Details of the Target

General Information of Target

Target ID LDTP01286
Target Name Centriole and centriolar satellite protein OFD1 (OFD1)
Gene Name OFD1
Gene ID 8481
Synonyms
CXorf5; Centriole and centriolar satellite protein OFD1; Oral-facial-digital syndrome 1 protein; Protein 71-7A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMAQSNMFTVADVLSQDELRKKLYQTFKDRGILDTLKTQLRNQLIHELMHPVLSGELQPR
SISVEGSSLLIGASNSLVADHLQRCGYEYSLSVFFPESGLAKEKVFTMQDLLQLIKINPT
SSLYKSLVSGSDKENQKGFLMHFLKELAEYHQAKESCNMETQTSSTFNRDSLAEKLQLID
DQFADAYPQRIKFESLEIKLNEYKREIEEQLRAEMCQKLKFFKDTEIAKIKMEAKKKYEK
ELTMFQNDFEKACQAKSEALVLREKSTLERIHKHQEIETKEIYAQRQLLLKDMDLLRGRE
AELKQRVEAFELNQKLQEEKHKSITEALRRQEQNIKSFEETYDRKLKNELLKYQLELKDD
YIIRTNRLIEDERKNKEKAVHLQEELIAINSKKEELNQSVNRVKELELELESVKAQSLAI
TKQNHMLNEKVKEMSDYSLLKEEKLELLAQNKLLKQQLEESRNENLRLLNRLAQPAPELA
VFQKELRKAEKAIVVEHEEFESCRQALHKQLQDEIEHSAQLKAQILGYKASVKSLTTQVA
DLKLQLKQTQTALENEVYCNPKQSVIDRSVNGLINGNVVPCNGEISGDFLNNPFKQENVL
ARMVASRITNYPTAWVEGSSPDSDLEFVANTKARVKELQQEAERLEKAFRSYHRRVIKNS
AKSPLAAKSPPSLHLLEAFKNITSSSPERHIFGEDRVVSEQPQVGTLEERNDVVEALTGS
AASRLRGGTSSRRLSSTPLPKAKRSLESEMYLEGLGRSHIASPSPCPDRMPLPSPTESRH
SLSIPPVSSPPEQKVGLYRRQTELQDKSEFSDVDKLAFKDNEEFESSFESAGNMPRQLEM
GGLSPAGDMSHVDAAAAAVPLSYQHPSVDQKQIEEQKEEEKIREQQVKERRQREERRQSN
LQEVLERERRELEKLYQERKMIEESLKIKIKKELEMENELEMSNQEIKDKSAHSENPLEK
YMKIIQQEQDQESADKSSKKMVQEGSLVDTLQSSDKVESLTGFSHEELDDSW
Target Bioclass
Other
Family
OFD1 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function
Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation.
Uniprot ID
O75665
Ensemble ID
ENST00000340096.11
HGNC ID
HGNC:2567

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ETK1 SNV: p.Q189Ter .
HCT15 SNV: p.I387T; p.Q538H .
JURKAT Deletion: p.K393RfsTer8 .
KELLY SNV: p.A722S .
NCIH2286 SNV: p.N681K .
RBE SNV: p.S973L .
SSP25 SNV: p.Q189Ter .
YSCCC SNV: p.S74C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y353(7.16)  LDD3495  [1]
NAIA_5
 Probe Info  		C503(0.74)  LDD2227  [2]
AHL-Pu-1
 Probe Info  		C503(2.66); C216(2.11)  LDD0168  [3]
DBIA
 Probe Info  		C503(0.94)  LDD0531  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		C503(0.00); C766(0.00)  LDD0147  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C383
 Probe Info  		11.47  LDD2042  [9]
C388
 Probe Info  		39.40  LDD2047  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C503(2.66); C216(2.11)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C503(2.06)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C503(0.94)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C157(1.04)  LDD0532  [4]
 LDCM0216  AC100 HEK-293T C503(0.95)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C503(1.01)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C503(0.92)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C503(0.89)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C503(0.79)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C503(1.05)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C503(0.87)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C503(0.82)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C503(0.84)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C503(0.83)  LDD0823  [4]
 LDCM0226  AC11 HCT 116 C157(0.91)  LDD0543  [4]
 LDCM0227  AC110 HEK-293T C503(0.78)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C503(0.88)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C503(0.95)  LDD0827  [4]
 LDCM0230  AC113 HCT 116 C503(1.06)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C503(1.02)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C503(0.96)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C503(0.91)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C503(1.03)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C503(1.01)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C503(1.21)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C157(0.82)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C503(1.12)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C503(0.87)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C503(1.01)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C503(0.81)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C503(0.80)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C503(0.94)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C503(0.79)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C503(0.87)  LDD0562  [4]
 LDCM0246  AC128 HEK-293T C157(1.30); C503(1.15)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C157(0.80); C503(0.91)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C157(0.76); C503(0.85)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C157(1.19); C503(1.11)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C157(0.82); C503(0.95)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C157(0.49); C503(0.88)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C157(0.62); C503(0.82)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C157(0.68); C503(0.90)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C157(0.50); C503(0.70)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C157(0.33); C503(0.68)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C157(0.30); C503(0.65)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C157(0.34); C503(0.71)  LDD0856  [4]
 LDCM0259  AC14 HCT 116 C157(1.02)  LDD0576  [4]
 LDCM0260  AC140 HEK-293T C157(0.50); C503(0.75)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C157(0.33); C503(0.63)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C157(0.48); C503(0.80)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C157(0.55); C503(0.55)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C157(0.40); C503(0.40)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C157(0.41); C503(0.41)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C157(0.50); C503(0.50)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C157(0.40); C503(0.40)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C157(0.41); C503(0.41)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C157(1.18); C503(1.18)  LDD0867  [4]
 LDCM0270  AC15 HCT 116 C157(0.97)  LDD0587  [4]
 LDCM0271  AC150 HEK-293T