Details of the Target

General Information of Target

Target ID LDTP00407
Target Name Prostaglandin E synthase (PTGES)
Gene Name PTGES
Gene ID 9536
Synonyms
MGST1L1; MPGES1; PGES; PIG12; Prostaglandin E synthase; EC 5.3.99.3; Glutathione peroxidase PTGES; EC 1.11.1.-; Glutathione transferase PTGES; EC 2.5.1.18; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCR
SDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGK
LRAPIRSVTYTLAQLPCASMALQILWEAARHL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
MAPEG family
Subcellular location
Membrane
Function
Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli . Plays a key role in inflammation response, fever and pain. Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively.
TTD ID
T02562
Uniprot ID
O14684
DrugMap ID
TTYLQ8V
Ensemble ID
ENST00000340607.5
HGNC ID
HGNC:9599
ChEMBL ID
CHEMBL5658

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K42(5.91)  LDD0277  [1]
BTD
 Probe Info  		C59(10.26)  LDD1699  [2]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [3]
THZ1-DTB
 Probe Info  		C137(1.09)  LDD0460  [3]
Jackson_14
 Probe Info  		2.38  LDD0123  [4]
Acrolein
 Probe Info  		N.A.  LDD0221  [5]
DBIA
 Probe Info  		C59(0.95)  LDD0531  [6]
IA-alkyne
 Probe Info  		C137(0.00); C59(0.00)  LDD0162  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
WYneO
 Probe Info  		N.A.  LDD0022  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [5]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C59(0.95)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C59(0.84)  LDD0532  [6]
 LDCM0226  AC11 HCT 116 C59(0.78)  LDD0543  [6]
 LDCM0230  AC113 HCT 116 C59(0.97)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C59(0.84)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C59(0.87)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C59(0.86)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C59(0.79)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C59(0.90)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C59(0.96)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C59(0.99)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C59(1.08)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C59(1.14)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C59(0.96)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C59(0.96)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C59(1.12)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C59(1.05)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C59(1.04)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C59(1.07)  LDD0562  [6]
 LDCM0259  AC14 HCT 116 C59(0.85)  LDD0576  [6]
 LDCM0270  AC15 HCT 116 C59(0.93)  LDD0587  [6]
 LDCM0276  AC17 HCT 116 C59(1.30)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C59(0.67)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C59(1.56)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C59(1.00)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C59(1.19)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C59(0.87)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C59(1.30)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C59(1.60)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C59(1.74)  LDD0601  [6]
 LDCM0290  AC3 HCT 116 C59(1.03)  LDD0607  [6]
 LDCM0296  AC35 HCT 116 C59(1.22)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C59(1.11)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C59(1.24)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C59(1.32)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C59(1.28)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C59(1.14)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C59(1.35)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C59(0.84)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C59(1.02)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C59(0.87)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C59(0.96)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C59(1.01)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C59(1.41)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C59(1.72)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C59(1.04)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C59(1.21)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C59(1.07)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C59(1.14)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C59(1.52)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C59(1.09)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C59(0.89)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C59(1.23)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C59(1.18)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C59(1.10)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C59(1.01)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C59(1.08)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C59(0.92)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C59(0.88)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C59(0.96)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C59(0.98)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C59(0.95)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C59(0.93)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C59(0.91)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C59(1.03)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C59(0.95)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C59(0.91)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C59(1.20)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C59(1.21)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C59(0.92)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C59(0.96)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C59(1.13)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C59(1.20)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C59(0.97)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C59(1.07)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C59(1.09)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C59(1.08)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C59(1.05)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C59(1.05)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C59(1.02)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C59(0.81)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C59(0.96)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C59(0.97)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C59(0.95)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C59(0.94)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C59(0.94)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C59(0.76)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C59(0.94)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C59(1.00)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C59(1.13)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C59(0.85)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C59(0.88)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C59(0.95)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C59(0.92)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C59(0.97)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C59(0.90)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C59(0.99)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C59(0.89)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C59(0.84)  LDD0681  [6]
 LDCM0248  AKOS034007472 HCT 116 C59(0.97)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C59(0.83)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C59(0.80)  LDD0592  [6]
 LDCM0630  CCW28-3 231MFP C137(1.13)  LDD2214  [11]
 LDCM0108  Chloroacetamide HeLa C59(0.00); H53(0.00)  LDD0222  [5]
 LDCM0367  CL1 HCT 116 C59(1.50)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C59(0.69)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C59(0.98)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C59(0.84)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C59(0.95)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C59(1.00)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C59(1.04)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C59(0.95)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C59(0.75)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C59(1.05)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C59(0.70)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C59(1.03)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C59(0.83)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C59(0.95)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C59(1.39)  LDD0698  [6]
 LDCM0387  CL117 HCT 116 C59(1.19)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C59(1.03)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C59(0.95)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C59(0.91)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C59(0.82)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C59(1.10)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C59(1.11)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C59(0.73)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C59(0.98)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C59(0.93)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C59(0.90)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C59(1.18)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C59(1.04)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C59(0.80)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C59(1.20)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C59(0.85)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C59(1.52)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C59(1.07)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C59(0.91)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C59(1.11)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C59(1.61)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C59(0.77)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C59(0.82)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C59(0.82)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C59(1.56)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C59(0.74)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C59(0.89)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C59(0.87)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C59(0.84)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C59(0.98)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C59(0.95)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C59(1.21)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C59(0.75)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C59(0.87)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C59(0.73)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C59(1.26)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C59(0.77)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C59(0.73)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C59(0.84)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C59(0.83)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C59(0.80)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C59(1.15)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C59(0.76)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C59(0.84)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C59(0.74)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C59(0.76)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C59(0.85)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C59(0.72)  LDD0752  [6]
 LDCM0440  CL5 HCT 116 C59(1.18)  LDD0757  [6]
 LDCM0451  CL6 HCT 116 C59(0.93)  LDD0768  [6]
 LDCM0462  CL7 HCT 116 C59(0.89)  LDD0779  [6]
 LDCM0469  CL76 HCT 116 C59(1.01)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C59(1.40)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C59(1.02)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C59(1.18)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C59(0.79)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C59(1.11)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C59(1.45)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C59(1.30)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C59(1.51)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C59(1.09)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C59(1.16)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C59(1.27)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C59(1.59)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C59(1.52)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C59(1.23)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C59(1.23)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C59(1.40)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C59(0.95)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C59(0.88)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C59(1.01)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C59(0.94)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C59(0.87)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C59(1.06)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C59(1.03)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C59(1.03)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C59(0.85)  LDD0811  [6]
 LDCM0427  Fragment51 HCT 116 C59(0.90)  LDD0744  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [5]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [3]
 LDCM0022  KB02 8505C C59(1.24)  LDD2249  [12]
 LDCM0023  KB03 8505C C59(1.46)  LDD2666  [12]
 LDCM0024  KB05 HMCB C59(1.85)  LDD3312  [12]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.38  LDD0123  [4]
 LDCM0021  THZ1 HeLa S3 C137(1.09)  LDD0460  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peroxisomal bifunctional enzyme (EHHADH) Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family Q08426
GTPase IMAP family member 1 (GIMAP1) AIG1/Toc34/Toc159-like paraseptin GTPase family Q8WWP7
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vesicle-associated membrane protein 3 (VAMP3) Synaptobrevin family Q15836
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Proteolipid protein 2 (PLP2) . Q04941
Transmembrane protein 65 (TMEM65) . Q6PI78
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BET1 homolog (BET1) BET1 family O15155
Stress-associated endoplasmic reticulum protein 2 (SERP2) RAMP4 family Q8N6R1
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5
Vesicle-associated membrane protein 4 (VAMP4) Synaptobrevin family O75379
Vesicle-trafficking protein SEC22a (SEC22A) Synaptobrevin family Q96IW7
Transmembrane protein 19 (TMEM19) TMEM19 family Q96HH6
Protein YIF1A (YIF1A) YIF1 family O95070
Transmembrane protein 222 (TMEM222) . Q9H0R3

