Details of the Target

General Information of Target

Target ID LDTP05449
Target Name Tyrosine-protein phosphatase non-receptor type 12 (PTPN12)
Gene Name PTPN12
Gene ID 5782
Synonyms
Tyrosine-protein phosphatase non-receptor type 12; EC 3.1.3.48; PTP-PEST; Protein-tyrosine phosphatase G1; PTPG1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVK
KNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRM
IWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLL
EFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGA
ICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQL
YEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPH
PVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNE
STIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQE
LSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHG
PENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNP
LHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTH
SGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSE
NEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
Subcellular location
Cytoplasm
Function
Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
Uniprot ID
Q05209
Ensemble ID
ENST00000248594.11
HGNC ID
HGNC:9645
ChEMBL ID
CHEMBL3236

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.E284V DBIA    Probe Info 
HCC1395 SNV: p.H230Y DBIA    Probe Info 
JVM3 SNV: p.A111T DBIA    Probe Info 
LOXIMVI SNV: p.Q703Ter DBIA    Probe Info 
LS513 SNV: p.K141R DBIA    Probe Info 
MEC1 SNV: p.A289V DBIA    Probe Info 
NCIH358 SNV: p.Q183E DBIA    Probe Info 
OCILY3 Deletion: p.T279RfsTer34 DBIA    Probe Info 
RKO SNV: p.L285R DBIA    Probe Info 
SBC5 SNV: p.K411R DBIA    Probe Info 
TE1 SNV: p.K665N DBIA    Probe Info 
TGBC1TKB SNV: p.L481I DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y64(10.37)  LDD0257  [2]
STPyne
 Probe Info  		K18(1.84); K463(6.11); K65(5.64); K95(8.01)  LDD0277  [3]
Probe 1
 Probe Info  		Y48(4.85); Y98(27.81)  LDD3495  [4]
BTD
 Probe Info  		C470(1.16)  LDD1700  [5]
Jackson_14
 Probe Info  		2.04  LDD0123  [6]
AHL-Pu-1
 Probe Info  		C498(2.10); C495(2.04)  LDD0168  [7]
HHS-475
 Probe Info  		Y64(1.13)  LDD0264  [8]
HHS-465
 Probe Info  		Y64(10.00)  LDD2237  [9]
DBIA
 Probe Info  		C495(1.06); C498(1.06); C724(1.03); C736(1.03)  LDD0078  [10]
IA-alkyne
 Probe Info  		C470(0.00); C242(0.00)  LDD0162  [11]
NAIA_4
 Probe Info  		C242(0.00); C343(0.00)  LDD2226  [12]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
IPM
 Probe Info  		N.A.  LDD0005  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
AOyne
 Probe Info  		7.00  LDD0443  [15]
NAIA_5
 Probe Info  		C164(0.00); C242(0.00)  LDD2223  [12]
HHS-482
 Probe Info  		Y64(2.22)  LDD2239  [9]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DA-2
 Probe Info  		N.A.  LDD0070  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C470(0.58)  LDD2095  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C470(1.09)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C470(1.19)  LDD2152  [5]
 LDCM0025  4SU-RNA HEK-293T C498(2.10); C495(2.04)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C498(2.76); C495(2.45)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C470(1.49); C164(0.97); C343(1.03); C724(1.06)  LDD0531  [10]