C157(0.78); C503(0.78)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C157(0.59); C503(0.59)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C157(0.71); C503(0.71)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C157(0.79); C503(0.79)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C157(1.36); C503(1.36)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C157(0.78); C503(0.78)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C157(0.38); C503(0.38)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C157(0.39); C503(0.39)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C157(1.00)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C157(0.99)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C157(0.96)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C503(1.02)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C157(0.88)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C157(0.85)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C157(1.11)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C157(1.08)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C157(1.03)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C157(1.03)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C157(1.46)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C157(1.36)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C157(1.10)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C157(1.35)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C503(0.94)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C157(1.34)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C157(1.29)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C157(1.49)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C157(1.13)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C157(1.29)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C157(0.93)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C157(0.86)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C157(1.60)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C157(1.04)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C157(0.82)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C503(0.92)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C157(1.32)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C157(1.13)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C157(1.28)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C157(1.42)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C157(1.16)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C157(1.36)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C157(1.00); C503(1.01)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C157(0.94); C503(1.02)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C503(0.97); C157(1.01)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C503(1.14); C157(1.21)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C503(0.91)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C503(1.01); C157(1.07)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C157(0.99); C503(1.20)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C503(1.01); C157(1.03)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C503(0.96); C157(1.29)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C503(0.93); C157(1.09)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C157(1.14); C503(1.25)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C503(1.28); C157(1.53)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C503(0.96)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C503(0.98)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C503(0.97)  LDD0920  [4]
 LDCM0323  AC6 HCT 116 C157(0.98)  LDD0640  [4]
 LDCM0324  AC60 HEK-293T C503(0.98)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C503(0.93)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C503(0.91)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C503(0.97)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C503(0.96)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C503(1.05)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C503(0.90)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C503(0.99)  LDD0929  [4]
 LDCM0332  AC68 HCT 116 C157(1.12)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C157(0.98)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C157(0.95)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C157(0.87)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C157(1.12)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C157(0.95)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C157(1.11)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C157(1.36)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C157(1.94)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C157(1.10)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C157(1.07)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C157(1.06)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C157(1.19)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C157(0.94)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C157(0.92)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C157(1.16)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C157(1.24)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C157(0.99); C503(1.20)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C503(1.05); C157(1.22)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C157(0.82); C503(1.10)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C157(0.94); C503(0.97)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C157(0.93); C503(0.96)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C157(0.98); C503(1.01)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C157(0.99); C503(1.03)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C157(1.00); C503(1.14)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C157(0.84); C503(1.17)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C157(0.96); C503(1.11)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C157(1.02); C503(1.12)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C503(1.32); C157(1.34)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C503(1.14); C157(1.22)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C157(0.88); C503(1.20)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C157(1.02); C503(1.22)  LDD0681  [4]
 LDCM0365  AC98 HEK-293T C503(0.86)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C503(0.88)  LDD0964  [4]
 LDCM0248  AKOS034007472 HCT 116 C157(0.89)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C157(1.05)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C157(0.96)  LDD0592  [4]
 LDCM0632  CL-Sc Hep-G2 C503(0.74)  LDD2227  [2]
 LDCM0367  CL1 HEK-293T C503(1.33)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C503(1.37)  LDD0966  [4]
 LDCM0369  CL100 HCT 116 C503(1.09)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C157(0.97)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C157(0.95)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C157(0.80)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C157(1.00)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C157(1.00)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C157(1.27)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C157(1.15)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C157(1.26)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C157(0.98)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C503(1.12)  LDD0977  [4]
 LDCM0380  CL110 HCT 116 C157(1.07)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C157(1.04)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C157(0.95)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C157(1.11)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C157(1.14)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C157(0.98)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C157(1.20)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C157(1.45)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C157(0.96)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C157(1.37)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C503(1.05)  LDD0988  [4]
