Details of the Target

General Information of Target

Target ID LDTP00218
Target Name NADH dehydrogenase iron-sulfur protein 8, mitochondrial (NDUFS8)
Gene Name NDUFS8
Gene ID 4728
Synonyms
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; EC 7.1.1.2; Complex I-23kD; CI-23kD; NADH-ubiquinone oxidoreductase 23 kDa subunit; TYKY subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLL
WTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAI
CPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEE
LLYNKEKLLNNGDKWEAEIAANIQADYLYR
Target Bioclass
Enzyme
Family
Complex I 23 kDa subunit family
Subcellular location
Mitochondrion inner membrane
Function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.
Uniprot ID
O00217
Ensemble ID
ENST00000313468.10
HGNC ID
HGNC:7715
ChEMBL ID
CHEMBL2363065

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y38(20.00)  LDD0260  [1]
THZ1-DTB
 Probe Info  		C121(1.06)  LDD0460  [2]
DBIA
 Probe Info  		C117(0.38); C121(0.38)  LDD0563  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
IPM
 Probe Info  		N.A.  LDD2156  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
Crotonaldehyde
 Probe Info  		H99(0.00); C121(0.00)  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
MPP-AC
 Probe Info  		N.A.  LDD0428  [9]
NAIA_5
 Probe Info  		C3(0.00); C121(0.00); C117(0.00)  LDD2223  [10]
TER-AC
 Probe Info  		N.A.  LDD0426  [9]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		63.56  LDD1884  [11]
FFF probe11
 Probe Info  		8.31  LDD0471  [12]
FFF probe14
 Probe Info  		20.00  LDD0477  [12]
FFF probe3
 Probe Info  		5.39  LDD0464  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C121(1.26)  LDD0812  [3]
 LDCM0215  AC10 HEK-293T C121(0.94)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C117(0.86); C121(0.82)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C117(0.95); C121(0.99)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C117(0.86); C121(0.81)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C117(1.03); C121(1.06)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C117(1.15); C121(0.97)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C117(0.90); C121(0.92)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C117(1.11); C121(0.82)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C117(1.10); C121(0.84)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C117(1.09); C121(0.80)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C117(1.18); C121(0.73)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C121(0.89)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C117(0.72); C121(0.98)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C117(0.50); C121(1.13)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C117(0.62); C121(1.01)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C121(0.79)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C121(1.20)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C121(2.62)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C121(1.82)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C121(1.60)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C121(1.18)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C121(0.98)  LDD0834  [3]
 LDCM0237  AC12 HEK-293T C121(0.88)  LDD0835  [3]
 LDCM0238  AC120 HEK-293T C121(1.69)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C121(1.68)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C121(1.08)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C121(1.37)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C121(1.25)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C121(1.34)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C121(1.06)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C121(1.42)  LDD0843  [3]
 LDCM0246  AC128 HCT 116 C117(0.38); C121(0.38)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C117(0.80); C121(0.80)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C117(0.65); C121(0.65)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C117(1.58); C121(1.58)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C117(1.10); C121(1.10)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C117(0.85); C121(0.85)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C117(0.54); C121(0.54)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C117(0.95); C121(0.95)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C117(0.97); C121(0.97)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C117(1.01); C121(1.01)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C117(0.75); C121(0.75)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C117(0.72); C121(0.72)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C121(0.91)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C117(0.69); C121(0.69)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C117(0.78); C121(0.78)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C117(1.03); C121(1.03)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C117(0.80); C121(0.80)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C117(1.04); C121(1.06)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C121(1.09); C117(1.29)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C117(0.92); C121(1.07)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C121(0.92); C117(1.16)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C117(0.89); C121(1.24)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C117(0.90); C121(1.25)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C121(0.85)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C117(0.98); C121(1.10)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C117(0.95); C121(1.03)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C121(1.02); C117(1.36)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C117(0.79); C121(1.34)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C117(1.25); C121(1.29)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C117(0.94); C121(1.08)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C117(1.24); C121(1.04)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C117(0.99); C121(1.03)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C121(1.21)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C121(1.22)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C121(1.29)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C121(1.24)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C121(1.18)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C121(1.51)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C121(1.20)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C121(1.20)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C121(0.96)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C117(0.73)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C117(0.66)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C117(0.73)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C117(0.60)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C117(0.75)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C121(1.03)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C117(0.77)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C117(1.04)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C117(0.77)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C117(0.72)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C117(0.75)  LDD0893  [3]
