Details of the Target

General Information of Target

Target ID LDTP12269
Target Name Pre-mRNA-splicing factor SYF1 (XAB2)
Gene Name XAB2
Gene ID 56949
Synonyms
HCNP; KIAA1177; SYF1; Pre-mRNA-splicing factor SYF1; Protein HCNP; XPA-binding protein 2
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQR
DLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYP
GYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVP
VVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGA
VGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGL
PTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEM
RAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYG
KKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASSHGSMLDSPA
TPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPP
LLSRPLPLGSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKSAH
Target Bioclass
Other
Family
Crooked-neck family
Subcellular location
Nucleus
Function Involved in pre-mRNA splicing as component of the spliceosome. Involved in transcription-coupled repair (TCR), transcription and pre-mRNA splicing.
Uniprot ID
Q9HCS7
Ensemble ID
ENST00000358368.5
HGNC ID
HGNC:14089

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.08  LDD0402  [1]
STPyne
 Probe Info  		K62(10.00); K83(3.70)  LDD0277  [2]
Probe 1
 Probe Info  		Y186(26.37); Y405(15.25); Y469(20.81); Y533(11.97)  LDD3495  [3]
THZ1-DTB
 Probe Info  		C587(1.06)  LDD0460  [4]
BTD
 Probe Info  		C66(1.29)  LDD2093  [5]
AHL-Pu-1
 Probe Info  		C691(3.78)  LDD0170  [6]
DBIA
 Probe Info  		C676(0.87)  LDD0078  [7]
CY4
 Probe Info  		M1(0.00); M4(0.00)  LDD0247  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C676(0.00); C66(0.00); C260(0.00); C117(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C587(0.00); C676(0.00); C66(0.00); C117(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C587(0.00); C676(0.00); C66(0.00); C260(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
Acrolein
 Probe Info  		C676(0.00); C260(0.00); H159(0.00)  LDD0217  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [13]
Methacrolein
 Probe Info  		N.A.  LDD0218  [13]
W1
 Probe Info  		C66(0.00); C676(0.00)  LDD0236  [14]
AOyne
 Probe Info  		4.50  LDD0443  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C66(0.99)  LDD2117  [5]
 LDCM0025  4SU-RNA DM93 C691(3.78)  LDD0170  [6]
 LDCM0214  AC1 HCT 116 C117(0.88); C260(0.88); C437(0.97); C439(0.97)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C117(0.93); C260(0.92); C437(1.20); C439(1.16)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C260(0.46); C437(0.64); C439(0.64); C66(1.12)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C260(0.48); C437(0.67); C439(0.67); C66(1.10)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C260(0.47); C437(0.77); C439(0.77); C66(1.04)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C260(0.47); C437(0.67); C439(0.67); C66(1.19)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C260(0.47); C437(0.69); C439(0.69); C66(0.93)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C260(0.48); C437(0.62); C439(0.62); C66(1.10)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C260(0.46); C437(0.71); C439(0.71); C66(1.09)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C260(0.48); C437(0.68); C439(0.64); C66(1.04)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C260(0.78); C437(0.68); C439(0.65); C66(1.04)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C260(0.58); C437(0.85); C439(0.83); C66(1.03)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C117(0.85); C260(1.04); C437(1.33); C439(1.25)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C260(0.48); C437(0.64); C439(0.65); C66(1.14)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C260(0.49); C437(0.72); C439(0.71); C66(1.03)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C260(0.42); C437(0.73); C439(0.70); C66(1.04)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C260(1.82); C437(0.86); C439(0.86); C66(1.06)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C260(0.90); C437(0.75); C439(0.77); C66(1.13)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C260(0.67); C437(0.83); C439(0.80); C66(1.01)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C260(0.76); C437(0.83); C439(0.77); C66(1.09)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C260(1.01); C437(1.04); C439(0.89); C66(1.02)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C260(0.95); C437(0.86); C439(0.76); C66(1.09)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C260(0.84); C437(0.83); C439(0.90); C66(1.03)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C117(1.02); C260(1.02); C437(1.19); C439(1.18)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C260(0.82); C437(0.74); C439(0.82); C66(1.26)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C260(0.69); C437(0.99); C439(0.86); C66(1.02)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C260(1.07); C437(0.77); C439(0.87); C66(1.19)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C260(1.55); C437(0.78); C439(0.89); C66(1.01)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C260(0.78); C437(0.87); C439(0.80); C66(1.11)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C260(0.71); C437(0.68); C439(0.78); C66(1.32)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C260(0.72); C437(0.63); C439(0.78); C66(1.08)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C260(0.82); C437(0.82); C439(0.82); C66(1.13)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C117(0.98); C260(0.91); C437(1.27); C439(1.27)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C117(1.16); C260(1.17); C437(0.98); C439(0.