Details of the Target

General Information of Target

Target ID LDTP11379
Target Name TBC1 domain family member 10A (TBC1D10A)
Gene Name TBC1D10A
Gene ID 83874
Synonyms
EPI64; TBC1D10; TBC1 domain family member 10A; EBP50-PDX interactor of 64 kDa; EPI64 protein; Rab27A-GAP-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGQPREPQEPREPGPGAETAAAPVWEEAKIFYDNLAPKKKPKSPKPQNAVTIAVSSRA
LFRMDEEQQIYTEQGVEEYVRYQLEHENEPFSPGPAFPFVKALEAVNRRLRELYPDSEDV
FDIVLMTNNHAQVGVRLINSINHYDLFIERFCMTGGNSPICYLKAYHTNLYLSADAEKVR
EAIDEGIAAATIFSPSRDVVVSQSQLRVAFDGDAVLFSDESERIVKAHGLDRFFEHEKAH
ENKPLAQGPLKGFLEALGRLQKKFYSKGLRLECPIRTYLVTARSAASSGARALKTLRSWG
LETDEALFLAGAPKGPLLEKIRPHIFFDDQMFHVAGAQEMGTVAAHVPYGVAQTPRRTAP
AKQAPSAQ
Target Bioclass
Other
Subcellular location
Cell projection, microvillus
Function Acts as a GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A.
Uniprot ID
Q9BXI6
Ensemble ID
ENST00000215790.12
HGNC ID
HGNC:23609

