Details of the Target

General Information of Target

Target ID LDTP11433
Target Name Histone deacetylase 8 (HDAC8)
Gene Name HDAC8
Gene ID 55869
Synonyms
HDACL1; Histone deacetylase 8; HD8; EC 3.5.1.98; Protein deacetylase HDAC8; EC 3.5.1.-; Protein decrotonylase HDAC8; EC 3.5.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEA
VRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFAL
STGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFR
ALLELQEYFGSLAA
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Histone deacetylase family, HD type 1 subfamily
Subcellular location
Nucleus
Function
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.
TTD ID
T28887
Uniprot ID
Q9BY41
DrugMap ID
TTT6LFV
Ensemble ID
ENST00000373554.6
HGNC ID
HGNC:13315
ChEMBL ID
CHEMBL3192

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HDQP1 SNV: p.S93C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K374(0.15)  LDD0277  [2]
Probe 1
 Probe Info  		Y252(7.97)  LDD3495  [3]
SAHA-CA-4PAP
 Probe Info  		7.00  LDD0269  [4]
DBIA
 Probe Info  		C244(6.10)  LDD0204  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C314(0.00); C153(0.00); C244(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [7]
Lodoacetamide azide
 Probe Info  		C314(0.00); C153(0.00); C244(0.00)  LDD0037  [6]
IPM
 Probe Info  		C153(0.00); C314(0.00); C244(0.00); C352(0.00)  LDD2156  [8]
AOyne
 Probe Info  		13.30  LDD0443  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
SAHA-CA-8PAP
 Probe Info  		17.50  LDD0362  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C153(0.96)  LDD0812  [10]
 LDCM0215  AC10 PaTu 8988t C153(1.03)  LDD1094  [10]
 LDCM0226  AC11 PaTu 8988t C153(1.21)  LDD1105  [10]
 LDCM0230  AC113 HEK-293T C153(0.96)  LDD0828  [10]
 LDCM0231  AC114 HEK-293T C153(1.18)  LDD0829  [10]
 LDCM0232  AC115 HEK-293T C153(0.94)  LDD0830  [10]
 LDCM0233  AC116 HEK-293T C153(0.86)  LDD0831  [10]
 LDCM0234  AC117 HEK-293T C153(1.09)  LDD0832  [10]
 LDCM0235  AC118 HEK-293T C153(1.32)  LDD0833  [10]
 LDCM0236  AC119 HEK-293T C153(1.14)  LDD0834  [10]
 LDCM0237  AC12 PaTu 8988t C153(1.32)  LDD1116  [10]
 LDCM0238  AC120 HEK-293T C153(1.55)  LDD0836  [10]
 LDCM0239  AC121 HEK-293T C153(1.51)  LDD0837  [10]
 LDCM0240  AC122 HEK-293T C153(2.32)  LDD0838  [10]
 LDCM0241  AC123 HEK-293T C153(1.49)  LDD0839  [10]
 LDCM0242  AC124 HEK-293T C153(1.27)  LDD0840  [10]
 LDCM0243  AC125 HEK-293T C153(1.99)  LDD0841  [10]
 LDCM0244  AC126 HEK-293T C153(2.77)  LDD0842  [10]
 LDCM0245  AC127 HEK-293T C153(2.52)  LDD0843  [10]
 LDCM0259  AC14 PaTu 8988t C153(0.90)  LDD1138  [10]
 LDCM0263  AC143 HEK-293T C153(1.42)  LDD0861  [10]
 LDCM0264  AC144 HEK-293T C153(1.23)  LDD0862  [10]
 LDCM0265  AC145 HEK-293T C153(1.17)  LDD0863  [10]
 LDCM0266  AC146 HEK-293T C153(1.16)  LDD0864  [10]
 LDCM0267  AC147 HEK-293T C153(1.36)  LDD0865  [10]
 LDCM0268  AC148 HEK-293T C153(1.04)  LDD0866  [10]
 LDCM0269  AC149 HEK-293T C153(0.82)  LDD0867  [10]
 LDCM0270  AC15 PaTu 8988t C153(1.07)  LDD1149  [10]
 LDCM0271  AC150 HEK-293T C153(1.04)  LDD0869  [10]
 LDCM0272  AC151 HEK-293T C153(1.04)  LDD0870  [10]
 LDCM0273  AC152 HEK-293T C153(1.03)  LDD0871  [10]
 LDCM0274  AC153 HEK-293T C153(0.99)  LDD0872  [10]
 LDCM0621  AC154 HEK-293T C153(0.88)  LDD2162  [10]
