Details of the Target

General Information of Target

Target ID LDTP12369
Target Name Bromodomain-containing protein 7 (BRD7)
Gene Name BRD7
Gene ID 29117
Synonyms
BP75; CELTIX1; Bromodomain-containing protein 7; 75 kDa bromodomain protein; Protein CELTIX-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLQTSNYSLVLSLQFLLLSYDLFVNSFSELLQKTPVIQLVLFIIQDIAVLFNIIIIFLMF
FNTFVFQAGLVNLLFHKFKGTIILTAVYFALSISLHVWVMNLRWKNSNSFIWTDGLQMLF
VFQRLAAVLYCYFYKRTAVRLGDPHFYQDSLWLRKEFMQVRR
Target Type
Literature-reported
Target Bioclass
Other
Subcellular location
Nucleus
Function
Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
TTD ID
T23984
Uniprot ID
Q9NPI1
DrugMap ID
TT07ZS1
Ensemble ID
ENST00000394688.8
HGNC ID
HGNC:14310
ChEMBL ID
CHEMBL3085622

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.A165T .
HT115 SNV: p.A284T .
KMCH1 Insertion: p.E235PfsTer16 DBIA    Probe Info 
NCIH2172 SNV: p.N32I DBIA    Probe Info 
OVK18 SNV: p.T468I .
RL SNV: p.D391G DBIA    Probe Info 
RL952 SNV: p.A450G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C367(3.35)  LDD0168  [1]
DBIA
 Probe Info  		C107(7.30)  LDD0209  [2]
Acrolein
 Probe Info  		N.A.  LDD0227  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		C204(0.00); C338(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C646(0.00); C204(0.00); C574(0.00); C338(0.00)  LDD0037  [4]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
WYneO
 Probe Info  		N.A.  LDD0022  [5]
Compound 10
 Probe Info  		C338(0.00); C574(0.00)  LDD2216  [6]
Compound 11
 Probe Info  		C338(0.00); C574(0.00)  LDD2213  [6]
IPM
 Probe Info  		C367(0.00); C107(0.00)  LDD0005  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Phosphinate-6
 Probe Info  		C338(0.00); C574(0.00); C367(0.00)  LDD0018  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [3]
W1
 Probe Info  		N.A.  LDD0236  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		C367(0.00); C338(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C027
 Probe Info  		10.06  LDD1733  [12]
C266
 Probe Info  		9.92  LDD1937  [12]
C314
 Probe Info  		13.09  LDD1981  [12]
photo_BS
 Probe Info  		2.71  LDD0412  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C367(3.35)  LDD0168  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C107(2.09)  LDD0171  [1]
 LDCM0214  AC1 HEK-293T C107(1.06); C338(0.96); C574(0.99); C646(1.37)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C107(1.02); C338(0.98); C574(1.07); C646(1.07)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C107(1.10); C338(1.01); C574(1.09); C367(1.10)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C107(0.95); C338(1.06); C574(1.00); C646(0.83)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C107(0.95); C338(1.03); C574(1.10); C367(1.23)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C107(1.00); C338(0.95); C574(0.96)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C107(1.02); C338(0.97); C574(1.04); C646(1.93)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C107(1.00); C338(0.96); C574(0.99); C646(1.00)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C107(1.47); C338(1.30); C574(1.07); C367(1.08)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C107(0.93); C338(0.92); C574(1.00); C646(0.95)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C107(0.92); C338(1.13); C574(1.05); C646(0.56)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C338(0.95); C574(1.09); C204(1.27)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C107(0.97); C338(0.97); C574(0.94); C367(1.28)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C107(0.96); C338(0.96); C574(1.02)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C107(0.97); C338(1.08); C574(1.13); C367(1.13)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C107(1.05); C338(1.03); C574(1.07); C646(1.23)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C107(1.01); C338(0.99); C574(1.05); C646(0.99)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C107(0.97); C338(0.98); C574(1.07); C367(1.06)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C107(0.93); C338(1.01); C574(1.08); C646(0.67)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C338(0.93); C574(1.12); C204(1.16)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C107(1.04); C338(0.88); C574(1.04); C367(1.05)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C107(1.01); C338(0.97); C574(0.99); C367(1.11)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C107(0.97); C338(1.04); C574(0.93)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C107(0.95); C338(1.04); C574(1.21); C367(1.14)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C107(1.05); C338(1.00); C574(1.14); C646(1.34)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C107(1.02); C338(1.01); C574(1.06); C646(1.25)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C107(0.99); C338(0.97); C574(1.08); C367(1.13)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C107(0.90); C338(0.95); C574(1.07); C646(0.62)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C338(1.02); C574(1.13); C204(1.04)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C107(0.96); C338(1.06); C574(1.12); C367(1.04)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C107(0.95); C338(0.95); C574(1.05)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C107(0.91); C338(0.94); C574(1.01); C646(0.72)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C107(0.95); C338(0.96); C574(1.13); C367(1.11)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C107(0.99); C338(0.95); C574(1.04