Details of the Target

General Information of Target

Target ID LDTP16136
Target Name Claudin domain-containing protein 1 (CLDND1)
Gene Name CLDND1
Gene ID 56650
Synonyms
C3orf4; Claudin domain-containing protein 1; Membrane protein GENX-3745
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSHHGGAPKASTWVVASRRSSTVSRAPERRPAEELNRTGPEGYSVGRGGRWRGTSRPPEA
VAAGHEELPLCFALKSHFVGAVIGRGGSKIKNIQSTTNTTIQIIQEQPESLVKIFGSKAM
QTKAKAVIDNFVKKLEENYNSECGIDTAFQPSVGKDGSTDNNVVAGDRPLIDWDQIREEG
LKWQKTKWADLPPIKKNFYKESTATSAMSKVEADSWRKENFNITWDDLKDGEKRPIPNPT
CTFDDAFQCYPEVMENIKKAGFQKPTPIQSQAWPIVLQGIDLIGVAQTGTGKTLCYLMPG
FIHLVLQPSLKGQRNRPGMLVLTPTRELALQVEGECCKYSYKGLRSVCVYGGGNRDEQIE
ELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDEADKMLDMGFEPQIMKILLDVRPD
RQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDLVAVSSVKQNIIVTTEEEKWSHMQTF
LQSMSSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDREKALENFKTGKVRI
LIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAGRTGVSITTLTRNDWRVAS
ELINILERANQSIPEELVSMAERFKAHQQKREMERKMERPQGRPKKFH
Target Bioclass
Transporter and channel
Family
PMP-22/EMP/MP20 family
Subcellular location
Membrane
Uniprot ID
Q9NY35
Ensemble ID
ENST00000341181.11
HGNC ID
HGNC:1322

