Details of the Target

General Information of Target

Target ID LDTP06413
Target Name Microtubule-associated protein RP/EB family member 2 (MAPRE2)
Gene Name MAPRE2
Gene ID 10982
Synonyms
RP1; Microtubule-associated protein RP/EB family member 2; APC-binding protein EB2; End-binding protein 2; EB2
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MPGPTQTLSPNGENNNDIIQDNNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSR
HDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKL
LQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQGQDAIP
PPDPGEQIFNLPKKSHHANSPTAGAAKSSPAAKPGSTPSRPSSAKRASSSGSASKSDKDL
ETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQENDDLVQRLMDILYAS
EEHEGHTEEPEAEEQAHEQQPPQQEEY
Target Bioclass
Other
Family
MAPRE family
Subcellular location
Cytoplasm, cytoskeleton
Function May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.
Uniprot ID
Q15555
Ensemble ID
ENST00000300249.10
HGNC ID
HGNC:6891

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.S39Y .
CAL62 SNV: p.I245V .
LNCaP clone FGC SNV: p.Y75C DBIA    Probe Info 
MEWO SNV: p.S195F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y158(20.00); Y162(20.00); Y167(20.00); Y114(8.30)  LDD0257  [1]
TH216
 Probe Info  		Y162(20.00)  LDD0259  [1]
STPyne
 Probe Info  		K138(7.67); K194(9.98)  LDD0277  [2]
Probe 1
 Probe Info  		Y268(174.09)  LDD3495  [3]
DBIA
 Probe Info  		C279(1.66)  LDD3331  [4]
BTD
 Probe Info  		C279(1.03)  LDD2127  [5]
Acrolein
 Probe Info  		H112(0.00); H197(0.00)  LDD0221  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
ATP probe
 Probe Info  		K138(0.00); K141(0.00)  LDD0199  [8]
m-APA
 Probe Info  		H196(0.00); H197(0.00)  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
IPM
 Probe Info  		N.A.  LDD2156  [10]
NHS
 Probe Info  		N.A.  LDD0010  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
Ox-W18
 Probe Info  		N.A.  LDD2175  [13]
1c-yne
 Probe Info  		K156(0.00); K165(0.00)  LDD0228  [14]
1d-yne
 Probe Info  		N.A.  LDD0357  [14]
AOyne
 Probe Info  		15.00  LDD0443  [15]
HHS-465
 Probe Info  		N.A.  LDD2240  [16]
PAL-AfBPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C194
 Probe Info  		9.25  LDD1870  [17]
C231
 Probe Info  		16.11  LDD1904  [17]
C232
 Probe Info  		39.95  LDD1905  [17]
C233
 Probe Info  		10.93  LDD1906  [17]
C277
 Probe Info  		10.56  LDD1947  [17]
C289
 Probe Info  		29.65  LDD1959  [17]
C310
 Probe Info  		11.79  LDD1977  [17]
FFF probe11
 Probe Info  		12.30  LDD0472  [18]
FFF probe13
 Probe Info  		17.31  LDD0475  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
FFF probe3