98)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C117(0.89); C260(1.09); C437(0.99); C439(0.99)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C117(1.18); C260(0.86); C437(1.00); C439(1.00)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C117(1.26); C260(1.06); C437(1.06); C439(1.06)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C117(0.92); C260(0.90); C437(1.41); C439(1.41)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C117(1.10); C260(0.90); C437(1.09); C439(1.09)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C117(1.11); C260(0.94); C437(1.13); C439(1.13)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C117(1.22); C260(0.95); C437(1.07); C439(1.07)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C117(1.06); C260(0.97); C437(0.99); C439(0.99)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C117(1.07); C260(0.85); C437(1.13); C439(1.13)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C117(1.11); C260(0.90); C437(1.07); C439(1.07)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C117(0.99); C260(1.28); C437(1.22); C439(1.25)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C117(1.15); C260(0.83); C437(1.29); C439(1.29)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C117(1.29); C260(0.81); C437(1.07); C439(1.07)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C117(1.26); C260(1.10); C437(1.29); C439(1.29)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C439(0.83); C691(0.90); C695(0.90); C437(0.94)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C439(0.81); C437(0.88); C98(0.88); C86(0.95)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C439(0.87); C66(0.92); C98(0.94); C437(0.94)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C439(0.87); C66(0.91); C98(0.92); C437(1.02)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C439(0.89); C437(0.94); C66(0.97); C86(1.05)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C676(0.81); C66(0.84); C98(0.98); C439(1.06)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C98(0.85); C691(0.85); C695(0.85); C66(0.94)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C691(0.55); C695(0.55); C117(0.95); C98(0.96)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C439(0.81); C98(0.90); C437(0.90); C676(0.93)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C439(0.75); C676(0.84); C437(0.87); C66(1.01)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C676(0.94); C98(0.97); C86(1.00); C66(1.01)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C98(0.92); C66(1.01); C439(1.11); C437(1.18)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C437(0.94); C439(0.87); C66(0.92); C676(1.32)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C437(0.96); C439(0.82); C66(0.99); C676(1.04)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C437(1.04); C439(0.87); C66(1.03); C676(1.07)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C437(0.99); C439(0.90); C66(0.91); C676(1.11)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C437(0.80); C676(0.82); C587(0.83); C691(0.90)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C691(0.66); C695(0.66); C437(0.69); C439(0.78)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C691(0.65); C695(0.65); C437(0.79); C587(0.81)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C691(0.60); C695(0.60); C117(0.82); C260(0.87)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C676(0.79); C437(0.85); C587(0.86); C439(0.87)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C691(0.67); C695(0.67); C437(0.70); C676(0.71)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C437(0.80); C587(0.81); C439(0.85); C676(0.86)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C587(0.73); C676(0.77); C439(0.80); C437(0.81)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C587(0.81); C676(0.81); C437(0.87); C66(0.91)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C695(0.35); C691(0.65); C437(0.73); C439(0.75)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C695(0.41); C691(0.58); C439(0.63); C98(0.67)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C695(0.34); C691(0.57); C587(0.63); C260(0.73)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C695(0.31); C691(0.50); C260(0.66); C587(0.71)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C695(0.33); C691(0.51); C260(0.57); C587(0.67)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C691(0.66); C695(0.66); C260(0.79); C437(0.93)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C695(0.31); C691(0.51); C587(0.61); C260(0.75)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C695(0.39); C691(0.59); C587(0.68); C439(0.70)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C695(0.28); C691(0.47); C260(0.53); C98(0.63)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C695(0.27); C691(0.51); C587(0.60); C260(0.69)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C695(0.30); C691(0.56); C587(0.65); C98(0.76)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C691(0.85); C437(0.87); C439(0.89); C587(0.92)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C695(0.78); C587(0.80); C676(0.83); C691(0.83)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C691(0.78); C86(0.86); C695(0.87); C260(0.92)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C695(0.77); C691(0.85); C676(0.92); C437(0.95)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C695(0.73); C691(0.74); C437(0.92); C587(0.93)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C691(0.53); C695(0.53); C260(0.81); C117(0.89)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C695(0.81); C691(0.88); C587(0.88); C86(0.93)