Details of the Target

General Information of Target

Target ID LDTP00399
Target Name Torsin-1A (TOR1A)
Gene Name TOR1A
Gene ID 1861
Synonyms
DQ2; DYT1; TA; TORA; Torsin-1A; Dystonia 1 protein; Torsin ATPase-1A; EC 3.6.4.-; Torsin family 1 member A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLGRAVLGLLLLAPSVVQAVEPISLGLALAGVLTGYIYPRLYCLFAECCGQKRSLSREA
LQKDLDDNLFGQHLAKKIILNAVFGFINNPKPKKPLTLSLHGWTGTGKNFVSKIIAENIY
EGGLNSDYVHLFVATLHFPHASNITLYKDQLQLWIRGNVSACARSIFIFDEMDKMHAGLI
DAIKPFLDYYDLVDGVSYQKAMFIFLSNAGAERITDVALDFWRSGKQREDIKLKDIEHAL
SVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEIDEDIVSRV
AEEMTFFPKEERVFSDKGCKTVFTKLDYYYDD
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
ClpA/ClpB family, Torsin subfamily
Subcellular location
Endoplasmic reticulum lumen
Function
Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues.
TTD ID
T70027
Uniprot ID
O14656
DrugMap ID
TTF85KW
Ensemble ID
ENST00000351698.5
HGNC ID
HGNC:3098

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
BXPC3 SNV: p.T35P; p.Y39S .
HT115 SNV: p.L98F .
MOLM13 SNV: p.R223K .
PC9 SNV: p.F306V .
TOV21G SNV: p.Q52H; p.D194G .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K234(1.28)  LDD0277  [1]
Probe 1
 Probe Info  		Y290(44.86)  LDD3495  [2]
DBIA
 Probe Info  		C44(1.24)  LDD0078  [3]
5E-2FA
 Probe Info  		N.A.  LDD2235  [4]
ATP probe
 Probe Info  		K108(0.00); K113(0.00)  LDD0199  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
IA-alkyne
 Probe Info  		C319(0.00); C44(0.00)  LDD0165  [6]
ATP probe
 Probe Info  		N.A.  LDD0035  [7]
IPM
 Probe Info  		N.A.  LDD2156  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]
AOyne
 Probe Info  		8.90  LDD0443  [10]
NAIA_5
 Probe Info  		C49(0.00); C319(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C231
 Probe Info  		12.13  LDD1904  [12]
C289
 Probe Info  		31.12  LDD1959  [12]
FFF probe11
 Probe Info  		20.00  LDD0471  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]
OEA-DA
 Probe Info  		5.73  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C50(1.03)  LDD1507  [16]
 LDCM0215  AC10 HEK-293T C44(1.24); C49(1.24)  LDD0813  [3]
 LDCM0216  AC100 HCT 116 C44(0.96); C49(0.58)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C44(1.01); C49(0.82)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C44(0.85); C49(0.90)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C44(1.05); C49(0.83)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C44(0.96); C49(0.99)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C44(0.96); C49(0.72)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C44(0.86); C49(0.77)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C44(1.00); C49(0.88)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C44(0.79); C49(0.95)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C44(1.06); C49(1.04)  LDD0542  [3]
 LDCM0226  AC11 HEK-293T C44(1.19); C49(1.19)  LDD0824  [3]
 LDCM0227  AC110 HCT 116 C44(0.96); C49(1.00)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C44(0.91); C49(0.82)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C44(1.09); C49(1.04)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C44(0.96); C50(1.14)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C44(0.98); C50(0.99)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C44(0.99); C50(1.02)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C44(0.99); C50(0.98)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C44(1.17); C50(1.07)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C44(1.22); C50(0.96)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C44(1.45); C50(0.99)  LDD0553  [3]
 LDCM0237  AC12 HEK-293T C44(1.10); C49(1.10)  LDD0835  [3]
 LDCM0238  AC120 HCT 116 C44(0.77); C50(1.03)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C44(0.59); C50(1.12)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C44(0.94); C50(1.04)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C44(0.52); C50(1.03)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C44(0.91); C50(1.11)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C44(0.72); C50(0.97)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C44(0.76); C50(1.04)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C44(0.91); C50(0.97)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C44(0.60); C50(0.60)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C44(0.97); C50(0.97)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C44(0.86); C50(0.86)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C44(1.00); C50(1.00)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C44(0.82); C50(0.82)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C44(0.82); C50(0.82)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C44(0.75); C50(0.75)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C44(0.79); C50(0.79)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C44(0.77); C50(0.77)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C44(0.88); C50(0.88)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C44(0.87); C50(0.87)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C44(0.69); C50(0.69)  LDD0575  [3]
 LDCM0259  AC14 HEK-293T C44(1.21); C49(1.21)  LDD0857  [3]
 LDCM0260  AC140 HCT 116 C44(0.77); C50(0.77)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C44(0.87); C50(0.87)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C44(0.90); C50(0.90)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C44(0.87); C49(0.87); C50(0.91)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C44(0.74); C49(0.74); C50(1.11)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C44(0.90); C49(0.90); C50(1.02)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C50(1.01); C44(1.07); C49(1.07)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C44(0.79); C49(0.79); C50(1.07)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C44(0.85); C49(0.85); C50(1.12)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C44(0.99); C49(0.99); C50(1.00)  LDD0586  [3]