 Probe Info  		12.29  LDD0465  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C98(0.92)  LDD0812  [20]
 LDCM0215  AC10 HEK-293T C279(0.96); C88(1.13)  LDD1508  [21]
 LDCM0226  AC11 HEK-293T C279(0.99); C98(1.02)  LDD1509  [21]
 LDCM0230  AC113 HEK-293T C98(0.69)  LDD0828  [20]
 LDCM0231  AC114 HEK-293T C98(1.06)  LDD0829  [20]
 LDCM0232  AC115 HEK-293T C98(0.88)  LDD0830  [20]
 LDCM0233  AC116 HEK-293T C98(1.05)  LDD0831  [20]
 LDCM0234  AC117 HEK-293T C98(0.89)  LDD0832  [20]
 LDCM0235  AC118 HEK-293T C98(0.65)  LDD0833  [20]
 LDCM0236  AC119 HEK-293T C98(0.76)  LDD0834  [20]
 LDCM0237  AC12 HEK-293T C279(1.03); C88(1.02)  LDD1510  [21]
 LDCM0238  AC120 HEK-293T C98(1.08)  LDD0836  [20]
 LDCM0239  AC121 HEK-293T C98(0.57)  LDD0837  [20]
 LDCM0240  AC122 HEK-293T C98(0.28)  LDD0838  [20]
 LDCM0241  AC123 HEK-293T C98(0.28)  LDD0839  [20]
 LDCM0242  AC124 HEK-293T C98(0.70)  LDD0840  [20]
 LDCM0243  AC125 HEK-293T C98(0.27)  LDD0841  [20]
 LDCM0244  AC126 HEK-293T C98(0.31)  LDD0842  [20]
 LDCM0245  AC127 HEK-293T C98(0.36)  LDD0843  [20]
 LDCM0246  AC128 HEK-293T C98(0.83)  LDD0844  [20]
 LDCM0247  AC129 HEK-293T C98(1.36)  LDD0845  [20]
 LDCM0249  AC130 HEK-293T C98(1.16)  LDD0847  [20]
 LDCM0250  AC131 HEK-293T C98(1.33)  LDD0848  [20]
 LDCM0251  AC132 HEK-293T C98(1.17)  LDD0849  [20]
 LDCM0252  AC133 HEK-293T C98(0.67)  LDD0850  [20]
 LDCM0253  AC134 HEK-293T C98(1.22)  LDD0851  [20]
 LDCM0254  AC135 HEK-293T C98(0.91)  LDD0852  [20]
 LDCM0255  AC136 HEK-293T C98(1.08)  LDD0853  [20]
 LDCM0256  AC137 HEK-293T C98(0.37)  LDD0854  [20]
 LDCM0257  AC138 HEK-293T C98(0.35)  LDD0855  [20]
 LDCM0258  AC139 HEK-293T C98(0.39)  LDD0856  [20]
 LDCM0259  AC14 HEK-293T C279(1.03); C88(1.13)  LDD1512  [21]
 LDCM0260  AC140 HEK-293T C98(0.73)  LDD0858  [20]
 LDCM0261  AC141 HEK-293T C98(0.37)  LDD0859  [20]
 LDCM0262  AC142 HEK-293T C98(0.84)  LDD0860  [20]
 LDCM0263  AC143 HEK-293T C98(0.87)  LDD0861  [20]
 LDCM0264  AC144 HEK-293T C98(0.41)  LDD0862  [20]
 LDCM0265  AC145 HEK-293T C98(0.33)  LDD0863  [20]
 LDCM0266  AC146 HEK-293T C98(0.32)  LDD0864  [20]
 LDCM0267  AC147 HEK-293T C98(0.29)  LDD0865  [20]
 LDCM0268  AC148 HEK-293T C98(0.28)  LDD0866  [20]
 LDCM0269  AC149 HEK-293T C98(0.83)  LDD0867  [20]
 LDCM0270  AC15 HEK-293T C279(0.90)  LDD1513  [21]
 LDCM0271  AC150 HEK-293T C98(0.59)  LDD0869  [20]
 LDCM0272  AC151 HEK-293T C98(0.52)  LDD0870  [20]
 LDCM0273  AC152 HEK-293T C98(0.94)  LDD0871  [20]
 LDCM0274  AC153 HEK-293T C98(0.49)  LDD0872  [20]
 LDCM0621  AC154 HEK-293T C98(1.57)  LDD2162  [20]
 LDCM0622  AC155 HEK-293T C98(0.95)  LDD2163  [20]
