Details of the Target

General Information of Target

Target ID LDTP10810
Target Name Structural maintenance of chromosomes protein 6 (SMC6)
Gene Name SMC6
Gene ID 79677
Synonyms
SMC6L1; Structural maintenance of chromosomes protein 6; SMC protein 6; SMC-6; hSMC6
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPN
DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET
ALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN
YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR
SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
KRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVI
EVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSE
VSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLV
NPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACM
AFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHI
TKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
Target Bioclass
Other
Family
SMC family, SMC6 subfamily
Subcellular location
Nucleus
Function
Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
Uniprot ID
Q96SB8
Ensemble ID
ENST00000351948.8
HGNC ID
HGNC:20466

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.R152Ter DBIA    Probe Info 
HCC1954 SNV: p.A292V DBIA    Probe Info 
HCT116 SNV: p.Y502C .
HEC1 SNV: p.G92S DBIA    Probe Info 
IGROV1 SNV: p.L1061P DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.L530H DBIA    Probe Info 
MDST8 SNV: p.L413S DBIA    Probe Info 
NB1 SNV: p.D743H DBIA    Probe Info 
OVK18 SNV: p.D805E DBIA    Probe Info 
PEO1 SNV: p.M624V DBIA    Probe Info 
TE1 SNV: p.I783L DBIA    Probe Info 
TE8 SNV: p.H768R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K409(10.00)  LDD0277  [2]
IPM
 Probe Info  		C385(0.00); C251(0.00)  LDD0241  [3]
DBIA
 Probe Info  		C411(1.04)  LDD3312  [4]
BTD
 Probe Info  		C385(0.52)  LDD2092  [5]
HHS-465
 Probe Info  		Y461(5.98); Y818(10.00)  LDD2237  [6]
CY-1
 Probe Info  		Q143(0.00); Q144(0.00)  LDD0246  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C526(0.00); C346(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C346(0.00); C385(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C346(0.00); C385(0.00); C251(0.00)  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [11]
AOyne
 Probe Info  		12.40  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C275
 Probe Info  		4.92  LDD1945  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C385(0.97)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C385(0.79)  LDD2112  [5]
 LDCM0214  AC1 HEK-293T C385(0.91); C58(1.30); C1013(0.93); C346(0.93)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C385(0.92); C511(0.78); C58(1.14); C1013(1.24)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C385(0.97); C58(1.09); C1013(0.92); C346(1.01)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C385(1.02); C511(0.79); C58(0.95); C1013(0.98)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C385(0.95); C58(0.91); C1013(1.03); C346(0.97)  LDD1512  [15]
 LDCM0270  AC15 HEK-293T C385(1.13); C58(0.92); C1013(1.09); C526(0.95)  LDD1513  [15]
 LDCM0276  AC17 HEK-293T C385(0.90); C58(1.06); C1013(1.02); C346(0.88)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C385(0.94); C511(0.88); C58(1.19); C1013(0.97)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C385(0.84); C58(1.16); C1013(1.27); C346(0.92)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C385(0.95); C511(0.86); C58(1.25); C1013(1.12)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C385(0.95); C511(1.00); C58(1.11); C1013(1.12)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C385(0.99); C58(1.00); C526(0.99); C346(0.96)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C385(0.92); C58(1.06); C1013(1.06); C346(0.96)  LDD1521  [15]
 LDCM0283  AC23 HEK-293T C385(1.15); C58(0.95); C1013(1.17); C526(0.86)  LDD1522  [15]
 LDCM0284  AC24 HEK-293T C385(1.04); C511(1.02); C58(0.91); C1013(0.99)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C385(0.91); C58(1.19); C1013(1.07); C346(0.90)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C385(0.93); C511(0.91); C58(0.95); C1013(1.11)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C385(0.98); C58(1.12); C1013(0.99); C346(1.00)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C385(0.96); C511(0.87); C58(1.09); C1013(0.92)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C385(1.01); C58(0.92); C526(1.03); C346(0.91)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C385(0.99); C58(1.36); C1013(0.90); C346(1.01)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C385(0.92); C58(1.17); C1013(1.14); C346(1.05)  LDD1530  [15]
