Details of the Target

General Information of Target

Target ID LDTP07851
Target Name FYVE, RhoGEF and PH domain-containing protein 6 (FGD6)
Gene Name FGD6
Gene ID 55785
Synonyms
KIAA1362; ZFYVE24; FYVE, RhoGEF and PH domain-containing protein 6; Zinc finger FYVE domain-containing protein 24
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSAAEIKKPPVAPKPKFVVANNKPAPPPIAPKPDIVISSVPQSTKKMKPAIAPKPKVLK
TSPVREIGQSPSRKIMLNLEGHKQELAESTDNFNCKYEGNQSNDYISPMCSCSSECIHKL
GHRENLCVKQLVLEPLEMNENLENSKIDETLTIKTRSKCDLYGEKAKNQGGVVLKASVLE
EELKDALIHQMPPFISAQKHRPTDSPEMNGGCNSNGQFRIEFADLSPSPSSFEKVPDHHS
CHLQLPSDECEHFETCQDDSEKSNNCFQSSELEALENGKRSTLISSDGVSKKSEVKDLGP
LEIHLVPYTPKFPTPKPRKTRTARLLRQKCVDTPSESTEEPGNSDSSSSCLTENSLKINK
ISVLHQNVLCKQEQVDKMKLGNKSELNMESNSDAQDLVNSQKAMCNETTSFEKMAPSFDK
DSNLSSDSTTVDGSSMSLAVDEGTGFIRCTVSMSLPKQLKLTCNEHLQSGRNLGVSAPQM
QKESVIKEENSLRIVPKKPQRHSLPATGVLKKAASEELLEKSSYPSSEEKSSEKSLERNH
LQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK
PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICFMKSDFQKFWSKSSQLGDTTTG
HLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAANGLRAE
SLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRKTQELEWQNS
SSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQNDLGLGDLPSDEEEIINS
SDEDDVSSESSKGEPDPLEDKQDEDNGMKSKVHHIAKEIMSSEKVFVDVLKLLHIDFRDA
VAHASRQLGKPVIEDRILNQILYYLPQLYELNRDLLKELEERMLHWTEQQRIADIFVKKG
PYLKMYSTYIKEFDKNIALLDEQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIP
QYRLLLTDYLKNLIEDAGDYRDTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGH
HEIVQPGRVFLKEGILMKLSRKVMQPRMFFLFNDALLYTTPVQSGMYKLNNMLSLAGMKV
RKPTQEAYQNELKIESVERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDE
ADSENKEEVSPLGSKAPIWIPDTRATMCMICTSEFTLTWRRHHCRACGKIVCQACSSNKY
GLDYLKNQPARVCEHCFQELQKLDHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKI
PAALKEVSANTEDSSMSGYLYRSKGNKKPWKHFWFVIKNKVLYTYAASEDVAALESQPLL
GFTVIQVKDENSESKVFQLLHKNMLFYVFKAEDAHSAQKWIEAFQEGTIL
Target Bioclass
Other
Subcellular location
Cytoplasm
Function May activate CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. May play a role in regulating the actin cytoskeleton and cell shape.
Uniprot ID
Q6ZV73
Ensemble ID
ENST00000343958.9
HGNC ID
HGNC:21740

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.T2A .
CCK81 SNV: p.N1391S .
COLO792 SNV: p.L1163F .
DANG SNV: p.W1239G .
DU145 SNV: p.K623N DBIA    Probe Info 
HEC1 SNV: p.R493Ter .
HEC1B SNV: p.P28H; p.R493Ter .
JHH7 SNV: p.Q1278Ter .
MEWO SNV: p.E747V .
MOLT4 SNV: p.G1381Ter .
RKO SNV: p.N1150K .
SKMEL3 SNV: p.D556E .
SKN SNV: p.D1333G .
SUIT2 SNV: p.L510P .
SW756 SNV: p.L890F .