 LDCM0623  AC156 HEK-293T C98(0.36)  LDD2164  [20]
 LDCM0624  AC157 HEK-293T C98(0.41)  LDD2165  [20]
 LDCM0276  AC17 HEK-293T C98(1.39)  LDD0874  [20]
 LDCM0277  AC18 HEK-293T C98(1.59)  LDD0875  [20]
 LDCM0278  AC19 HEK-293T C98(1.70)  LDD0876  [20]
 LDCM0279  AC2 HEK-293T C98(0.99)  LDD0877  [20]
 LDCM0280  AC20 HEK-293T C98(1.49)  LDD0878  [20]
 LDCM0281  AC21 HEK-293T C98(0.94)  LDD0879  [20]
 LDCM0282  AC22 HEK-293T C98(1.48)  LDD0880  [20]
 LDCM0283  AC23 HEK-293T C98(0.88)  LDD0881  [20]
 LDCM0284  AC24 HEK-293T C98(1.96)  LDD0882  [20]
 LDCM0285  AC25 PaTu 8988t C82(0.88); C88(0.88); C98(0.88)  LDD1164  [20]
 LDCM0286  AC26 PaTu 8988t C82(0.86); C88(0.86); C98(0.86)  LDD1165  [20]
 LDCM0287  AC27 PaTu 8988t C82(1.03); C88(1.03); C98(1.03)  LDD1166  [20]
 LDCM0288  AC28 PaTu 8988t C82(0.94); C88(0.94); C98(0.94)  LDD1167  [20]
 LDCM0289  AC29 PaTu 8988t C82(0.81); C88(0.81); C98(0.81)  LDD1168  [20]
 LDCM0290  AC3 HEK-293T C98(0.84)  LDD0888  [20]
 LDCM0291  AC30 PaTu 8988t C82(1.00); C88(1.00); C98(1.00)  LDD1170  [20]
 LDCM0292  AC31 PaTu 8988t C82(0.88); C88(0.88); C98(0.88)  LDD1171  [20]
 LDCM0293  AC32 PaTu 8988t C82(1.09); C88(1.09); C98(1.09)  LDD1172  [20]
 LDCM0294  AC33 PaTu 8988t C82(0.91); C88(0.91); C98(0.91)  LDD1173  [20]
 LDCM0295  AC34 PaTu 8988t C82(1.06); C88(1.06); C98(1.06)  LDD1174  [20]
 LDCM0296  AC35 PaTu 8988t C82(0.77); C88(0.77); C98(0.77)  LDD1175  [20]
 LDCM0297  AC36 PaTu 8988t C82(0.69); C88(0.69); C98(0.69)  LDD1176  [20]
 LDCM0298  AC37 PaTu 8988t C82(0.80); C88(0.80); C98(0.80)  LDD1177  [20]
 LDCM0299  AC38 PaTu 8988t C82(0.64); C88(0.64); C98(0.64)  LDD1178  [20]
 LDCM0300  AC39 PaTu 8988t C82(0.68); C88(0.68); C98(0.68)  LDD1179  [20]
 LDCM0301  AC4 HEK-293T C98(0.98)  LDD0899  [20]
 LDCM0302  AC40 PaTu 8988t C82(0.64); C88(0.64); C98(0.64)  LDD1181  [20]
 LDCM0303  AC41 PaTu 8988t C82(0.87); C88(0.87); C98(0.87)  LDD1182  [20]
 LDCM0304  AC42 PaTu 8988t C82(0.88); C88(0.88); C98(0.88)  LDD1183  [20]
 LDCM0305  AC43 PaTu 8988t C82(0.83); C88(0.83); C98(0.83)  LDD1184  [20]
 LDCM0306  AC44 PaTu 8988t C82(0.85); C88(0.85); C98(0.85)  LDD1185  [20]
 LDCM0307  AC45 PaTu 8988t C82(0.72); C88(0.72); C98(0.72)  LDD1186  [20]
 LDCM0308  AC46 PaTu 8988t C82(0.61); C88(0.77); C98(0.77)  LDD1187  [20]
 LDCM0309  AC47 PaTu 8988t C82(0.54); C88(0.57); C98(0.57)  LDD1188  [20]
 LDCM0310  AC48 PaTu 8988t C82(0.51); C88(0.60); C98(0.60)  LDD1189  [20]
 LDCM0311  AC49 PaTu 8988t C82(0.53); C88(0.63); C98(0.63)  LDD1190  [20]
 LDCM0312  AC5 HEK-293T C98(1.37)  LDD0910  [20]
 LDCM0313  AC50 PaTu 8988t C82(0.59); C88(0.65); C98(0.65)  LDD1192  [20]