 LDCM0292  AC31 HEK-293T C385(1.00); C58(1.03); C1013(1.00); C526(0.92)  LDD1531  [15]
 LDCM0293  AC32 HEK-293T C385(1.01); C511(0.96); C58(1.04); C1013(0.91)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C385(0.86); C58(1.22); C1013(0.94); C346(0.92)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C385(0.85); C511(0.79); C58(0.94); C1013(1.25)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C385(1.07); C58(1.13); C1013(0.88); C346(1.02)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C385(0.98); C511(0.83); C58(1.15); C1013(1.12)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C385(1.21); C58(0.92); C526(1.15); C346(0.96)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C385(0.94); C58(0.99); C1013(1.12); C346(0.96)  LDD1538  [15]
 LDCM0300  AC39 HEK-293T C385(1.10); C58(1.04); C1013(1.04); C526(1.01)  LDD1539  [15]
 LDCM0301  AC4 HEK-293T C385(0.90); C511(0.91); C58(1.36); C1013(0.92)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C385(1.08); C511(1.00); C58(0.84); C1013(1.15)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C385(0.90); C58(1.18); C1013(0.98); C346(0.88)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C385(0.94); C511(0.85); C58(1.27); C1013(1.15)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C385(0.92); C58(1.25); C1013(1.04); C346(0.99)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C385(1.03); C511(1.00); C58(1.22); C1013(1.00)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C385(0.99); C58(1.19); C526(1.25); C346(0.95)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C385(0.94); C58(1.03); C1013(1.02); C346(0.99)  LDD1547  [15]
 LDCM0309  AC47 HEK-293T C385(1.11); C58(1.15); C1013(1.13); C526(0.97)  LDD1548  [15]
 LDCM0310  AC48 HEK-293T C385(1.07); C511(0.93); C58(1.12); C1013(1.02)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C385(0.93); C58(1.36); C1013(1.00); C346(0.89)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C385(1.02); C58(1.14); C526(1.05); C346(0.90)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C385(0.98); C511(0.92); C58(1.23); C1013(1.02)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C385(0.96); C58(1.25); C1013(0.98); C346(1.02)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C385(0.99); C511(0.88); C58(1.01); C1013(0.94)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C385(1.15); C58(1.03); C526(1.02); C346(0.96)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C385(0.99); C58(1.11); C1013(1.05); C346(0.96)  LDD1556  [15]
 LDCM0318  AC55 HEK-293T C385(1.10); C58(1.13); C1013(1.08); C526(0.84)  LDD1557  [15]
 LDCM0319  AC56 HEK-293T C385(1.02); C511(0.91); C58(0.96); C1013(1.12)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C385(0.91); C58(1.30); C1013(1.04); C346(0.84)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C385(1.01); C511(0.99); C58(1.12); C1013(1.08)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C385(1.08); C58(1.20); C1013(1.00); C346(1.06)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C385(0.97); C58(1.32); C1013(1.01); C346(1.01)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C385(0.95); C511(0.82); C58(1.12); C1013(1.05)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C385(0.98); C58(1.09); C526(0.43); C346(0.85)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C385(0.91); C58(1.15); C1013(0.94); C346(0.96)  LDD1565  [15]
 LDCM0327  AC63 HEK-293T C385(1.05); C58(1.18); C1013(1.15); C526(1.14)  LDD1566  [15]
 LDCM0328  AC64 HEK-293T C385(1.03); C511(0.97); C58(1.26); C1013(1.18)  LDD1567  [15]
 LDCM0334  AC7 HEK-293T C385(1.00); C58(1.11); C1013(1.07); C526(1.04)  LDD1568  [15]
 LDCM0345  AC8 HEK-293T C385(0.98); C511(0.92); C58(1.05); C1013(1.33)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C385(1.04); C58(1.02); C526(1.29); C346(0.97)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C385(0.98); C58(1.13); C1013(1.04); C346(0.93)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C385(1.04); C511(1.06); C58(0.91); C1013(0.84)  LDD1514  [15]