 LDCM0215  AC10 HCT 116 C164(0.99); C495(1.05); C498(1.05); C736(0.64)  LDD0532  [10]
 LDCM0216  AC100 HCT 116 C470(1.44)  LDD0533  [10]
 LDCM0217  AC101 HCT 116 C470(1.51)  LDD0534  [10]
 LDCM0218  AC102 HCT 116 C470(1.16)  LDD0535  [10]
 LDCM0219  AC103 HCT 116 C470(1.35)  LDD0536  [10]
 LDCM0220  AC104 HCT 116 C470(1.15)  LDD0537  [10]
 LDCM0221  AC105 HCT 116 C470(1.67)  LDD0538  [10]
 LDCM0222  AC106 HCT 116 C470(1.41)  LDD0539  [10]
 LDCM0223  AC107 HCT 116 C470(1.46)  LDD0540  [10]
 LDCM0224  AC108 HCT 116 C470(1.07)  LDD0541  [10]
 LDCM0225  AC109 HCT 116 C470(1.07)  LDD0542  [10]
 LDCM0226  AC11 HCT 116 C164(0.98); C495(1.64); C498(1.64); C736(0.54)  LDD0543  [10]
 LDCM0227  AC110 HCT 116 C470(1.23)  LDD0544  [10]
 LDCM0228  AC111 HCT 116 C470(1.18)  LDD0545  [10]
 LDCM0229  AC112 HCT 116 C470(1.39)  LDD0546  [10]
 LDCM0230  AC113 HCT 116 C164(1.00); C343(1.07)  LDD0547  [10]
 LDCM0231  AC114 HCT 116 C164(0.94); C343(0.92)  LDD0548  [10]
 LDCM0232  AC115 HCT 116 C164(0.89); C343(1.22)  LDD0549  [10]
 LDCM0233  AC116 HCT 116 C164(1.05); C343(1.16)  LDD0550  [10]
 LDCM0234  AC117 HCT 116 C164(0.91); C343(1.05)  LDD0551  [10]
 LDCM0235  AC118 HCT 116 C164(1.14); C343(0.99)  LDD0552  [10]
 LDCM0236  AC119 HCT 116 C164(0.87); C343(1.12)  LDD0553  [10]
 LDCM0237  AC12 HCT 116 C164(0.87); C495(0.87); C498(0.87); C736(0.62)  LDD0554  [10]
 LDCM0238  AC120 HCT 116 C164(0.88); C343(0.94)  LDD0555  [10]
 LDCM0239  AC121 HCT 116 C164(1.03); C343(1.25)  LDD0556  [10]
 LDCM0240  AC122 HCT 116 C164(1.00); C343(1.08)  LDD0557  [10]
 LDCM0241  AC123 HCT 116 C164(1.02); C343(1.65)  LDD0558  [10]
 LDCM0242  AC124 HCT 116 C164(1.20); C343(1.06)  LDD0559  [10]
 LDCM0243  AC125 HCT 116 C164(1.22); C343(0.82)  LDD0560  [10]
 LDCM0244  AC126 HCT 116 C164(1.02); C343(0.91)  LDD0561  [10]
 LDCM0245  AC127 HCT 116 C164(1.05); C343(0.99)  LDD0562  [10]
 LDCM0246  AC128 HCT 116 C470(1.56); C164(1.74); C343(2.30)  LDD0563  [10]
 LDCM0247  AC129 HCT 116 C470(0.96); C164(1.67); C343(1.11)  LDD0564  [10]
 LDCM0249  AC130 HCT 116 C470(1.63); C164(1.15); C343(1.62)  LDD0566  [10]
 LDCM0250  AC131 HCT 116 C470(1.04); C164(1.61); C343(1.81)  LDD0567  [10]
 LDCM0251  AC132 HCT 116 C470(1.06); C164(1.76); C343(1.17)  LDD0568  [10]
 LDCM0252  AC133 HCT 116 C470(1.24); C164(1.43); C343(1.15)  LDD0569  [10]
 LDCM0253  AC134 HCT 116 C470(1.23); C164(1.69); C343(1.35)  LDD0570  [10]
 LDCM0254  AC135 HCT 116 C470(1.42); C164(1.54); C343(1.58)  LDD0571  [10]
 LDCM0255  AC136 HCT 116 C470(1.37); C164(1.44); C343(1.12)  LDD0572  [10]
 LDCM0256  AC137 HCT 116 C470(1.01); C164(1.49); C343(1.10)  LDD0573  [10]
 LDCM0257  AC138 HCT 116 C470(1.15); C164(1.39); C343(1.03)  LDD0574  [10]
 LDCM0258  AC139 HCT 116 C470(1.14); C164(1.23); C343(1.38)  LDD0575  [10]
 LDCM0259  AC14 HCT 116 C164(0.86); C495(1.18); C498(1.18); C736(0.87)  LDD0576  [10]
 LDCM0260  AC140 HCT 116 C470(1.22); C164(1.35); C343(1.18)  LDD0577  [10]
 LDCM0261  AC141 HCT 116 C470(1.24); C164(1.53); C343(1.03)  LDD0578  [10]
 LDCM0262  AC142 HCT 116 C470(1.08); C164(1.34); C343(0.84)  LDD0579  [10]
 LDCM0263  AC143 HCT 116 C470(1.14); C724(1.08); C736(1.08); C495(1.10)  LDD0580  [10]
 LDCM0264  AC144 HCT 116 C495(0.96); C498(0.96); C724(1.44); C736(1.44)  LDD0581  [10]
 LDCM0265  AC145 HCT 116 C724(0.78); C736(0.78); C495(0.83); C498(0.83)  LDD0582  [10]