); C646(1.33)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C107(1.03); C338(0.99); C574(1.06); C646(1.01)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C107(1.03); C338(0.95); C574(1.04); C367(1.07)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C107(0.99); C338(0.99); C574(1.09); C646(0.70)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C338(1.03); C574(1.08); C204(1.12)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C107(0.99); C338(1.01); C574(1.16); C367(1.02)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C107(1.00); C338(1.01); C574(1.02)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C107(0.95); C338(1.01); C574(1.17); C367(1.09)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C107(1.04); C338(0.96); C574(1.13); C646(1.21)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C338(0.98); C574(0.97); C204(1.14)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C107(0.97); C338(0.95); C574(1.03); C646(1.01)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C107(1.00); C338(1.01); C574(1.20); C367(1.10)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C107(0.96); C338(1.00); C574(1.13); C646(0.70)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C338(1.00); C574(1.04); C204(1.09)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C107(0.98); C338(0.94); C574(1.22); C367(0.91)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C107(0.95); C338(1.04); C574(1.07)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C107(0.92); C338(0.95); C574(1.13); C367(1.26)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C107(1.00); C338(0.99); C574(0.96); C646(1.08)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C107(0.98); C338(1.00); C574(0.96); C646(0.96)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C107(1.02); C338(0.95); C574(1.03); C367(0.95)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C107(1.00); C338(0.96); C574(1.11); C367(0.99)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C107(0.91); C338(1.10); C574(1.03); C646(0.69)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C338(0.98); C574(1.15); C204(1.04)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C107(0.99); C338(0.99); C574(1.02); C367(0.88)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C107(0.98); C338(1.01); C574(1.13)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C107(0.91); C338(0.95); C574(1.08); C367(0.98)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C107(0.94); C338(0.94); C574(1.08)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C107(0.89); C338(1.13); C574(0.97); C367(1.09)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C338(0.98); C574(0.98); C204(1.00)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C107(1.00); C338(0.97); C574(1.08); C646(1.36)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C107(0.94); C338(0.99); C574(1.10); C367(1.15)  LDD1514  [14]
 LDCM0160  Bromosprine HEK-293T 2.71  LDD0412  [13]
 LDCM0632  CL-Sc Hep-G2 C367(20.00); C338(20.00)  LDD2227  [11]
 LDCM0367  CL1 HEK-293T C107(0.90); C338(1.00); C574(1.03); C204(1.08)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C107(0.93); C338(1.02); C574(1.20); C367(1.81)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C107(1.17); C338(1.02); C574(1.01); C646(0.85)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C107(0.96); C338(1.04); C574(0.94); C204(1.01)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C107(1.00); C338(1.21); C574(1.05); C367(1.28)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C107(0.91); C338(0.94); C574(1.07); C204(0.89)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C107(1.18); C338(0.90); C574(1.04); C646(0.88)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C107(1.03); C338(1.04); C574(0.94); C204(1.07)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C107(0.94); C338(1.04); C574(0.99); C367(1.21)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C107(0.91); C338(1.00); C574(1.07); C204(1.06)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C107(0.79); C338(1.02); C574(1.11); C646(0.88)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C107(1.02); C338(0.93); C574(0.93); C204(1.31)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C107(1.05); C338(1.02); C574(0.91)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C107(0.91); C338(0.97); C574(1.04); C367(1.25)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C107(0.95); C338(1.00); C574(0.96); C204(1.16)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C107(1.23); C338(0.94); C574(1.05); C646(1.07)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C107(1.05); C338(0.99); C574(1.05); C204(1.08)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C107(0.97); C338(1.05); C574(1.14); C367(1.16)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C107(0.93); C338(1.02); C574(0.93); C204(1.00)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C107(1.15); C338(0.97); C574(1.12); C646(1.07)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C107(1.00); C338(1.01); C574(1.00); C204(1.19)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C107(1.04); C338(1.05); C574(1.14); C367(1.31)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C107(0.93); C338(0.96); C574(1.09); C204(0.81)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C107(0.96); C338(0.93); C574(0.99); C367(1.32)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C107(1.28); C338(0.95); C574(1.16); C646(1.01)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C107(1.00); C338