 LDCM0314  AC51 PaTu 8988t C82(1.22); C88(0.97); C98(0.97)  LDD1193  [20]
 LDCM0315  AC52 PaTu 8988t C82(0.53); C88(0.66); C98(0.66)  LDD1194  [20]
 LDCM0316  AC53 PaTu 8988t C82(0.63); C88(0.73); C98(0.73)  LDD1195  [20]
 LDCM0317  AC54 PaTu 8988t C82(0.64); C88(0.69); C98(0.69)  LDD1196  [20]
 LDCM0318  AC55 PaTu 8988t C82(0.55); C88(0.65); C98(0.65)  LDD1197  [20]
 LDCM0319  AC56 PaTu 8988t C82(0.59); C88(0.73); C98(0.73)  LDD1198  [20]
 LDCM0320  AC57 HEK-293T C98(0.88)  LDD0918  [20]
 LDCM0321  AC58 HEK-293T C98(1.00)  LDD0919  [20]
 LDCM0322  AC59 HEK-293T C98(1.07)  LDD0920  [20]
 LDCM0323  AC6 HEK-293T C279(1.05); C88(1.06)  LDD1562  [21]
 LDCM0324  AC60 HEK-293T C98(0.84)  LDD0922  [20]
 LDCM0325  AC61 HEK-293T C98(0.98)  LDD0923  [20]
 LDCM0326  AC62 HEK-293T C98(1.00)  LDD0924  [20]
 LDCM0327  AC63 HEK-293T C98(0.90)  LDD0925  [20]
 LDCM0328  AC64 HEK-293T C98(1.06)  LDD0926  [20]
 LDCM0329  AC65 HEK-293T C98(0.86)  LDD0927  [20]
 LDCM0330  AC66 HEK-293T C98(0.99)  LDD0928  [20]
 LDCM0331  AC67 HEK-293T C98(1.29)  LDD0929  [20]
 LDCM0332  AC68 PaTu 8988t C82(0.90); C88(0.90); C98(0.90)  LDD1211  [20]
 LDCM0333  AC69 PaTu 8988t C82(0.78); C88(0.78); C98(0.78)  LDD1212  [20]
 LDCM0334  AC7 HEK-293T C279(0.96)  LDD1568  [21]
 LDCM0335  AC70 PaTu 8988t C82(0.90); C88(0.90); C98(0.90)  LDD1214  [20]
 LDCM0336  AC71 PaTu 8988t C82(0.87); C88(0.87); C98(0.87)  LDD1215  [20]
 LDCM0337  AC72 PaTu 8988t C82(1.04); C88(1.04); C98(1.04)  LDD1216  [20]
 LDCM0338  AC73 PaTu 8988t C82(1.07); C88(1.07); C98(1.07)  LDD1217  [20]
 LDCM0339  AC74 PaTu 8988t C82(0.96); C88(0.96); C98(0.96)  LDD1218  [20]
 LDCM0340  AC75 PaTu 8988t C82(0.84); C88(0.84); C98(0.84)  LDD1219  [20]
 LDCM0341  AC76 PaTu 8988t C82(0.91); C88(0.91); C98(0.91)  LDD1220  [20]
 LDCM0342  AC77 PaTu 8988t C82(0.87); C88(0.87); C98(0.87)  LDD1221  [20]
 LDCM0343  AC78 PaTu 8988t C82(0.93); C88(0.93); C98(0.93)  LDD1222  [20]
 LDCM0344  AC79 PaTu 8988t C82(0.89); C88(0.89); C98(0.89)  LDD1223  [20]
 LDCM0345  AC8 HEK-293T C279(0.99); C88(1.16)  LDD1569  [21]
 LDCM0346  AC80 PaTu 8988t C82(0.93); C88(0.93); C98(0.93)  LDD1225  [20]
 LDCM0347  AC81 PaTu 8988t C82(0.94); C88(0.94); C98(0.94)  LDD1226  [20]
 LDCM0348  AC82 PaTu 8988t C82(0.97); C88(0.97); C98(0.97)  LDD1227  [20]
 LDCM0349  AC83 HEK-293T C98(0.82)  LDD0947  [20]
 LDCM0350  AC84 HEK-293T C98(1.07)  LDD0948  [20]
 LDCM0351  AC85 HEK-293T C98(1.18)  LDD0949  [20]
 LDCM0352  AC86 HEK-293T C98(0.83)  LDD0950  [20]
 LDCM0353  AC87 HEK-293T C98(0.95)  LDD0951  [20]
 LDCM0354  AC88 HEK-293T C98(0.73)  LDD0952  [20]
