Details of the Target

General Information of Target

Target ID LDTP05443
Target Name Proteolipid protein 2 (PLP2)
Gene Name PLP2
Gene ID 5355
Synonyms
A4; Proteolipid protein 2; Differentiation-dependent protein A4; Intestinal membrane A4 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADSERLSAPGCWAACTNFSRTRKGILLFAEIILCLVILICFSASTPGYSSLSVIEMILA
AIFFVVYMCDLHTKIPFINWPWSDFFRTLIAAILYLITSIVVLVERGNHSKIVAGVLGLI
ATCLFGYDAYVTFPVRQPRHTAAPTDPADGPV
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Function May play a role in cell differentiation in the intestinal epithelium.
TTD ID
T50072
Uniprot ID
Q04941
DrugMap ID
TTK5OG6
Ensemble ID
ENST00000376322.7
HGNC ID
HGNC:9087

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH358 SNV: p.Ter153LextTer39 .
TOV21G SNV: p.P10H; p.C12Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		6.23  LDD0066  [1]
Jackson_14
 Probe Info  		2.22  LDD0123  [2]
IA-alkyne
 Probe Info  		C12, C16(10.39)  LDD1707  [3]
DBIA
 Probe Info  		C12(0.94); C16(0.94)  LDD0078  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
TFBX
 Probe Info  		C12(0.00); C16(0.00)  LDD0027  [5]
Acrolein
 Probe Info  		N.A.  LDD0217  [6]
Crotonaldehyde
 Probe Info  		H140(0.00); C12(0.00); C16(0.00)  LDD0219  [6]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [7]
STS-2
 Probe Info  		N.A.  LDD0138  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C12(0.55)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C16(1.34); C12(1.29)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C16(1.09); C12(1.19)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C16(1.15); C12(1.05)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C16(1.09); C12(1.15)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C16(1.25); C12(1.36)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C16(1.14); C12(1.16)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C16(1.16); C12(1.19)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C16(1.12); C12(1.27)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C16(1.09); C12(1.21)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C16(1.23); C12(1.26)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C16(1.16); C12(1.24)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C16(1.20); C12(1.10)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C16(1.57); C12(1.51)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C16(1.14); C12(1.08)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C16(1.11); C12(0.99)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C16(0.85); C12(0.95)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C16(1.01); C12(1.05)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C16(0.99); C12(1.01)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C16(1.01); C12(1.06)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C16(1.02); C12(1.14)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C16(1.11); C12(1.07)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C16(1.16); C12(1.05)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C16(1.00); C12(0.97)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C16(1.14); C12(1.22)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C16(1.24); C12(1.29)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C16(1.13); C12(1.13)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C16(1.26); C12(1.19)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C16(1.22); C12(1.11)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C16(1.36); C12(1.22)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C16(1.38); C12(1.15)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C16(1.22); C12(1.08)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C12(1.11)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C12(1.10)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C12(1.39)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C12(1.41)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C12(1.26)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C12(1.28)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C12(1.50)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C12(1.21)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C12(1.28)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C12(1.03)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C12(1.44)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C12(1.29)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C16(1.31); C12(1.17)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C12(1.29)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C12(1.34)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C12(1.17)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C16(1.19); C12(1.06)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C12(1.06); C16(1.18)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C12(0.98); C16(1.11)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C12(1.12); C16(1.28)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C16(1.08); C12(1.12)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C16(1.37); C12(1.40)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C12(1.14); C16(1.24)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C12(1.17); C16(1.28)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C12(1.05); C16(1.14)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C12(1.04); C16(1.07)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C16(1.44); C12(1.48)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C12(1.55); C16(1.69)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C16(1.28); C12(1.22)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C16(1.27); C12(1.18)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C16(1.08); C12(0.93)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C16(1.18); C12(1.06)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C16(0.88); C12(1.05)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C16(1.11); C12(1.12)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C16(1.05); C12(1.09)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C12(0.62)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C16(1.17); C12(1.17)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C16(0.85); C12(1.09)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C16(0.77); C12(0.93)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C16(1.07); C12(1.28)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C16(0.96); C12(1.16)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C16(1.03); C12(1.10)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C12(1.12); C16(1.26)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C16(1.14); C12(1.20)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C12(1.40); C16(1.58)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C12(1.34); C16(1.42)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C12(0.56)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C16(1.47); C12(1.50)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C12(1.10); C16(1.15)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C12(1.24); C16(1.39)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C16(0.99); C12(1.06)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C16(1.18); C12(1.39)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C12(0.72)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C12(0.72)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C12(0.75)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C12(0.70)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C12(0.72)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C12(0.55)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C12(0.77)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C12(0.81)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C12(0.98)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C12(0.71)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C12(0.83)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C12(0.87)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C12(1.09); C16(1.39)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C16(1.11); C12(1.20)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C12(0.82); C16(1.14)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C12(1.04); C16(1.47)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