Details of the Target

General Information of Target

Target ID LDTP06089
Target Name Eukaryotic initiation factor 4A-II (EIF4A2)
Gene Name EIF4A2
Gene ID 1974
Synonyms
DDX2B; EIF4F; Eukaryotic initiation factor 4A-II; eIF-4A-II; eIF4A-II; EC 3.6.4.13; ATP-dependent RNA helicase eIF4A-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQ
QRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKV
ILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMF
VLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKE
ELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTV
SALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHR
IGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI
Target Bioclass
Enzyme
Family
DEAD box helicase family, eIF4A subfamily
Function
ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.
Uniprot ID
Q14240
Ensemble ID
ENST00000323963.10
HGNC ID
HGNC:3284
ChEMBL ID
CHEMBL4105952

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.81  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
STPyne
 Probe Info  		K147(7.21); K175(6.79); K239(5.00)  LDD0277  [3]
AZ-9
 Probe Info  		E54(1.00); E255(0.77)  LDD2208  [4]
ONAyne
 Probe Info  		K147(7.69)  LDD0275  [3]
DBIA
 Probe Info  		C266(2.09)  LDD3323  [5]
SAHA-CA-4PAP
 Probe Info  		15.30  LDD0269  [6]
NAIA_5
 Probe Info  		C132(0.53)  LDD2227  [7]
HHS-482
 Probe Info  		Y49(1.10); Y51(1.36); Y71(0.87)  LDD0293  [8]
HHS-475
 Probe Info  		Y51(0.82); Y171(0.88); Y71(0.89); Y49(1.27)  LDD0264  [9]
IPM
 Probe Info  		C135(0.91)  LDD1701  [10]
HHS-465
 Probe Info  		Y357(10.00); Y49(10.00); Y51(10.00); Y71(4.38)  LDD2237  [11]
Acrolein
 Probe Info  		N.A.  LDD0222  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C132(0.00); C135(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C132(0.00); C135(0.00)  LDD0036  [13]
Lodoacetamide azide
 Probe Info  		C132(0.00); C135(0.00)  LDD0037  [13]
SF
 Probe Info  		Y71(0.00); K69(0.00); Y8(0.00); Y171(0.00)  LDD0028  [14]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
MPP-AC
 Probe Info  		N.A.  LDD0428  [16]
TPP-AC
 Probe Info  		N.A.  LDD0427  [16]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		6.13  LDD0472  [17]
FFF probe13
 Probe Info  		6.24  LDD0476  [17]
FFF probe14
 Probe Info  		5.37  LDD0477  [17]
FFF probe2
 Probe Info  		5.21  LDD0463  [17]
FFF probe3
 Probe Info  		6.17  LDD0464  [17]
JN0003
 Probe Info  		5.22  LDD0469  [17]
VE-P
 Probe Info  		N.A.  LDD0396  [18]
DA-2
 Probe Info  		N.A.  LDD0072  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C265(2.22)  LDD0372  [20]
 LDCM0214  AC1 HEK-293T C67(0.95); C265(0.92); C135(0.98)  LDD1507  [21]
 LDCM0215  AC10 HEK-293T C67(1.12); C265(0.87); C135(0.92)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C67(1.08); C265(0.92); C135(0.97)  LDD1509  [21]
 LDCM0237  AC12 HEK-293T C67(1.09); C265(1.06); C135(1.00)  LDD1510  [21]
 LDCM0259  AC14 HEK-293T C67(1.11); C265(1.02); C135(0.99)  LDD1512  [21]
 LDCM0270  AC15 HEK-293T C67(0.99); C265(0.96); C135(0.90)  LDD1513  [21]
 LDCM0276  AC17 HEK-293T C67(0.97); C265(0.96); C135(1.01)  LDD1515  [21]
 LDCM0277  AC18 HEK-293T C67(1.13); C265(0.91); C135(0.87)  LDD1516  [21]
 LDCM0278  AC19 HEK-293T C67(1.00); C265(0.79); C135(0.81)  LDD1517  [21]
