Details of the Target

General Information of Target

Target ID LDTP16037
Target Name Solute carrier family 38 member 10 (SLC38A10)
Gene Name SLC38A10
Gene ID 124565
Synonyms
Solute carrier family 38 member 10; Amino acid transporter SLC38A10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSEEEEEVPQPMPSIPEDLESQKAMVAFFNSAVASAEEEQARLCGQLKECTASAWLICW
PRPRRNLRQQPQPQELGVIPCVGRPTRPCRGPWRSCGRVHRTVPEPEGSAEGGGVHQQAG
PGQGRGEGEAAGAGVACGRLQQVA
Target Bioclass
Transporter and channel
Family
Amino acid/polyamine transporter 2 family
Subcellular location
Membrane
Function
Facilitates bidirectional transport of amino acids. May act as a glutamate sensor that regulates glutamate-glutamine cycle and mTOR signaling in the brain. The transport mechanism remains to be elucidated.
Uniprot ID
Q9HBR0
Ensemble ID
ENST00000288439.9
HGNC ID
HGNC:28237

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ABC1 SNV: p.D782V .
AN3CA SNV: p.P783H .
COLO320 SNV: p.Y249Ter .
COLO678 SNV: p.Y249Ter .
COLO792 SNV: p.T225I .
HCT15 SNV: p.A724V .
KASUMI2 SNV: p.V250A .
MOLT4 SNV: p.A406T; p.A699V .
NALM6 SNV: p.Q563H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Jackson_1
 Probe Info  		14.50  LDD0122  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
AHL-Pu-1
 Probe Info  		C301(3.89)  LDD0168  [3]
Acrolein
 Probe Info  		N.A.  LDD0224  [4]
DBIA
 Probe Info  		C301(0.98)  LDD0531  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
YN-1
 Probe Info  		N.A.  LDD0446  [7]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C301(3.89)  LDD0168  [3]
 LDCM0214  AC1 HCT 116 C301(0.98)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C301(1.12)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C301(0.83)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C301(0.87)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C301(0.80)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C301(0.84)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C301(1.08)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C301(0.92)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C301(0.88)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C301(0.90)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C301(0.75)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C301(0.78)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C301(1.08)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C301(0.84)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C301(0.77)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C301(0.96)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C301(1.06)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C301(1.30)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C301(1.24)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C301(1.28)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C301(1.21)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C301(1.26)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C301(1.40)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C301(1.17)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C301(1.40)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C301(0.99)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C301(1.11)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C301(0.76)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C301(1.18)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C301(1.17)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C301(0.87)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C301(1.09)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C301(1.03)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C301(1.28)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C301(1.44)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C301(1.08)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C301(1.33)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C301(1.32)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C301(1.21)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C301(1.22)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C301(1.25)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C301(1.24)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C301(1.19)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C301(1.42)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C301(1.23)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C301(1.54)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C301(1.40)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C301(1.25)  LDD0579  [5]
 LDCM0270  AC15 HCT 116 C301(1.13)  LDD0587  [5]
 LDCM0276  AC17 HCT 116 C301(0.95)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C301(1.11)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C301(0.93)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C301(0.96)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C301(0.98)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C301(0.97)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C301(0.95)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C301(0.99)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C301(0.89)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C301(1.03)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C301(1.02)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C301(0.79)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C301(1.08)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C301(0.75)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C301(1.01)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C301(1.03)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C301(1.13)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C301(0.90)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C301(0.68)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C301(0.97)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C301(0.90)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C301(0.82)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C301(0.92)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C301(1.13)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C301(0.80)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C301(0.98)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C301(1.06)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C301(0.97)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C301(0.94)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C301(1.28)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C301(0.78)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C301(0.71)  LDD0624  [5]
 LDCM0312  AC5 HCT 116 C301(1.13)  LDD0629  [5]
