Details of the Target

General Information of Target

Target ID LDTP06853
Target Name TBC1 domain family member 10B (TBC1D10B)
Gene Name TBC1D10B
Gene ID 26000
Synonyms
TBC1 domain family member 10B; Rab27A-GAP-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METGTAPLVAPPRRHGAPAAPSPPPRGSRAGPVVVVAPGPPVTTATSAPVTLVAPGEARP
AWVPGSAETSAPAPAPAPAPAPAVTGSTVVVLTLEASPEAPKPQLPSGPESPEPAAVAGV
ETSRALAAGADSPKTEEARPSPAPGPGTPTGTPTRTPSRTAPGALTAKPPLAPKPGTTVA
SGVTARSASGQVTGGHGAAAATSASAGQAPEDPSGPGTGPSGTCEAPVAVVTVTPAPEPA
ENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLA
LRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKG
IPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAAR
GGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYY
SAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRV
WDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEV
TNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLL
SLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKE
TRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLS
LRRKADGPPGPHDGGDRPSAEARQDAYF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A.
Uniprot ID
Q4KMP7
Ensemble ID
ENST00000409939.8
HGNC ID
HGNC:24510

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Insertion: p.R366SfsTer38 .
COLO800 SNV: p.G317A .
DETROIT562 SNV: p.K550N .
HCT116 SNV: p.V537A DBIA    Probe Info 
HEC1 SNV: p.R331W .
HEC1B SNV: p.R331W .
L428 SNV: p.G217C .
LS123 SNV: p.G317A .
LS180 SNV: p.P213T .
MELJUSO SNV: p.G478S .
MFE296 SNV: p.Q724K .
MOLT4 SNV: p.E599D .
NCIH1666 SNV: p.L355R .
SNU245 SNV: p.R647Q .
UACC62 SNV: p.K474Ter .
VMRCRCW SNV: p.E492G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.82  LDD0402  [1]
TH211
 Probe Info  		Y577(20.00)  LDD0257  [2]
STPyne
 Probe Info  		K368(8.93)  LDD0277  [3]
OPA-S-S-alkyne
 Probe Info  		K784(0.23)  LDD3494  [4]
Probe 1
 Probe Info  		Y429(7.30)  LDD3495  [5]
YY4-yne
 Probe Info  		2.07  LDD0400  [6]
Acrolein
 Probe Info  		N.A.  LDD0221  [7]
DBIA
 Probe Info  		C573(0.97)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C590(0.00); C573(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C590(0.00); C573(0.00)  LDD0037  [9]
IPM
 Probe Info  		C573(0.00); C590(0.00)  LDD2156  [11]
AOyne
 Probe Info  		8.00  LDD0443  [12]
NAIA_5
 Probe Info  		C526(0.00); C590(0.00); C573(0.00); C546(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C265
 Probe Info  		13.09  LDD1936  [14]
C383
 Probe Info  		13.00  LDD2042  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C573(1.09)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C546(0.97); C573(1.17)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C573(0.77)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C573(0.76)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C573(0.87)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C573(0.84)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C573(0.89)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C573(0.80)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C573(0.85)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C573(0.82)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C573(0.73)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C573(0.86)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C546(1.01); C573(1.05)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C573(0.77)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C573(0.80)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C573(0.87)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C546(0.99); C573(1.16)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C546(1.00); C573(1.09)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C546(1.02); C573(1.23)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C546(1.16); C573(1.24)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C546(1.07); C573(1.22)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C546(0.98); C573(1.17)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C546(1.12); C573(1.12)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C546(0.99); C573(1.02)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C546(1.11); C573(1.41)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C546(1.11); C573(1.27)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C546(1.02); C573(1.36)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C546(0.98); C573(1.23)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C546(0.90); C573(1.12)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C546(1.06); C573(1.16)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C546(1.11); C573(1.46)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C546(1.05); C573(1.37)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C573(1.20)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C573(1.08)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C573(1.39)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C573(1.04)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C573(1.26)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C573(1.13)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C573(1.28)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C573(1.12)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C573(1.16)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C573(0.97)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C573(1.21)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C573(1.35)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C546(1.08); C573(0.99)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C573(1.40)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C573(1.29)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C573(1.11)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C546(0.81); C573(1.07)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C546(0.94); C573(0.98)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C546(0.77); C573(1.03)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C546(0.86); C573(0.98)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C573(0.83); C546(0.89)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C546(1.14); C573(1.37)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C546(0.86); C573(1.30)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C546(1.04); C573(1.04)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C546(0.78); C573(0.97)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C546(0.72); C573(1.09)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C546(0.85); C573(1.29)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C546(1.14); C573(1.27)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C546(0.73); C573(1.09)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C546(0.71); C573(1.07)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C546(0.74); C573(1.00)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C546(0.66); C573(1.05)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C573(0.92)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C573(1.14)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C573(0.94)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C573(1.10)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C573(0.93)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C573(1.03)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C573(1.02)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C573(1.10)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C573(1.35)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C573(0.70)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C573(0.98)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C573(0.79)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C573(0.99)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C573(1.04)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C573(1.06)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C573(1.13)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C573(0.90)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