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEL SNV: p.R80W .
HEL9217 SNV: p.R80W .
RL952 SNV: p.W235Ter .
SW756 Deletion: p.K201NfsTer5 .
ZR751 SNV: p.E61K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C81(0.26)  LDD2091  [1]
Jackson_14
 Probe Info  		2.27  LDD0123  [2]
DBIA
 Probe Info  		C106(0.96)  LDD1507  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C81(1.39)  LDD2112  [1]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C81(0.46)  LDD2095  [1]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C81(0.42)  LDD2132  [1]
 LDCM0214  AC1 HEK-293T C106(0.96)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C106(1.03)  LDD1508  [3]
 LDCM0226  AC11 HEK-293T C106(0.96)  LDD1509  [3]
 LDCM0237  AC12 HEK-293T C106(1.07)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C106(0.81)  LDD1512  [3]
 LDCM0276  AC17 HEK-293T C106(0.91)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C106(1.20)  LDD1516  [3]
 LDCM0278  AC19 HEK-293T C106(1.06)  LDD1517  [3]
 LDCM0279  AC2 HEK-293T C106(1.17)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C106(1.20)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C106(0.95)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C106(0.97)  LDD1521  [3]
 LDCM0284  AC24 HEK-293T C106(0.92)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C106(0.88)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C106(1.28)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C106(1.04)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C106(0.92)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C106(1.06)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C106(0.92)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C106(0.79)  LDD1530  [3]
 LDCM0293  AC32 HEK-293T C106(0.94)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C106(0.89)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C106(1.13)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C106(0.98)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C106(1.24)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C106(0.88)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C106(1.04)  LDD1538  [3]
 LDCM0301  AC4 HEK-293T C106(1.19)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C106(1.00)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C106(1.09)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C106(1.21)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C106(0.99)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C106(1.09)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C106(0.99)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C106(1.14)  LDD1547  [3]
 LDCM0310  AC48 HEK-293T C106(0.89)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C106(0.91)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C106(0.86)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C106(1.02)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C106(0.98)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C106(1.06)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C106(1.08)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C106(0.78)  LDD1556  [3]
 LDCM0319  AC56 HEK-293T C106(0.92)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C106(1.02)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C106(1.03)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C106(1.00)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C106(0.89)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C106(1.13)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C106(0.87)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C106(1.00)  LDD1565  [3]
 LDCM0328  AC64 HEK-293T C106(1.01)  LDD1567  [3]
 LDCM0345  AC8 HEK-293T C106(0.94)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C106(1.05)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C106(1.00)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C106(0.98)  LDD1514  [3]
 LDCM0498  BS-3668 MDA-MB-231 C81(0.26)  LDD2091  [1]
 LDCM0368  CL10 HEK-293T C106(1.65)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C106(0.93)  LDD1573  [3]
 LDCM0372  CL103 HEK-293T C106(0.97)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C106(1.02)  LDD1577  [3]
 LDCM0376  CL107 HEK-293T C106(0.99)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C106(0.90)  LDD1581  [3]
 LDCM0381  CL111 HEK-293T C106(1.12)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C106(0.88)  LDD1586  [3]
 LDCM0385  CL115 HEK-293T C106(1.04)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C106(0.98)  LDD1590  [3]
 LDCM0389  CL119 HEK-293T C106(1.08)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C106(1.32)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C106(1.00)  LDD1595  [3]
 LDCM0394  CL123 HEK-293T C106(1.39)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C106(1.07)  LDD1599  [3]
 LDCM0398  CL127 HEK-293T C106(1.09)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C106(0.94)  LDD1603  [3]
 LDCM0402  CL15 HEK-293T C106(1.49)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C106(0.91)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C106(1.33)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C106(1.07)  LDD1609  [3]
 LDCM0406  CL19 HEK-293T C106(1.10)  LDD1610  [3]
 LDCM0408  CL20 HEK-293T C106(1.13)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C106(1.77)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C106(1.02)  LDD1614  [3]
 LDCM0412  CL24 HEK-293T C106(1.13)  LDD1616  [3]
 LDCM0415  CL27 HEK-293T C106(0.93)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C106(1.11)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C106(0.88)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C106(0.97)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C106(1.18)  LDD1623  [3]
 LDCM0420  CL31 HEK-293T C106(1.08)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C106(1.24)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C106(1.37)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C106(1.23)  LDD1627  [3]
 LDCM0425  CL36 HEK-293T C106(1.09)  LDD1629  [3]
 LDCM0428  CL39 HEK-293T C106(1.22)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C106(1.17)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C106(1.11)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C106(1.12)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C106(1.04)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C106(1.10)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C106(1.13)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C106(1.13)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C106(1.38)  LDD1640  [3]
 LDCM0438  CL48 HEK-293T C106(1.15)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C106(0.96)  LDD1644  [3]
 LDCM0443  CL52 HEK-293T C106(0.93)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C106(1.19)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C106(1.45)  LDD1648  [3]
 LDCM0446  CL55 HEK-293T C106(0.98)  LDD1649  [3]
 LDCM0447  CL56 HEK-293T C106(1.24)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C106(1.43)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C106(1.14)  LDD1652  [3]
 LDCM0451  CL6 HEK-293T C106(1.51)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C106(1.15)  LDD1655  [3]
 LDCM0455  CL63 HEK-293T C106(1.09)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C106(1.05)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C106(0.98)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C106(1.24)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C106(1.20)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C106(1.18)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C106(1.15)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C106(1.06)  LDD1665  [3]
 LDCM0463  CL70 HEK-293T C106(1.04)  LDD1666  [3]
 LDCM0465  CL72 HEK-293T C106(1.05)  LDD1668  [3]
 LDCM0469  CL76 HEK-293T C106(0.96)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C106(1.15)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C106(1.04)  LDD1674  [3]
 LDCM0472  CL79 HEK-293T C106(1.15)  LDD1675  [3]
 LDCM0473  CL8 HEK-293T C106(1.63)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C106(1.02)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C106(1.00)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C106(1.08)  LDD1679  [3]
 LDCM0478  CL84 HEK-293T C106(1.20)  LDD1681  [3]
 LDCM0481  CL87 HEK-293T C106(0.98)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C106(1.09)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C106(1.02)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C106(1.16)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C106(1.70)  LDD1688  [3]
 LDCM0486  CL91 HEK-293T C106(1.01)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C106(1.48)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C106(1.40)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C106(1.14)  LDD1692  [3]
 LDCM0491  CL96 HEK-293T C106(1.26)  LDD1694  [3]
 LDCM0494  CL99 HEK-293T C106(1.03)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C106(0.95)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C106(1.06)  LDD1671  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C81(1.96)  LDD2094  [1]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C81(0.98)  LDD2099  [1]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C81(1.06)  LDD2100  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C81(0.91)  LDD2107  [1]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C81(0.76)  LDD2108  [1]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C81(0.86)  LDD2114  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C81(0.87)  LDD2135  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C81(0.90)  LDD2141  [1]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.27  LDD0123  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Palmitoyltransferase ZDHHC4 (ZDHHC4) DHHC palmitoyltransferase family Q9NPG8
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-X-C chemokine receptor type 1 (CXCR1) G-protein coupled receptor 1 family P25024
G-protein coupled receptor 61 (GPR61) G-protein coupled receptor 1 family Q9BZJ8

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060