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Aad-2004 Small molecular drug D00MBY
Patented
Click To Hide/Show 31 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alpha-substituted Pirinixic Acid And Pirinixic Acid Ester Derivative 1 Small molecular drug D0OE9W
Benzamide Derivative 14 Small molecular drug D0YO3X
Benzamide Derivative 15 Small molecular drug D0FX6I
Benzamide Derivative 16 Small molecular drug D0AH1A
Benzamide Derivative 18 Small molecular drug D02DXA
Benzimidazole Derivative 11 Small molecular drug D0N2DJ
Benzimidazole Derivative 12 Small molecular drug D0ZT9I
Benzimidazole Derivative 13 Small molecular drug D07YPE
Benzimidazole Derivative 14 Small molecular drug D0I5DE
Benzimidazole Derivative 15 Small molecular drug D0HH5B
Benzimidazole Derivative 16 Small molecular drug D0KY1Y
Benzimidazole Derivative 17 Small molecular drug D0T1UU
Betais-sulfonylamino Derivative 1 Small molecular drug D07WOT
Boswellia Acid Derivative 1 Small molecular drug D0RM0U
Carboxylic Acid Derivative 1 Small molecular drug D00PHK
Imidazole Benzamide Derivative 1 Small molecular drug D0F8KE
Imidazopyridine Derivative 5 Small molecular drug D0BR7G
Imidazopyridine Derivative 6 Small molecular drug D0C3ZN
Imidazopyridine Derivative 7 Small molecular drug D0UJ5D
Methyl-piperidine Compound 1 Small molecular drug D0XM9M
Phthalazinone Derivative 1 Small molecular drug D00XFM
Piperidine Carboxamide Derivative 1 Small molecular drug D0V4FE
Pmid28627961-compound-22 Small molecular drug D0EB9M
Pmid28627961-compound-30 Small molecular drug D0S2UD
Pmid28627961-compound-31 Small molecular drug D0LY6S
Pmid28627961-compound-32 Small molecular drug D0I1GO
Pmid28627961-compound-33 Small molecular drug D0JH7Q
Pmid28627961-compound-41 Small molecular drug D0O2DY
Pmid28627961-compound-44 Small molecular drug D0WG5P
Polycyclic Compound 1 Small molecular drug D0U9LS
Pyrimidine Derivative 2 Small molecular drug D0WR0Q
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
L-655240 Small molecular drug D0I9JH

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840