TE4 SNV: p.N144K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K158(8.33)  LDD0274  [2]
BTD
 Probe Info  		C1003(0.40)  LDD2113  [3]
DBIA
 Probe Info  		C330(1.05); C350(1.05)  LDD0078  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
WYneN
 Probe Info  		N.A.  LDD0021  [6]
IPM
 Probe Info  		C545(0.00); C1193(0.00)  LDD0147  [7]
YN-1
 Probe Info  		N.A.  LDD0446  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1252(0.95); C1255(0.95)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C330(0.92); C350(0.92)  LDD0532  [4]
 LDCM0216  AC100 PaTu 8988t C1252(0.97); C1255(0.97); C1273(1.28); C1276(1.28)  LDD1095  [4]
 LDCM0217  AC101 PaTu 8988t C1252(0.95); C1255(0.95); C1273(1.35); C1276(1.35)  LDD1096  [4]
 LDCM0218  AC102 PaTu 8988t C1252(0.86); C1255(0.86); C1273(1.09); C1276(1.09)  LDD1097  [4]
 LDCM0219  AC103 PaTu 8988t C1252(0.92); C1255(0.92); C1273(1.03); C1276(1.03)  LDD1098  [4]
 LDCM0220  AC104 PaTu 8988t C1252(1.20); C1255(1.20); C1273(1.30); C1276(1.30)  LDD1099  [4]
 LDCM0221  AC105 PaTu 8988t C1252(0.87); C1255(0.87); C1273(1.10); C1276(1.10)  LDD1100  [4]
 LDCM0222  AC106 PaTu 8988t C1252(0.85); C1255(0.85); C1273(1.18); C1276(1.18)  LDD1101  [4]
 LDCM0223  AC107 PaTu 8988t C1252(0.90); C1255(0.90); C1273(0.99); C1276(0.99)  LDD1102  [4]
 LDCM0224  AC108 PaTu 8988t C1252(0.79); C1255(0.79); C1273(1.01); C1276(1.01)  LDD1103  [4]
 LDCM0225  AC109 PaTu 8988t C1252(0.91); C1255(0.91); C1273(1.11); C1276(1.11)  LDD1104  [4]
 LDCM0226  AC11 HCT 116 C330(1.71); C350(1.71)  LDD0543  [4]
 LDCM0227  AC110 PaTu 8988t C1252(0.79); C1255(0.79); C1273(1.03); C1276(1.03)  LDD1106  [4]
 LDCM0228  AC111 PaTu 8988t C1252(0.89); C1255(0.89); C1273(1.10); C1276(1.10)  LDD1107  [4]
 LDCM0229  AC112 PaTu 8988t C1252(0.82); C1255(0.82); C1273(1.06); C1276(1.06)  LDD1108  [4]
 LDCM0230  AC113 PaTu 8988t C1252(0.96); C1255(0.96); C1273(1.07); C1276(1.07)  LDD1109  [4]
 LDCM0231  AC114 PaTu 8988t C1252(1.09); C1255(1.09); C1273(1.46); C1276(1.46)  LDD1110  [4]
 LDCM0232  AC115 PaTu 8988t C1252(1.12); C1255(1.12); C1273(1.11); C1276(1.11)  LDD1111  [4]
 LDCM0233  AC116 PaTu 8988t C1252(1.03); C1255(1.03); C1273(0.94); C1276(0.94)  LDD1112  [4]
 LDCM0234  AC117 PaTu 8988t C1252(0.95); C1255(0.95); C1273(1.27); C1276(1.27)  LDD1113  [4]
 LDCM0235  AC118 PaTu 8988t C1252(1.02); C1255(1.02); C1273(1.14); C1276(1.14)  LDD1114  [4]
 LDCM0236  AC119 PaTu 8988t C1252(1.10); C1255(1.10); C1273(1.03); C1276(1.03)  LDD1115  [4]
 LDCM0237  AC12 HCT 116 C330(0.98); C350(0.98)  LDD0554  [4]
 LDCM0238  AC120 PaTu 8988t C1252(0.93); C1255(0.93); C1273(1.27); C1276(1.27)  LDD1117  [4]
 LDCM0239  AC121 PaTu 8988t C1252(1.06); C1255(1.06); C1273(1.07); C1276(1.07)  LDD1118  [4]
 LDCM0240  AC122 PaTu 8988t C1252(1.00); C1255(1.00); C1273(1.30); C1276(1.30)  LDD1119  [4]
 LDCM0241  AC123 PaTu 8988t C1252(0.93); C1255(0.93); C1273(1.42); C1276(1.42)  LDD1120  [4]
 LDCM0242  AC124 PaTu 8988t C1252(0.87); C1255(0.87); C1273(1.04); C1276(1.04)  LDD1121  [4]
 LDCM0243  AC125 PaTu 8988t C1252(0.96); C1255(0.96); C1273(1.31); C1276(1.31)  LDD1122  [4]
 LDCM0244  AC126 PaTu 8988t C1252(1.01); C1255(1.01); C1273(1.30); C1276(1.30)  LDD1123  [4]
 LDCM0245  AC127 PaTu 8988t C1252(1.09); C1255(1.09); C1273(1.17); C1276(1.17)  LDD1124  [4]
 LDCM0246  AC128 HCT 116 C330(0.46); C350(0.46)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C330(0.39); C350(0.39)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C330(0.40); C350(0.40)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C330(0.50); C350(0.50)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C330(0.54); C350(0.54)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C330(0.42); C350(0.42)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C330(0.48); C350(0.48)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C330(0.46); C350(0.46)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C330(0.51); C350(0.51)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C330(0.51); C350(0.51)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C330(0.51); C350(0.51)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C330(0.57); C350(0.57)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