 LDCM0266  AC146 HCT 116 C495(0.76); C498(0.76); C724(1.13); C736(1.13)  LDD0583  [10]
 LDCM0267  AC147 HCT 116 C495(1.03); C498(1.03); C724(1.10); C736(1.10)  LDD0584  [10]
 LDCM0268  AC148 HCT 116 C495(0.78); C498(0.78); C724(1.61); C736(1.61)  LDD0585  [10]
 LDCM0269  AC149 HCT 116 C495(0.95); C498(0.95); C724(1.32); C736(1.32)  LDD0586  [10]
 LDCM0270  AC15 HCT 116 C495(0.77); C498(0.77); C736(0.91); C164(1.03)  LDD0587  [10]
 LDCM0271  AC150 HCT 116 C724(0.77); C736(0.77); C495(0.83); C498(0.83)  LDD0588  [10]
 LDCM0272  AC151 HCT 116 C495(0.99); C498(0.99); C724(1.10); C736(1.10)  LDD0589  [10]
 LDCM0273  AC152 HCT 116 C495(0.90); C498(0.90); C724(1.26); C736(1.26)  LDD0590  [10]
 LDCM0274  AC153 HCT 116 C495(0.68); C498(0.68); C724(1.66); C736(1.66)  LDD0591  [10]
 LDCM0621  AC154 HCT 116 C470(1.63); C495(0.85); C498(0.85); C724(1.07)  LDD2158  [10]
 LDCM0622  AC155 HCT 116 C470(1.64); C495(0.76); C498(0.76); C724(1.27)  LDD2159  [10]
 LDCM0623  AC156 HCT 116 C470(1.21); C495(0.85); C498(0.85); C724(1.14)  LDD2160  [10]
 LDCM0624  AC157 HCT 116 C470(1.20); C495(0.82); C498(0.82); C724(1.09)  LDD2161  [10]
 LDCM0276  AC17 HCT 116 C495(0.70); C498(0.70); C724(0.76); C736(0.76)  LDD0593  [10]
 LDCM0277  AC18 HCT 116 C343(1.02); C495(1.07); C498(1.07); C724(1.12)  LDD0594  [10]
 LDCM0278  AC19 HCT 116 C495(0.85); C498(0.85); C724(0.99); C736(0.99)  LDD0595  [10]
 LDCM0279  AC2 HCT 116 C164(1.09); C343(1.15); C724(1.28); C736(1.28)  LDD0596  [10]
 LDCM0280  AC20 HCT 116 C343(0.83); C724(0.88); C736(0.88); C495(0.94)  LDD0597  [10]
 LDCM0281  AC21 HCT 116 C495(0.77); C498(0.77); C164(0.85); C724(0.86)  LDD0598  [10]
 LDCM0282  AC22 HCT 116 C495(0.71); C498(0.71); C724(0.71); C736(0.71)  LDD0599  [10]
 LDCM0283  AC23 HCT 116 C495(0.65); C498(0.65); C724(0.68); C736(0.68)  LDD0600  [10]
 LDCM0284  AC24 HCT 116 C724(0.60); C736(0.60); C495(0.62); C498(0.62)  LDD0601  [10]
 LDCM0285  AC25 HCT 116 C495(0.86); C498(0.86); C164(1.04); C343(1.15)  LDD0602  [10]
 LDCM0286  AC26 HCT 116 C164(0.99); C495(1.13); C498(1.13); C343(1.41)  LDD0603  [10]
 LDCM0287  AC27 HCT 116 C164(1.06); C495(1.28); C498(1.28); C343(1.54)  LDD0604  [10]
 LDCM0288  AC28 HCT 116 C164(0.96); C495(0.99); C498(0.99); C343(1.68)  LDD0605  [10]
 LDCM0289  AC29 HCT 116 C164(0.89); C495(1.04); C498(1.04); C343(1.61)  LDD0606  [10]
 LDCM0290  AC3 HCT 116 C343(0.87); C724(1.01); C736(1.01); C164(1.07)  LDD0607  [10]
 LDCM0291  AC30 HCT 116 C164(0.99); C495(1.07); C498(1.07); C343(1.54)  LDD0608  [10]
 LDCM0292  AC31 HCT 116 C164(0.84); C495(1.12); C498(1.12); C343(1.35)  LDD0609  [10]
 LDCM0293  AC32 HCT 116 C164(0.89); C495(1.28); C498(1.28); C343(2.12)  LDD0610  [10]
 LDCM0294  AC33 HCT 116 C495(0.84); C498(0.84); C164(0.97); C343(1.34)  LDD0611  [10]
 LDCM0295  AC34 HCT 116 C164(0.91); C343(0.96); C495(1.49); C498(1.49)  LDD0612  [10]
 LDCM0296  AC35 HCT 116 C164(1.14)  LDD0613  [10]
 LDCM0297  AC36 HCT 116 C164(1.03)  LDD0614  [10]
 LDCM0298  AC37 HCT 116 C164(0.97)  LDD0615  [10]
 LDCM0299  AC38 HCT 116 C164(1.15)  LDD0616  [10]
 LDCM0300  AC39 HCT 116 C164(1.08)  LDD0617  [10]
 LDCM0301  AC4 HCT 116 C343(0.83); C724(0.98); C736(0.98); C164(1.30)  LDD0618  [10]
 LDCM0302  AC40 HCT 116 C164(1.01)  LDD0619  [10]
