Details of the Target

General Information of Target

Target ID LDTP10681
Target Name NADPH oxidase 5 (NOX5)
Gene Name NOX5
Gene ID 79400
Synonyms
NADPH oxidase 5; EC 1.6.3.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKFGMGSAQACPCQVPRAASTTWVPCQICGPRERHGPRTPGGQLPGARRGPGPRRPAPLP
ARPPGALGSVLRPLRARPGCRPRRPHPAARCLPLRPHRPTRRHRRPGGFPLAWGSPQPAP
RPAPGRSSALALAGGAAPGVARAQRPGGSGGRSHPGGPGSPRGGGTVGPGDRGPAAADGG
RPQRTVRAAETRGAAAAPPLTLEGPVQSHHGTPALTQGPQSPRDGAQLGACTRPVDVRDS
GGRPLPPPDTLASAGDFLCTM
Target Bioclass
Enzyme
Subcellular location
Membrane; Endoplasmic reticulum
Function
Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. May play a role in cell growth and apoptosis.; [Isoform v2]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.; [Isoform v1]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor.; [Isoform v5]: Calcium-dependent NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. According tolacks enzyme activity. Involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.; [Isoform v4]: Lacks calcium-dependent NADPH oxidase activity.; [Isoform v3]: Lacks calcium-dependent NADPH oxidase activity.
Uniprot ID
Q96PH1
Ensemble ID
ENST00000388866.8
HGNC ID
HGNC:14874
ChEMBL ID
CHEMBL1926497

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.M201I .
DU145 SNV: p.L554I .
EFO27 Deletion: p.H470TfsTer10 .
FADU SNV: p.A216D .
HCC1395 SNV: p.D659H .
HT SNV: p.T294S .
HT115 SNV: p.L412I; p.I591T .
Ishikawa (Heraklio) 02 ER SNV: p.H583Y .
LS180 Deletion: p.H470TfsTer10 .
MFE319 SNV: p.P467L .
NCIH1793 SNV: p.Q312R .
OVK18 Deletion: p.F596LfsTer34 .
PF382 SNV: p.G122D .
RL952 Deletion: p.H470TfsTer10 .
SW1271 Deletion: p.A125QfsTer45 .
TOV21G Deletion: p.H470TfsTer10 .
VCAP SNV: p.Q725H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		N.A.  LDD0446  [1]

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.