07)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C272(1.17)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C272(1.15)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C272(1.01)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C272(1.08)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C272(1.08)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C272(1.03)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C272(1.03)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C272(1.25)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C272(1.29)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C272(1.21)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C272(0.88)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C272(0.88)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C272(0.88)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C272(1.03)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C272(1.01)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C272(0.93)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C272(0.86)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C272(0.89)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C272(1.01)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C272(1.03)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C272(0.91)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C272(0.90)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C272(0.91)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C272(0.84)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C272(0.94)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C272(0.93)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C272(0.90)  LDD0769  [4]
 LDCM0453  CL61 HEK-293T C384(2.06)  LDD1656  [8]
 LDCM0456  CL64 HEK-293T C452(0.97)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C452(0.86)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C452(0.96)  LDD1661  [8]
 LDCM0460  CL68 HEK-293T C452(1.03)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C384(1.76)  LDD1664  [8]
 LDCM0462  CL7 HCT 116 C272(1.02)  LDD0779  [4]
 LDCM0464  CL71 HEK-293T C452(0.98)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C452(1.12)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C384(1.84)  LDD1669  [8]
 LDCM0469  CL76 HEK-293T C452(0.92)  LDD1672  [8]
 LDCM0470  CL77 HEK-293T C452(0.80)  LDD1673  [8]
 LDCM0471  CL78 HEK-293T C452(0.95)  LDD1674  [8]
 LDCM0473  CL8 HCT 116 C272(1.15)  LDD0790  [4]
 LDCM0474  CL80 HEK-293T C452(0.94)  LDD1677  [8]
 LDCM0475  CL81 HEK-293T C384(1.89)  LDD1678  [8]
 LDCM0477  CL83 HEK-293T C452(1.00)  LDD1680  [8]
 LDCM0478  CL84 HEK-293T C452(0.94)  LDD1681  [8]
 LDCM0479  CL85 HEK-293T C384(3.26)  LDD1682  [8]
 LDCM0482  CL88 HEK-293T C452(0.89)  LDD1685  [8]
 LDCM0483  CL89 HEK-293T C452(0.90)  LDD1686  [8]
 LDCM0484  CL9 HCT 116 C272(1.02)  LDD0801  [4]
 LDCM0485  CL90 HEK-293T C452(1.10)  LDD1688  [8]
 LDCM0487  CL92 HEK-293T C452(0.99)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C384(1.95)  LDD1691  [8]
 LDCM0490  CL95 HEK-293T C452(1.04)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C452(0.92)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C384(1.61)  LDD1695  [8]
 LDCM0625  F8 Ramos C228(0.97)  LDD2187  [9]
 LDCM0572  Fragment10 Ramos C452(0.68)  LDD2189  [9]
 LDCM0573  Fragment11 Ramos C452(3.02); C228(2.03)  LDD2190  [9]
 LDCM0574  Fragment12 Ramos C452(0.62)  LDD2191  [9]
 LDCM0575  Fragment13 Ramos C452(1.02)  LDD2192  [9]
 LDCM0576  Fragment14 Ramos C228(0.34)  LDD2193  [9]
 LDCM0579  Fragment20 Ramos C452(0.71)  LDD2194  [9]
 LDCM0580  Fragment21 Ramos C452(0.60)  LDD2195  [9]
 LDCM0582  Fragment23 Ramos C452(0.66)  LDD2196  [9]
 LDCM0578  Fragment27 Ramos C452(0.78)  LDD2197  [9]
 LDCM0586  Fragment28 Ramos C452(0.84)  LDD2198  [9]
 LDCM0588  Fragment30 Ramos C452(0.93)  LDD2199  [9]
 LDCM0589  Fragment31 Ramos C452(1.16)  LDD2200  [9]
 LDCM0590  Fragment32 Ramos C452(0.48)  LDD2201  [9]
 LDCM0468  Fragment33 Ramos C452(0.86)  LDD2202  [9]
 LDCM0596  Fragment38 Ramos C452(0.65)  LDD2203  [9]
 LDCM0566  Fragment4 Ramos C452(0.87); C228(0.52)  LDD2184  [9]
 LDCM0427  Fragment51 HCT 116 C272(1.03)  LDD0744  [4]
 LDCM0610  Fragment52 Ramos C452(0.49)  LDD2204  [9]
 LDCM0569  Fragment7 Ramos C452(1.06); C228(1.83)  LDD2186  [9]
 LDCM0571  Fragment9 Ramos C452(0.71)  LDD2188  [9]
 LDCM0116  HHS-0101 DM93 Y641(0.64)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y641(0.89)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y641(0.95)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y641(1.00)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y641(1.21)  LDD0268  [3]
 LDCM0022  KB02 Ramos C452(1.22)  LDD2182  [9]
 LDCM0023  KB03 Ramos C452(1.25); C228(0.82)  LDD2183  [9]
 LDCM0024  KB05 SKMEL24 C98(3.18)  LDD3323  [10]
 LDCM0021  THZ1 HeLa S3 C356(1.05)  LDD0460  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase TBK1 (TBK1) Ser/Thr protein kinase family Q9UHD2
Histone acetyltransferase p300 (EP300) . Q09472
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 6 (STAT6) Transcription factor STAT family P42226
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-4 receptor subunit alpha (IL4R) Type I cytokine receptor family P24394
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-myc-interactor (NMI) NMI family Q13287

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840