Details of the Target

General Information of Target

Target ID LDTP05064
Target Name Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)
Gene Name PPP2CA
Gene ID 5515
Synonyms
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; EC 3.1.3.16; Replication protein C; RP-C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDEKVFTKELDQWIEQLNECKQLSESQVKSLCEKAKEILTKESNVQEVRCPVTVCGDVHG
QFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVALKVRYRERITILRGNHES
RQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHI
RALDRLQEVPHEGPMCDLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHANGLTLVSRA
HQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDTLKYSFLQFDPAPRRGEPHV
TRRTPDYFL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
PPP phosphatase family, PP-1 subfamily
Subcellular location
Cytoplasm
Function
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'. Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint. Mediates dephosphorylation of MYC; promoting its ubiquitin-mediated proteolysis: interaction with AMBRA1 enhances interaction between PPP2CA and MYC. Mediates dephosphorylation of FOXO3; promoting its stabilization: interaction with AMBRA1 enhances interaction between PPP2CA and FOXO3. Catalyzes dephosphorylation of the pyrin domain of NLRP3, promoting assembly of the NLRP3 inflammasome.
TTD ID
T40491
Uniprot ID
P67775
DrugMap ID
TTHTKNY
Ensemble ID
ENST00000481195.6
HGNC ID
HGNC:9299
ChEMBL ID
CHEMBL4703

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NB1 SNV: p.D202Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		50.00  LDD0214  [1]
TH211
 Probe Info  		Y127(17.20); Y267(7.38)  LDD0257  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K34(10.00)  LDD0277  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
OPA-S-S-alkyne
 Probe Info  		K41(1.68)  LDD3494  [6]
m-APA
 Probe Info  		11.64  LDD0403  [7]
BTD
 Probe Info  		C251(2.15)  LDD2117  [8]
AHL-Pu-1
 Probe Info  		C269(3.37)  LDD0169  [9]
HHS-482
 Probe Info  		Y127(1.19)  LDD0285  [10]
HHS-475
 Probe Info  		Y218(0.81); Y284(0.81); Y265(0.95); Y267(0.96)  LDD0264  [11]
HHS-465
 Probe Info  		Y127(10.00); Y248(3.23); Y265(10.00); Y267(10.00)  LDD2237  [12]
DBIA
 Probe Info  		C251(1.14); C266(0.91)  LDD0078  [13]
ATP probe
 Probe Info  		N.A.  LDD0199  [14]
CY-1
 Probe Info  		E47(0.00); Q46(0.00)  LDD0246  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C251(0.00); C269(0.00); C20(0.00); C196(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C269(0.00); C20(0.00); C196(0.00); C133(0.00)  LDD0032  [17]
IPIAA_H
 Probe Info  		C251(0.00); C20(0.00); C133(0.00); C196(0.00)  LDD0030  [18]
IPIAA_L
 Probe Info  		C20(0.00); C269(0.00); C196(0.00); C251(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C251(0.00); C269(0.00); C20(0.00); C196(0.00)  LDD0037  [16]
JW-RF-010
 Probe Info  		C20(0.00); C266(0.00)  LDD0026  [19]
Acrolein
 Probe Info  		N.A.  LDD0217  [20]
Methacrolein
 Probe Info  		N.A.  LDD0218  [20]
W1
 Probe Info  		N.A.  LDD0236  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.65  LDD0472  [22]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe2
 Probe Info  		12.81  LDD0463  [22]
FFF probe3
 Probe Info  		5.12  LDD0465  [22]
STS-1
 Probe Info  		N.A.  LDD0068  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C251(2.15)  LDD2117  [8]
 LDCM0025  4SU-RNA DM93 C196(20.00); C133(2.01)  LDD0170  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C269(3.37)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C133(0.90); C196(1.06); C251(1.09); C266(0.87)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C133(0.93); C196(0.92); C20(0.93); C251(0.71)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C133(1.09); C196(1.20); C251(1.07); C266(0.83)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C133(1.18); C196(0.93); C251(0.91); C266(1.02)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C133(0.87); C196(0.85); C251(0.94); C266(0.94)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C133(1.05); C196(0.83); C251(1.10); C266(0.94)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C133(0.99); C196(1.06); C251(1.06); C266(0.90)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C133(0.93); C196(0.92); C251(0.99); C266(0.91)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C133(0.96); C196(0.87); C251(1.04); C266(0.95)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C133(1.06); C196(0.63); C251(0.96); C266(0.82)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C133(1.00); C196(1.46); C251(0.88); C266(0.79)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C133(0.94); C196(1.66); C251(0.99); C266(0.95)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C133(0.94); C196(0.82