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C691(0.80); C98(0.81); C260(0.85); C695(0.85)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C695(0.79); C691(0.84); C98(0.85); C86(0.96)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C691(0.82); C695(0.89); C587(0.95); C439(0.96)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C98(0.87); C86(0.95); C695(0.96); C260(0.97)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C260(0.88); C587(0.89); C691(0.91); C695(0.94)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C98(0.90); C260(1.00); C86(1.01); C587(1.01)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C260(0.87); C98(0.94); C587(0.94); C86(0.98)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C260(0.97); C66(0.97); C439(1.07); C86(1.08)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C66(0.98); C98(1.00); C587(1.07); C439(1.11)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C691(0.54); C695(0.54); C260(0.79); C117(0.84)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C98(0.93); C587(0.94); C66(0.98); C260(0.99)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C86(0.96); C587(0.98); C66(0.99); C98(0.99)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C587(0.85); C98(0.95); C260(1.01); C439(1.03)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C98(0.92); C66(0.96); C587(1.02); C676(1.03)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C66(0.91); C260(0.97); C587(0.97); C676(0.98)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C98(0.86); C260(0.99); C86(1.06); C587(1.08)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C98(1.02); C587(1.10); C66(1.13); C260(1.17)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C98(0.71); C260(0.79); C86(0.88); C437(0.88)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C260(0.68); C98(0.71); C86(0.82); C676(0.85)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C98(0.76); C676(0.86); C260(0.87); C86(0.91)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C691(0.67); C695(0.67); C260(0.81); C117(0.87)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C98(0.74); C676(0.86); C86(0.91); C691(0.94)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C98(0.68); C86(0.76); C260(0.77); C437(0.78)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C98(0.73); C86(0.85); C260(0.86); C437(0.90)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C260(0.64); C98(0.69); C86(0.86); C437(0.87)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C260(0.85); C98(0.86); C437(0.95); C439(0.95)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C98(0.66); C691(0.79); C695(0.79); C260(0.83)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C98(0.73); C691(0.81); C695(0.81); C86(0.91)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C98(0.72); C260(0.73); C691(0.84); C695(0.84)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C117(0.95); C676(0.96); C691(0.96); C695(0.96)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C676(0.81); C691(0.88); C695(0.88); C117(0.89)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C691(0.69); C695(0.69); C260(0.85); C117(0.94)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C117(0.66); C691(0.78); C695(0.78); C676(0.78)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C117(0.74); C676(0.96); C437(0.97); C439(0.97)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C676(0.79); C691(0.86); C695(0.86); C98(0.99)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C98(0.94); C691(0.98); C695(0.98); C676(0.99)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C676(0.93); C691(0.93); C695(0.93); C117(1.10)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C676(0.89); C117(0.92); C98(1.04); C691(1.06)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C117(0.92); C676(0.96); C260(0.96); C691(1.00)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C691(0.78); C695(0.78); C676(0.85); C260(0.90)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C117(0.74); C676(0.95); C691(0.96); C695(0.96)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C117(0.86); C691(0.88); C695(0.88); C676(0.97)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C691(0.67); C695(0.67); C117(0.80); C66(0.93)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C691(0.92); C695(0.92); C117(0.93); C260(0.96)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C437(0.97); C439(0.97); C260(1.12); C86(1.12)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C117(1.02); C676(1.05); C260(1.11); C691(1.13)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C437(0.59); C439(0.59); C587(0.60); C98(0.79)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C437(0.56); C439(0.56); C587(0.58); C98(0.69)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C437(0.49); C439(0.49); C587(0.64); C98(0.76)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C437(0.43); C439(0.43); C587(0.57); C98(0.69)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C437(0.47); C439(0.47); C587(0.68); C98(0.78)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C437(0.48); C439(0.48); C587(0.56); C98(0.76)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C587(0.54); C437(0.60); C439(0.60); C98(0.75)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C437(0.60); C439(0.60); C587(0.77); C691(0.85)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C437(0.54); C439(0.54); C587(0.58); C98(0.74)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C691(0.54); C695(0.54); C437(0.54); C439(0.54)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C437(0.52); C439(0.52); C587(0.56); C98(0.76)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C691(0.50); C695(0.50); C437(0.51); C439(0.51)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C437(0.51); C439(0.51); C587(0.70); C98(0.91)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C691(0.46); C695(0.46); C587(0.50); C437(0.52)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C437(0.56); C439(0.56); C587(0.56); C98(0.67)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C260(0.43); C98(0.59); C691(0.60); C437(0.68)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C260(0.58); C437(0.59); C439(0.59); C691(0.68)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C117(1.03); C260(0.98); C437(1.34); C439(1.28)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C691(0.72); C695(0.72); C117(0.91); C260(0.94)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C691(0.53); C695(0.53); C117(0.85); C260(0.86)  LDD0592  [7]
