Details of the Target

General Information of Target

Target ID LDTP07710
Target Name Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1)
Gene Name CCBE1
Gene ID 147372
Synonyms
KIAA1983; Collagen and calcium-binding EGF domain-containing protein 1; Full of fluid protein homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVPPPPSRGGAARGQLGRSLGPLLLLLALGHTWTYREEPEDGDREICSESKIATTKYPCL
KSSGELTTCYRKKCCKGYKFVLGQCIPEDYDVCAEAPCEQQCTDNFGRVLCTCYPGYRYD
RERHRKREKPYCLDIDECASSNGTLCAHICINTLGSYRCECREGYIREDDGKTCTRGDKY
PNDTGHEKSENMVKAGTCCATCKEFYQMKQTVLQLKQKIALLPNNAADLGKYITGDKVLA
SNTYLPGPPGLPGGQGPPGSPGPKGSPGFPGMPGPPGQPGPRGSMGPMGPSPDLSHIKQG
RRGPVGPPGAPGRDGSKGERGAPGPRGSPGPPGSFDFLLLMLADIRNDITELQEKVFGHR
THSSAEEFPLPQEFPSYPEAMDLGSGDDHPRRTETRDLRAPRDFYP
Target Bioclass
Other
Family
CCBE1 family
Subcellular location
Secreted
Function Required for lymphangioblast budding and angiogenic sprouting from venous endothelium during embryogenesis.
Uniprot ID
Q6UXH8
Ensemble ID
ENST00000439986.9
HGNC ID
HGNC:29426

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCFSTTG1 SNV: p.L229M .
CORL23 SNV: p.E137K .
HUH1 SNV: p.A380T .
ICC4 SNV: p.C198F .
JHH6 SNV: p.I86M .
NCIH23 SNV: p.E319D .
RKO SNV: p.K317R .
SKMEL2 SNV: p.K72I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_4
 Probe Info  		N.A.  LDD2226  [1]
YN-1
 Probe Info  		N.A.  LDD0446  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
COP9 signalosome complex subunit 6 (COPS6) Peptidase M67A family Q7L5N1
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Syntaxin-11 (STX11) Syntaxin family O75558
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Kelch-like protein 12 (KLHL12) . Q53G59

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.