 LDCM0270  AC15 HEK-293T C44(1.15); C49(1.15)  LDD0868  [3]
 LDCM0271  AC150 HCT 116 C50(0.99); C44(1.03); C49(1.03)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C44(0.67); C49(0.67); C50(1.00)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C50(0.90); C44(1.25); C49(1.25)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C44(0.97); C49(0.97); C50(1.02)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C44(0.83); C49(0.83); C50(1.01)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C44(0.70); C49(0.70); C50(1.05)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C44(0.83); C49(0.83); C50(1.12)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C44(0.81); C49(0.81); C50(0.98)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C50(0.96); C44(1.04)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C50(0.75); C44(0.83)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C50(1.02); C44(1.02)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C50(0.90)  LDD1518  [16]
 LDCM0280  AC20 HCT 116 C44(0.82); C50(0.82)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C44(0.89); C50(1.01)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C44(0.91); C50(0.91)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C44(0.81); C50(0.82)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C44(1.08); C50(1.17)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C49(1.03)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C49(1.13)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C49(1.16)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C49(1.29)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C49(1.33)  LDD0606  [3]
 LDCM0291  AC30 HCT 116 C49(1.31)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C49(1.28)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C49(1.49)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C49(1.16)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C49(1.17)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C44(0.74); C49(0.75)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C44(0.66); C49(0.93)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C44(0.64); C49(0.79)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C49(0.77); C44(0.83)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C44(0.73); C49(0.82)  LDD0617  [3]
 LDCM0302  AC40 HCT 116 C44(0.48); C49(0.59)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C44(0.74); C49(1.20)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C44(0.87); C49(0.94)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C44(0.61); C49(0.99)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C44(0.56); C49(1.04)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C44(0.61); C49(0.85)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C50(0.85); C49(1.05)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C49(0.71); C50(0.73)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C49(0.73); C50(0.99)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C50(0.58); C49(1.03)  LDD0628  [3]
 LDCM0313  AC50 HCT 116 C50(0.58); C49(0.94)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C49(0.88); C50(0.95)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C50(0.74); C49(0.83)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C49(0.67); C50(0.71)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C50(0.62); C49(0.64)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C50(0.69); C49(0.91)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C49(0.56); C50(0.65)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C44(0.97); C49(0.99)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C49(0.84); C44(0.98)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C49(0.91); C44(0.99)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C44(1.28); C49(1.28)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C49(0.81); C44(1.01)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C49(0.89); C44(0.91)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C49(0.73); C44(0.94)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C49(0.86); C44(1.03)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C49(0.99); C44(1.07)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C49(0.79); C44(0.94)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C49(0.94); C44(0.98)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C49(0.53); C44(0.76)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C44(0.96); C50(0.96)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C44(1.05); C50(1.05)  LDD0650  [3]
 LDCM0334  AC7 HEK-293T C44(1.41); C49(1.41)  LDD0932  [3]
 LDCM0335  AC70 HCT 116 C44(1.00); C50(1.00)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C44(0.99); C50(0.99)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C44(0.89); C50(0.89)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C44(0.83); C50(0.83)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C44(0.81); C50(0.81)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C44(0.86); C50(0.86)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C44(1.02); C50(1.02)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C44(1.06); C50(1.06)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C44(0.99); C50(0.99)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C44(1.02); C50(1.02)  LDD0661  [3]
 LDCM0345  AC8 HEK-293T C44(1.30); C49(1.30)  LDD0943  [3]