 LDCM0622  AC155 HEK-293T C153(0.98)  LDD2163  [10]
 LDCM0623  AC156 HEK-293T C153(1.26)  LDD2164  [10]
 LDCM0624  AC157 HEK-293T C153(1.40)  LDD2165  [10]
 LDCM0276  AC17 HEK-293T C153(0.95); C275(1.00); C352(1.08); C244(0.93)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C153(1.04); C275(0.91); C352(0.97)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C153(0.91); C275(0.80); C352(1.14); C314(0.92)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C153(1.20)  LDD0877  [10]
 LDCM0280  AC20 HEK-293T C153(1.01); C275(0.98); C244(0.96)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C153(0.95); C275(0.92); C352(1.15)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C153(0.98); C275(0.95); C352(1.04); C244(0.96)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C153(1.07); C275(1.00); C352(0.86); C244(1.00)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C153(1.05); C275(0.99); C352(0.95)  LDD1523  [11]
 LDCM0285  AC25 PaTu 8988t C153(0.97)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C153(1.27)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C153(1.42)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C153(1.44)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C153(1.17)  LDD1168  [10]
 LDCM0290  AC3 HEK-293T C153(1.06)  LDD0888  [10]
 LDCM0291  AC30 PaTu 8988t C153(1.49)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C153(1.20)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C153(0.82)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C153(1.24)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C153(1.21)  LDD1174  [10]
 LDCM0296  AC35 PaTu 8988t C153(1.26)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C153(1.42)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C153(1.57)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C153(1.33)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C153(1.44)  LDD1179  [10]
 LDCM0301  AC4 HEK-293T C153(1.01)  LDD0899  [10]
 LDCM0302  AC40 PaTu 8988t C153(1.38)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C153(1.16)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C153(1.07)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C153(1.35)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C153(1.54)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C153(1.29)  LDD1186  [10]
 LDCM0308  AC46 PaTu 8988t C153(0.95)  LDD1187  [10]
 LDCM0309  AC47 PaTu 8988t C153(1.02)  LDD1188  [10]
 LDCM0310  AC48 PaTu 8988t C153(1.23)  LDD1189  [10]
 LDCM0311  AC49 PaTu 8988t C153(1.33)  LDD1190  [10]
 LDCM0312  AC5 HEK-293T C153(0.95)  LDD0910  [10]
 LDCM0313  AC50 PaTu 8988t C153(1.33)  LDD1192  [10]
 LDCM0314  AC51 PaTu 8988t C153(0.38)  LDD1193  [10]
 LDCM0315  AC52 PaTu 8988t C153(0.91)  LDD1194  [10]
 LDCM0316  AC53 PaTu 8988t C153(1.06)  LDD1195  [10]
 LDCM0317  AC54 PaTu 8988t C153(1.15)  LDD1196  [10]
 LDCM0318  AC55 PaTu 8988t C153(1.12)  LDD1197  [10]
 LDCM0319  AC56 PaTu 8988t C153(1.26)  LDD1198  [10]
 LDCM0320  AC57 PaTu 8988t C153(1.36)  LDD1199  [10]
 LDCM0321  AC58 PaTu 8988t C153(1.16)  LDD1200  [10]
 LDCM0322  AC59 PaTu 8988t C153(1.28)  LDD1201  [10]
 LDCM0323  AC6 PaTu 8988t C153(0.95)  LDD1202  [10]
 LDCM0324  AC60 PaTu 8988t C153(1.50)  LDD1203  [10]
 LDCM0325  AC61 PaTu 8988t C153(1.28)  LDD1204  [10]