(1.03); C574(1.05); C204(1.09)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C107(1.01); C338(1.03); C574(1.07); C367(1.13)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C107(0.87); C338(0.95); C574(1.38); C204(0.87)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C107(0.99); C338(0.78); C574(1.15); C646(0.77)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C107(0.99); C338(0.94); C574(1.02); C204(1.10)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C107(0.95); C338(0.96); C574(1.07); C367(1.07)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C107(0.93); C338(0.90); C574(0.94); C204(1.04)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C107(1.14); C338(0.80); C574(1.08); C646(1.04)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C107(0.97); C338(1.08); C574(1.10); C204(1.05)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C107(0.92); C338(1.13); C574(1.05); C367(1.48)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C107(0.87); C338(0.92); C574(1.16); C204(0.76)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C107(0.94); C338(0.84); C574(1.12); C646(0.88)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C107(0.96); C338(1.02); C574(1.08); C646(1.12)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C107(1.01); C338(0.99); C574(1.08); C646(1.26)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C107(1.01); C338(0.94); C574(1.00); C367(1.14)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C107(0.98); C338(0.98); C574(1.03); C367(1.52)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C107(1.07); C338(1.03); C574(1.01); C646(0.59)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C338(0.99); C574(0.94); C204(0.69)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C107(0.95); C338(0.96); C574(1.07); C367(1.32)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C107(1.05); C338(0.96); C574(1.01)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C107(0.97); C338(1.01); C574(1.10); C367(1.48)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C107(0.92); C338(0.94); C574(1.01); C204(1.08)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C107(1.00); C338(1.05); C574(1.06); C367(1.21)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C107(0.96); C338(0.92); C574(1.00); C204(0.95)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C107(1.05); C338(0.79); C574(1.10); C646(0.96)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C107(1.01); C338(1.05); C574(0.96); C646(1.26)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C107(0.92); C338(0.91); C574(1.16); C204(0.89)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C107(1.05); C338(0.95); C574(0.97); C646(0.91)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C107(1.00); C338(1.01); C574(1.10); C367(1.21)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C107(1.02); C338(1.03); C574(1.05); C646(0.66)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C338(1.01); C574(1.07); C204(0.60)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C107(0.99); C338(0.97); C574(1.02); C367(1.29)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C107(1.06); C338(1.01); C574(1.06)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C107(0.98); C338(1.04); C574(1.12); C367(1.59)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C107(0.97); C338(1.01); C574(1.08); C204(1.33)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C107(0.89); C338(1.13); C574(1.44); C204(0.93)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C107(0.83); C338(0.88); C574(1.02); C646(1.09)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C107(0.99); C338(1.03); C574(1.11); C646(0.84)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C107(1.01); C338(1.12); C574(0.97); C646(1.03)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C107(1.07); C338(1.01); C574(1.03); C646(1.03)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C107(1.07); C338(1.01); C574(1.05); C367(1.13)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C107(0.97); C338(1.05); C574(1.01); C646(0.53)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C338(1.00); C574(1.11); C204(0.68)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C107(1.01); C338(1.06); C574(1.06); C367(1.19)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C107(1.15); C338(1.11); C574(1.02)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C107(0.93); C338(0.98); C574(1.17); C367(1.23)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C107(0.92); C338(0.98); C574(1.02); C204(1.17)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C107(1.03); C338(0.94); C574(1.08); C646(1.43)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C107(1.02); C338(1.06); C574(1.07); C367(1.40)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C107(0.96); C338(0.91); C574(1.03); C646(0.93)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C107(0.98); C338(0.99); C574(1.07); C646(1.13)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C107(0.98); C338(0.86); C574(1.17); C646(1.07)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C107(1.02); C338(1.05); C574(1.04); C367(1.23)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C107(1.00); C338(1.12); C574(1.08); C646(0.49)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C338(0.99); C574(1.03); C204(0.76)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C107(0.98); C338(1.03); C574(1.13); C367(1.59)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C107(1.10); C338(0.99); C574(1.02)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