 LDCM0279  AC2 HEK-293T C67(1.12); C265(0.99); C135(0.88)  LDD1518  [21]
 LDCM0280  AC20 HEK-293T C67(1.17); C265(0.96); C135(0.93)  LDD1519  [21]
 LDCM0281  AC21 HEK-293T C67(1.13); C135(0.99)  LDD1520  [21]
 LDCM0282  AC22 HEK-293T C67(1.13); C265(0.92); C135(1.07)  LDD1521  [21]
 LDCM0283  AC23 HEK-293T C67(1.09); C265(0.99); C135(0.97)  LDD1522  [21]
 LDCM0284  AC24 HEK-293T C67(1.16); C265(1.19); C135(0.91)  LDD1523  [21]
 LDCM0285  AC25 HEK-293T C67(1.02); C265(1.28); C135(0.95)  LDD1524  [21]
 LDCM0286  AC26 HEK-293T C67(1.20); C265(0.92); C135(0.86)  LDD1525  [21]
 LDCM0287  AC27 HEK-293T C67(1.11); C265(0.98); C135(0.91)  LDD1526  [21]
 LDCM0288  AC28 HEK-293T C67(1.23); C265(0.94); C135(0.95)  LDD1527  [21]
 LDCM0289  AC29 HEK-293T C67(0.97); C135(0.98)  LDD1528  [21]
 LDCM0290  AC3 HEK-293T C67(1.13); C265(0.96); C135(0.84)  LDD1529  [21]
 LDCM0291  AC30 HEK-293T C67(1.18); C265(1.02); C135(0.91)  LDD1530  [21]
 LDCM0292  AC31 HEK-293T C67(1.08); C265(0.91); C135(0.94)  LDD1531  [21]
 LDCM0293  AC32 HEK-293T C67(1.14); C265(0.98); C135(0.78)  LDD1532  [21]
 LDCM0294  AC33 HEK-293T C67(1.02); C265(0.95); C135(0.88)  LDD1533  [21]
 LDCM0295  AC34 HEK-293T C67(1.13); C265(0.97); C135(0.88)  LDD1534  [21]
 LDCM0296  AC35 HEK-293T C67(1.06); C265(1.14); C135(0.83)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C67(1.06); C265(1.03); C135(0.90)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C67(1.07); C135(1.12)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C67(1.14); C265(1.00); C135(0.92)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C67(1.06); C265(0.91); C135(0.88)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C67(1.04); C265(1.03); C135(1.03)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C67(1.16); C265(0.94); C135(0.85)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C67(0.97); C265(0.87); C135(1.00)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C67(1.12); C265(0.88); C135(0.91)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C67(1.14); C265(0.95); C135(0.90)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C67(1.10); C265(1.04); C135(1.05)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C67(1.03); C135(1.02)  LDD1546  [21]
 LDCM0308  AC46 HEK-293T C67(1.14); C265(0.95); C135(0.95)  LDD1547  [21]
 LDCM0309  AC47 HEK-293T C67(1.08); C265(0.92); C135(0.92)  LDD1548  [21]
 LDCM0310  AC48 HEK-293T C67(1.10); C265(1.23); C135(0.87)  LDD1549  [21]
 LDCM0311  AC49 HEK-293T C67(1.01); C265(0.84); C135(1.04)  LDD1550  [21]
 LDCM0312  AC5 HEK-293T C67(1.06); C135(1.01)  LDD1551  [21]
 LDCM0313  AC50 HEK-293T C67(1.13); C265(0.90); C135(0.99)  LDD1552  [21]
 LDCM0314  AC51 HEK-293T C67(1.11); C265(0.84); C135(0.83)  LDD1553  [21]
 LDCM0315  AC52 HEK-293T C67(1.12); C265(1.07); C135(0.94)  LDD1554  [21]
 LDCM0316  AC53 HEK-293T C67(1.02); C135(0.99)  LDD1555  [21]
 LDCM0317  AC54 HEK-293T C67(1.15); C265(0.96); C135(1.00)  LDD1556  [21]
 LDCM0318  AC55 HEK-293T C67(1.01); C265(0.83); C135(0.81)  LDD1557  [21]
 LDCM0319  AC56 HEK-293T C67(1.11); C265(0.97); C135(0.94)  LDD1558  [21]
 LDCM0320  AC57 HEK-293T C67(1.06); C265(1.06); C135(1.04)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C67(1.19); C265(1.08); C135(0.89)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C67(1.17); C265(1.01); C135(0.98)  LDD1561  [21]