 LDCM0355  AC89 HEK-293T C98(0.60)  LDD0953  [20]
 LDCM0357  AC90 HEK-293T C98(0.88)  LDD0955  [20]
 LDCM0358  AC91 HEK-293T C98(0.78)  LDD0956  [20]
 LDCM0359  AC92 HEK-293T C98(1.28)  LDD0957  [20]
 LDCM0360  AC93 HEK-293T C98(1.15)  LDD0958  [20]
 LDCM0361  AC94 HEK-293T C98(0.48)  LDD0959  [20]
 LDCM0362  AC95 HEK-293T C98(0.88)  LDD0960  [20]
 LDCM0363  AC96 HEK-293T C98(1.18)  LDD0961  [20]
 LDCM0364  AC97 HEK-293T C98(0.19)  LDD0962  [20]
 LDCM0248  AKOS034007472 HEK-293T C279(1.03); C82(0.95)  LDD1511  [21]
 LDCM0356  AKOS034007680 HEK-293T C279(0.94); C82(0.96); C88(1.15)  LDD1570  [21]
 LDCM0275  AKOS034007705 HEK-293T C279(1.02); C88(0.98)  LDD1514  [21]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [6]
 LDCM0367  CL1 HEK-293T C98(1.53)  LDD0965  [20]
 LDCM0368  CL10 HEK-293T C98(0.35)  LDD0966  [20]
 LDCM0369  CL100 HEK-293T C98(0.87)  LDD0967  [20]
 LDCM0370  CL101 HEK-293T C279(1.06); C82(1.38); C88(1.07)  LDD1574  [21]
 LDCM0371  CL102 HEK-293T C279(0.89); C88(0.95)  LDD1575  [21]
 LDCM0372  CL103 HEK-293T C279(1.05); C88(0.95)  LDD1576  [21]
 LDCM0373  CL104 HEK-293T C279(1.04); C88(1.11)  LDD1577  [21]
 LDCM0374  CL105 HEK-293T C98(1.22)  LDD0972  [20]
 LDCM0375  CL106 HEK-293T C98(1.04)  LDD0973  [20]
 LDCM0376  CL107 HEK-293T C98(1.60)  LDD0974  [20]
 LDCM0377  CL108 HEK-293T C98(1.08)  LDD0975  [20]
 LDCM0378  CL109 HEK-293T C98(1.01)  LDD0976  [20]
 LDCM0379  CL11 HEK-293T C98(0.27)  LDD0977  [20]
 LDCM0380  CL110 HEK-293T C98(0.95)  LDD0978  [20]
 LDCM0381  CL111 HEK-293T C98(1.26)  LDD0979  [20]
 LDCM0382  CL112 PaTu 8988t C82(0.82); C88(0.82); C98(0.82)  LDD1261  [20]
 LDCM0383  CL113 PaTu 8988t C82(1.04); C88(1.04); C98(1.04)  LDD1262  [20]
 LDCM0384  CL114 PaTu 8988t C82(0.89); C88(0.89); C98(0.89)  LDD1263  [20]
 LDCM0385  CL115 PaTu 8988t C82(0.80); C88(0.80); C98(0.80)  LDD1264  [20]
 LDCM0386  CL116 PaTu 8988t C82(0.75); C88(0.75); C98(0.75)  LDD1265  [20]
 LDCM0387  CL117 PaTu 8988t C82(0.83); C88(0.83); C98(0.83)  LDD1266  [20]
 LDCM0388  CL118 PaTu 8988t C82(1.07); C88(1.07); C98(1.07)  LDD1267  [20]
 LDCM0389  CL119 PaTu 8988t C82(0.89); C88(0.89); C98(0.89)  LDD1268  [20]
 LDCM0390  CL12 HEK-293T C98(1.26)  LDD0988  [20]
 LDCM0391  CL120 PaTu 8988t C82(1.02); C88(1.02); C98(1.02)  LDD1270  [20]
 LDCM0392  CL121 PaTu 8988t C82(0.61); C88(0.63); C98(0.63)  LDD1271  [20]
 LDCM0393  CL122 PaTu 8988t C82(0.57); C88(0.82); C98(0.82)  LDD1272  [20]
 LDCM0394  CL123 PaTu 8988t C82(0.53); C88(0.57); C98(0.57)  LDD1273  [20]
 LDCM0395  CL124 PaTu 8988t C82(0.56); C88(0.63); C98(0.63)  LDD1274  [20]