); C20(0.95); C251(0.97)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C133(1.07); C196(1.30); C251(1.04); C266(0.92)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C133(0.97); C196(1.44); C251(0.96); C266(0.89)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C133(0.92); C196(0.95); C251(0.96); C266(0.82)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C133(1.05); C196(0.88); C251(1.16); C266(0.95)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C133(1.11); C196(0.79); C251(1.14); C266(1.06)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C133(1.21); C196(0.72); C251(0.98); C266(1.17)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C133(1.20); C196(0.80); C251(0.93); C266(0.98)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C133(1.20); C196(0.92); C251(1.13); C266(0.93)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C133(1.21); C196(0.86); C251(1.09); C266(0.98)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C133(1.15); C196(0.97); C251(1.02); C266(0.86)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C133(1.03); C196(0.72); C20(1.11); C251(0.90)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C133(1.12); C196(0.82); C251(1.08); C266(0.97)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C133(0.99); C196(0.94); C251(1.20); C266(0.92)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C133(1.27); C196(0.76); C251(1.26); C266(0.86)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C133(1.21); C196(0.96); C251(1.55); C266(1.12)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C133(1.08); C196(0.92); C251(1.05); C266(0.85)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C133(1.16); C196(0.81); C251(1.02); C266(1.18)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C133(1.19); C196(0.79); C251(1.21); C266(0.92)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C133(1.23); C196(0.83); C251(1.06); C266(0.91)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C196(0.79); C251(1.30); C266(0.94); C269(1.00)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C196(0.80); C251(0.92); C266(1.13); C269(1.07)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C196(0.87); C251(1.99); C266(1.05); C269(1.11)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C196(1.07); C251(1.13); C266(1.58); C269(1.11)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C196(1.00); C251(1.17); C266(0.95); C269(1.15)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C196(0.79); C251(1.31); C266(1.07); C269(1.16)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C196(0.90); C251(1.27); C266(1.17); C269(1.07)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C196(0.92); C251(0.64); C266(1.03); C269(1.20)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C196(0.94); C251(1.42); C266(0.91); C269(1.21)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C196(0.91); C251(1.06); C266(1.13); C269(0.99)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C196(0.82); C251(1.27); C266(1.12); C269(0.94)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C196(0.93); C251(1.46); C266(0.88); C269(1.13)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C133(0.99); C196(0.83); C20(1.23); C251(0.97)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C196(0.89); C251(1.41); C266(1.18); C269(0.97)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C196(0.78); C251(1.31); C266(1.03); C269(1.02)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C196(0.98); C251(1.11); C266(1.08); C269(1.16)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C269(0.92); C50(0.92); C55(0.92); C266(1.00)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C50(0.64); C55(0.64); C133(0.67); C196(0.88)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C266(0.80); C50(0.83); C55(0.83); C269(0.97)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C50(0.80); C55(0.80); C133(0.90); C269(0.96)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C50(0.60); C55(0.60); C133(0.83); C196(0.94)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C50(0.40); C55(0.40); C133(0.60); C196(0.77)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C50(0.63); C55(0.63); C133(0.71); C196(0.98)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C196(0.83); C55(0.85); C251(0.85); C50(0.95)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C269(0.80); C50(0.91); C55(0.91); C196(0.98)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C50(0.88); C55(0.88); C196(1.03); C133(1.04)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C50(0.53); C55(0.53); C133(0.79); C196(0.88)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C50(0.32); C55(0.32); C133(0.58); C196(0.77)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