 LDCM0346  AC80 HCT 116 C44(1.04); C50(1.04)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C44(0.93); C50(0.93)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C44(0.92); C50(0.92)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C50(0.62)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C50(0.66)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C50(1.05)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C50(1.03)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C50(0.98)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C50(0.88)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C50(0.81)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C50(0.98)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C50(0.57)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C50(0.60)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C50(0.87)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C50(1.03)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C50(1.10)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C50(0.86)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C50(0.79)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C49(0.80); C44(0.95)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C49(0.70); C44(0.89)  LDD0683  [3]
 LDCM0248  AKOS034007472 HEK-293T C44(1.41); C49(1.41)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C44(1.10); C49(1.10)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C44(1.38); C49(1.38)  LDD0873  [3]
 LDCM0020  ARS-1620 HCC44 C44(1.24)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C44(1.06); C49(1.06)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C44(1.04); C49(1.04)  LDD0966  [3]
 LDCM0370  CL101 HEK-293T C44(1.39); C49(1.39)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C44(1.31); C49(1.31)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C44(1.26); C49(1.26)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C44(1.20); C49(1.20)  LDD0971  [3]
 LDCM0374  CL105 HCT 116 C50(1.01); C44(1.08)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C44(0.81); C50(0.85)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C44(0.80); C50(0.81)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C50(0.87); C44(0.95)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C44(0.90); C50(1.06)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C44(0.90); C49(0.90)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C50(1.04); C44(1.08)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C50(0.88); C44(0.95)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C49(1.16)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C49(1.30)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C49(1.38)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C49(1.28)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C49(1.08)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C44(0.51); C49(0.63)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C44(0.83); C49(0.87)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C49(0.82); C44(0.84)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C44(0.69); C49(0.69)  LDD0988  [3]
 LDCM0391  CL120 HCT 116 C44(0.60); C49(0.94)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C50(0.55); C49(0.76)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C49(0.74); C50(0.83)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C49(0.52); C50(0.60)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C49(0.65); C50(0.68)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C44(1.25); C49(1.44)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C49(1.20); C44(1.21)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C49(1.11); C44(1.13)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C49(0.84); C44(0.91)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C44(0.84); C49(0.84)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C44(0.98); C49(0.98)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C44(1.16); C49(1.16)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C44(1.04); C49(1.04)  LDD0720  [3]
 LDCM0404  CL17 PaTu 8988t C50(0.50); C44(0.50)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C50(0.47); C44(0.47)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C50(0.86); C44(0.86)  LDD1285  [3]
 LDCM0407  CL2 HEK-293T C44(0.90); C49(0.90)  LDD1005  [3]
 LDCM0408  CL20 PaTu 8988t C50(0.59); C44(0.59)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C50(0.68); C44(0.68)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C50(0.74); C44(0.74)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C50(0.47); C44(0.47)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C50(0.72); C44(0.72)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C50(0.75); C44(0.75)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C50(0.56); C44(0.56)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C50(0.73); C44(0.73)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C50(0.79); C44(0.79)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C50(0.62); C44(0.62)  LDD1296  [3]
 LDCM0418  CL3 HEK-293T C44(0.83); C49(0.83)  LDD1016  [3]
 LDCM0419  CL30 PaTu 8988t C50(0.60); C44(0.60)  LDD1298  [3]
 LDCM0421  CL32 HCT 116 C44(1.03); C49(1.03)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C44(1.13); C49(1.13)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C44(1.61); C49(1.61)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C44(1.07); C49(1.07)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C44(1.65); C49(1.65)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C44(0.72); C49(0.72)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C44(1.16); C49(1.16)  LDD0745  [3]
 LDCM0429  CL4 HEK-293T C44(1.03); C49(1.03)  LDD1027  [3]
 LDCM0430  CL40 HCT 116 C44(0.88); C49(0.88)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C44(1.31); C49(1.31)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C44(1.13); C49(1.13)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C44(1.13); C49(1.13)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C44(0.93); C49(0.93)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C44(1.08); C49(1.08)  LDD0752  [3]