 LDCM0303  AC41 HCT 116 C164(0.98)  LDD0620  [10]
 LDCM0304  AC42 HCT 116 C164(1.05)  LDD0621  [10]
 LDCM0305  AC43 HCT 116 C164(1.20)  LDD0622  [10]
 LDCM0306  AC44 HCT 116 C164(1.14)  LDD0623  [10]
 LDCM0307  AC45 HCT 116 C164(1.28)  LDD0624  [10]
 LDCM0308  AC46 HCT 116 C164(0.94)  LDD0625  [10]
 LDCM0309  AC47 HCT 116 C164(1.18)  LDD0626  [10]
 LDCM0310  AC48 HCT 116 C164(1.08)  LDD0627  [10]
 LDCM0311  AC49 HCT 116 C164(1.05)  LDD0628  [10]
 LDCM0312  AC5 HCT 116 C343(0.78); C724(1.08); C736(1.08); C164(1.28)  LDD0629  [10]
 LDCM0313  AC50 HCT 116 C164(1.06)  LDD0630  [10]
 LDCM0314  AC51 HCT 116 C164(1.89)  LDD0631  [10]
 LDCM0315  AC52 HCT 116 C164(1.01)  LDD0632  [10]
 LDCM0316  AC53 HCT 116 C164(0.88)  LDD0633  [10]
 LDCM0317  AC54 HCT 116 C164(1.07)  LDD0634  [10]
 LDCM0318  AC55 HCT 116 C164(0.96)  LDD0635  [10]
 LDCM0319  AC56 HCT 116 C164(1.18)  LDD0636  [10]
 LDCM0320  AC57 HCT 116 C343(0.77); C164(0.87); C470(1.50)  LDD0637  [10]
 LDCM0321  AC58 HCT 116 C164(0.91); C343(0.96); C470(1.74)  LDD0638  [10]
 LDCM0322  AC59 HCT 116 C164(0.83); C470(1.07); C343(1.20)  LDD0639  [10]
 LDCM0323  AC6 HCT 116 C736(0.83); C164(0.99); C495(1.05); C498(1.05)  LDD0640  [10]
 LDCM0324  AC60 HCT 116 C470(0.79); C164(1.01); C343(1.07)  LDD0641  [10]
 LDCM0325  AC61 HCT 116 C164(0.80); C343(0.92); C470(1.09)  LDD0642  [10]
 LDCM0326  AC62 HCT 116 C164(0.79); C470(1.09); C343(1.29)  LDD0643  [10]
 LDCM0327  AC63 HCT 116 C343(1.04); C164(1.04); C470(2.15)  LDD0644  [10]
 LDCM0328  AC64 HCT 116 C164(0.86); C343(1.14); C470(1.22)  LDD0645  [10]
 LDCM0329  AC65 HCT 116 C470(0.41); C164(0.84); C343(0.84)  LDD0646  [10]
 LDCM0330  AC66 HCT 116 C470(0.45); C343(0.89); C164(0.96)  LDD0647  [10]
 LDCM0331  AC67 HCT 116 C470(0.54); C164(0.99); C343(1.38)  LDD0648  [10]
 LDCM0332  AC68 HCT 116 C724(0.86); C736(0.86); C343(1.01); C164(1.20)  LDD0649  [10]
 LDCM0333  AC69 HCT 116 C724(0.68); C736(0.68); C343(1.14); C164(1.15)  LDD0650  [10]
 LDCM0334  AC7 HCT 116 C736(0.56); C164(0.87); C495(1.01); C498(1.01)  LDD0651  [10]
 LDCM0335  AC70 HCT 116 C724(0.77); C736(0.77); C343(1.06); C164(1.09)  LDD0652  [10]
 LDCM0336  AC71 HCT 116 C724(0.72); C736(0.72); C343(0.82); C164(0.93)  LDD0653  [10]
 LDCM0337  AC72 HCT 116 C724(1.02); C736(1.02); C164(1.20); C470(1.34)  LDD0654  [10]
 LDCM0338  AC73 HCT 116 C724(0.98); C736(0.98); C164(1.26); C343(1.74)  LDD0655  [10]
 LDCM0339  AC74 HCT 116 C724(0.71); C736(0.71); C164(1.10); C343(1.46)  LDD0656  [10]
 LDCM0340  AC75 HCT 116 C724(0.99); C736(0.99); C164(1.23); C343(2.68)  LDD0657  [10]
 LDCM0341  AC76 HCT 116 C724(0.88); C736(0.88); C164(1.11); C343(1.15)  LDD0658  [10]
 LDCM0342  AC77 HCT 116 C724(0.89); C736(0.89); C164(1.20); C343(1.35)  LDD0659  [10]
 LDCM0343  AC78 HCT 116 C724(0.79); C736(0.79); C164(1.17); C343(1.20)  LDD0660  [10]
 LDCM0344  AC79 HCT 116 C724(0.77); C736(0.77); C343(1.08); C470(1.35)  LDD0661  [10]
 LDCM0345  AC8 HCT 116 C736(0.74); C164(1.06); C495(1.10); C498(1.10)  LDD0662  [10]
 LDCM0346  AC80 HCT 116 C724(0.94); C736(0.94); C164(0.98); C343(1.49)  LDD0663  [10]
 LDCM0347  AC81 HCT 116 C724(0.69); C736(0.69); C343(0.92); C164(1.16)  LDD0664  [10]
 LDCM0348  AC82 HCT 116 C724(0.76); C736(0.76); C164(1.44); C343(2.29)  LDD0665  [10]
 LDCM0349  AC83 HCT 116 C495(0.99); C498(0.99); C164(1.05); C724(1.63)  LDD0666  [10]