C133(0.74); C196(0.98); C251(1.06); C266(1.09)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C133(0.89); C196(1.01); C251(1.03); C266(1.58)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C133(1.09); C196(1.33); C251(0.95); C266(1.16)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C133(1.11); C196(0.99); C251(0.87); C266(1.09)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C251(0.76); C269(0.96); C50(1.00); C55(1.00)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C50(0.73); C55(0.73); C133(0.85); C269(0.90)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C251(0.86); C133(0.98); C196(0.98); C269(1.02)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C133(1.04); C196(1.06); C50(1.08); C266(1.13)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C251(0.79); C269(0.94); C50(1.05); C55(1.05)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C251(0.74); C269(0.91); C50(0.93); C55(0.93)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C269(0.90); C251(0.92); C196(1.02); C133(1.13)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C251(0.81); C269(0.83); C196(0.84); C50(0.84)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C269(0.95); C50(1.05); C55(1.05); C196(1.05)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C266(0.72); C251(0.73); C133(0.89); C55(0.93)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C266(0.75); C133(0.87); C55(0.95); C251(0.97)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C266(0.80); C251(0.86); C133(0.89); C55(0.93)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C266(0.66); C55(0.80); C133(0.92); C269(0.93)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C133(0.78); C266(0.79); C55(0.97); C269(1.00)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C266(0.92); C133(1.09); C50(1.10); C55(1.10)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C133(0.76); C55(0.83); C266(0.86); C50(0.93)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C266(0.83); C133(0.88); C196(0.97); C55(1.04)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C133(0.66); C55(0.75); C266(0.85); C251(0.99)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C133(0.74); C266(0.95); C251(0.97); C55(0.99)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C55(0.66); C133(0.71); C50(0.82); C269(0.91)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C50(0.73); C266(0.87); C269(0.91); C20(1.05)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C196(0.89); C50(0.98); C266(1.03); C269(1.04)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C50(0.89); C196(0.91); C20(0.95); C266(0.96)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C266(1.07); C50(1.07); C196(1.08); C269(1.09)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C266(0.73); C20(1.00); C269(1.02); C196(1.03)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C50(1.00); C55(1.02); C133(1.07); C196(1.14)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C20(0.86); C196(0.89); C133(0.92); C50(1.01)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C50(0.94); C20(0.96); C196(0.96); C269(1.08)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C50(0.93); C196(0.94); C20(0.94); C269(1.04)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C196(0.96); C20(1.00); C269(1.01); C50(1.12)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C196(0.88); C50(0.97); C133(1.02); C20(1.11)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C196(0.82); C133(0.88); C20(0.96); C50(0.98)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C266(0.80); C50(0.98); C55(0.98); C196(0.99)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C266(0.71); C133(0.95); C269(0.98); C50(1.02)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C266(0.98); C133(1.01); C269(1.12); C196(1.15)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C50(0.75); C55(0.75); C133(0.80); C20(0.85)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C196(0.96); C266(0.97); C50(1.10); C55(1.12)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C133(0.74); C50(0.76); C55(0.76); C20(0.92)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C269(1.05); C266(1.11); C50(1.14); C55(1.14)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C266(0.94); C50(0.96); C55(0.96); C133(1.03)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C266(0.76); C133(0.81); C269(0.92); C50(0.95)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C133(0.80); C20(0.86); C50(0.90); C55(0.90)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C133(0.84); C266(0.86); C20(0.88); C196(0.88)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C133(0.64); C20(0.65); C50(0.68); C55(0.68)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C133(0.85