Details of the Target

General Information of Target

Target ID LDTP14080
Target Name U6 snRNA-associated Sm-like protein LSm5 (LSM5)
Gene Name LSM5
Gene ID 23658
Synonyms
U6 snRNA-associated Sm-like protein LSm5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG
LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV
NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSS
AQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILV
DDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCG
RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHM
VCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNR
YMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAF
YLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLL
QHVHEGYEKDLWEYIED
Target Bioclass
Other
Family
SnRNP Sm proteins family
Subcellular location
Nucleus
Function
Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.
Uniprot ID
Q9Y4Y9
Ensemble ID
ENST00000409292.5
HGNC ID
HGNC:17162

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C21(0.98)  LDD2136  [1]
IPM
 Probe Info  		N.A.  LDD0025  [2]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [2]
TFBX
 Probe Info  		N.A.  LDD0027  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C134
 Probe Info  		22.16  LDD1816  [4]
C140
 Probe Info  		9.85  LDD1822  [4]
C178
 Probe Info  		15.35  LDD1857  [4]
C399
 Probe Info  		13.93  LDD2058  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C21(20.00)  LDD2227  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C21(0.98)  LDD2136  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C21(0.29)  LDD2145  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase PLK3 (PLK3) Ser/Thr protein kinase family Q9H4B4
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TATA box-binding protein-like 1 (TBPL1) TBP family P62380
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
Small nuclear ribonucleoprotein E (SNRPE) SnRNP Sm proteins family P62304
U6 snRNA-associated Sm-like protein LSm3 (LSM3) SnRNP Sm proteins family P62310
U6 snRNA-associated Sm-like protein LSm7 (LSM7) SnRNP Sm proteins family Q9UK45
Small nuclear ribonucleoprotein F (SNRPF) SnRNP Sm proteins family P62306
U6 snRNA-associated Sm-like protein LSm6 (LSM6) SnRNP Sm proteins family P62312
T-cell leukemia/lymphoma protein 1B (TCL1B) TCL1 family O95988
Sperm-associated microtubule inner protein 10 (SPMIP10) . Q6ZNM6

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587