C107(1.02); C338(0.94); C574(0.95); C646(1.04)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C107(0.99); C338(0.96); C574(1.10); C367(1.48)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C107(0.97); C338(0.98); C574(0.95); C204(1.25)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C107(0.97); C338(1.00); C574(1.04); C367(1.23)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C107(0.94); C338(0.92); C574(1.08); C204(0.91)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C107(0.99); C338(1.09); C574(1.09); C646(0.91)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C107(1.04); C338(0.97); C574(1.05); C646(1.19)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C107(1.00); C338(0.98); C574(1.07); C646(1.11)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C107(0.97); C338(1.04); C574(1.08); C367(1.10)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C107(0.90); C338(1.19); C574(1.01); C646(0.51)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C338(0.98); C574(1.02); C204(0.73)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C107(0.98); C338(0.89); C574(0.95); C367(1.19)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C107(1.05); C338(0.99); C574(0.91); C367(1.12)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C107(1.05); C338(0.98); C574(0.97)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C107(0.94); C338(1.15); C574(1.21); C367(1.26)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C107(0.95); C338(0.95); C574(1.08); C204(1.22)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C107(1.03); C338(1.05); C574(1.03); C367(1.16)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C107(0.95); C338(1.02); C574(1.06); C646(0.89)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C107(0.97); C338(1.02); C574(1.05); C646(1.28)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C107(1.02); C338(1.02); C574(1.11); C646(1.16)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C107(1.06); C338(0.98); C574(1.04); C367(1.15)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C107(0.83); C338(0.85); C574(1.29); C646(0.42)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C107(0.96); C338(0.95); C574(1.05); C646(0.44)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C338(0.95); C574(1.00); C204(0.79)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C107(0.98); C338(1.05); C574(1.06); C367(1.15)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C107(1.03); C338(1.02); C574(0.94)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C107(0.95); C338(1.04); C574(1.13); C367(1.21)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C107(0.95); C338(0.98); C574(0.91); C204(1.04)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C107(0.97); C338(0.95); C574(1.01); C367(0.88)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C107(0.92); C338(0.92); C574(1.04); C204(1.06)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C107(0.96); C338(1.09); C574(1.02); C646(0.99)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C107(1.07); C338(0.89); C574(1.07); C646(1.31)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C338(0.98); C574(0.95); C204(0.67)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C107(0.97); C338(0.88); C574(1.10); C646(0.77)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C107(1.02); C338(0.86); C574(1.08); C367(1.04)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C107(0.91); C338(0.98); C574(1.16); C646(0.55)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C338(0.92); C574(1.07); C204(0.72)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C107(1.02); C338(1.03); C574(1.02); C367(1.37)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C107(1.03); C338(1.08); C574(1.21)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C107(0.90); C338(0.91); C574(0.97); C367(1.01)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C107(1.00); C338(0.94); C574(0.97); C204(1.13)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C107(0.93); C338(1.03); C574(0.97); C367(1.12)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C107(0.89); C338(1.02); C574(1.11); C204(1.01)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C107(0.96); C338(0.97); C574(0.95); C204(1.06)  LDD1698  [14]
 LDCM0625  F8 Ramos C574(1.08)  LDD2187  [15]
 LDCM0576  Fragment14 Ramos C574(1.17)  LDD2193  [15]
 LDCM0468  Fragment33 HEK-293T C107(0.92); C338(0.98); C574(0.93); C204(1.14)  LDD1671  [14]
 LDCM0566  Fragment4 Ramos C574(1.03)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C107(0.96); C338(1.03); C574(1.01); C367(1.17)  LDD1631  [14]
 LDCM0569  Fragment7 Ramos C574(1.06)  LDD2186  [15]
 LDCM0022  KB02 HEK-293T C107(0.88); C646(0.92); C338(0.98); C574(0.93)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C107(7.30)  LDD0209  [2]
 LDCM0024  KB05 COLO792 C107(1.77)  LDD3310  [16]
 LDCM0109  NEM HeLa N.A.  LDD0227  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase p300 (EP300) . Q09472
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heterogeneous nuclear ribonucleoprotein U-like protein 1 (HNRNPUL1) . Q9BUJ2
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lp99 Small molecular drug D08LXU

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Chemical Proteomic Profiling of Bromodomains Enables the Wide-Spectrum Evaluation of Bromodomain Inhibitors in Living Cells. J Am Chem Soc. 2019 Jul 24;141(29):11497-11505. doi: 10.1021/jacs.9b02738. Epub 2019 Jul 9.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840