 LDCM0296  AC35 HEK-293T C121(0.88)  LDD0894  [3]
 LDCM0297  AC36 HEK-293T C121(1.13)  LDD0895  [3]
 LDCM0298  AC37 HEK-293T C121(1.07)  LDD0896  [3]
 LDCM0299  AC38 HEK-293T C121(0.98)  LDD0897  [3]
 LDCM0300  AC39 HEK-293T C121(1.20)  LDD0898  [3]
 LDCM0301  AC4 HEK-293T C121(1.51)  LDD0899  [3]
 LDCM0302  AC40 HEK-293T C121(1.15)  LDD0900  [3]
 LDCM0303  AC41 HEK-293T C121(1.19)  LDD0901  [3]
 LDCM0304  AC42 HEK-293T C121(1.27)  LDD0902  [3]
 LDCM0305  AC43 HEK-293T C121(1.10)  LDD0903  [3]
 LDCM0306  AC44 HEK-293T C121(1.23)  LDD0904  [3]
 LDCM0307  AC45 HEK-293T C121(1.01)  LDD0905  [3]
 LDCM0308  AC46 HEK-293T C117(1.05); C121(0.96)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C117(1.11); C121(1.02)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C117(0.99); C121(1.02)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C117(0.95); C121(1.04)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C121(1.77)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C117(0.90); C121(0.86)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C117(1.08); C121(0.88)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C117(0.97); C121(0.89)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C117(1.06); C121(1.00)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C117(1.14); C121(1.05)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C117(1.14); C121(1.08)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C117(0.90); C121(0.84)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C117(1.34); C121(1.34)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C117(1.66); C121(1.66)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C117(1.04); C121(1.04)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C121(0.98)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C117(1.54); C121(1.54)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C117(1.76); C121(1.76)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C117(1.02); C121(1.02)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C117(1.32); C121(1.32)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C117(0.92); C121(0.92)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C117(1.17); C121(1.17)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C117(1.34); C121(1.34)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C117(0.34); C121(0.34)  LDD0648  [3]
 LDCM0332  AC68 HEK-293T C121(1.01)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C121(1.05)  LDD0931  [3]
 LDCM0334  AC7 HEK-293T C121(1.02)  LDD0932  [3]
 LDCM0335  AC70 HEK-293T C121(1.18)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C121(1.41)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C121(1.20)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C121(1.31)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C121(1.64)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C121(1.10)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C121(1.25)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C121(1.44)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C121(1.14)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C121(1.10)  LDD0942  [3]
 LDCM0345  AC8 HEK-293T C121(1.15)  LDD0943  [3]
 LDCM0346  AC80 HEK-293T C121(1.22)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C121(1.66)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C121(1.60)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C117(0.37); C121(0.37)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C117(0.56); C121(0.56)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C117(0.81); C121(0.81)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C117(1.06); C121(1.06)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C117(0.77); C121(0.77)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C117(0.93); C121(0.93)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C117(0.75); C121(0.75)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C117(1.47); C121(1.47)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C117(0.42); C121(0.42)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C117(0.51); C121(0.51)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C117(0.74); C121(0.74)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C117(1.69); C121(1.69)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C117(1.29); C121(1.29)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C117(1.05); C121(1.05)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C117(0.82); C121(0.82)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C117(1.08); C121(1.01)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C117(1.72); C121(0.87)  LDD0964  [3]
 LDCM0248  AKOS034007472 HEK-293T C121(0.96)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C121(1.30)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C121(1.25)  LDD0873  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HCT 116 C117(1.20); C121(1.20)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C117(0.91); C121(0.91)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C121(1.47)  LDD0967  [3]
 LDCM0370  CL101 HEK-293T C121(1.09)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C121(1.07)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C121(1.18)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C121(1.26)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C121(1.01)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C121(1.08)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C121(1.20)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C121(1.08)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C121(1.01)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C117(1.01); C121(1.01)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C121(1.22)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C121(1.16)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C117(0.66)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C117(0.98)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C117(0.48)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C117(0.56)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C117(0.57)  LDD0984  [3]
 LDCM0387  CL117 HEK-293T C121(0.97)  LDD0985  [3]
 LDCM0388  CL118 HEK-293T C121(0.99)  LDD0986  [3]
 LDCM0389  CL119 HEK-293T C121(1.10)  LDD0987  [3]
 LDCM0390  CL12 HCT 116 C117(0.90); C121(0.90)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C121(1.13)  LDD0989  [3]
 LDCM0392  CL121 HEK-293T C117(1.11); C121(0.98)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C117(1.17); C121(1.05)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C117(1.50); C121(1.15)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C117(0.91); C121(0.90)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C117(2.03); C121(2.03)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C117(1.60); C121(1.60)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C117(1.76); C121(1.76)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C117(1.67); C121(1.67)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C117(0.85); C121(0.85)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C117(0.89); C121(0.89)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C117(1.36); C121(1.36)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C117(1.01); C121(1.10)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C117(1.16); C121(1.06)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C117(0.99); C121(0.99)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C117(0.89); C121(0.97)  LDD1004  [3]