 LDCM0020  ARS-1620 HCC44 C676(0.87)  LDD0078  [7]
 LDCM0108  Chloroacetamide HeLa C260(0.00); H159(0.00)  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C86(0.78)  LDD2227  [10]
 LDCM0367  CL1 HCT 116 C437(0.94); C439(0.94); C676(0.95); C98(0.98)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C98(0.87); C86(0.89); C676(0.92); C260(0.94)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C691(0.57); C695(0.57); C437(0.82); C439(0.82)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C691(0.60); C695(0.60); C66(0.74); C676(0.85)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C691(0.76); C695(0.76); C66(0.80); C676(0.85)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C691(0.76); C695(0.76); C66(0.81); C260(0.83)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C691(0.82); C695(0.82); C66(0.90); C98(0.96)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C691(0.51); C695(0.51); C437(0.78); C587(0.82)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C691(0.68); C695(0.68); C437(0.86); C439(0.86)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C691(0.52); C695(0.52); C439(0.79); C587(0.81)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C691(0.50); C695(0.50); C587(0.83); C66(0.87)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C676(0.71); C691(0.74); C695(0.74); C437(0.75)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C676(0.89); C117(0.91); C86(0.95); C98(0.97)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C691(0.55); C695(0.55); C676(0.74); C587(0.74)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C437(0.74); C691(0.76); C695(0.76); C587(0.78)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C695(0.47); C691(0.61); C587(0.79); C260(0.80)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C695(0.35); C260(0.44); C691(0.54); C439(0.66)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C695(0.42); C691(0.54); C260(0.63); C587(0.65)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C695(0.32); C691(0.60); C439(0.70); C98(0.70)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C695(0.44); C691(0.65); C98(0.72); C587(0.73)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C691(0.88); C676(0.93); C695(0.96); C98(1.03)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C691(0.85); C587(0.88); C695(0.91); C98(0.95)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C691(0.82); C695(0.88); C676(0.93); C98(0.93)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C86(0.89); C98(0.90); C676(0.98); C260(0.98)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C691(0.83); C587(0.85); C695(0.86); C260(0.86)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C676(0.76); C86(0.80); C66(0.97); C260(1.00)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C260(0.96); C66(0.99); C587(1.01); C98(1.08)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C260(0.88); C587(0.93); C66(1.00); C676(1.04)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C260(0.92); C587(0.97); C98(1.03); C676(1.05)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C98(0.79); C260(0.81); C691(0.81); C695(0.81)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C676(0.80); C98(0.82); C691(0.89); C695(0.89)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C98(0.70); C86(0.81); C437(0.90); C439(0.90)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C98(0.75); C260(0.76); C691(0.81); C695(0.81)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C98(0.87); C676(0.88); C86(0.90); C66(0.97)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C98(0.86); C86(0.88); C117(0.96); C260(0.96)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C98(0.85); C86(0.86); C676(0.88); C117(0.98)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C437(0.76); C439(0.76); C98(0.89); C587(0.91)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C587(0.88); C98(0.88); C676(0.91); C437(0.96)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C98(0.88); C676(0.91); C86(0.94); C587(0.96)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C98(0.86); C66(0.89); C691(0.91); C695(0.91)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C117(0.91); C676(0.93); C260(0.99); C86(1.02)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C98(0.76); C587(0.81); C691(0.83); C695(0.83)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C691(0.64); C695(0.64); C587(0.77); C98(0.85)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C98(0.86); C691(0.86); C695(0.86); C66(0.96)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C587(0.72); C98(0.84); C691(0.86); C695(0.86)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C260(0.96); C437(0.85); C439(0.85); C587(0.85)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C260(1.02); C437(0.94); C439(0.94); C587(0.72)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