 LDCM0350  AC84 HCT 116 C495(0.92); C498(0.92); C164(1.07); C724(1.71)  LDD0667  [10]
 LDCM0351  AC85 HCT 116 C495(0.79); C498(0.79); C164(1.05); C724(1.33)  LDD0668  [10]
 LDCM0352  AC86 HCT 116 C164(1.04); C495(1.07); C498(1.07); C724(1.25)  LDD0669  [10]
 LDCM0353  AC87 HCT 116 C164(1.16); C495(1.29); C498(1.29); C724(1.40)  LDD0670  [10]
 LDCM0354  AC88 HCT 116 C164(1.19); C495(1.27); C498(1.27); C343(1.71)  LDD0671  [10]
 LDCM0355  AC89 HCT 116 C495(1.14); C498(1.14); C164(1.25); C470(1.62)  LDD0672  [10]
 LDCM0357  AC90 HCT 116 C724(0.89); C736(0.89); C343(0.93); C470(1.07)  LDD0674  [10]
 LDCM0358  AC91 HCT 116 C164(0.99); C495(1.14); C498(1.14); C724(1.77)  LDD0675  [10]
 LDCM0359  AC92 HCT 116 C495(0.90); C498(0.90); C164(1.28); C724(2.18)  LDD0676  [10]
 LDCM0360  AC93 HCT 116 C164(0.91); C495(1.23); C498(1.23); C470(1.50)  LDD0677  [10]
 LDCM0361  AC94 HCT 116 C495(0.75); C498(0.75); C164(0.99); C470(1.54)  LDD0678  [10]
 LDCM0362  AC95 HCT 116 C164(1.19); C343(1.49); C495(1.55); C498(1.55)  LDD0679  [10]
 LDCM0363  AC96 HCT 116 C495(0.97); C498(0.97); C164(1.13); C470(1.90)  LDD0680  [10]
 LDCM0364  AC97 HCT 116 C164(1.08); C495(1.40); C498(1.40); C724(2.07)  LDD0681  [10]
 LDCM0365  AC98 HCT 116 C470(2.34)  LDD0682  [10]
 LDCM0366  AC99 HCT 116 C470(1.44)  LDD0683  [10]
 LDCM0248  AKOS034007472 HCT 116 C164(0.81); C495(1.17); C498(1.17); C736(0.80)  LDD0565  [10]
 LDCM0356  AKOS034007680 HCT 116 C736(0.62); C164(0.93); C495(1.58); C498(1.58)  LDD0673  [10]
 LDCM0275  AKOS034007705 HCT 116 C495(0.76); C498(0.76); C164(0.89); C736(1.06)  LDD0592  [10]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0020  ARS-1620 HCC44 C495(1.06); C498(1.06); C724(1.03); C736(1.03)  LDD0078  [10]
 LDCM0367  CL1 HCT 116 C495(0.98); C498(0.98); C164(1.01); C470(1.05)  LDD0684  [10]
 LDCM0368  CL10 HCT 116 C495(0.37); C498(0.37); C164(0.92); C470(1.27)  LDD0685  [10]
 LDCM0369  CL100 HCT 116 C164(0.95); C343(1.11); C724(1.13); C736(1.13)  LDD0686  [10]
 LDCM0370  CL101 HCT 116 C736(0.76); C164(1.02); C495(1.27); C498(1.27)  LDD0687  [10]
 LDCM0371  CL102 HCT 116 C736(0.71); C495(0.85); C498(0.85); C164(0.86)  LDD0688  [10]
 LDCM0372  CL103 HCT 116 C736(0.41); C495(0.81); C498(0.81); C164(0.87)  LDD0689  [10]
 LDCM0373  CL104 HCT 116 C736(0.55); C495(0.94); C498(0.94); C164(1.01)  LDD0690  [10]
 LDCM0374  CL105 HCT 116 C724(0.54); C736(0.54); C495(0.67); C498(0.67)  LDD0691  [10]
 LDCM0375  CL106 HCT 116 C495(0.60); C498(0.60); C724(0.70); C736(0.70)  LDD0692  [10]
 LDCM0376  CL107 HCT 116 C495(0.63); C498(0.63); C724(0.86); C736(0.86)  LDD0693  [10]
 LDCM0377  CL108 HCT 116 C495(0.45); C498(0.45); C724(0.62); C736(0.62)  LDD0694  [10]
 LDCM0378  CL109 HCT 116 C495(0.57); C498(0.57); C724(1.01); C736(1.01)  LDD0695  [10]
 LDCM0379  CL11 HCT 116 C495(0.46); C498(0.46); C164(0.93); C470(1.06)  LDD0696  [10]
 LDCM0380  CL110 HCT 116 C495(0.49); C498(0.49); C724(0.77); C736(0.77)  LDD0697  [10]
 LDCM0381  CL111 HCT 116 C495(0.59); C498(0.59); C724(0.91); C736(0.91)  LDD0698  [10]
 LDCM0382  CL112 HCT 116 C164(1.04); C495(1.10); C498(1.10); C343(1.26)  LDD0699  [10]
 LDCM0383  CL113 HCT 116 C164(0.87); C343(1.33); C495(1.40); C498(1.40)  LDD0700  [10]