); C251(0.99); C266(1.00); C269(1.08)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C50(0.82); C55(0.82); C133(0.84); C251(1.07)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C133(0.81); C196(0.91); C266(1.03); C50(1.07)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C196(0.77); C20(0.84); C133(0.88); C266(0.94)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C133(0.91); C50(0.97); C55(0.97); C266(1.04)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C266(1.12); C50(1.13); C55(1.13); C269(1.13)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C133(0.71); C196(0.96); C251(1.02); C50(1.05)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C133(0.85); C266(0.99); C251(1.01); C50(1.08)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C133(0.78); C196(0.90); C266(0.99); C251(1.11)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C266(0.80); C133(0.97); C196(1.05); C251(1.09)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C266(0.79); C50(0.95); C55(0.95); C133(0.98)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C196(0.61); C266(0.63); C133(0.64); C251(1.02)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C20(0.79); C133(0.81); C196(0.85); C266(0.90)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C133(0.75); C55(0.81); C20(0.82); C50(0.87)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C196(0.70); C133(0.75); C266(0.85); C269(0.87)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C133(0.57); C55(0.67); C266(0.67); C20(0.70)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C20(0.85); C50(0.92); C55(0.93); C251(0.95)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C133(0.68); C20(0.80); C55(0.85); C266(0.87)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C133(0.55); C55(0.69); C20(0.72); C50(0.77)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C20(0.57); C133(0.66); C196(0.73); C55(0.74)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C20(0.50); C133(0.52); C55(0.70); C266(0.77)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C133(0.72); C196(0.83); C55(0.84); C266(0.84)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C133(0.65); C196(0.90); C55(0.90); C251(0.91)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C20(0.82); C133(0.82); C266(0.87); C55(0.89)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C133(0.78); C266(0.82); C55(0.91); C20(0.93)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C196(0.71); C133(0.75); C20(0.81); C55(0.85)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C133(0.73); C20(0.79); C55(0.83); C266(0.87)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C20(0.54); C251(0.79); C133(0.81); C196(0.83)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C20(0.32); C133(0.45); C266(0.53); C251(0.54)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C133(0.59); C266(0.94); C269(0.96); C196(1.01)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C133(0.58); C266(0.74); C269(0.87); C196(0.91)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C133(0.73); C266(0.84); C269(0.95); C196(0.96)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C133(0.71); C266(0.89); C196(0.91); C269(0.99)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C266(0.79); C196(0.91); C269(0.91); C50(0.93)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C133(0.64); C50(0.86); C55(0.86); C269(0.95)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C133(0.60); C266(0.91); C269(0.94); C196(0.94)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C266(0.76); C196(0.87); C269(1.03); C251(1.20)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C133(0.60); C196(1.00); C266(1.02); C269(1.03)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C133(0.54); C266(0.85); C269(0.95); C196(1.05)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C133(0.70); C50(0.75); C55(0.75); C266(0.80)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C266(0.82); C133(0.91); C269(1.05); C196(1.14)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C266(0.92); C133(0.93); C196(0.99); C269(1.00)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C133(0.73); C196(0.92); C266(1.00); C269(1.06)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C133(0.57); C266(0.86); C196(0.99); C50(1.07)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C50(0.26); C55(0.26); C269(0.33); C196(0.63)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C269(0.62); C50(0.71); C55(0.71); C266(0.84)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C133(0.89); C196(0.73); C20(0.96); C251(0.86)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C133(0.88); C196(0.90); C55(0.91); C20(0.93)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C196(0.70); C55(0.74); C50(0.75); C133(0.87)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 11.64  LDD0403  [7]