 LDCM0396  CL125 HEK-293T C98(0.90)  LDD0994  [20]
 LDCM0397  CL126 HEK-293T C98(0.58)  LDD0995  [20]
 LDCM0398  CL127 HEK-293T C98(0.75)  LDD0996  [20]
 LDCM0399  CL128 HEK-293T C98(1.05)  LDD0997  [20]
 LDCM0400  CL13 HEK-293T C98(0.96)  LDD0998  [20]
 LDCM0401  CL14 HEK-293T C98(1.10)  LDD0999  [20]
 LDCM0402  CL15 HEK-293T C98(0.77)  LDD1000  [20]
 LDCM0403  CL16 HEK-293T C98(1.53)  LDD1001  [20]
 LDCM0404  CL17 HEK-293T C98(0.95)  LDD1002  [20]
 LDCM0405  CL18 HEK-293T C98(1.33)  LDD1003  [20]
 LDCM0406  CL19 HEK-293T C98(0.97)  LDD1004  [20]
 LDCM0407  CL2 HEK-293T C98(1.10)  LDD1005  [20]
 LDCM0408  CL20 HEK-293T C98(1.30)  LDD1006  [20]
 LDCM0409  CL21 HEK-293T C98(0.63)  LDD1007  [20]
 LDCM0410  CL22 HEK-293T C98(0.67)  LDD1008  [20]
 LDCM0411  CL23 HEK-293T C98(0.91)  LDD1009  [20]
 LDCM0412  CL24 HEK-293T C98(1.27)  LDD1010  [20]
 LDCM0413  CL25 HEK-293T C98(0.89)  LDD1011  [20]
 LDCM0414  CL26 HEK-293T C98(1.16)  LDD1012  [20]
 LDCM0415  CL27 HEK-293T C98(0.84)  LDD1013  [20]
 LDCM0416  CL28 HEK-293T C98(0.67)  LDD1014  [20]
 LDCM0417  CL29 HEK-293T C98(1.03)  LDD1015  [20]
 LDCM0418  CL3 HEK-293T C98(1.41)  LDD1016  [20]
 LDCM0419  CL30 HEK-293T C98(0.23)  LDD1017  [20]
 LDCM0420  CL31 PaTu 8988t C82(0.92); C88(0.92); C98(0.92)  LDD1299  [20]
 LDCM0421  CL32 PaTu 8988t C82(0.78); C88(0.78); C98(0.78)  LDD1300  [20]
 LDCM0422  CL33 PaTu 8988t C82(0.65); C88(0.65); C98(0.65)  LDD1301  [20]
 LDCM0423  CL34 PaTu 8988t C82(0.75); C88(0.75); C98(0.75)  LDD1302  [20]
 LDCM0424  CL35 PaTu 8988t C82(0.78); C88(0.78); C98(0.78)  LDD1303  [20]
 LDCM0425  CL36 PaTu 8988t C82(0.28); C88(0.28); C98(0.28)  LDD1304  [20]
 LDCM0426  CL37 PaTu 8988t C82(0.64); C88(0.64); C98(0.64)  LDD1305  [20]
 LDCM0428  CL39 PaTu 8988t C82(0.67); C88(0.67); C98(0.67)  LDD1307  [20]
 LDCM0429  CL4 HEK-293T C98(1.03)  LDD1027  [20]
 LDCM0430  CL40 PaTu 8988t C82(0.78); C88(0.78); C98(0.78)  LDD1309  [20]
 LDCM0431  CL41 PaTu 8988t C82(0.62); C88(0.62); C98(0.62)  LDD1310  [20]
 LDCM0432  CL42 PaTu 8988t C82(0.71); C88(0.71); C98(0.71)  LDD1311  [20]
 LDCM0433  CL43 PaTu 8988t C82(0.64); C88(0.64); C98(0.64)  LDD1312  [20]
 LDCM0434  CL44 PaTu 8988t C82(0.69); C88(0.69); C98(0.69)  LDD1313  [20]
 LDCM0435  CL45 PaTu 8988t C82(0.64); C88(0.64); C98(0.64)  LDD1314  [20]
 LDCM0436  CL46 HEK-293T C98(1.62)  LDD1034  [20]
 LDCM0437  CL47 HEK-293T C98(1.14)  LDD1035  [20]
 LDCM0438  CL48 HEK-293T C98(1.35)  LDD1036  [20]
 LDCM0439  CL49 HEK-293T C98(0.92)  LDD1037  [20]
 LDCM0440  CL5 HEK-293T C98(1.41)  LDD1038  [20]
 LDCM0441  CL50 HEK-293T C98(0.32)  LDD1039  [20]