 LDCM0326  AC62 PaTu 8988t C153(1.23)  LDD1205  [10]
 LDCM0327  AC63 PaTu 8988t C153(1.41)  LDD1206  [10]
 LDCM0328  AC64 PaTu 8988t C153(1.39)  LDD1207  [10]
 LDCM0329  AC65 PaTu 8988t C153(1.01)  LDD1208  [10]
 LDCM0330  AC66 PaTu 8988t C153(1.02)  LDD1209  [10]
 LDCM0331  AC67 PaTu 8988t C153(1.43)  LDD1210  [10]
 LDCM0332  AC68 HEK-293T C153(0.91)  LDD0930  [10]
 LDCM0333  AC69 HEK-293T C153(0.81)  LDD0931  [10]
 LDCM0334  AC7 PaTu 8988t C153(0.94)  LDD1213  [10]
 LDCM0335  AC70 HEK-293T C153(1.08)  LDD0933  [10]
 LDCM0336  AC71 HEK-293T C153(1.32)  LDD0934  [10]
 LDCM0337  AC72 HEK-293T C153(1.27)  LDD0935  [10]
 LDCM0338  AC73 HEK-293T C153(1.15)  LDD0936  [10]
 LDCM0339  AC74 HEK-293T C153(0.92)  LDD0937  [10]
 LDCM0340  AC75 HEK-293T C153(1.37)  LDD0938  [10]
 LDCM0341  AC76 HEK-293T C153(1.32)  LDD0939  [10]
 LDCM0342  AC77 HEK-293T C153(1.23)  LDD0940  [10]
 LDCM0343  AC78 HEK-293T C153(1.16)  LDD0941  [10]
 LDCM0344  AC79 HEK-293T C153(0.91)  LDD0942  [10]
 LDCM0345  AC8 PaTu 8988t C153(0.97)  LDD1224  [10]
 LDCM0346  AC80 HEK-293T C153(1.05)  LDD0944  [10]
 LDCM0347  AC81 HEK-293T C153(1.30)  LDD0945  [10]
 LDCM0348  AC82 HEK-293T C153(2.41)  LDD0946  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C153(1.20)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C153(1.63)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C153(1.55)  LDD1154  [10]
 LDCM0156  Aniline NCI-H1299 13.15  LDD0403  [1]
 LDCM0102  BDHI 8 Jurkat C244(6.10)  LDD0204  [5]
 LDCM0367  CL1 HEK-293T C153(1.16)  LDD0965  [10]
 LDCM0368  CL10 HEK-293T C153(2.51)  LDD0966  [10]
 LDCM0369  CL100 HEK-293T C153(1.22)  LDD0967  [10]
 LDCM0370  CL101 PaTu 8988t C153(0.78)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C153(1.17)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C153(1.74)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C153(0.98)  LDD1252  [10]
 LDCM0374  CL105 HEK-293T C153(0.96); C275(1.01); C352(1.07)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C153(1.00); C275(0.91); C352(1.28)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C153(0.91); C275(1.00); C352(1.18)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C153(0.96); C275(0.90); C352(1.02)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C153(1.01); C275(0.95); C352(0.99)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C153(2.07)  LDD0977  [10]
 LDCM0380  CL110 HEK-293T C153(0.88); C275(0.95); C352(1.01)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C153(0.89); C275(0.97); C352(1.06)  LDD1585  [11]
 LDCM0382  CL112 PaTu 8988t C153(1.15)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C153(1.25)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C153(1.22)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C153(1.31)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C153(1.26)  LDD1265  [10]
 LDCM0387  CL117 PaTu 8988t C153(1.05)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C153(1.18)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C153(1.14)  LDD1268  [10]
 LDCM0390  CL12 HEK-293T C153(1.14)  LDD0988  [10]
 LDCM0391  CL120 PaTu 8988t C153(1.18)  LDD1270  [10]
 LDCM0392  CL121 PaTu 8988t C153(1.12)  LDD1271  [10]
 LDCM0393  CL122 PaTu 8988t C153(1.08)  LDD1272  [10]
 LDCM0394  CL123 PaTu 8988t C153(1.08)  LDD1273  [10]