 LDCM0323  AC6 HEK-293T C67(1.03); C265(0.89); C135(1.00)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C67(1.13); C265(1.14); C135(0.89)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C67(1.12); C135(0.98)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C67(1.14); C265(0.97); C135(0.99)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C67(1.13); C265(0.91); C135(1.05)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C67(1.20); C265(0.99); C135(0.73)  LDD1567  [21]
 LDCM0334  AC7 HEK-293T C67(1.05); C265(0.93); C135(0.90)  LDD1568  [21]
 LDCM0345  AC8 HEK-293T C67(1.07); C265(0.94); C135(0.77)  LDD1569  [21]
 LDCM0248  AKOS034007472 HEK-293T C67(0.97); C135(1.01)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C67(0.96); C265(1.18); C135(0.97)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C67(1.06); C265(1.03); C135(0.88)  LDD1514  [21]
 LDCM0156  Aniline NCI-H1299 11.38  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C132(1.59)  LDD2214  [22]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C132(0.53)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C67(1.08); C135(1.02)  LDD1571  [21]
 LDCM0368  CL10 HEK-293T C67(0.99); C265(2.00); C135(0.97)  LDD1572  [21]
 LDCM0369  CL100 HEK-293T C67(0.98); C135(0.79)  LDD1573  [21]
 LDCM0370  CL101 HEK-293T C67(0.98); C135(0.99)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C67(1.03); C135(0.80)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C67(1.03); C135(0.93)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C67(1.07); C135(0.97)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C67(1.05); C135(1.05)  LDD1578  [21]
 LDCM0375  CL106 HEK-293T C67(1.10); C135(0.96)  LDD1579  [21]
 LDCM0376  CL107 HEK-293T C67(1.10); C135(0.99)  LDD1580  [21]
 LDCM0377  CL108 HEK-293T C67(1.10); C135(0.88)  LDD1581  [21]
 LDCM0378  CL109 HEK-293T C67(1.04); C135(0.92)  LDD1582  [21]
 LDCM0379  CL11 HEK-293T C67(0.96); C265(2.68); C135(1.04)  LDD1583  [21]
 LDCM0380  CL110 HEK-293T C67(1.01); C135(0.93)  LDD1584  [21]
 LDCM0381  CL111 HEK-293T C67(1.02); C135(0.86)  LDD1585  [21]
 LDCM0382  CL112 HEK-293T C67(1.03); C135(0.94)  LDD1586  [21]
 LDCM0383  CL113 HEK-293T C67(1.05); C135(0.95)  LDD1587  [21]
 LDCM0384  CL114 HEK-293T C67(1.02); C135(0.75)  LDD1588  [21]
 LDCM0385  CL115 HEK-293T C67(1.13); C135(0.98)  LDD1589  [21]
 LDCM0386  CL116 HEK-293T C67(1.09); C135(0.96)  LDD1590  [21]
 LDCM0387  CL117 HEK-293T C67(1.04); C135(1.06)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C67(1.10); C135(1.07)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C67(1.17); C135(0.90)  LDD1593  [21]
 LDCM0390  CL12 HEK-293T C67(1.23); C265(2.44); C135(1.02)  LDD1594  [21]
 LDCM0391  CL120 HEK-293T C67(1.11); C135(0.88)  LDD1595  [21]
 LDCM0392  CL121 HEK-293T C67(1.05); C135(0.97)  LDD1596  [21]
 LDCM0393  CL122 HEK-293T C67(1.03); C135(0.97)  LDD1597  [21]
 LDCM0394  CL123 HEK-293T C67(1.01); C135(0.92)  LDD1598  [21]
 LDCM0395  CL124 HEK-293T C67(1.01); C135(0.88)  LDD1599  [21]