 LDCM0020  ARS-1620 HCC44 C251(1.14); C266(0.91)  LDD0078  [13]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [20]
 LDCM0632  CL-Sc Hep-G2 C251(0.70)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C196(0.78); C50(0.85); C133(0.87); C55(0.89)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C133(0.63); C55(0.65); C50(0.69); C196(0.80)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C55(0.95); C196(0.97); C251(1.00); C50(1.00)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C196(0.65); C133(0.83); C269(0.87); C251(0.89)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C251(0.65); C196(0.67); C269(0.82); C133(0.84)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C196(0.68); C251(0.79); C55(0.83); C266(0.87)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C196(0.68); C20(0.80); C251(0.83); C269(0.92)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C251(0.68); C133(0.86); C50(0.90); C55(0.90)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C50(0.76); C55(0.76); C251(0.76); C133(0.80)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C133(0.81); C50(0.85); C55(0.85); C251(0.86)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C50(0.69); C55(0.69); C133(0.79); C196(0.90)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C50(0.81); C55(0.81); C269(0.85); C133(0.89)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C55(0.55); C133(0.56); C50(0.65); C196(0.72)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C133(0.69); C196(0.78); C50(0.78); C55(0.78)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C50(0.74); C55(0.74); C269(0.82); C251(0.85)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C55(0.72); C251(0.73); C196(0.76); C269(0.83)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C55(0.70); C133(0.74); C266(0.92); C50(0.93)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C133(0.68); C55(0.72); C196(0.76); C266(0.87)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C133(0.72); C55(0.82); C269(0.89); C266(0.98)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C266(0.85); C133(0.87); C251(0.91); C55(0.95)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C133(0.63); C196(0.65); C50(0.77); C20(0.79)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C196(0.94); C50(1.01); C20(1.06); C269(1.06)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C20(0.86); C269(0.90); C196(0.91); C50(0.96)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C55(0.56); C133(0.58); C50(0.70); C196(0.77)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C196(0.88); C266(0.90); C50(0.99); C20(1.09)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C133(0.70); C20(0.87); C196(0.91); C266(1.02)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C133(0.85); C50(0.96); C55(0.96); C269(1.03)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C133(0.60); C50(0.62); C55(0.62); C196(0.69)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C133(0.69); C50(0.79); C55(0.79); C266(0.84)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C50(0.91); C55(0.91); C266(0.97); C251(0.98)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C50(0.75); C55(0.75); C196(0.80); C251(0.81)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C266(0.95); C196(1.01); C133(1.02); C50(1.05)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C133(0.76); C266(0.92); C50(1.03); C55(1.03)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C133(0.73); C55(0.83); C50(0.86); C196(0.95)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C133(0.76); C196(0.78); C55(0.79); C50(0.83)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C133(0.53); C196(0.62); C50(0.76); C55(0.81)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C133(0.75); C196(0.80); C20(0.91); C269(0.96)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C269(0.66); C133(0.76); C20(0.77); C251(0.81)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C133(0.94); C269(0.98); C50(1.01); C55(1.01)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C133(0.78); C50(0.99); C55(0.99); C20(1.03)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C133(0.92); C50(0.94); C55(0.96); C196(0.97)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C133(0.67); C50(0.77); C55(0.77); C20(0.86)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C133(0.56); C50(0.61); C55(0.61); C196(0.69)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C50(0.46); C55(0.46); C20(0.58); C133(0.58)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C133(0.78); C50(0.79); C55(0.79); C269(0.81)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C133(