 LDCM0395  CL124 PaTu 8988t C153(1.19)  LDD1274  [10]
 LDCM0396  CL125 PaTu 8988t C153(1.21)  LDD1275  [10]
 LDCM0397  CL126 PaTu 8988t C153(1.40)  LDD1276  [10]
 LDCM0398  CL127 PaTu 8988t C153(1.18)  LDD1277  [10]
 LDCM0399  CL128 PaTu 8988t C153(1.21)  LDD1278  [10]
 LDCM0400  CL13 HEK-293T C153(1.26)  LDD0998  [10]
 LDCM0401  CL14 HEK-293T C153(1.36)  LDD0999  [10]
 LDCM0402  CL15 HEK-293T C153(1.81)  LDD1000  [10]
 LDCM0403  CL16 HEK-293T C153(1.10); C275(0.94); C352(0.94)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C153(0.81); C275(0.86); C352(0.93); C244(0.93)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C153(1.05); C275(1.06); C352(0.86)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C153(0.94); C275(0.90); C352(0.93); C314(1.05)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C153(1.28)  LDD1005  [10]
 LDCM0408  CL20 HEK-293T C153(1.05); C275(1.02); C244(1.18)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C153(0.75); C275(0.95); C352(0.91)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C153(0.94); C275(1.02); C352(0.96); C244(0.98)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C153(1.29); C275(1.07); C352(1.27); C244(0.99)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C153(1.11); C275(1.07); C352(0.80)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C153(0.96); C275(0.88); C352(1.07)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C153(0.98); C275(1.03); C352(1.03)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C153(1.22); C275(0.97); C352(1.04)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C153(0.94); C275(0.92); C352(0.98)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C153(0.99); C275(0.87); C352(0.93); C244(1.12)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C153(1.15)  LDD1016  [10]
 LDCM0419  CL30 HEK-293T C153(1.06); C275(0.98); C352(0.84)  LDD1623  [11]
 LDCM0420  CL31 PaTu 8988t C153(0.93)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C153(1.02)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C153(0.74)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C153(1.03)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C153(1.06)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C153(0.37)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C153(0.94)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C153(0.95)  LDD1307  [10]
 LDCM0429  CL4 HEK-293T C153(1.21)  LDD1027  [10]
 LDCM0430  CL40 PaTu 8988t C153(1.12)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C153(0.85)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C153(0.99)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C153(1.02)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C153(1.14)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C153(1.18)  LDD1314  [10]
 LDCM0436  CL46 PaTu 8988t C153(1.18)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C153(1.27)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C153(1.30)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C153(1.30)  LDD1318  [10]
 LDCM0440  CL5 HEK-293T C153(1.24)  LDD1038  [10]