C573(1.01)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C573(0.88)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C573(0.98)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C546(0.96)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C546(0.91)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C546(0.96)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C546(1.08)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C546(1.07)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C573(1.13)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C546(1.07)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C546(0.98)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C546(1.13)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C546(1.10)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C546(1.05)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C546(1.12)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C573(1.00); C546(1.05)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C546(1.04); C573(1.23)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C546(0.98); C573(1.11)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C573(0.90); C546(1.22)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C573(1.28)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C573(0.80); C546(1.16)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C573(0.91); C546(0.96)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C546(0.90); C573(1.05)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C546(1.16); C573(1.26)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C573(0.84); C546(1.05)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C573(0.99); C546(1.07)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C573(1.22); C546(1.32)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C546(1.08); C573(1.10)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C573(1.05); C546(1.34)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C573(1.10); C546(1.12)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C546(0.96); C573(1.03)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C573(1.20); C546(1.31)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C546(1.06); C573(1.11)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C573(1.12); C546(1.22)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C573(1.12); C546(1.18)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C573(1.18); C546(1.34)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C573(0.99); C546(1.69)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C573(1.09); C546(1.68)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C573(1.04); C546(1.60)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C573(1.25); C546(1.29)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C573(1.12); C546(1.30)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C573(0.99); C546(0.99)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C573(1.20); C546(1.24)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C573(1.20); C546(1.39)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C546(1.09); C573(1.15)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C573(1.37); C546(1.55)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C573(1.47); C546(1.86)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C573(1.46); C546(1.83)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C573(1.33); C546(1.36)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C573(1.32); C546(1.36)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C573(1.07); C546(1.17)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C573(1.12); C546(1.28)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C573(0.94); C546(1.00)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C546(1.32); C573(1.43)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C546(0.97); C573(1.53)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C573(1.60); C546(1.87)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C573(1.30)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C573(1.30)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C573(1.36)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C573(1.21)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C573(1.22)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C573(1.24)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C573(1.22)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C573(1.19)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C573(1.43)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C573(1.38)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C573(1.10)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C573(1.07)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C573(1.17)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C573(1.02)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C573(1.33)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C573(0.86)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C573(0.82)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C546(1.05); C573(1.09)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C546(0.91); C573(0.91)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C546(1.17); C573(1.19)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 13.74  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C573(0.97)  LDD0078  [8]
 LDCM0367  CL1 HCT 116 C546(0.88); C573(1.13)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C546(0.91); C573(1.31)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C573(1.08)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C546(0.91); C573(0.93)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C546(0.95); C573(1.00)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C546(0.82); C573(0.94)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C546(0.94); C573(1.01)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C573(1.08)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C573(1.70)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C573(2.16)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C573(1.49)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C573(0.94)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C546(1.24); C573(1.59)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C573(1.08)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C573(0.88)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C573(0.76)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C573(0.88)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C573(1.04)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C573(1.57)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C573(0.85)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C546(1.29)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C546(1.00)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C546(0.99)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C546(1.18); C573(1.39)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C546(0.98)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C546(0.69); C573(0.97)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C573(0.92); C546(1.07)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C546(0.94); C573(1.21)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C546(1.09); C573(1.20)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C573(0.94); C546(1.01)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C546(0.94); C573(1.23)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C546(0.96); C573(1.14)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C573(1.00); C546(1.19)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C546(1.05); C573(1.08)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C546(0.91); C573(1.01)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C573(0.95); C546(0.98)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C546(0.80); C573(0.84)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C546(0.86); C573(1.05)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C546(0.85); C573(0.89)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C546(0.92); C573(0.95)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C546(0.91); C573(1.02)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C546(0.96); C573(1.01)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C573(0.94); C546(0.97)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C573(1.06); C546(1.39)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C573(0.88); C546(0.90)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C546(1.02); C573(1.15)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C546(0.85); C573(0.92)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C546(0.97); C573(0.97)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C546(1.05); C573(1.01)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C546(0.88); C573(1.02)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C546(1.02); C573(0.96)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C546(0.95); C573(1.28)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C546(0.87); C573(0.81)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C573(1.04)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C573(1.12)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C573(1.02)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C573(1.14)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C573(1.13)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C573(1.13)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C573(1.24)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C573(1.22)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C546(0.89); C573(0.93)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C573(0.98)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C573(1.03)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C573(1.25)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C573(1.32)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C573(1.01)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C573(1.39)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C573(0.91)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C573(0.87)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C573(0.85)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C573(0.98)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C546(0.94); C573(1.09)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C573(0.84)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C573(0.93)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C573(0.83)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C573(0.91)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C573(0.88)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C573(0.83)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C573(0.84)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C573(0.82)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C573(0.80)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C573(0.90)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C546(0.92); C573(1.08)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C573(0.92)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C546(1.08); C573(1.09)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C546(1.17); C573(1.13)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C546(1.19); C573(1.27)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C546(1.07); C573(1.19)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C546(1.09); C573(1.15)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C546(1.35); C573(1.29)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C546(1.31); C573(1.12)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C546(1.18); C573(1.08)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C546(0.98); C573(1.04)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C546(1.11); C573(1.06)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C546(1.15); C573(1.15)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C546(1.03); C573(1.17)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C546(1.03); C573(1.01)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C546(1.20); C573(1.19)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C546(1.20); C573(1.11)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C573(0.98)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C573(0.91)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C573(0.92)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C573(1.22)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C546(0.91); C573(1.15)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C573(0.97)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C573(1.11)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C573(1.26)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C573(1.21)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C573(1.29)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C573(1.16)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C573(0.99)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C573(1.07)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C573(1.18)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C573(1.37)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C546(0.99); C573(1.31)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C573(0.87)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C573(1.04)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C573(0.99)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C573(1.08)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C573(1.04)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C573(1.03)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C573(1.02)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C573(1.00)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C573(1.23)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C573(1.15)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C573(0.97); C590(0.87); C546(0.95)  LDD1698  [15]
 LDCM0625  F8 Ramos C573(1.16)  LDD2187  [16]
 LDCM0572  Fragment10 Ramos C573(1.20)  LDD2189  [16]
 LDCM0573  Fragment11 Ramos C573(0.33)  LDD2190  [16]
 LDCM0574  Fragment12 Ramos C573(0.97)  LDD2191  [16]
 LDCM0575  Fragment13 Ramos C573(0.97)  LDD2192  [16]
 LDCM0576  Fragment14 Ramos C573(1.06)  LDD2193  [16]
 LDCM0579  Fragment20 Ramos C573(1.02)  LDD2194  [16]
 LDCM0580  Fragment21 Ramos C573(0.86)  LDD2195  [16]
 LDCM0582  Fragment23 Ramos C573(0.65)  LDD2196  [16]
 LDCM0578  Fragment27 Ramos C573(0.95)  LDD2197  [16]
 LDCM0586  Fragment28 Ramos C573(0.70)  LDD2198  [16]
 LDCM0588  Fragment30 Ramos C573(1.18)  LDD2199  [16]
 LDCM0589  Fragment31 Ramos C573(0.81)  LDD2200  [16]
 LDCM0590  Fragment32 Ramos C573(0.98)  LDD2201  [16]
 LDCM0468  Fragment33 HCT 116 C546(1.15); C573(1.16)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C573(0.76)  LDD2203  [16]
 LDCM0566  Fragment4 Ramos C573(1.10)  LDD2184  [16]
 LDCM0427  Fragment51 HCT 116 C573(1.19)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C573(0.91)  LDD2204  [16]
 LDCM0614  Fragment56 Ramos C573(1.37)  LDD2205  [16]
 LDCM0569  Fragment7 Ramos C573(0.97)  LDD2186  [16]
 LDCM0571  Fragment9 Ramos C573(1.11)  LDD2188  [16]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0022  KB02 HEK-293T C573(0.92); C590(1.03); C546(0.85)  LDD1492  [15]
 LDCM0023  KB03 HEK-293T C573(0.96); C590(1.08); C546(0.91)  LDD1497  [15]
 LDCM0024  KB05 MOLM-13 C573(2.48)  LDD3333  [17]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C573(1.05)  LDD2206  [18]
 LDCM0628  OTUB2-COV-1 HEK-293T C573(0.35)  LDD2207  [18]
 LDCM0154  YY4 T cell 2.07  LDD0400  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 70 (CCDC70) . Q6NSX1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
16 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
17 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
18 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.