0.63); C50(0.64); C55(0.64); C20(0.77)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C133(0.61); C196(0.74); C20(0.81); C251(1.10)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C133(0.77); C196(0.87); C20(0.87); C251(1.17)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C133(0.73); C196(0.92); C20(0.95); C251(1.16)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C133(0.68); C196(0.90); C20(0.75); C251(1.11)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C133(0.73); C196(1.06); C20(0.92); C251(1.21)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C133(0.91); C196(1.01); C251(1.20); C266(0.98)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C133(0.85); C196(0.91); C20(1.09); C251(1.27)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C133(0.84); C196(0.77); C20(0.54); C251(0.86)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C133(1.09); C196(0.88); C20(0.55); C251(0.83)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C133(0.76); C196(0.85); C20(0.49); C251(0.78)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C133(0.68); C196(0.80); C20(0.62); C251(0.82)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C133(0.66); C196(0.80); C20(0.74); C251(0.99)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C133(0.63); C196(0.78); C20(0.61); C251(0.76)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C133(0.67); C196(0.93); C20(0.63); C251(0.76)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C133(0.63); C196(0.77); C20(0.54); C251(0.70)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C133(0.85); C196(0.81); C251(1.25); C266(1.00)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C133(0.50); C196(0.67); C20(0.69); C251(0.71)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C133(0.75); C196(0.86); C20(0.78); C251(0.68)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C133(0.58); C196(0.57); C20(0.37); C251(0.61)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C133(0.68); C196(0.74); C20(0.62); C251(0.65)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C133(0.71); C196(0.69); C20(0.73); C251(0.80)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C133(0.66); C196(0.69); C20(0.59); C251(0.83)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C133(1.04); C196(0.86); C251(0.94); C266(1.22)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C133(0.86); C196(0.63); C251(0.86); C266(1.03)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C133(0.87); C196(0.78); C251(0.83); C266(1.25)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C133(1.04); C196(0.75); C251(0.93); C266(1.22)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C133(0.80); C196(0.87); C251(1.21); C266(0.90)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C133(0.94); C196(0.64); C251(0.78); C266(1.36)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C133(0.87); C196(0.86); C251(0.86); C266(1.49)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C133(0.92); C196(0.78); C251(1.06); C266(1.25)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C133(0.78); C196(0.67); C251(1.02); C266(1.15)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C133(0.81); C196(0.55); C251(0.78); C266(0.85)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C133(0.91); C196(0.75); C251(0.81); C266(1.33)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C133(0.83); C196(0.80); C251(0.96); C266(1.03)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C133(1.03); C196(0.70); C251(0.94); C266(1.28)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C133(1.27); C196(0.77); C251(0.89); C266(1.15)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C133(1.00); C196(0.81); C251(0.97); C266(1.03)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C133(0.80); C196(0.88); C251(1.50); C266(1.23)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C133(0.93); C196(0.69); C251(1.01); C266(1.34)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C133(0.87); C196(0.97); C20(0.82); C251(1.12)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C133(0.81); C196(0.96); C20(0.80); C251(1.17)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C133(0.75); C196(1.04); C20(0.68); C251(0.82)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C133(0.73); C196(0.93); C20(0.90); C251(1.02)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C133(0.88); C196(0.95); C20(0.89); C251(0.87)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C133(0.65); C196(0.72); C20(0.79); C251(0.92)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C133(0.82); C196(1.06); C20(0.83); C251(0.90)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C133(0.77); C196(0.85); C20(0.86); C251(1.41)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