 LDCM0441  CL50 PaTu 8988t C153(1.23)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C153(1.29)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C153(1.32)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C153(1.12)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C153(1.22)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C153(1.21)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C153(0.69)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C153(1.74)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C153(1.43)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C153(1.58)  LDD1329  [10]
 LDCM0451  CL6 HEK-293T C153(1.36)  LDD1049  [10]
 LDCM0452  CL60 PaTu 8988t C153(1.47)  LDD1331  [10]
 LDCM0453  CL61 HEK-293T C153(0.82)  LDD1051  [10]
 LDCM0454  CL62 HEK-293T C153(1.20)  LDD1052  [10]
 LDCM0455  CL63 HEK-293T C153(1.41)  LDD1053  [10]
 LDCM0456  CL64 HEK-293T C153(1.04)  LDD1054  [10]
 LDCM0457  CL65 HEK-293T C153(1.15)  LDD1055  [10]
 LDCM0458  CL66 HEK-293T C153(1.10)  LDD1056  [10]
 LDCM0459  CL67 HEK-293T C153(1.61)  LDD1057  [10]
 LDCM0460  CL68 HEK-293T C153(1.24)  LDD1058  [10]
 LDCM0461  CL69 HEK-293T C153(1.08)  LDD1059  [10]
 LDCM0462  CL7 HEK-293T C153(1.33)  LDD1060  [10]
 LDCM0463  CL70 HEK-293T C153(1.03)  LDD1061  [10]
 LDCM0464  CL71 HEK-293T C153(1.29)  LDD1062  [10]
 LDCM0465  CL72 HEK-293T C153(1.17)  LDD1063  [10]
 LDCM0466  CL73 HEK-293T C153(1.45)  LDD1064  [10]
 LDCM0467  CL74 HEK-293T C153(2.34)  LDD1065  [10]
 LDCM0469  CL76 HEK-293T C153(1.10)  LDD1067  [10]
 LDCM0470  CL77 HEK-293T C153(1.23)  LDD1068  [10]
 LDCM0471  CL78 HEK-293T C153(1.05)  LDD1069  [10]
 LDCM0472  CL79 HEK-293T C153(1.15)  LDD1070  [10]
 LDCM0473  CL8 HEK-293T C153(1.06)  LDD1071  [10]
 LDCM0474  CL80 HEK-293T C153(1.19)  LDD1072  [10]
 LDCM0475  CL81 HEK-293T C153(1.14)  LDD1073  [10]
 LDCM0476  CL82 HEK-293T C153(1.08)  LDD1074  [10]
 LDCM0477  CL83 HEK-293T C153(1.20)  LDD1075  [10]
 LDCM0478  CL84 HEK-293T C153(1.11)  LDD1076  [10]
 LDCM0479  CL85 HEK-293T C153(1.12)  LDD1077  [10]
 LDCM0480  CL86 HEK-293T C153(1.29)  LDD1078  [10]
 LDCM0481  CL87 HEK-293T C153(1.16)  LDD1079  [10]
 LDCM0482  CL88 HEK-293T C153(1.21)  LDD1080  [10]
 LDCM0483  CL89 HEK-293T C153(1.15)  LDD1081  [10]
 LDCM0484  CL9 HEK-293T C153(0.96)  LDD1082  [10]
 LDCM0485  CL90 HEK-293T C153(1.69)  LDD1083  [10]
 LDCM0486  CL91 HEK-293T C153(0.94)  LDD1084  [10]
 LDCM0487  CL92 HEK-293T C153(1.06)  LDD1085  [10]
 LDCM0488  CL93 HEK-293T C153(1.05)  LDD1086  [10]
 LDCM0489  CL94 HEK-293T C153(1.38)  LDD1087  [10]
 LDCM0490  CL95 HEK-293T C153(1.33)  LDD1088  [10]
 LDCM0491  CL96 HEK-293T C153(1.04)  LDD1089  [10]
 LDCM0492  CL97 HEK-293T C153(1.07)  LDD1090  [10]
 LDCM0493  CL98 HEK-293T C153(1.17)  LDD1091  [10]
 LDCM0494  CL99 HEK-293T C153(1.16)  LDD1092  [10]
 LDCM0495  E2913 HEK-293T C153(1.08); C275(0.64); C352(1.19)  LDD1698  [11]
 LDCM0468  Fragment33 HEK-293T C153(2.21)  LDD1066  [10]
 LDCM0427  Fragment51 PaTu 8988t C153(1.09)  LDD1306  [10]
 LDCM0022  KB02 HEK-293T C352(1.09); C153(1.06); C275(0.99); C244(1.13)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C244(4.17)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C153(1.02)  LDD3310  [12]
 LDCM0096  SAHA K562 7.00  LDD0269  [4]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Decitabine Small molecular drug DB01262
Iron Small molecular drug DB01592
Phenylbutyric Acid Small molecular drug DB06819
Propanoic Acid Small molecular drug DB03766