 LDCM0156  Aniline NCI-H1299 12.02  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C385(0.99); C58(0.95); C1013(1.23); C526(1.07)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C385(0.81); C58(0.36); C1013(2.06); C346(0.70)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C385(0.99); C511(1.04); C58(1.19); C346(0.93)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C385(0.92); C58(1.16); C1013(1.10); C526(0.86)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C385(0.94); C511(0.93); C58(1.16); C346(0.93)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C385(1.06); C58(0.93); C1013(1.12); C346(0.93)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C385(1.05); C511(0.95); C58(1.03); C346(1.01)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C385(0.91); C58(1.17); C1013(1.23); C526(1.03)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C385(1.06); C511(0.89); C58(1.16); C346(0.97)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C385(1.10); C58(0.96); C1013(0.98); C346(0.94)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C385(0.97); C511(0.80); C58(1.13); C346(0.95)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C385(0.89); C58(1.15); C1013(1.35); C526(1.01)  LDD1582  [15]
 LDCM0379  CL11 HEK-293T C385(1.17); C58(0.35); C1013(1.22); C526(0.92)  LDD1583  [15]
 LDCM0380  CL110 HEK-293T C385(0.92); C511(0.91); C58(0.82); C346(0.85)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C385(1.14); C58(0.88); C1013(1.25); C346(0.92)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C385(0.94); C511(1.03); C58(1.11); C346(0.94)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C385(1.01); C58(1.18); C1013(1.20); C526(1.07)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C385(0.90); C511(0.90); C58(1.07); C346(0.85)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C385(1.10); C58(0.93); C1013(0.91); C346(0.85)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C385(1.01); C511(1.01); C58(1.25); C346(0.94)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C385(0.93); C58(1.22); C1013(1.03); C526(1.07)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C385(0.99); C511(0.96); C58(1.16); C346(0.97)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C385(1.21); C58(1.21); C1013(0.93); C346(0.86)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C385(1.07); C511(1.50); C58(0.30); C1013(1.32)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C385(1.03); C511(1.18); C58(1.09); C346(1.02)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C385(0.94); C58(1.26); C1013(1.01); C526(1.05)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C385(1.01); C511(1.11); C58(1.14); C346(0.94)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C385(1.03); C58(1.01); C1013(1.16); C346(0.84)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C385(0.98); C511(0.95); C58(1.30); C346(0.89)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C385(0.87); C58(1.54); C1013(1.01); C526(1.09)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C385(0.92); C511(1.04); C58(1.34); C346(0.98)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C385(1.05); C58(1.10); C1013(0.79); C346(0.86)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C385(1.04); C511(1.04); C58(1.53); C346(0.94)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C385(0.94); C58(1.12); C1013(1.18); C526(0.98)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C385(1.05); C511(1.19); C58(0.85); C346(1.00)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C385(0.98); C58(0.76); C1013(0.93); C346(0.71)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C385(1.04); C511(1.14); C58(0.75); C346(0.99)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C385(0.81); C58(0.70); C1013(1.17); C346(0.72)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C385(0.88); C511(1.12); C58(0.51); C1013(1.04)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C385(1.04); C58(0.51); C1013(0.95); C346(1.03)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C385(1.15); C511(1.07); C58(0.72); C346(1.02)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C385(1.01); C511(1.67); C58(0.44); C1013(1.12)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C385(1.02); C58(0.41); C526(1.13); C346(0.73)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C385(1.02); C58(0.36); C1013(1.27); C346(0.91)  LDD1614  [15]
 LDCM0411  CL23 HEK-293T C385(1.33); C58(0.34); C1013(1.31); C526(1.17)  LDD1615  [15]