C260(1.13); C437(0.97); C439(0.97); C587(0.75)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C260(0.90); C437(0.92); C439(0.92); C587(0.83)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C260(1.16); C437(0.95); C439(0.95); C587(0.77)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C260(1.18); C437(0.91); C439(0.91); C587(0.91)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C117(0.92); C260(0.96); C437(0.98); C439(0.98)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C260(1.31); C437(0.87); C439(0.87); C587(0.87)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C437(0.81); C439(0.81); C66(0.98); C676(0.92)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C437(0.85); C439(0.85); C66(1.18); C676(1.06)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C437(0.77); C439(0.77); C66(1.10); C676(0.99)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C437(0.98); C439(0.98); C66(1.16); C676(1.11)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C437(0.99); C439(0.99); C66(1.10); C676(1.01)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C437(0.82); C439(0.82); C66(1.04); C676(1.01)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C437(0.89); C439(0.89); C66(1.16); C676(1.11)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C437(0.81); C439(0.81); C66(1.27); C676(1.01)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C117(1.07); C260(0.97); C437(1.09); C439(1.09)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C437(0.81); C439(0.81); C66(1.17); C676(0.94)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C437(0.80); C439(0.80); C66(1.10); C676(0.89)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C437(1.09); C439(1.09); C66(1.46); C676(1.06)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C437(0.99); C439(0.99); C66(1.30); C676(0.95)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C437(0.85); C439(0.85); C66(1.11); C676(1.05)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C437(0.97); C439(0.97); C66(1.25); C676(1.04)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C260(0.84); C437(1.09); C439(1.09); C587(0.88)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C260(0.97); C437(0.86); C439(0.86); C587(0.82)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C260(1.16); C437(0.90); C439(0.90); C587(0.81)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C260(1.12); C437(0.81); C439(0.81); C587(0.82)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C117(1.00); C260(1.00); C437(1.06); C439(1.06)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C260(0.81); C437(0.91); C439(0.91); C587(0.81)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C260(1.01); C437(0.85); C439(0.85); C587(0.89)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C260(1.06); C437(0.87); C439(0.87); C587(0.93)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C260(1.08); C437(0.75); C439(0.75); C587(0.81)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C260(0.97); C437(1.01); C439(1.01); C587(0.85)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C260(1.06); C437(0.88); C439(0.88); C587(0.88)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C260(1.46); C437(0.91); C439(0.91); C587(0.83)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C260(1.20); C437(0.88); C439(0.88); C587(0.84)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C260(1.63); C437(0.83); C439(0.83); C587(0.88)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C260(1.03); C437(0.79); C439(0.79); C587(0.87)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C117(0.87); C260(0.98); C437(1.12); C439(1.12)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C260(1.14); C437(0.93); C439(0.93); C587(0.82)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C260(0.91); C437(0.92); C439(0.92); C66(1.07)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C260(0.88); C437(1.03); C439(1.03); C66(1.09)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C260(0.76); C437(0.91); C439(0.91); C66(0.92)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C260(0.78); C437(1.03); C439(1.03); C66(1.03)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C260(0.94); C437(0.90); C439(0.90); C66(0.98)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C260(0.87); C437(1.05); C439(1.05); C66(0.96)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C260(0.94); C437(1.02); C439(1.02); C66(0.93)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C260(0.88); C437(0.93); C439(0.93); C66(0.98)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C260(1.15); C437(1.07); C439(1.07); C66(1.08)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C117(0.82); C260(1.18); C437(1.03); C439(1.03)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C260(0.95); C437(0.92); C439(0.92); C66(1.06)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C260(0.80); C437(0.96); C439(0.96); C66(1.16)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C260(0.97); C437(1.00); C439(1.00); C66(1.05)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C260(1.12); C437(0.97); C439(0.97); C66(1.07)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C260(0.91); C437(1.00); C439(1.00); C66(1.01)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C117(1.08); C260(2.19); C437(0.89); C439(0.89)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C117(1.65); C260(1.54); C437(0.76); C439(0.76)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C117(0.87); C260(1.27); C437(0.64); C439(0.64)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C117(1.06); C260(1.15); C437(0.78); C439(0.78)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