Romidepsin Small molecular drug DB06176
Valproic Acid Small molecular drug DB00313
Vorinostat Small molecular drug DB02546
Ferrous Ascorbate . DB14490
Ferrous Fumarate . DB14491
Ferrous Gluconate . DB14488
Ferrous Glycine Sulfate . DB14501
Ferrous Succinate . DB14489
Zinc . DB01593
Zinc Acetate . DB14487
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nbm-bmx Small molecular drug D0SOG8
Investigative
Click To Hide/Show 78 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(E)-8-biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one Small molecular drug D0KE3I
2-(Methylsulfonylthio)Ethyl 2-propylpentanoate Small molecular drug D0H1FZ
4-benzoylamino-n-hydroxy-benzamide Small molecular drug D09ZNU
4-butyrylamino-n-hydroxy-benzamide Small molecular drug D05LLX
4-chloro-n-(5-hydroxycarbamoyl-pentyl)-benzamide Small molecular drug D0A5LS
4-dimethylamino-n-(6-mercapto-hexyl)-benzamide Small molecular drug D06XNP
4-hydroxy-n-(5-hydroxycarbamoyl-pentyl)-benzamide Small molecular drug D04NSP
4-phenylbutyrohydroxamic Acid Small molecular drug D02NWS
5-(4-chloro-phenyl)-pentanoic Acid Hydroxyamide Small molecular drug D0V2ZO
5-(4-hydroxyphenyl)-3h-1,2-dithiole-3-thione Small molecular drug D06IQB
5-mercapto-pentanoic Acid Phenylamide Small molecular drug D0D2KE
6-(2-bromo-acetylamino)-hexanoic Acid Phenylamide Small molecular drug D02MQM
6-(2-mercaptoacetamido)-n-phenylhexanamide Small molecular drug D0R2HF
6-benzenesulfinylhexanoic Acid Hydroxamide Small molecular drug D00ZSD
6-benzenesulfonylhexanoic Acid Hydroxamide Small molecular drug D05AHZ
6-mercapto-hexanoic Acid Phenylamide Small molecular drug D0B3ZM
6-phenoxy-hexane-1-thiol Small molecular drug D09YBN
6-phenylsulfanylhexanoic Acid Hydroxamide Small molecular drug D0S9JF
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D0B2ZJ
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one Small molecular drug D0Z3BM
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D02WZK
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one Small molecular drug D05VFP
7-mercapto-heptanoic Acid Benzothiazol-2-ylamide Small molecular drug D0Z5KX
7-mercapto-heptanoic Acid Biphenyl-3-ylamide Small molecular drug D05XAN
7-mercapto-heptanoic Acid Biphenyl-4-ylamide Small molecular drug D01XWZ
7-mercapto-heptanoic Acid Phenylamide Small molecular drug D00SEE
7-mercapto-heptanoic Acid Pyridin-3-ylamide Small molecular drug D07FJU
7-mercapto-heptanoic Acid Quinolin-3-ylamide Small molecular drug D0T4IY
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one Small molecular drug D0AX7B
8-mercapto-octanoic Acid Phenylamide Small molecular drug D0XZ9Q
8-oxo-8-phenyl-octanoic Acid Small molecular drug D0RU1X
9,9,9-trifluoro-8-oxo-nonanoic Acid Phenylamide Small molecular drug D00KFF
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one Small molecular drug D05FEJ
9-mercapto-8-oxo-n-phenylnonanamide Small molecular drug D09LVY
Abexinostat Small molecular drug DB12565
Coumarin 120 Small molecular drug DB08168
Cyclostellettamine Derivative Small molecular drug D0C0VP
Desclasinose Azithromycinarylalkyl Hydroxamate Small molecular drug D06THS
Droxinostat Small molecular drug D00VXM
N-(2-mercapto-ethyl)-n'-phenyl-oxalamide Small molecular drug D0F0KS