C133(1.07); C196(0.77); C20(0.78); C251(0.91)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C133(0.81); C196(0.97); C251(1.60); C266(0.88)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C133(0.92); C196(0.99); C20(1.03); C251(0.99)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C133(0.71); C196(0.93); C20(0.83); C251(0.94)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C133(0.84); C196(1.04); C20(0.81); C251(1.09)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C133(0.75); C196(0.83); C20(0.90); C251(1.13)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C133(0.69); C196(0.88); C20(0.87); C251(1.21)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C133(1.03); C196(0.98); C20(0.88); C251(1.01)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C133(0.99); C196(0.45); C20(0.47); C251(0.78)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C133(0.85); C196(0.85); C20(0.63); C251(0.93)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C133(0.76); C196(0.92); C20(0.89); C251(1.05)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C133(0.56); C196(0.68); C251(0.99); C266(1.05)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C133(2.64); C196(1.01); C20(0.86); C251(0.96)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C133(1.00); C196(0.95); C20(0.92); C251(0.94)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C133(0.68); C196(0.90); C20(0.88); C251(1.19)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C133(0.79); C196(0.79); C20(0.99); C251(1.07)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C133(0.74); C196(0.78); C20(0.96); C251(0.98)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C133(0.85); C196(1.00); C20(0.85); C251(0.99)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C133(1.03); C196(0.94); C20(0.71); C251(1.08)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C133(0.87); C196(0.96); C20(0.83); C251(1.10)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C133(0.77); C196(0.90); C20(0.78); C251(1.02)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C133(0.60); C196(0.81); C20(0.85); C251(1.06)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C133(0.78); C196(1.06); C251(1.18); C266(0.87)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C133(0.72); C196(0.55); C20(0.57); C251(0.90)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C133(0.75); C196(1.16); C251(1.15); C266(1.20)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C133(0.90); C196(0.87); C251(0.86); C266(2.15)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C133(1.05); C196(0.86); C251(0.97); C266(1.61)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C133(0.95); C196(0.80); C251(0.94); C266(1.27)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C133(0.83); C196(0.89); C251(1.16); C266(1.15)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C133(0.91); C196(1.10); C251(1.09); C266(0.98)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C133(0.92); C196(0.95); C251(1.62); C266(1.25)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C133(0.94); C196(1.08); C251(1.44); C266(1.02)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C133(1.01); C196(0.99); C251(1.20); C266(1.04)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C20(1.02)  LDD1698  [24]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C251(1.77); C133(1.42); C269(0.88); C266(0.80)  LDD1702  [8]
 LDCM0625  F8 Ramos C20(0.61); C266(0.84); C269(0.92); C196(1.03)  LDD2187  [25]
 LDCM0572  Fragment10 Ramos C20(0.69); C266(0.73); C269(0.82); C196(1.04)  LDD2189  [25]
 LDCM0573  Fragment11 Ramos C20(0.39); C266(0.20); C269(0.19); C196(0.10)  LDD2190  [25]
 LDCM0574  Fragment12 Ramos C20(0.76); C266(0.76); C269(1.09); C196(0.88)  LDD2191  [25]
 LDCM0575  Fragment13 Ramos C20(1.01); C266(0.97); C269(1.17); C196(1.08)  LDD2192  [25]
 LDCM0576  Fragment14 Ramos C20(1.18); C266(0.64); C269(0.96); C196(0.79)  LDD2193  [25]
 LDCM0579  Fragment20 Ramos C20(0.78); C266(0.70); C269(0.93); C196(0.69)  LDD2194  [25]
 LDCM0580  Fragment21 Ramos C20(0.98); C266(0.88); C269(0.99); C196(0.77)  LDD2195  [25]
 LDCM0582  Fragment23 Ramos C20(1.13); C266(0.67); C269(0.71); C196(0.98)  LDD2196  [25]
 LDCM0578  Fragment27 Ramos C20(1.16); C266(1.00); C269(1.01); C196(1.07)  LDD2197  [25]
 LDCM0586  Fragment28 Ramos C20(0.64); C266(1.14); C269(0.98); C196(0.50)  LDD2198  [25]
 LDCM0588  Fragment30 Ramos C20(1.12); C266(0.78); C269(1.09); C196(1.53)  LDD2199  [25]
 LDCM0589  Fragment31 Ramos C20(1.44); C266(1.14); C269(1.14); C196(1.79)  LDD2200  [25]
 LDCM0590  Fragment32 Ramos C20(0.71); C266(0.56); C269(0.63); C196(1.06)  LDD2201  [25]
 LDCM0468  Fragment33 HCT 116 C133(0.77); C196(0.98); C20(0.82); C251(1.09)  LDD0785  [13]