C12(0.55)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C12(1.23); C16(1.39)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C12(0.86); C16(1.19)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C12(1.35); C16(1.44)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C12(1.06); C16(1.28)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C12(0.96); C16(1.23)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C16(1.11); C12(1.13)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C12(1.30); C16(1.33)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C16(1.01); C12(1.01)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C16(1.28); C12(1.28)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C16(1.13); C12(1.13)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C12(1.12); C16(1.19)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C16(1.03); C12(1.03)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C16(1.31); C12(1.31)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C16(0.99); C12(0.99)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C16(1.00); C12(1.00)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C16(0.98); C12(0.98)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C16(1.16); C12(1.16)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C16(1.03); C12(1.03)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C16(1.13); C12(1.13)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C16(1.11); C12(1.25)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C16(1.03); C12(1.08)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C12(1.37); C16(1.45)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C16(0.96); C12(0.97)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C16(0.94); C12(1.00)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C12(0.94); C16(0.97)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C12(0.97); C16(0.97)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C16(0.86); C12(0.90)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C16(1.09); C12(1.10)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C16(1.01); C12(1.03)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C16(1.13); C12(1.34)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C16(1.05); C12(1.23)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C16(1.30); C12(1.45)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C12(1.17); C16(1.22)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C16(1.19); C12(1.33)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C16(1.17); C12(1.20)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C16(1.63); C12(1.71)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C12(1.03); C16(1.34)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C12(0.81); C16(0.88)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C12(0.92); C16(1.03)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C12(0.93); C16(1.04)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C12(0.91); C16(0.96)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C12(1.04); C16(1.21)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C12(0.91); C16(1.10)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C12(0.87); C16(0.95)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C12(0.91); C16(1.13)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C12(0.75); C16(0.85)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C16(0.79); C12(0.81)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C12(0.81); C16(0.97)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C12(0.79); C16(0.81)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C12(0.80); C16(0.92)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C12(0.81); C16(0.94)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C12(1.05); C16(1.11)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C12(1.07); C16(1.09)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C16(1.12); C12(1.05)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C12(0.96); C16(1.01)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C12(1.30); C16(1.38)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C12(0.94); C16(0.94)  LDD0078  [4]
 LDCM0108  Chloroacetamide HeLa H140(0.00); C16(0.00)  LDD0222  [6]
 LDCM0367  CL1 HCT 116 C12(1.20); C16(1.32)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C16(1.15); C12(1.19)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C12(0.53)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C12(1.46); C16(1.58)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C12(1.55); C16(1.88)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C12(1.40); C16(1.52)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C12(1.40); C16(1.51)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C16(0.98); C12(1.14)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C16(1.01); C12(1.15)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C16(0.90); C12(1.04)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C16(1.01); C12(1.15)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C16(1.01); C12(1.26)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C12(1.22); C16(1.85)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C16(1.25); C12(1.47)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C16(1.08); C12(1.31)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C16(1.15); C12(1.18)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C16(1.28); C12(1.49)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C16(1.86); C12(2.05)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C16(1.44); C12(1.62)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C16(1.03); C12(1.15)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C12(0.78)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C12(0.78)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C12(0.78)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C16(1.05); C12(1.15)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C12(0.70)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C12(0.82); C16(1.24)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C12(0.95); C16(1.34)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C12(1.49); C16(1.80)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C16(1.44); C12(1.55)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C16(0.99); C12(0.99)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C16(1.96); C12(1.96)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C16(1.03); C12(1.03)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C16(1.32); C12(1.32)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C12(1.02); C16(1.07)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C12(1.08); C16(1.27)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C12(1.28); C16(1.78)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C12(1.16); C16(1.18)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C12(1.46); C16(1.56)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C12(1.12); C16(1.14)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C12(1.10); C16(1.11)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C12(0.84); C16(1.03)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C12(1.22); C16(1.26)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C12(2.06); C16(2.18)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C12(1.43); C16(1.47)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C16(1.24); C12(1.25)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C12(1.20); C16(1.21)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C16(1.42); C12(1.35)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C16(1.01); C12(1.05)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C16(0.96); C12(0.95)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C16(1.27); C12(1.28)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C16(1.08); C12(1.02)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C16(1.10); C12(0.97)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C16(0.98); C12(1.03)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C16(1.03); C12(1.36)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C16(1.13); C12(1.26)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C16(3.63); C12(1.96)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C16(1.04); C12(1.47)