 LDCM0391  CL120 HCT 116 C157(0.95)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C157(0.88); C503(1.18)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C157(0.99); C503(1.29)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C157(1.15); C503(1.46)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C157(1.11); C503(1.36)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C503(0.92)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C503(1.25)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C503(0.89)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C503(1.12)  LDD0997  [4]
 LDCM0400  CL13 HEK-293T C503(1.09)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C503(1.07)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C503(1.37)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C157(1.01)  LDD1001  [4]
 LDCM0404  CL17 HCT 116 C503(1.55)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C503(1.01)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C503(1.19)  LDD0723  [4]
 LDCM0407  CL2 HEK-293T C503(1.35)  LDD1005  [4]
 LDCM0408  CL20 HCT 116 C503(1.53)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C503(1.33)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C503(0.99)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C503(1.34)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C503(1.05)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C503(1.24)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C503(1.09)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C503(1.21)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C503(1.35)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C503(1.07)  LDD0734  [4]
 LDCM0418  CL3 HEK-293T C503(1.36)  LDD1016  [4]
 LDCM0419  CL30 HCT 116 C503(1.10)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C157(1.21); C503(1.13)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C157(1.28)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C157(1.29)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C157(1.21)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C157(0.97)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C157(1.26)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C157(1.11)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C157(1.13)  LDD0745  [4]
 LDCM0429  CL4 HEK-293T C503(1.24)  LDD1027  [4]
 LDCM0430  CL40 HCT 116 C157(1.17)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C157(1.18)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C157(1.22)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C157(0.89)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C157(1.06)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C157(1.24)  LDD0752  [4]
 LDCM0436  CL46 HEK-293T C503(0.77)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C503(0.87)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C503(0.96)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C503(0.91)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C503(1.17)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C503(0.94)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C503(0.84)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C503(0.93)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C503(0.99)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C503(0.86)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C503(0.75)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C503(0.84)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C503(0.84)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C503(0.98)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C503(0.91)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C503(1.44)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C503(0.97)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C157(1.05)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C157(1.06)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C157(1.20)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C157(0.99)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C157(0.91)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C157(1.14)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C157(0.81)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C157(0.91)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C157(1.39)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C503(0.91)  LDD1060  [4]
 LDCM0463  CL70 HCT 116 C157(1.06)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C157(0.99)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C157(0.95)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C157(1.01)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C157(0.91)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C157(0.93)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C157(0.94)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C157(0.84)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C157(0.93)  LDD0789  [4]
 LDCM0473  CL8 HEK-293T C503(2.32)  LDD1071  [4]
 LDCM0474  CL80 HCT 116 C157(1.09)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C157(0.95)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C157(1.23)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C157(0.86)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C157(0.80)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C157(0.89)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C157(0.91)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C157(0.91)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C157(1.03)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C157(0.68)  LDD0800  [4]
 LDCM0484  CL9 HEK-293T C503(1.18)  LDD1082  [4]
 LDCM0485  CL90 HCT 116 C157(0.85)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C503(0.96)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C503(1.20)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C503(1.09)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C503(1.02)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C503(1.37)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C503(0.87)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C503(0.95)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C503(1.16)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C503(1.04)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C766(1.07); C503(1.08)  LDD1698  [10]
 LDCM0468  Fragment33 HCT 116 C157(1.24)  LDD0785  [4]
 LDCM0427  Fragment51 HCT 116 C157(1.68)  LDD0744  [4]
 LDCM0022  KB02 HEK-293T C766(1.27); C503(1.06); C581(0.94)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C766(1.12); C503(1.02); C581(0.88)  LDD1497  [10]
 LDCM0024  KB05 SKMEL24 C766(1.38)  LDD3323  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoside diphosphate kinase homolog 7 (NME7) NDK family Q9Y5B8
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
RuvB-like 1 (RUVBL1) RuvB family Q9Y265
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy-related protein 13 (ATG13) ATG13 family O75143
Pericentriolar material 1 protein (PCM1) PCM1 family Q15154
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) ATG8 family Q9GZQ8
Centriole and centriolar satellite protein OFD1 (OFD1) OFD1 family O75665
C2 domain-containing protein 3 (C2CD3) . Q4AC94

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840