 LDCM0596  Fragment38 Ramos C20(1.38); C266(1.14); C269(1.33); C196(1.13)  LDD2203  [25]
 LDCM0566  Fragment4 Ramos C20(0.95); C266(1.07); C269(0.89); C196(1.13)  LDD2184  [25]
 LDCM0427  Fragment51 HCT 116 C133(0.48); C196(0.64); C20(0.60); C251(0.68)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C20(1.17); C266(1.06); C269(1.33); C196(1.69)  LDD2204  [25]
 LDCM0614  Fragment56 Ramos C20(1.21); C266(1.08); C269(0.99); C196(1.41)  LDD2205  [25]
 LDCM0569  Fragment7 Ramos C20(0.81); C266(0.72); C269(1.00); C196(0.83)  LDD2186  [25]
 LDCM0571  Fragment9 Ramos C20(0.69); C266(0.80); C269(0.76); C196(0.80)  LDD2188  [25]
 LDCM0116  HHS-0101 DM93 Y218(0.81); Y284(0.81); Y265(0.95); Y267(0.96)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y284(0.67); Y248(0.80); Y267(0.82); Y265(0.82)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y218(0.61); Y130(0.67); Y284(0.71); Y267(0.78)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y284(0.62); Y265(0.87); Y267(0.88); Y130(0.94)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y284(0.76); Y265(0.89); Y267(0.90); Y248(1.33)  LDD0268  [11]
 LDCM0107  IAA HeLa N.A.  LDD0221  [20]
 LDCM0123  JWB131 DM93 Y127(1.19)  LDD0285  [10]
 LDCM0124  JWB142 DM93 Y127(0.54)  LDD0286  [10]
 LDCM0125  JWB146 DM93 Y127(1.61); Y265(0.69)  LDD0287  [10]
 LDCM0126  JWB150 DM93 Y127(1.69); Y265(5.24)  LDD0288  [10]
 LDCM0127  JWB152 DM93 Y127(1.49)  LDD0289  [10]
 LDCM0128  JWB198 DM93 Y127(1.14); Y265(2.65)  LDD0290  [10]
 LDCM0129  JWB202 DM93 Y127(0.47); Y265(0.63)  LDD0291  [10]
 LDCM0130  JWB211 DM93 Y127(0.89)  LDD0292  [10]
 LDCM0022  KB02 HCT 116 C266(1.41); C251(1.45)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C266(1.10); C251(1.67)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C266(1.52); C251(1.41)  LDD0082  [13]
 LDCM0131  RA190 MM1.R C20(1.29)  LDD0304  [26]
 LDCM0021  THZ1 HCT 116 C20(1.10); C266(1.25); C251(1.14); C50(1.15)  LDD2173  [13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
Protein phosphatase methylesterase 1 (PPME1) AB hydrolase superfamily Q9Y570
ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) Peptidase S14 family Q16740
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) Phosphatase 2A regulatory subunit A family P30153
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B) Phosphatase 2A regulatory subunit A family P30154
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) Phosphatase 2A regulatory subunit B family Q9Y2T4
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) Phosphatase 2A regulatory subunit B56 family Q15172
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PPP2R5B) Phosphatase 2A regulatory subunit B56 family Q15173
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C) Phosphatase 2A regulatory subunit B56 family Q13362
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) Ser/Thr protein kinase family O14920
RAF proto-oncogene serine/threonine-protein kinase (RAF1) TKL Ser/Thr protein kinase family P04049
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interferon regulatory factor 3 (IRF3) IRF family Q14653
Transcription factor p65 (RELA) . Q04206
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
KiSS-1 receptor (KISS1R) G-protein coupled receptor 1 family Q969F8
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Acidic leucine-rich nuclear phosphoprotein 32 family member A (ANP32A) ANP32 family P39687
Eukaryotic translation initiation factor 4E (EIF4E) Eukaryotic initiation factor 4E family P06730
Radiation-inducible immediate-early gene IEX-1 (IER3) IER3 family P46695
Immunoglobulin-binding protein 1 (IGBP1) IGBP1/TAP42 family P78318
Retinoblastoma-like protein 1 (RBL1) Retinoblastoma protein (RB) family P28749
Retinoblastoma-like protein 2 (RBL2) Retinoblastoma protein (RB) family Q08999
Shugoshin 1 (SGO1) Shugoshin family Q5FBB7
Striatin-interacting protein 1 (STRIP1) STRIP family Q5VSL9
TIP41-like protein (TIPRL) TIP41 family O75663
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Striatin (STRN) WD repeat striatin family O43815
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2
Uncharacterized protein C3orf36 (C3orf36) . Q3SXR2

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vitamin E Small molecular drug DB00163
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Vp-102 . D01HZQ
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lb-100 Small molecular drug D02RNR
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2s3s4e6e8s9s)-3-amino-9-methoxy-268-trimethyl-10-phenyldeca-46-dienoic Acid . DB06905
268-trimethyl-3-amino-9-benzyl-9-methoxynonanoic Acid . DB02506

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.