Details of the Target

General Information of Target

Target ID LDTP06592
Target Name T-box brain protein 1 (TBR1)
Gene Name TBR1
Gene ID 10716
Synonyms
T-box brain protein 1; T-brain-1; TBR-1; TES-56
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTDNLERSSPLKKITRGMT
NQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAADRYLLSQSSQPQSAATAP
SAMFPYPGQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSLLSNSSPQGYPTAGYPYPQQY
GHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFN
ISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWM
RQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQPRLHVVEVNEDGTEDTSQPGRVQTFT
FPETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDTIYTGCDMDRLTPSPNDSPRSQIV
PGARYAMAGSFLQDQFVSNYAKARFHPGAGAGPGPGTDRSVPHTNGLLSPQQAEDPGAPS
PQRWFVTPANNRLDFAASAYDTATDFAGNAATLLSYAAAGVKALPLQAAGCTGRPLGYYA
DPSGWGARSPPQYCGTKSGSVLPCWPNSAAAAARMAGANPYLGEEAEGLAAERSPLPPGA
AEDAKPKDLSDSSWIETPSSIKSIDSSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLA
QRDCEKNCAKDISGYYGFYSHS
Target Bioclass
Transcription factor
Subcellular location
Nucleus
Function
Transcriptional repressor involved in multiple aspects of cortical development, including neuronal migration, laminar and areal identity, and axonal projection. As transcriptional repressor of FEZF2, it blocks the formation of the corticospinal (CS) tract from layer 6 projection neurons, thereby restricting the origin of CS axons specifically to layer 5 neurons.
Uniprot ID
Q16650
Ensemble ID
ENST00000389554.8
HGNC ID
HGNC:11590

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AU565 SNV: p.S620W .
COLO678 SNV: p.T247A .
HCT15 SNV: p.L199P .
HEC1 Insertion: p.I55NfsTer16
SNV: p.Q433R		 .
HEC1B Insertion: p.I55NfsTer16
SNV: p.Q433R		 .
IGR1 SNV: p.F445L .
IPC298 SNV: p.D36N .
MFE319 SNV: p.R232H; p.S627N .
NCIH82 SNV: p.A297S .
OVK18 SNV: p.P125L .
RD SNV: p.D70Y .
SUPT1 SNV: p.I672T .
SW1271 SNV: p.Q352H .
SW480 SNV: p.R57K .
WM115 SNV: p.H263Y .
WM2664 SNV: p.H263Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C209(1.51)  LDD3376  [1]
N1
 Probe Info  		S10(0.00); S14(0.00)  LDD0245  [2]
YN-1
 Probe Info  		N.A.  LDD0446  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 D283 Med C209(1.81); C274(1.97)  LDD2312  [1]
 LDCM0023  KB03 D283 Med C209(1.83); C274(1.81)  LDD2729  [1]
 LDCM0024  KB05 ONS-76 C209(1.51)  LDD3376  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858
Alpha-synuclein (SNCA) Synuclein family P37840
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.