 LDCM0396  CL125 HEK-293T C67(1.12); C135(1.09)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C67(1.15); C135(0.87)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C67(1.11); C135(1.14)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C67(1.11); C135(0.97)  LDD1603  [21]
 LDCM0400  CL13 HEK-293T C67(0.86); C135(0.93)  LDD1604  [21]
 LDCM0401  CL14 HEK-293T C67(1.16); C135(0.85)  LDD1605  [21]
 LDCM0402  CL15 HEK-293T C67(0.85); C135(0.94)  LDD1606  [21]
 LDCM0403  CL16 HEK-293T C67(1.10); C135(0.91)  LDD1607  [21]
 LDCM0404  CL17 HEK-293T C67(0.79); C265(1.09); C135(0.91)  LDD1608  [21]
 LDCM0405  CL18 HEK-293T C67(1.15); C265(1.38); C135(0.97)  LDD1609  [21]
 LDCM0406  CL19 HEK-293T C67(0.91); C265(0.85); C135(0.97)  LDD1610  [21]
 LDCM0407  CL2 HEK-293T C67(0.90); C135(0.89)  LDD1611  [21]
 LDCM0408  CL20 HEK-293T C67(0.92); C265(1.77); C135(1.10)  LDD1612  [21]
 LDCM0409  CL21 HEK-293T C67(1.06); C135(1.00)  LDD1613  [21]
 LDCM0410  CL22 HEK-293T C67(0.99); C265(1.96); C135(1.15)  LDD1614  [21]
 LDCM0411  CL23 HEK-293T C67(0.93); C265(2.48); C135(1.15)  LDD1615  [21]
 LDCM0412  CL24 HEK-293T C67(1.01); C265(2.03); C135(1.04)  LDD1616  [21]
 LDCM0413  CL25 HEK-293T C67(0.94); C135(0.97)  LDD1617  [21]
 LDCM0414  CL26 HEK-293T C67(0.94); C135(0.83)  LDD1618  [21]
 LDCM0415  CL27 HEK-293T C67(1.01); C135(1.01)  LDD1619  [21]
 LDCM0416  CL28 HEK-293T C67(1.02); C135(0.87)  LDD1620  [21]
 LDCM0417  CL29 HEK-293T C67(1.01); C265(1.80); C135(1.00)  LDD1621  [21]
 LDCM0418  CL3 HEK-293T C67(0.90); C135(0.94)  LDD1622  [21]
 LDCM0419  CL30 HEK-293T C67(1.07); C265(1.11); C135(0.95)  LDD1623  [21]
 LDCM0420  CL31 HEK-293T C67(1.01); C265(0.93); C135(0.92)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C67(1.06); C265(1.61); C135(1.06)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C67(1.02); C135(0.92)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C67(1.08); C265(2.59); C135(1.01)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C67(1.11); C265(2.66); C135(1.05)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C67(1.14); C265(2.34); C135(0.91)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C67(1.07); C135(0.99)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C67(1.07); C135(0.83)  LDD1632  [21]
 LDCM0429  CL4 HEK-293T C67(0.94); C135(0.96)  LDD1633  [21]
 LDCM0430  CL40 HEK-293T C67(1.06); C135(0.87)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C67(1.05); C265(1.11); C135(0.82)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C67(1.19); C265(0.98); C135(0.97)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C67(1.25); C265(0.79); C135(0.92)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C67(1.07); C265(1.50); C135(0.98)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C67(1.04); C135(0.92)  LDD1639  [21]
 LDCM0436  CL46 HEK-293T C67(1.17); C265(2.09); C135(0.98)  LDD1640  [21]
 LDCM0437  CL47 HEK-293T C67(1.12); C265(2.41); C135(0.92)  LDD1641  [21]
 LDCM0438  CL48 HEK-293T C67(1.26); C265(2.77); C135(0.87)  LDD1642  [21]
 LDCM0439  CL49 HEK-293T C67(1.05); C135(1.02)  LDD1643  [21]
 LDCM0440  CL5 HEK-293T C67(0.79); C265(1.10); C135(0.99)  LDD1644  [21]
 LDCM0441  CL50 HEK-293T C67(1.00); C135(0.91)  LDD1645  [21]
 LDCM0443  CL52 HEK-293T C67(0.94); C135(0.91)  LDD1646  [21]
 LDCM0444  CL53 HEK-293T C67(0.89); C265(1.06); C135(0.92)  LDD1647  [21]