 LDCM0439  CL49 HEK-293T C50(1.19)  LDD1643  [16]
 LDCM0440  CL5 HEK-293T C44(0.88); C49(0.88)  LDD1038  [3]
 LDCM0444  CL53 HEK-293T C50(1.12)  LDD1647  [16]
 LDCM0445  CL54 HEK-293T C50(1.22)  LDD1648  [16]
 LDCM0451  CL6 HEK-293T C44(0.93); C49(0.93)  LDD1049  [3]
 LDCM0453  CL61 HCT 116 C50(1.18)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C50(1.22)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C50(1.25)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C50(1.44)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C50(1.19)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C50(1.19)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C50(1.14)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C50(1.04)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C50(1.28)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C44(0.86); C49(0.86)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C50(0.94)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C50(1.11)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C50(1.25)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C50(1.21)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C50(1.14)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C44(1.14); C49(0.99); C50(0.98)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C44(1.28); C49(1.38); C50(0.95)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C44(1.17); C49(1.08); C50(0.96)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C44(1.27); C49(1.27); C50(0.96)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C44(1.27); C49(0.58)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C44(1.29); C49(1.19); C50(0.90)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C44(1.25); C49(1.32); C50(0.95)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C44(1.37); C49(1.26); C50(0.96)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C44(1.03); C49(0.94); C50(0.86)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C44(1.15); C49(1.03); C50(0.91)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C44(1.17); C49(1.16); C50(0.89)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C44(1.14); C49(1.09); C50(0.99)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C44(1.09); C49(0.98); C50(0.86)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C44(1.11); C49(0.99); C50(0.87)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C44(1.32); C49(1.19); C50(0.82)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C44(1.31); C49(0.79)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C44(1.29); C49(1.28); C50(1.19)  LDD0802  [3]
 LDCM0492  CL97 HEK-293T C50(1.10)  LDD1695  [16]
 LDCM0468  Fragment33 HCT 116 C50(1.17)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C44(1.17); C49(1.17)  LDD0744  [3]
 LDCM0022  KB02 HCT 116 C44(4.72); C50(4.72)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C44(5.68); C50(5.68)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C44(6.30); C50(6.30)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C44(1.05); C49(1.05)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha/beta hydrolase domain-containing protein 17C (ABHD17C) ABHD17 family Q6PCB6
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
COP9 signalosome complex subunit 3 (COPS3) CSN3 family Q9UNS2
Probable ATP-dependent RNA helicase DDX20 (DDX20) DEAD box helicase family Q9UHI6
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Parkinson disease protein 7 (PARK7) Peptidase C56 family Q99497
Zinc-regulated GTPase metalloprotein activator 1C (ZNG1C) SIMIBI class G3E GTPase family Q5JTY5
Ras-related protein Rab-38 (RAB38) Rab family P57729
TNF receptor-associated factor 4 (TRAF4) TNF receptor-associated factor family Q9BUZ4
GTPase Era, mitochondrial (ERAL1) Era GTPase family O75616
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
ATPase inhibitor, mitochondrial (ATP5IF1) ATPase inhibitor family Q9UII2
MyoD family inhibitor (MDFI) MDFI family Q99750
Solute carrier family 52, riboflavin transporter, member 3 (SLC52A3) Riboflavin transporter family Q9NQ40
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deoxynucleotidyltransferase terminal-interacting protein 1 (DNTTIP1) . Q9H147
Forkhead box protein R1 (FOXR1) . Q6PIV2
Myeloid cell nuclear differentiation antigen (MNDA) . P41218
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
DAP3-binding cell death enhancer 1 (DELE1) DELE1 family Q14154
Golgi phosphoprotein 3-like (GOLPH3L) GOLPH3/VPS74 family Q9H4A5
Histone H2A.Z (H2AZ1) Histone H2A family P0C0S5
Keratin-associated protein 10-7 (KRTAP10-7) KRTAP type 10 family P60409
Keratin-associated protein 19-1 (KRTAP19-1) KRTAP type 19 family Q8IUB9
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Prolactin-inducible protein (PIP) PIP family P12273
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1) SNF5 family Q12824
Charged multivesicular body protein 6 (CHMP6) SNF7 family Q96FZ7
Syntaxin-11 (STX11) Syntaxin family O75558
Torsin-1A-interacting protein 1 (TOR1AIP1) TOR1AIP family Q5JTV8
Torsin-1A-interacting protein 2 (TOR1AIP2) TOR1AIP family Q8NFQ8
C-type lectin domain family 2 member B (CLEC2B) . Q92478
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Insulin-like growth factor-binding protein 4 (IGFBP4) . P22692
IQ motif and ubiquitin-like domain-containing protein (IQUB) . Q8NA54
PDZK1-interacting protein 1 (PDZK1IP1) . Q13113
Protein MGARP (MGARP) . Q8TDB4
Spermatogenesis-associated protein 12 (SPATA12) . Q7Z6I5

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
8 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
16 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402