 LDCM0407  CL2 HCT 116 C117(1.15); C121(1.15)  LDD0724  [3]
 LDCM0408  CL20 HEK-293T C117(1.05); C121(1.02)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C117(1.22); C121(1.05)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C117(1.08); C121(1.03)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C117(1.00); C121(0.90)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C117(1.09); C121(1.01)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C117(1.30); C121(1.14)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C117(1.01); C121(0.97)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C117(0.99); C121(0.97)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C117(1.19); C121(1.12)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C117(0.95); C121(0.95)  LDD1015  [3]
 LDCM0418  CL3 HCT 116 C117(1.13); C121(1.13)  LDD0735  [3]
 LDCM0419  CL30 HEK-293T C117(0.96); C121(0.93)  LDD1017  [3]
 LDCM0420  CL31 HCT 116 C117(1.01); C121(1.01)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C117(1.10); C121(1.10)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C117(1.01); C121(1.01)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C117(0.65); C121(0.65)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C117(0.64); C121(0.64)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C117(0.73); C121(0.73)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C117(0.56); C121(0.56)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C117(0.64); C121(0.64)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C117(1.16); C121(1.16)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C117(0.85); C121(0.85)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C117(1.08); C121(1.08)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C117(0.34); C121(0.34)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C117(0.47); C121(0.47)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C117(1.21); C121(1.21)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C117(0.61); C121(0.61)  LDD0752  [3]
 LDCM0436  CL46 HEK-293T C117(1.28); C121(1.28)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C117(1.42); C121(1.42)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C117(1.40); C121(1.40)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C117(1.16); C121(1.16)  LDD1037  [3]
 LDCM0440  CL5 HCT 116 C117(1.11); C121(1.11)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C117(1.98); C121(1.98)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C117(1.64); C121(1.64)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C117(1.22); C121(1.22)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C117(1.27); C121(1.27)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C117(1.73); C121(1.73)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C117(1.12); C121(1.12)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C117(1.11); C121(1.11)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C117(1.98); C121(1.98)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C117(1.25); C121(1.25)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C117(1.11); C121(1.11)  LDD1048  [3]
 LDCM0451  CL6 HCT 116 C117(1.21); C121(1.21)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C117(1.17); C121(1.17)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C117(1.09); C121(1.37)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C117(1.18); C121(1.25)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C117(1.07); C121(1.17)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C117(1.26); C121(1.14)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C117(1.04); C121(1.36)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C117(1.18); C121(1.16)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C117(0.88); C121(0.96)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C117(1.06); C121(1.02)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C117(1.28); C121(1.17)  LDD1059  [3]
 LDCM0462  CL7 HCT 116 C117(0.87); C121(0.87)  LDD0779  [3]
 LDCM0463  CL70 HEK-293T C117(1.15); C121(1.15)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C117(0.96); C121(1.06)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C117(1.11); C121(0.97)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C117(1.03); C121(1.02)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C117(1.01); C121(1.26)  LDD1065  [3]
 LDCM0469  CL76 HCT 116 C117(0.74); C121(0.74)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C117(0.91); C121(0.91)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C117(0.86); C121(0.86)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C117(0.68); C121(0.68)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C117(1.21); C121(1.21)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C117(1.08); C121(1.08)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C117(1.11); C121(1.11)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C117(0.47); C121(0.47)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C117(0.46); C121(0.46)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C117(0.30); C121(0.30)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C117(0.78); C121(0.78)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C117(0.83); C121(0.83)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C117(0.85); C121(0.85)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C117(0.63); C121(0.63)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C117(0.30); C121(0.30)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C117(0.93); C121(0.93)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C117(0.68); C121(0.68)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C121(1.66)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C121(1.70)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C121(1.10)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C121(1.53)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C121(1.47)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C121(1.38)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C121(1.94)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C121(1.68)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C121(1.50)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C117(0.95); C156(1.24)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C117(1.08); C121(1.17)  LDD1066  [3]
 LDCM0427  Fragment51 HCT 116 C117(0.41); C121(0.41)  LDD0744  [3]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C117(0.86)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C117(1.01)  LDD1497  [13]
 LDCM0024  KB05 HEK-293T C117(0.97)  LDD1502  [13]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0021  THZ1 HeLa S3 C121(1.06)  LDD0460  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nadh Small molecular drug DB00157

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402