 LDCM0445  CL54 HEK-293T C67(1.12); C265(1.24); C135(0.86)  LDD1648  [21]
 LDCM0446  CL55 HEK-293T C67(1.08); C265(0.93); C135(0.96)  LDD1649  [21]
 LDCM0447  CL56 HEK-293T C67(1.08); C265(2.00); C135(1.09)  LDD1650  [21]
 LDCM0448  CL57 HEK-293T C67(1.01); C135(0.92)  LDD1651  [21]
 LDCM0449  CL58 HEK-293T C67(1.17); C265(1.96); C135(1.04)  LDD1652  [21]
 LDCM0450  CL59 HEK-293T C67(1.10); C265(2.39); C135(1.18)  LDD1653  [21]
 LDCM0451  CL6 HEK-293T C67(1.08); C265(1.25); C135(0.88)  LDD1654  [21]
 LDCM0452  CL60 HEK-293T C67(1.15); C265(1.98); C135(1.13)  LDD1655  [21]
 LDCM0453  CL61 HEK-293T C67(1.00); C135(1.00)  LDD1656  [21]
 LDCM0454  CL62 HEK-293T C67(1.10); C135(0.86)  LDD1657  [21]
 LDCM0455  CL63 HEK-293T C67(1.10); C135(0.94)  LDD1658  [21]
 LDCM0456  CL64 HEK-293T C67(1.01); C135(0.78)  LDD1659  [21]
 LDCM0457  CL65 HEK-293T C67(0.93); C265(0.98); C135(0.96)  LDD1660  [21]
 LDCM0458  CL66 HEK-293T C67(1.06); C265(1.06); C135(0.95)  LDD1661  [21]
 LDCM0459  CL67 HEK-293T C67(1.10); C265(0.78); C135(1.01)  LDD1662  [21]
 LDCM0460  CL68 HEK-293T C67(1.18); C265(1.85); C135(1.10)  LDD1663  [21]
 LDCM0461  CL69 HEK-293T C67(1.07); C135(0.97)  LDD1664  [21]
 LDCM0462  CL7 HEK-293T C67(1.00); C265(0.78); C135(0.94)  LDD1665  [21]
 LDCM0463  CL70 HEK-293T C67(1.11); C265(2.05); C135(1.03)  LDD1666  [21]
 LDCM0464  CL71 HEK-293T C67(1.04); C265(1.89); C135(1.01)  LDD1667  [21]
 LDCM0465  CL72 HEK-293T C67(1.06); C265(2.44); C135(0.91)  LDD1668  [21]
 LDCM0466  CL73 HEK-293T C67(1.07); C135(0.92)  LDD1669  [21]
 LDCM0467  CL74 HEK-293T C67(1.04); C135(0.90)  LDD1670  [21]
 LDCM0469  CL76 HEK-293T C67(1.01); C135(1.05)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C67(0.90); C265(0.83); C135(0.83)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C67(1.12); C265(1.09); C135(0.96)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C67(1.16); C265(0.85); C135(0.99)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C67(1.11); C265(1.99); C135(0.82)  LDD1676  [21]
 LDCM0474  CL80 HEK-293T C67(1.07); C265(1.34); C135(0.98)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C67(1.02); C135(1.03)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C67(1.19); C265(1.54); C135(0.97)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C67(1.15); C265(1.80); C135(0.88)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C67(1.22); C265(1.73); C135(0.88)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C67(1.04); C135(1.06)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C67(1.09); C135(0.94)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C67(1.09); C135(1.11)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C67(1.06); C135(0.99)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C67(1.00); C265(1.16); C135(1.10)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C67(1.03); C135(1.17)  LDD1687  [21]
