Details of the Target

General Information of Target

Target ID LDTP12276
Target Name Short transient receptor potential channel 7 (TRPC7)
Gene Name TRPC7
Gene ID 57113
Synonyms
TRP7; Short transient receptor potential channel 7; TrpC7; Transient receptor protein 7; TRP-7; hTRP7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAVLMDRVQSCVTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATLGFWCEAE
HEAPSEQSVSVEGVSQVRTAESGLFQKAHPCEMCDPLLKDILHLAEHQGSHLTQKLCTRG
LCRRRFSFSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHMLGRSFTCREEGMDLPDSS
GLFQHQTTYNRVSPCRRTECMESFPHSSSLRQHQGDYDGQMLFSCGDEGKAFLDTFTLLD
SQMTHAEVRPFRCLPCGNVFKEKSALINHRKIHSGEISHVCKECGKAFIHLHHLKMHQKF
HTGKRHYTCSECGKAFSRKDTLVQHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGE
RPYKCNKCGKAFSRKDTLVQHQRFHTGERPYECSECGKFFSQSSHLIEHWRIHTGARPYE
CIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQHQIIHTGARPYECSEC
GKAFSRKDTLVQHQKIHTGERPYECGECGKFFSHSSNLIVHQRIHTGAKPYECNECGKCF
SHNSSLILHQRVHTGARPYVCSECGKAYISSSHLVQHKKVHTGARPYECSECGKFFSRNS
GLILHQRVHTGEKPYVCSECGKAYSRSSHLVRHQKAHTGERAHECNSFGGPLAASLKLV
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC7 sub-subfamily
Subcellular location
Cell membrane
Function
Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion.
TTD ID
T10918
Uniprot ID
Q9HCX4
DrugMap ID
TT06GRA
Ensemble ID
ENST00000352189.8
HGNC ID
HGNC:20754
ChEMBL ID
CHEMBL4105799

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A204 Deletion: p.S619IfsTer15 .
COLO800 SNV: p.P193L .
CORL23 SNV: p.R60W .
FUOV1 SNV: p.S717L .
HCC1395 SNV: p.A368T .
HCT116 SNV: p.R192L .
HCT15 SNV: p.T497M .
HSC4 SNV: p.E43Q .
KMCH1 SNV: p.K387N .
KMRC20 SNV: p.E822Ter .
MELJUSO SNV: p.V59I .
MSTO211H SNV: p.V180A .
NCIH1048 Deletion: p.Q79RfsTer13 .
NCIH3122 SNV: p.L774F .
OVK18 SNV: p.L91I .
PC9 SNV: p.V685M .
SNGM SNV: p.A153V .
SW1116 SNV: p.R46C .
UMUC3 SNV: p.R464Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		N.A.  LDD0446  [1]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-apb Small molecular drug D00HCI
Oag Small molecular drug D0T6DU

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.