C117(0.95); C260(1.01); C437(1.18); C439(1.18)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C117(1.45); C260(1.15); C437(0.77); C439(0.77)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C117(0.88); C260(1.10); C437(0.75); C439(0.75)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C117(0.96); C260(1.76); C437(1.16); C439(1.16)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C117(1.03); C260(1.09); C437(0.82); C439(0.82)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C117(0.95); C260(1.22); C437(1.35); C439(1.35)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C117(0.87); C260(0.96); C437(0.64); C439(0.64)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C117(1.14); C260(1.37); C437(0.66); C439(0.66)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C117(0.96); C260(1.68); C437(0.88); C439(0.88)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C117(0.91); C260(1.50); C437(1.16); C439(1.16)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C117(1.02); C260(1.51); C437(1.06); C439(1.06)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C117(0.93); C260(1.00); C437(0.96); C439(0.96)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C117(0.93); C260(1.10); C437(1.02); C439(1.02)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C117(0.79); C260(0.92); C437(0.79); C439(0.79)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C117(0.77); C260(0.97); C437(0.82); C439(0.82)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C117(1.03); C260(0.96); C437(0.88); C439(0.88)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C117(0.77); C260(0.93); C437(0.72); C439(0.72)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C117(0.81); C260(0.99); C437(0.72); C439(0.72)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C117(0.76); C260(0.98); C437(0.72); C439(0.72)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C117(0.94); C260(1.09); C437(0.94); C439(0.94)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C117(0.79); C260(0.80); C437(0.89); C439(0.89)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C117(0.94); C260(0.96); C437(0.91); C439(0.91)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C66(0.95); C587(0.94); C260(1.01); C676(0.90)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C66(1.00)  LDD1702  [5]
 LDCM0572  Fragment10 Ramos C587(0.51)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C587(1.84)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C587(0.52)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C587(0.77)  LDD2192  [18]
 LDCM0580  Fragment21 Ramos C587(0.79)  LDD2195  [18]
 LDCM0578  Fragment27 Ramos C587(0.60)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C587(0.38)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C587(0.86)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C587(0.59)  LDD2200  [18]
 LDCM0468  Fragment33 HCT 116 C260(0.93); C437(0.94); C439(0.94); C66(1.07)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C587(1.04)  LDD2203  [18]
 LDCM0427  Fragment51 HCT 116 C437(1.13); C439(1.13); C66(1.44); C676(0.93)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C587(0.50)  LDD2204  [18]
 LDCM0107  IAA HeLa H159(0.00); H446(0.00); H714(0.00)  LDD0221  [13]
 LDCM0022  KB02 HCT 116 C676(1.68); C86(1.31)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C676(1.80); C86(1.26)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C676(1.80); C86(1.18)  LDD0082  [7]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C66(1.43)  LDD2102  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C66(1.29)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C66(0.86)  LDD2099  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C66(0.74)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C66(1.05)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C66(0.96)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C66(0.95); C676(1.03)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C66(1.09)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C66(0.82)  LDD2114  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C66(0.91); C676(0.93)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C66(1.09)  LDD2127  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C66(1.37)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C66(1.09)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C66(1.11); C676(0.97)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C66(1.22)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C66(0.74)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C66(2.23)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C66(0.94)  LDD2146  [5]
 LDCM0021  THZ1 HeLa S3 C587(1.06)  LDD0460  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA helicase aquarius (AQR) CWF11 family O60306
Peptidyl-prolyl cis-trans isomerase E (PPIE) Cyclophilin-type PPIase family Q9UNP9
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 (DHX16) DEAD box helicase family O60231
DNA-directed RNA polymerase II subunit RPB1 (POLR2A) RNA polymerase beta' chain family P24928
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein Red (IK) RED family Q13123
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pre-mRNA-splicing factor ISY1 homolog (ISY1) ISY1 family Q9ULR0
SNW domain-containing protein 1 (SNW1) SNW family Q13573
U2 small nuclear ribonucleoprotein A' (SNRPA1) U2 small nuclear ribonucleoprotein A family P09661
DNA repair protein complementing XP-A cells (XPA) XPA family P23025
DNA excision repair protein ERCC-8 (ERCC8) . Q13216
Splicing factor 3B subunit 2 (SF3B2) . Q13435

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578