 LDCM0320  AC57 HCT 116 C301(0.91)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C301(0.83)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C301(0.99)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C301(1.02)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C301(0.89)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C301(0.93)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C301(1.00)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C301(0.85)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C301(0.96)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C301(0.94)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C301(0.79)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C301(0.88)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C301(1.14)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C301(1.10)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C301(1.11)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C301(1.25)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C301(1.02)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C301(0.97)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C301(1.37)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C301(1.47)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C301(1.54)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C301(1.15)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C301(1.15)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C301(1.07)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C301(1.17)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C301(1.11)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C301(1.17)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C301(1.04)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C301(1.43)  LDD0665  [5]
 LDCM0365  AC98 HCT 116 C301(0.92)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C301(0.85)  LDD0683  [5]
 LDCM0248  AKOS034007472 HCT 116 C301(1.19)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C301(1.28)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C301(1.48)  LDD0592  [5]
 LDCM0367  CL1 HCT 116 C301(0.96)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C301(0.98)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C301(1.08)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C301(1.17)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C301(1.09)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C301(1.14)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C301(0.94)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C301(1.06)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C301(1.10)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C301(1.35)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C301(1.36)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C301(1.03)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C301(1.03)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C301(1.21)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C301(1.09)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C301(0.94)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C301(1.14)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C301(1.13)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C301(0.75)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C301(0.93)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C301(1.11)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C301(1.12)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C301(1.05)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C301(0.92)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C301(0.97)  LDD0708  [5]
 LDCM0393  CL122 HEK-293T C301(1.18)  LDD1597  [8]
 LDCM0396  CL125 HCT 116 C301(1.21)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C301(0.91)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C301(0.89)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C301(0.90)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C301(0.98)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C301(1.13)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C301(1.15)  LDD0719  [5]
 LDCM0407  CL2 HCT 116 C301(0.97)  LDD0724  [5]
 LDCM0414  CL26 HEK-293T C301(1.07)  LDD1618  [8]
 LDCM0418  CL3 HCT 116 C301(0.91)  LDD0735  [5]
 LDCM0420  CL31 HCT 116 C301(1.14)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C301(0.94)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C301(1.10)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C301(1.22)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C301(1.05)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C301(1.06)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C301(1.03)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C301(1.14)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C301(2.03)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C301(1.26)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C301(1.06)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C301(1.24)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C301(1.12)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C301(1.15)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C301(1.47)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C301(1.34)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C301(1.29)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C301(1.25)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C301(1.31)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C301(0.96)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C301(1.22)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C301(1.29)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C301(1.49)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C301(1.02)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C301(1.20)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C301(1.25)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C301(1.06)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C301(1.42)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C301(1.26)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C301(1.25)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C301(1.06)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C301(1.36)  LDD0769  [5]
 LDCM0454  CL62 HEK-293T C301(0.92)  LDD1657  [8]
 LDCM0462  CL7 HCT 116 C301(1.00)  LDD0779  [5]
 LDCM0467  CL74 HEK-293T C301(1.02)  LDD1670  [8]
 LDCM0473  CL8 HCT 116 C301(0.93)  LDD0790  [5]
 LDCM0480  CL86 HEK-293T C301(1.01)  LDD1683  [8]
 LDCM0484  CL9 HCT 116 C301(1.04)  LDD0801  [5]
 LDCM0486  CL91 HCT 116 C301(1.08)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C301(0.90)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C301(1.10)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C301(0.99)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C301(0.98)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C301(1.03)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C301(1.00)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C301(0.99)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C301(1.09)  LDD0811  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C301(1.33)  LDD1702  [9]
 LDCM0427  Fragment51 HCT 116 C301(1.81)  LDD0744  [5]
 LDCM0022  KB02 AU565 C301(2.38)  LDD2265  [10]
 LDCM0023  KB03 AU565 C301(3.29)  LDD2682  [10]
 LDCM0024  KB05 UACC257 C301(3.83)  LDD3325  [10]
 LDCM0109  NEM HeLa N.A.  LDD0224  [4]

References

1 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840