 LDCM0412  CL24 HEK-293T C385(1.11); C511(1.55); C58(0.31); C1013(1.46)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C385(0.88); C58(1.26); C1013(1.08); C526(1.14)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C385(1.07); C511(0.93); C58(0.92); C346(0.97)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C385(1.18); C58(0.75); C1013(0.87); C346(0.78)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C385(1.02); C511(1.12); C58(0.81); C346(0.87)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C385(1.01); C58(0.77); C1013(0.85); C346(0.83)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C385(1.08); C58(0.76); C1013(1.16); C346(0.88)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C385(1.06); C511(1.08); C58(0.51); C1013(1.21)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C385(1.00); C58(0.48); C1013(1.24); C346(0.91)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C385(1.06); C511(1.44); C58(0.45); C1013(1.48)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C385(0.96); C58(0.41); C526(1.09); C346(0.72)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C385(1.07); C58(0.36); C1013(1.08); C346(0.95)  LDD1627  [15]
 LDCM0424  CL35 HEK-293T C385(1.19); C58(0.30); C1013(1.23); C526(0.89)  LDD1628  [15]
 LDCM0425  CL36 HEK-293T C385(1.15); C511(1.53); C58(0.31); C1013(1.34)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C385(0.95); C58(1.37); C1013(0.99); C526(1.06)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C385(1.04); C58(0.92); C1013(1.02); C346(0.85)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C385(0.98); C511(1.08); C58(0.84); C346(0.89)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C385(1.03); C511(0.96); C58(0.83); C346(0.92)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C385(0.94); C58(0.73); C1013(1.14); C346(0.82)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C385(1.05); C511(1.13); C58(0.57); C1013(1.02)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C385(0.99); C58(0.45); C1013(1.21); C346(1.04)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C385(0.99); C511(0.87); C58(0.46); C1013(1.13)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C385(1.00); C58(0.43); C526(1.09); C346(0.81)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C385(1.09); C58(0.36); C1013(1.17); C346(0.94)  LDD1640  [15]
 LDCM0437  CL47 HEK-293T C385(1.15); C58(0.31); C1013(1.39); C526(1.08)  LDD1641  [15]
 LDCM0438  CL48 HEK-293T C385(1.13); C511(1.38); C58(0.32); C1013(1.43)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C385(0.93); C58(1.34); C1013(1.09); C526(1.09)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C385(0.89); C58(0.85); C1013(1.16); C346(0.86)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C385(0.98); C511(1.17); C58(0.83); C346(0.90)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C385(1.10); C511(1.14); C58(0.85); C346(0.87)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C385(0.85); C58(0.79); C1013(1.01); C346(0.71)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C385(0.82); C511(0.98); C58(0.60); C1013(1.52)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C385(0.98); C58(0.46); C1013(1.09); C346(0.93)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C385(1.04); C511(1.20); C58(0.42); C1013(0.98)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C385(0.98); C58(0.45); C526(1.00); C346(0.74)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C385(0.96); C58(0.43); C1013(1.37); C346(0.87)  LDD1652  [15]
 LDCM0450  CL59 HEK-293T C385(1.23); C58(0.35); C1013(1.60); C526(1.01)  LDD1653  [15]
 LDCM0451  CL6 HEK-293T C385(0.91); C511(1.04); C58(0.54); C1013(1.25)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C385(1.16); C511(1.45); C58(0.30); C1013(1.20)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C385(1.02); C58(1.38); C1013(1.00); C526(1.11)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C385(1.06); C511(0.93); C58(1.08); C346(1.03)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C385(1.16); C58(0.75); C1013(0.92); C346(0.89)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C385(0.98); C511(1.13); C58(0.87); C346(0.88)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C385(0.97); C58(0.87); C1013(0.99); C346(0.88)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C385(0.90); C511(1.11); C58(0.70); C1013(1.15)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C385(1.08); C58(0.57); C1013(0.99); C346(1.03)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C385(1.02); C511(1.65); C58(0.45); C1013(1.33)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C385(1.02); C58(0.46); C526(1.12); C346(0.80)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C385(0.97); C58(0.56); C1013(0.96); C346(0.99)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C385(1.06); C58(0.41); C1013(1.39); C346(0.92)  LDD1666  [15]