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL27 SNV: p.E68K .
CAL51 Deletion: p.G173AfsTer11 .
HCT116 SNV: p.P425S .
Ishikawa (Heraklio) 02 ER SNV: p.F138I DBIA    Probe Info 
NCIH1155 SNV: p.G63C .
RL952 SNV: p.R376Q DBIA    Probe Info 
RT112 SNV: p.P408S DBIA    Probe Info 
SW1116 SNV: p.R53L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YY4-yne
 Probe Info  		2.01  LDD0400  [1]
DBIA
 Probe Info  		C381(5.38)  LDD0209  [2]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [3]
IA-alkyne
 Probe Info  		C324(0.00); C277(0.00)  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [3]
WYneN
 Probe Info  		N.A.  LDD0021  [4]
WYneO
 Probe Info  		N.A.  LDD0022  [4]
IPM
 Probe Info  		N.A.  LDD0005  [4]
SF
 Probe Info  		N.A.  LDD0028  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C383
 Probe Info  		21.26  LDD2042  [9]
C390
 Probe Info  		20.82  LDD2049  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C324(0.92)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C324(0.87)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C324(0.98)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C324(1.02); C464(1.13)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C324(0.99); C464(1.10)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C324(0.97); C464(1.19)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C324(0.90)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C324(1.01)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C324(1.17)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C324(0.96)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C324(1.00); C464(1.06)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C324(0.89)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C324(0.99); C464(0.86)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C324(1.12); C464(0.75)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C324(0.98)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C324(1.01)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C324(0.97)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C324(1.05)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C324(0.92); C464(1.07)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C324(0.92)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C324(1.02)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C324(1.07); C464(1.00)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C324(1.08); C464(0.84)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C324(1.01)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C324(0.99)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C324(0.86)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C324(0.94)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C324(0.89); C464(1.00)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C324(0.84)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C324(0.91); C464(1.17)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C324(1.09); C464(0.93)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C324(1.05); C464(1.00)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C324(1.00)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C324(1.00)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C324(1.02)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C324(0.96)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C324(1.00); C464(1.16)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C324(0.99)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C324(0.94); C464(0.92)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C324(1.04); C464(1.20)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C324(1.01)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C324(0.94)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C324(0.84)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C324(1.02)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C324(1.03)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C324(0.99); C464(1.01)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C324(0.93)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C324(0.89); C464(0.99)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C324(0.99); C464(1.08)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C324(1.01)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C324(1.12)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C324(0.97)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C324(0.91)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C324(1.05); C464(0.83)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C324(0.96); C464(1.03)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C324(0.98)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C324(0.92); C464(1.00)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C324(1.11); C464(0.90)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C324(1.07)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C324(1.02); C464(0.95)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C324(0.96)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C324(0.89)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C324(0.96)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C324(1.02)  LDD1514  [10]
 LDCM0632  CL-Sc Hep-G2 C324(0.87)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C324(1.04)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C324(1.21); C464(0.79)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C324(0.98)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C324(0.99)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C324(1.10)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C324(1.05)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C324(1.02)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C324(0.95)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C324(1.07)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C324(0.92)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C324(1.04)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C324(1.05)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C324(1.06); C464(1.05)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C324(1.17)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C324(1.00)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C324(1.00)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C324(0.98)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C324(1.14)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C324(1.09)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C324(1.04)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C324(1.10)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C324(1.07)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C324(1.01)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C324(1.11)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C324(0.99)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C324(1.14)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C324(1.02)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C324(1.14)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C324(1.05)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C324(0.95)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C324(1.07)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C324(1.05)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C324(1.01)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C324(1.04)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C324(1.07)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C324(1.28)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C324(1.07)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C324(1.21)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C324(0.95)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C324(1.05)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C324(1.10)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C324(1.05); C464(1.07)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C324(1.27)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C324(0.90); C464(1.08)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C324(1.04); C464(1.10)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C324(1.10)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C324(1.42)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C324(1.00)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C324(1.06)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C324(1.03)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C324(0.88)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C324(1.02)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C324(0.96)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C324(1.10)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C324(1.07); C464(1.08)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C324(1.46)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C324(0.96); C464(1.03)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C324(1.17); C464(0.89)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C324(1.06)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C324(0.97)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C324(1.08)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C324(1.14)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C324(1.14)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C324(1.21)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C324(0.97)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C324(1.01)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C324(1.09); C464(1.08)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C324(0.95)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C324(0.98); C464(1.05)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C324(1.14); C464(1.06)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C324(1.06)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C324(0.87)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C324(1.09)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C324(1.00)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C324(1.10)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C324(1.06)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C324(1.17)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C324(1.09)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C324(1.11); C464(1.21)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C324(1.00)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C324(0.98); C464(0.91)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C324(1.08); C464(0.94)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C324(1.08)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C324(1.11)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C324(0.97)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C324(1.08)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C324(1.13)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C324(1.23)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C324(1.02)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C324(0.93)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C324(1.00)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C324(1.08); C464(1.02)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C324(1.12)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C324(1.08)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C324(0.97); C464(0.90)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C324(1.08); C464(1.01)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C324(1.00)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C324(1.05)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C324(1.00)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C324(0.97)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C324(1.08)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C324(1.02)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C324(1.01)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C324(1.70); C464(0.79)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C324(1.03); C464(1.13)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C324(0.96)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C324(0.99); C464(0.93)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C324(1.04); C464(1.06)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C324(1.09)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C324(0.96)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C324(1.06)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C324(1.02)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C324(1.04)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C324(0.91)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C324(1.13)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C324(1.73)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C324(1.17)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C324(0.97); C464(0.99)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C324(0.93)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C324(0.91); C464(1.10)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C324(1.76); C464(0.91)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C324(1.06)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C324(1.10)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C324(1.14)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C324(0.96)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C324(0.98)  LDD1698  [10]
 LDCM0625  F8 Ramos C324(0.86)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C324(1.97)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C324(3.68)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C324(3.66)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C324(0.98)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C324(1.06)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C324(5.75)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C324(1.34)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C324(2.56)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C324(1.00)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C324(0.59)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C324(1.18)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C324(1.16)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C324(3.48)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C324(1.01)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C324(1.31)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C324(2.83)  LDD2184  [11]
 LDCM0427  Fragment51 HEK-293T C324(1.05)  LDD1631  [10]
 LDCM0610  Fragment52 Ramos C324(1.37)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C324(1.00)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C324(1.88)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C324(6.67)  LDD2188  [11]
 LDCM0022  KB02 HEK-293T C324(0.89); C464(1.16)  LDD1492  [10]
 LDCM0023  KB03 Jurkat C381(5.38)  LDD0209  [2]
 LDCM0024  KB05 MEL167 C331(1.04)  LDD3316  [12]
 LDCM0627  NUDT7-COV-1 HEK-293T C324(0.64)  LDD2206  [13]
 LDCM0628  OTUB2-COV-1 HEK-293T C324(0.71)  LDD2207  [13]
 LDCM0154  YY4 T cell 2.01  LDD0400  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Testis-expressed protein 13A (TEX13A) TEX13 family Q9BXU3
Adrenocortical dysplasia protein homolog (ACD) . Q96AP0

References

1 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
5 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
13 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.