Details of the Target

General Information of Target

Target ID LDTP06659
Target Name Tumor protein D53 (TPD52L1)
Gene Name TPD52L1
Gene ID 7164
Synonyms
Tumor protein D53; hD53; Tumor protein D52-like 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEAQAQGLLETEPLQGTDEDAVASADFSSMLSEEEKEELKAELVQLEDEITTLRQVLSAK
ERHLVEIKQKLGMNLMNELKQNFSKSWHDMQTTTAYKKTHETLSHAGQKATAAFSNVGTA
ISKKFGDMSYSIRHSISMPAMRNSPTFKSFEERVETTVTSLKTKVGGTNPNGGSFEEVLS
STAHASAQSLAGGSRRTKEEELQC
Target Bioclass
Other
Family
TPD52 family
Uniprot ID
Q16890
Ensemble ID
ENST00000368388.6
HGNC ID
HGNC:12006

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.V154A .
KASUMI1 SNV: p.E199Ter .
NCIH1155 SNV: p.T11I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y96(15.38)  LDD0259  [1]
STPyne
 Probe Info  		K109(7.49); K124(5.25); K60(5.56); K68(5.04)  LDD0277  [2]
HHS-465
 Probe Info  		Y96(10.00)  LDD2237  [3]
5E-2FA
 Probe Info  		H105(0.00); H184(0.00)  LDD2235  [4]
m-APA
 Probe Info  		H105(0.00); H184(0.00); H100(0.00)  LDD2231  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
TFBX
 Probe Info  		N.A.  LDD0148  [6]
YN-1
 Probe Info  		N.A.  LDD0446  [7]
Acrolein
 Probe Info  		H100(0.00); H63(0.00)  LDD0217  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]
HHS-475
 Probe Info  		Y96(1.90)  LDD2238  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C362
 Probe Info  		26.91  LDD2023  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H100(0.00); H105(0.00); H63(0.00)  LDD0222  [8]
 LDCM0107  IAA HeLa H100(0.00); H63(0.00)  LDD0221  [8]
 LDCM0109  NEM HeLa H100(0.00); H63(0.00)  LDD0223  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor protein D52 (TPD52) TPD52 family P55327
Tumor protein D53 (TPD52L1) TPD52 family Q16890

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587