 LDCM0464  CL71 HEK-293T C385(1.27); C58(0.37); C1013(1.43); C526(0.91)  LDD1667  [15]
 LDCM0465  CL72 HEK-293T C385(1.14); C511(1.25); C58(0.35); C1013(1.31)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C385(0.95); C58(1.35); C1013(1.08); C526(1.03)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C385(1.04); C511(0.91); C58(1.26); C346(0.98)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C385(1.04); C511(1.07); C58(0.93); C346(0.98)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C385(0.84); C58(0.96); C1013(1.30); C346(0.64)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C385(0.96); C511(0.97); C58(0.65); C1013(1.09)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C385(1.08); C58(0.61); C1013(1.16); C346(0.94)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C385(0.71); C511(1.54); C58(0.49); C1013(1.42)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C385(1.04); C511(1.27); C58(0.51); C1013(1.07)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C385(1.24); C58(0.48); C526(1.10); C346(0.84)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C385(1.00); C58(0.46); C1013(1.49); C346(0.93)  LDD1679  [15]
 LDCM0477  CL83 HEK-293T C385(1.19); C58(0.39); C1013(1.39); C526(0.95)  LDD1680  [15]
 LDCM0478  CL84 HEK-293T C385(1.04); C511(1.30); C58(0.38); C1013(1.25)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C385(0.93); C58(2.26); C1013(1.32); C526(1.05)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C385(0.99); C511(0.98); C58(1.48); C346(0.97)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C385(0.95); C58(1.56); C1013(0.88); C346(0.85)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C385(1.00); C511(1.06); C58(1.09); C346(1.01)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C385(0.96); C58(1.16); C1013(0.85); C346(0.89)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C385(1.10); C58(0.43); C526(1.14); C346(0.80)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C385(0.66); C511(1.04); C58(0.63); C1013(1.32)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C385(1.02); C58(0.77); C1013(0.86); C346(1.01)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C385(0.98); C511(1.35); C58(0.67); C1013(1.02)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C385(0.99); C58(0.54); C526(1.13); C346(0.78)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C385(0.98); C58(0.52); C1013(1.08); C346(0.95)  LDD1692  [15]
 LDCM0490  CL95 HEK-293T C385(0.95); C58(0.45); C1013(1.99); C526(0.90)  LDD1693  [15]
 LDCM0491  CL96 HEK-293T C385(1.02); C511(1.24); C58(0.57); C1013(1.12)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C385(0.87); C58(1.22); C1013(1.19); C526(1.05)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C385(0.95); C511(0.93); C58(0.90); C346(0.91)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C385(1.03); C58(1.09); C1013(1.11); C346(0.91)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C385(1.30); C58(0.95); C1013(1.12); C346(0.86)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C385(1.11); C58(0.99); C1013(1.00); C346(0.76)  LDD1671  [15]
 LDCM0427  Fragment51 HEK-293T C385(1.06); C511(0.83); C58(0.82); C346(1.01)  LDD1631  [15]
 LDCM0022  KB02 HEK-293T C385(0.99); C346(1.02); C35(0.98); C511(0.98)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C385(0.99); C346(0.99); C35(0.96); C511(0.94)  LDD1497  [15]
 LDCM0024  KB05 HMCB C411(1.04)  LDD3312  [4]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C385(0.52)  LDD2092  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C936(1.71)  LDD2094  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C385(0.67)  LDD2098  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C385(0.81)  LDD2100  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C385(1.05)  LDD2105  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C385(0.88)  LDD2118  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C385(0.63)  LDD2141  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Non-structural maintenance of chromosomes element 1 homolog (NSMCE1) NSE1 family Q8WV22
E3 SUMO-protein ligase NSE2 (NSMCE2) NSE2 family Q96MF7
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SMC5-SMC6 complex localization factor protein 2 (SLF2) FAM178 family Q8IX21
Structural maintenance of chromosomes protein 5 (SMC5) SMC family Q8IY18
Non-structural maintenance of chromosomes element 3 homolog (NSMCE3) . Q96MG7

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402