 LDCM0384  CL114 HCT 116 C164(0.87); C343(1.12); C495(2.00); C498(2.00)  LDD0701  [10]
 LDCM0385  CL115 HCT 116 C164(0.96); C343(1.42); C495(1.44); C498(1.44)  LDD0702  [10]
 LDCM0386  CL116 HCT 116 C495(0.89); C498(0.89); C164(0.94); C343(1.20)  LDD0703  [10]
 LDCM0387  CL117 HCT 116 C164(1.06)  LDD0704  [10]
 LDCM0388  CL118 HCT 116 C164(0.98)  LDD0705  [10]
 LDCM0389  CL119 HCT 116 C164(1.10)  LDD0706  [10]
 LDCM0390  CL12 HCT 116 C495(0.42); C498(0.42); C164(1.04); C470(1.12)  LDD0707  [10]
 LDCM0391  CL120 HCT 116 C164(1.05)  LDD0708  [10]
 LDCM0392  CL121 HCT 116 C164(0.64)  LDD0709  [10]
 LDCM0393  CL122 HCT 116 C164(0.90)  LDD0710  [10]
 LDCM0394  CL123 HCT 116 C164(1.07)  LDD0711  [10]
 LDCM0395  CL124 HCT 116 C164(1.34)  LDD0712  [10]
 LDCM0396  CL125 HCT 116 C164(0.77); C470(0.90); C343(0.93)  LDD0713  [10]
 LDCM0397  CL126 HCT 116 C164(0.80); C470(0.81); C343(1.00)  LDD0714  [10]
 LDCM0398  CL127 HCT 116 C470(0.67); C164(0.70); C343(1.03)  LDD0715  [10]
 LDCM0399  CL128 HCT 116 C343(0.92); C164(1.00); C470(1.96)  LDD0716  [10]
 LDCM0400  CL13 HCT 116 C495(0.38); C498(0.38); C164(0.92); C470(1.11)  LDD0717  [10]
 LDCM0401  CL14 HCT 116 C495(0.45); C498(0.45); C164(1.00); C470(1.21)  LDD0718  [10]
 LDCM0402  CL15 HCT 116 C495(0.50); C498(0.50); C164(0.84); C470(0.99)  LDD0719  [10]
 LDCM0403  CL16 HCT 116 C495(0.93); C498(0.93); C470(0.95); C724(1.05)  LDD0720  [10]
 LDCM0404  CL17 HCT 116 C495(0.76); C498(0.76); C164(0.80); C724(0.85)  LDD0721  [10]
 LDCM0405  CL18 HCT 116 C164(0.65); C495(0.67); C498(0.67); C470(1.15)  LDD0722  [10]
 LDCM0406  CL19 HCT 116 C495(0.65); C498(0.65); C164(0.86); C724(1.03)  LDD0723  [10]
 LDCM0407  CL2 HCT 116 C495(0.53); C498(0.53); C470(1.17); C164(1.33)  LDD0724  [10]
 LDCM0408  CL20 HCT 116 C495(0.64); C498(0.64); C164(0.71); C724(1.08)  LDD0725  [10]
 LDCM0409  CL21 HCT 116 C495(0.51); C498(0.51); C164(0.71); C724(0.78)  LDD0726  [10]
 LDCM0410  CL22 HCT 116 C495(0.46); C498(0.46); C724(0.78); C736(0.78)  LDD0727  [10]
 LDCM0411  CL23 HCT 116 C164(0.93); C495(1.03); C498(1.03); C724(1.08)  LDD0728  [10]
 LDCM0412  CL24 HCT 116 C470(1.95); C164(0.89); C495(0.81); C498(0.81)  LDD0729  [10]
 LDCM0413  CL25 HCT 116 C470(1.76); C164(0.71); C495(0.71); C498(0.71)  LDD0730  [10]
 LDCM0414  CL26 HCT 116 C470(1.41); C164(0.87); C495(0.78); C498(0.78)  LDD0731  [10]
 LDCM0415  CL27 HCT 116 C470(1.69); C164(1.02); C495(0.61); C498(0.61)  LDD0732  [10]
 LDCM0416  CL28 HCT 116 C470(1.70); C164(0.81); C495(0.68); C498(0.68)  LDD0733  [10]
 LDCM0417  CL29 HCT 116 C470(2.49); C164(0.84); C495(0.71); C498(0.71)  LDD0734  [10]
 LDCM0418  CL3 HCT 116 C470(1.06); C164(0.96); C495(0.52); C498(0.52)  LDD0735  [10]
 LDCM0419  CL30 HCT 116 C470(1.02); C164(0.98); C495(0.71); C498(0.71)  LDD0736  [10]
 LDCM0420  CL31 HCT 116 C164(0.88)  LDD0737  [10]
 LDCM0421  CL32 HCT 116 C164(0.87)  LDD0738  [10]
 LDCM0422  CL33 HCT 116 C164(0.78)  LDD0739  [10]
 LDCM0423  CL34 HCT 116 C164(0.92)  LDD0740  [10]
 LDCM0424  CL35 HCT 116 C164(0.99)  LDD0741  [10]
 LDCM0425  CL36 HCT 116 C164(0.82)  LDD0742  [10]
 LDCM0426  CL37 HCT 116 C164(1.01)  LDD0743  [10]
 LDCM0428  CL39 HCT 116 C164(1.12)  LDD0745  [10]
 LDCM0429  CL4 HCT 116 C470(1.02); C164(0.91); C495(0.65); C498(0.65)  LDD0746  [10]
 LDCM0430  CL40 HCT 116 C164(0.83)  LDD0747  [10]