 LDCM0442  CL51 HEK-293T C98(0.84)  LDD1040  [20]
 LDCM0443  CL52 HEK-293T C98(1.28)  LDD1041  [20]
 LDCM0444  CL53 HEK-293T C98(0.94)  LDD1042  [20]
 LDCM0445  CL54 HEK-293T C98(0.84)  LDD1043  [20]
 LDCM0446  CL55 HEK-293T C98(1.26)  LDD1044  [20]
 LDCM0447  CL56 HEK-293T C98(1.19)  LDD1045  [20]
 LDCM0448  CL57 HEK-293T C98(0.87)  LDD1046  [20]
 LDCM0449  CL58 HEK-293T C98(0.87)  LDD1047  [20]
 LDCM0450  CL59 HEK-293T C98(0.84)  LDD1048  [20]
 LDCM0451  CL6 HEK-293T C98(0.84)  LDD1049  [20]
 LDCM0452  CL60 HEK-293T C98(0.34)  LDD1050  [20]
 LDCM0453  CL61 HEK-293T C98(1.43)  LDD1051  [20]
 LDCM0454  CL62 HEK-293T C98(1.08)  LDD1052  [20]
 LDCM0455  CL63 HEK-293T C98(1.05)  LDD1053  [20]
 LDCM0456  CL64 HEK-293T C98(1.08)  LDD1054  [20]
 LDCM0457  CL65 HEK-293T C98(1.17)  LDD1055  [20]
 LDCM0458  CL66 HEK-293T C98(0.96)  LDD1056  [20]
 LDCM0459  CL67 HEK-293T C98(0.92)  LDD1057  [20]
 LDCM0460  CL68 HEK-293T C98(0.89)  LDD1058  [20]
 LDCM0461  CL69 HEK-293T C98(0.94)  LDD1059  [20]
 LDCM0462  CL7 HEK-293T C98(1.38)  LDD1060  [20]
 LDCM0463  CL70 HEK-293T C98(0.92)  LDD1061  [20]
 LDCM0464  CL71 HEK-293T C98(0.81)  LDD1062  [20]
 LDCM0465  CL72 HEK-293T C98(1.55)  LDD1063  [20]
 LDCM0466  CL73 HEK-293T C98(0.70)  LDD1064  [20]
 LDCM0467  CL74 HEK-293T C98(0.20)  LDD1065  [20]
 LDCM0469  CL76 HEK-293T C279(1.12); C88(0.83)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C279(0.97); C82(0.95); C88(1.10)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C279(1.12); C88(1.03)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C279(0.96); C98(0.92)  LDD1675  [21]
 LDCM0473  CL8 HEK-293T C98(0.82)  LDD1071  [20]
 LDCM0474  CL80 HEK-293T C279(1.03); C88(1.18)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C279(1.13); C82(0.96)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C279(1.20); C88(1.10)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C279(0.92)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C279(0.96); C88(1.74)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C279(1.02); C82(1.29); C88(1.11)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C279(1.05); C88(1.06)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C279(1.09); C88(1.07)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C279(1.01); C88(0.95)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C279(1.04); C82(1.13); C88(1.02)  LDD1686  [21]
 LDCM0484  CL9 HEK-293T C98(0.83)  LDD1082  [20]
 LDCM0485  CL90 HEK-293T C279(0.97); C88(0.94)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C98(1.29)  LDD1084  [20]
 LDCM0487  CL92 HEK-293T C98(0.82)  LDD1085  [20]