 LDCM0485  CL90 HEK-293T C67(1.04); C265(0.97); C135(0.84)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C67(1.19); C265(0.87); C135(1.00)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C67(1.10); C265(1.38); C135(1.01)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C67(1.08); C135(0.95)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C67(1.10); C265(1.82); C135(0.95)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C67(1.00); C265(1.24); C135(1.10)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C67(1.21); C265(1.65); C135(0.76)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C67(1.00); C135(0.95)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C67(1.02); C135(0.93)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C67(1.05); C135(0.90)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C67(1.07); C135(0.84)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C135(0.43)  LDD1702  [10]
 LDCM0468  Fragment33 HEK-293T C67(1.12); C135(0.98)  LDD1671  [21]
 LDCM0427  Fragment51 HEK-293T C67(1.01); C135(0.87)  LDD1631  [21]
 LDCM0116  HHS-0101 DM93 Y51(0.82); Y171(0.88); Y71(0.89); Y49(1.27)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y51(0.70); Y171(0.71); Y71(0.77); Y49(0.88)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y51(0.74); Y71(0.78); Y171(0.81); Y49(0.95)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y51(0.78); Y71(0.80); Y171(0.80); Y49(1.63)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y71(0.78); Y51(0.78); Y171(0.93); Y49(1.04)  LDD0268  [9]
 LDCM0125  JWB146 DM93 Y49(1.10); Y51(1.36); Y71(0.87)  LDD0293  [8]
 LDCM0127  JWB152 DM93 Y49(3.07); Y51(2.16); Y71(1.15)  LDD0294  [8]
 LDCM0128  JWB198 DM93 Y49(1.38); Y51(1.09); Y71(0.97)  LDD0295  [8]
 LDCM0022  KB02 HEK-293T C67(0.99); C135(0.95)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C67(0.97); C135(1.11)  LDD1497  [21]
 LDCM0024  KB05 SKMEL24 C266(2.09)  LDD3323  [5]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C67(2.10)  LDD2206  [23]
 LDCM0628  OTUB2-COV-1 HEK-293T C67(0.91)  LDD2207  [23]
 LDCM0131  RA190 MM1.R C135(0.92)  LDD0304  [24]
 LDCM0096  SAHA K562 15.30  LDD0269  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM36 (TRIM36) TRIM/RBCC family Q9NQ86
E3 ubiquitin-protein ligase TRIM39 (TRIM39) TRIM/RBCC family Q9HCM9
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Importin-11 (IPO11) Importin beta family Q9UI26
Monocarboxylate transporter 9 (SLC16A9) Monocarboxylate porter (TC 2.A.1.13) family Q7RTY1
MyoD family inhibitor (MDFI) MDFI family Q99750
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 620 (ZNF620) Krueppel C2H2-type zinc-finger protein family Q6ZNG0
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Afadin- and alpha-actinin-binding protein (SSX2IP) ADIP family Q9Y2D8
Ataxin-1 (ATXN1) ATXN1 family P54253
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Programmed cell death protein 4 (PDCD4) PDCD4 family Q53EL6
PIH1 domain-containing protein 2 (PIH1D2) PIH1 family Q8WWB5
Heat shock protein beta-1 (HSPB1) Small heat shock protein (HSP20) family P04792
Developmental pluripotency-associated protein 4 (DPPA4) . Q7L190

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Streamlined Target Deconvolution Approach Utilizing a Single Photoreactive Chloroalkane Capture Tag. ACS Chem Biol. 2021 Feb 19;16(2):404-413. doi: 10.1021/acschembio.0c00987. Epub 2021 Feb 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
19 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
20 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
23 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.