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C16(0.66); C12(1.69)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C16(1.44); C12(1.87)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C16(0.66); C12(1.51)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C16(1.01); C12(1.35)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C16(1.31); C12(1.51)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C16(1.87); C12(1.99)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C16(1.39); C12(1.47)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C16(0.87); C12(1.63)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C16(0.98); C12(1.58)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C16(0.90); C12(1.36)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C16(0.61); C12(1.16)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C16(1.24); C12(1.17)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C16(1.10); C12(1.04)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C16(1.12); C12(1.02)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C16(1.19); C12(1.08)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C16(1.04); C12(0.96)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C16(1.47); C12(1.38)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C16(1.31); C12(1.25)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C16(1.82); C12(1.76)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C16(1.38); C12(1.62)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C16(1.42); C12(1.55)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C16(1.25); C12(1.22)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C16(0.99); C12(1.04)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C16(0.99); C12(1.03)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C16(1.51); C12(1.38)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C16(1.20); C12(1.14)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C16(1.48); C12(1.19)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C16(1.20); C12(1.09)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C16(0.82); C12(0.77)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C16(0.78); C12(0.93)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C16(1.31); C12(1.01)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C16(0.77); C12(0.71)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C16(0.70); C12(0.87)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C16(0.80); C12(0.78)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C16(0.75); C12(0.70)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C16(1.08); C12(1.35)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C16(1.20); C12(0.99)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C16(1.01); C12(0.96)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C16(1.00); C12(0.89)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C16(0.91); C12(0.88)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C16(1.14); C12(0.88)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C16(0.89); C12(0.77)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C16(0.90); C12(0.80)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C16(1.00); C12(1.09)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C16(1.27); C12(1.52)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C16(1.04); C12(1.14)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C16(1.35); C12(1.39)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C16(4.32); C12(2.28)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C16(1.06); C12(1.06)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C16(1.14); C12(1.21)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C16(1.43); C12(1.68)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C16(1.50); C12(1.76)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C16(1.57); C12(1.76)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C16(1.13); C12(1.26)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C16(1.01); C12(1.16)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C16(1.20); C12(1.45)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C16(1.32); C12(1.51)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C16(1.47); C12(1.70)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C16(1.30); C12(1.09)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C16(1.30); C12(2.12)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C12(0.82)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C12(0.97)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C12(1.07)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C12(0.99)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C12(0.85)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C12(0.90)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C12(0.85)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C12(0.59)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C12(0.57)  LDD0811  [4]
 LDCM0468  Fragment33 HCT 116 C16(0.86); C12(0.76)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C16(1.12); C12(1.78)  LDD0744  [4]
 LDCM0107  IAA HeLa H140(0.00); C16(0.00)  LDD0221  [6]
 LDCM0022  KB02 T cell C12, C16(10.39)  LDD1707  [3]
 LDCM0024  KB05 T cell C12, C16(20.00)  LDD1709  [3]
 LDCM0109  NEM HeLa H140(0.00); C16(0.00)  LDD0223  [6]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.22  LDD0123  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Aspartate--tRNA ligase, mitochondrial (DARS2) Class-II aminoacyl-tRNA synthetase family Q6PI48
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 5 (ELOVL5) ELO family Q9NYP7
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Sphingosine-1-phosphate lyase 1 (SGPL1) Group II decarboxylase family O95470
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Prostaglandin E synthase (PTGES) MAPEG family O14684
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
Phosphatidylinositol N-acetylglucosaminyltransferase subunit P (PIGP) PIGP family P57054
E3 ubiquitin-protein ligase RNF5 (RNF5) RNF5 family Q99942
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Ceramide synthase 4 (CERS4) . Q9HA82
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Claudin-5 (CLDN5) Claudin family O00501
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) Eukaryotic ATPase subunit F6 family P18859
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Proton myo-inositol cotransporter (SLC2A13) Sugar transporter (TC 2.A.1.1) family Q96QE2
Aquaporin-3 (AQP3) MIP/aquaporin (TC 1.A.8) family Q92482
Aquaporin-8 (AQP8) MIP/aquaporin (TC 1.A.8) family O94778
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) NIP3 family Q12983
Proton-activated chloride channel (PACC1) Proton-activated chloride channel family Q9H813
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Urea transporter 2 (SLC14A2) Urea transporter family Q15849
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transmembrane protein 79 (TMEM79) . Q9BSE2
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
DnaJ homolog subfamily C member 1 (DNAJC1) . Q96KC8
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-C chemokine receptor type 1 (CCR1) G-protein coupled receptor 1 family P32246
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
Immunoglobulin
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Poliovirus receptor (PVR) Nectin family P15151
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Leucine-rich repeat-containing protein 4C (LRRC4C) . Q9HCJ2
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Protein EVI2A (EVI2A) EVI2A family P22794
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Heat shock factor-binding protein 1-like protein 1 (HSBP1L1) HSBP1 family C9JCN9
LHFPL tetraspan subfamily member 1 protein (LHFPL1) LHFP family Q86WI0
Cytosolic iron-sulfur assembly component 2A (CIAO2A) MIP18 family Q9H5X1
Epithelial membrane protein 3 (EMP3) PMP-22/EMP/MP20 family P54852
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Arfaptin-2 (ARFIP2) . P53365
Bcl-2-interacting killer (BIK) . Q13323
Fetal and adult testis-expressed transcript protein (FATE1) . Q969F0
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Leukosialin (SPN) . P16150
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Protein KASH5 (KASH5) . Q8N6L0
Transmembrane protein 51 (TMEM51) . Q9NW97

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.