 LDCM0488  CL93 HEK-293T C98(0.92)  LDD1086  [20]
 LDCM0489  CL94 HEK-293T C98(1.18)  LDD1087  [20]
 LDCM0490  CL95 HEK-293T C98(0.86)  LDD1088  [20]
 LDCM0491  CL96 HEK-293T C98(1.02)  LDD1089  [20]
 LDCM0492  CL97 HEK-293T C98(1.11)  LDD1090  [20]
 LDCM0493  CL98 HEK-293T C98(1.01)  LDD1091  [20]
 LDCM0494  CL99 HEK-293T C98(0.80)  LDD1092  [20]
 LDCM0495  E2913 HEK-293T C279(1.17); C88(0.93)  LDD1698  [21]
 LDCM0625  F8 Ramos C279(0.84)  LDD2187  [22]
 LDCM0572  Fragment10 Ramos C279(0.64)  LDD2189  [22]
 LDCM0573  Fragment11 Ramos C279(0.99)  LDD2190  [22]
 LDCM0574  Fragment12 Ramos C279(0.92)  LDD2191  [22]
 LDCM0575  Fragment13 Ramos C279(1.13)  LDD2192  [22]
 LDCM0576  Fragment14 Ramos C279(1.15)  LDD2193  [22]
 LDCM0579  Fragment20 Ramos C279(0.92)  LDD2194  [22]
 LDCM0580  Fragment21 Ramos C279(0.91)  LDD2195  [22]
 LDCM0582  Fragment23 Ramos C279(1.22)  LDD2196  [22]
 LDCM0578  Fragment27 Ramos C279(1.00)  LDD2197  [22]
 LDCM0586  Fragment28 Ramos C279(0.98)  LDD2198  [22]
 LDCM0588  Fragment30 Ramos C279(0.98)  LDD2199  [22]
 LDCM0589  Fragment31 Ramos C279(1.10)  LDD2200  [22]
 LDCM0590  Fragment32 Ramos C279(0.56)  LDD2201  [22]
 LDCM0468  Fragment33 HEK-293T C98(0.94)  LDD1066  [20]
 LDCM0596  Fragment38 Ramos C279(0.95)  LDD2203  [22]
 LDCM0427  Fragment51 PaTu 8988t C82(0.58); C88(0.58); C98(0.58)  LDD1306  [20]
 LDCM0610  Fragment52 Ramos C279(1.20)  LDD2204  [22]
 LDCM0614  Fragment56 Ramos C279(1.04)  LDD2205  [22]
 LDCM0569  Fragment7 Ramos C279(1.07)  LDD2186  [22]
 LDCM0571  Fragment9 Ramos C279(0.69)  LDD2188  [22]
 LDCM0107  IAA HeLa H112(0.00); H197(0.00)  LDD0221  [6]
 LDCM0022  KB02 HEK-293T C279(0.98); C98(1.07); C88(1.07); C98(1.07)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C279(0.95); C98(0.98); C88(1.04); C98(1.04)  LDD1497  [21]
 LDCM0024  KB05 MKN-1 C279(1.66)  LDD3331  [4]
 LDCM0109  NEM HeLa N.A.  LDD0225  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C279(1.03)  LDD2127  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
E3 ubiquitin-protein ligase TRAIP (TRAIP) TRAIP family Q9BWF2
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03
GAS2-like protein 2 (GAS2L2) GAS2 family Q8NHY3
Microtubule-associated protein RP/EB family member 1 (MAPRE1) MAPRE family Q15691
Microtubule-associated protein RP/EB family member 2 (MAPRE2) MAPRE family Q15555
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Cartilage acidic protein 1 (CRTAC1) . Q9NQ79
Rhombotin-2 (LMO2) . P25791
TNF receptor-associated factor 1 (TRAF1) . Q13077

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578