N-(2-mercapto-ethyl)-n'-phenyl-succinamide Small molecular drug D01MFV
N-(5-hydroxycarbamoyl-pentyl)-4-nitro-benzamide Small molecular drug D0C2KD
N-(6-hydroxycarbamoyl-hexyl)-benzamide Small molecular drug D0YY9M
N-(6-mercapto-hexyl)-benzamide Small molecular drug D04HSS
N-hydroxy-1-naphthamide Small molecular drug D01BCK
N-hydroxy-3-(Naphthalen-1-yl)Acrylamide Small molecular drug D0V1HA
N-hydroxy-3-phenoxybenzamide Small molecular drug D0P3SU
N-hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide Small molecular drug D04ZDI
N-hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide Small molecular drug D0QO0L
N-hydroxy-4-(2-phenyl-butyrylamino)-benzamide Small molecular drug D06VBN
N-hydroxy-4-(4-phenyl-butyrylamino)-benzamide Small molecular drug D0S7WQ
N-hydroxy-4-(5-phenyl-pentanoylamino)-benzamide Small molecular drug D0R5VG
N-hydroxy-4-(Naphthalen-1-yl)Benzamide Small molecular drug D03HNC
N-hydroxy-4-(Pentanoylamino-methyl)-benzamide Small molecular drug D0Z7YS
N-hydroxy-4-(Phenylacetylamino-methyl)-benzamide Small molecular drug D02UTC
N-hydroxy-4-phenylacetylamino-benzamide Small molecular drug D01XXN
Niltubacin Small molecular drug D0L7HP
Octanedioic Acid Bis-hydroxyamide Small molecular drug D07YZZ
Octanedioic Acid Hydroxyamide Pyridin-2-ylamide Small molecular drug D0E8KR
Octanedioic Acid Hydroxyamide Pyridin-4-ylamide Small molecular drug D04GGW
Pci-34051 Small molecular drug D0Q5MC
Psammaplin A Small molecular drug D0N0TS
S-2,9-dioxo-9-(Phenylamino)Nonyl Ethanethioate Small molecular drug D00DQZ
St-2986 Small molecular drug D0N9AK
St-2987 Small molecular drug D0T0SK
St-3050 Small molecular drug D01YBR
Thioacetic Acid S-(6-phenylcarbamoyl-hexyl) Ester Small molecular drug D05GVY
Trichostatin A Small molecular drug DB04297
(2e)-n-hydroxy-3-[1-methyl-4-(Phenylacetyl)-1h-pyrrol-2-yl]Prop-2-enamide . DB07350
4-(Dimethylamino)-n-[7-(Hydroxyamino)-7-oxoheptyl]Benzamide . DB02565
5-(4-methyl-benzoylamino)-biphenyl-34'-dicarboxylic Acid 3-dimethylamide-4'-hydroxyamide . DB07586
Azithromycin-n-benzyltriazolylhexahydroxamic Acid . D0I5XM
Azithromycin-n-benzyltriazolylnonahydroxamic Acid . D0H3RO
Azithromycin-n-benzyltriazolyloctahydroxamic Acid . D0D7KH
Azithromycinarylalkylhydroxamic Acid . D0P9CQ
N-hydroxy-4-(3-phenyl-propionylamino)-benzamide . D0R4BS
N-hydroxy-4-(Methyl{[5-(2-pyridinyl)-2-thienyl]Sulfonyl}Amino)Benzamide . DB02917
Nmb-t-bmx-os01 . D05PTL
Patented
Click To Hide/Show 14 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid29671355-compound-13 Small molecular drug D0ZG5X
Pmid29671355-compound-21 Small molecular drug D0LP1K
Pmid29671355-compound-23 Small molecular drug D00HXJ
Pmid29671355-compound-25 Small molecular drug D0RA0D
Pmid29671355-compound-31 Small molecular drug D0DI9S
Pmid29671355-compound-36 Small molecular drug D04JWR
Pmid29671355-compound-37 Small molecular drug D04UGJ
Pmid29671355-compound-43 Small molecular drug D0BP8I
Pmid29671355-compound-44 Small molecular drug D0N2DK
Pmid29671355-compound-56 Small molecular drug D0CH8Q
Pmid29671355-compound-61 Small molecular drug D0JB4S
Pmid29671355-compound-62 Small molecular drug D07WAT
Pmid29671355-compound-67 Small molecular drug D0M0RE
Pmid29671355-compound-68b Small molecular drug D0GD6R

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840