 LDCM0431  CL41 HCT 116 C164(1.04)  LDD0748  [10]
 LDCM0432  CL42 HCT 116 C164(1.05)  LDD0749  [10]
 LDCM0433  CL43 HCT 116 C164(1.02)  LDD0750  [10]
 LDCM0434  CL44 HCT 116 C164(0.77)  LDD0751  [10]
 LDCM0435  CL45 HCT 116 C164(0.93)  LDD0752  [10]
 LDCM0436  CL46 HCT 116 C164(0.86); C343(1.05)  LDD0753  [10]
 LDCM0437  CL47 HCT 116 C164(1.18); C343(0.95)  LDD0754  [10]
 LDCM0438  CL48 HCT 116 C164(1.09); C343(1.55)  LDD0755  [10]
 LDCM0439  CL49 HCT 116 C164(0.92); C343(0.99)  LDD0756  [10]
 LDCM0440  CL5 HCT 116 C470(0.95); C164(0.96); C495(0.47); C498(0.47)  LDD0757  [10]
 LDCM0441  CL50 HCT 116 C164(1.04); C343(2.03)  LDD0758  [10]
 LDCM0442  CL51 HCT 116 C164(1.05); C343(1.25)  LDD0759  [10]
 LDCM0443  CL52 HCT 116 C164(1.08); C343(0.91)  LDD0760  [10]
 LDCM0444  CL53 HCT 116 C164(1.23); C343(0.89)  LDD0761  [10]
 LDCM0445  CL54 HCT 116 C164(1.03); C343(0.92)  LDD0762  [10]
 LDCM0446  CL55 HCT 116 C164(0.90); C343(0.93)  LDD0763  [10]
 LDCM0447  CL56 HCT 116 C164(0.88); C343(0.90)  LDD0764  [10]
 LDCM0448  CL57 HCT 116 C164(1.21); C343(0.97)  LDD0765  [10]
 LDCM0449  CL58 HCT 116 C164(0.87); C343(0.99)  LDD0766  [10]
 LDCM0450  CL59 HCT 116 C164(0.94); C343(0.85)  LDD0767  [10]
 LDCM0451  CL6 HCT 116 C470(1.16); C164(0.89); C495(0.66); C498(0.66)  LDD0768  [10]
 LDCM0452  CL60 HCT 116 C164(1.01); C343(1.06)  LDD0769  [10]
 LDCM0453  CL61 HCT 116 C164(0.81); C343(1.08)  LDD0770  [10]
 LDCM0454  CL62 HCT 116 C164(0.75); C343(1.10)  LDD0771  [10]
 LDCM0455  CL63 HCT 116 C164(0.60); C343(1.20)  LDD0772  [10]
 LDCM0456  CL64 HCT 116 C164(0.65); C343(0.87)  LDD0773  [10]
 LDCM0457  CL65 HCT 116 C164(0.60); C343(0.91)  LDD0774  [10]
 LDCM0458  CL66 HCT 116 C164(0.72); C343(0.94)  LDD0775  [10]
 LDCM0459  CL67 HCT 116 C164(0.68); C343(1.05)  LDD0776  [10]
 LDCM0460  CL68 HCT 116 C164(0.73); C343(1.07)  LDD0777  [10]
 LDCM0461  CL69 HCT 116 C164(0.43); C343(1.32)  LDD0778  [10]
 LDCM0462  CL7 HCT 116 C470(1.05); C164(1.20); C495(0.35); C498(0.35)  LDD0779  [10]
 LDCM0463  CL70 HCT 116 C164(0.62); C343(1.10)  LDD0780  [10]
 LDCM0464  CL71 HCT 116 C164(0.65); C343(1.05)  LDD0781  [10]
 LDCM0465  CL72 HCT 116 C164(0.68); C343(1.13)  LDD0782  [10]
 LDCM0466  CL73 HCT 116 C164(0.58); C343(1.04)  LDD0783  [10]
 LDCM0467  CL74 HCT 116 C164(0.63); C343(1.21)  LDD0784  [10]
 LDCM0469  CL76 HCT 116 C164(0.84); C495(1.64); C498(1.64)  LDD0786  [10]
 LDCM0470  CL77 HCT 116 C164(0.96); C495(1.40); C498(1.40)  LDD0787  [10]
 LDCM0471  CL78 HCT 116 C164(0.89); C495(0.90); C498(0.90)  LDD0788  [10]
 LDCM0472  CL79 HCT 116 C164(0.96); C495(1.10); C498(1.10)  LDD0789  [10]
 LDCM0473  CL8 HCT 116 C470(1.21); C164(1.08); C495(1.36); C498(1.36)  LDD0790  [10]
 LDCM0474  CL80 HCT 116 C164(0.90); C495(0.67); C498(0.67)  LDD0791  [10]
 LDCM0475  CL81 HCT 116 C164(0.91); C495(0.91); C498(0.91)  LDD0792  [10]
 LDCM0476  CL82 HCT 116 C164(0.95); C495(1.19); C498(1.19)  LDD0793  [10]
 LDCM0477  CL83 HCT 116 C164(0.67); C495(0.91); C498(0.91)  LDD0794  [10]
 LDCM0478  CL84 HCT 116 C164(0.94); C495(0.93); C498(0.93)  LDD0795  [10]
 LDCM0479  CL85 HCT 116 C164(1.06); C495(0.97); C498(0.97)  LDD0796  [10]
 LDCM0480  CL86 HCT 116 C164(0.86); C495(1.30); C498(1.30)  LDD0797  [10]
 LDCM0481  CL87 HCT 116 C164(0.71); C495(1.33); C498(1.33)  LDD0798  [10]
 LDCM0482  CL88 HCT 116 C164(1.04); C495(1.27); C498(1.27)  LDD0799  [10]
 LDCM0483  CL89 HCT 116 C164(1.12); C495(0.90); C498(0.90)  LDD0800  [10]
 LDCM0484  CL9 HCT 116 C470(1.10); C164(0.99); C495(0.55); C498(0.55)  LDD0801  [10]
 LDCM0485  CL90 HCT 116 C164(0.63); C495(1.03); C498(1.03)  LDD0802  [10]
 LDCM0486  CL91 HCT 116 C470(1.84); C164(0.97); C343(0.96); C724(0.71)  LDD0803  [10]
 LDCM0487  CL92 HCT 116 C470(1.32); C164(0.98); C343(0.86); C724(0.87)  LDD0804  [10]
 LDCM0488  CL93 HCT 116 C470(1.03); C164(1.13); C343(0.86); C724(0.91)  LDD0805  [10]
 LDCM0489  CL94 HCT 116 C470(1.07); C164(0.87); C343(1.08); C724(0.97)  LDD0806  [10]
 LDCM0490  CL95 HCT 116 C470(2.08); C164(1.00); C343(0.80); C724(0.88)  LDD0807  [10]
 LDCM0491  CL96 HCT 116 C470(1.85); C164(1.04); C343(0.85); C724(1.13)  LDD0808  [10]
 LDCM0492  CL97 HCT 116 C470(1.60); C164(1.14); C343(1.02); C724(1.07)  LDD0809  [10]
 LDCM0493  CL98 HCT 116 C470(2.00); C164(1.11); C343(1.09); C724(1.13)  LDD0810  [10]
 LDCM0494  CL99 HCT 116 C470(1.87); C164(0.96); C343(0.96); C724(0.89)  LDD0811  [10]
 LDCM0495  E2913 HEK-293T C164(0.88); C470(1.02); C724(0.98)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C470(1.22)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C164(0.59); C343(0.84)  LDD0785  [10]
 LDCM0427  Fragment51 HCT 116 C164(0.92)  LDD0744  [10]
 LDCM0116  HHS-0101 DM93 Y64(1.13)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y64(0.59)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y64(0.66)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y64(0.74)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y64(0.87)  LDD0268  [8]
 LDCM0022  KB02 HCT 116 C495(1.96); C498(1.96)  LDD0080  [10]
 LDCM0023  KB03 HCT 116 C495(0.97); C498(0.97)  LDD0081  [10]
 LDCM0024  KB05 HCT 116 C495(1.26); C498(1.26)  LDD0082  [10]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C343(1.47)  LDD2089  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C470(1.08)  LDD2093  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C470(0.70)  LDD2099  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C470(0.79)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C470(0.96)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C470(0.87)  LDD2111  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C470(1.05)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C470(0.99)  LDD2127  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C470(1.62)  LDD2136  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C470(1.16)  LDD1700  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C470(0.94)  LDD2148  [5]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.04  LDD0123  [6]
 LDCM0021  THZ1 HCT 116 C495(1.11); C498(1.11)  LDD2173  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Angiopoietin-1 receptor (TEK) Tyr protein kinase family Q02763
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Breast cancer anti-estrogen resistance protein 1 (BCAR1) CAS family P56945
Paxillin (PXN) Paxillin family P49023
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586
SHC-transforming protein 1 (SHC1) . P29353

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Tiludronic Acid Small molecular drug DB01133

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402