C330(1.14); C350(1.14)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C330(0.58); C350(0.58)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C330(0.60); C350(0.60)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C330(0.47); C350(0.47)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C330(1.18); C350(1.18)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C330(1.07); C350(1.13)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C330(0.88); C350(1.22)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C330(0.82); C350(1.21)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C350(0.76); C330(1.05)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C330(0.88); C350(0.91)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C330(0.80); C350(1.07)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C330(0.94); C350(0.94)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C350(1.03); C330(1.12)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C350(0.79); C330(0.96)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C350(0.86); C330(1.06)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C330(0.63); C350(0.98)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C330(1.05); C350(0.88)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C330(0.98); C350(0.85)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C330(1.04); C350(0.92)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C330(0.90); C350(0.80)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C330(0.50); C350(0.50)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C330(0.72); C350(0.72)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C330(0.53); C350(0.53)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C1252(1.01); C1255(1.01)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C330(0.62); C350(0.62)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C330(0.56); C350(0.56)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C330(0.51); C350(0.51)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C330(0.50); C350(0.50)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C330(0.53); C350(0.53)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C1252(0.91); C1255(0.91)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C1252(1.03); C1255(1.03)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C1252(0.92); C1255(0.92)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C1252(1.00); C1255(1.00)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C1252(0.86); C1255(0.86)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C1252(1.07); C1255(1.07)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C1252(0.97); C1255(0.97)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C1252(0.99); C1255(0.99)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C1252(0.87); C1255(0.87)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C1252(0.85); C1255(0.85)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C1252(0.97); C1255(0.97)  LDD0612  [4]
 LDCM0296  AC35 PaTu 8988t C1252(1.01); C1255(1.01); C1273(0.92); C1276(0.92)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C1252(0.97); C1255(0.97); C1273(0.85); C1276(0.85)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C1252(0.78); C1255(0.78); C1273(0.96); C1276(0.96)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C1252(0.98); C1255(0.98); C1273(1.18); C1276(1.18)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C1252(0.98); C1255(0.98); C1273(0.85); C1276(0.85)  LDD1179  [4]
 LDCM0301  AC4 HCT 116 C1252(1.11); C1255(1.11)  LDD0618  [4]
 LDCM0302  AC40 PaTu 8988t C1252(0.92); C1255(0.92); C1273(1.02); C1276(1.02)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C1252(0.91); C1255(0.91); C1273(0.95); C1276(0.95)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C1252(0.94); C1255(0.94); C1273(0.84); C1276(0.84)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C1252(0.95); C1255(0.95); C1273(1.11); C1276(1.11)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C1252(0.94); C1255(0.94); C1273(0.97); C1276(0.97)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C1252(0.88); C1255(0.88); C1273(0.88); C1276(0.88)  LDD1186  [4]
 LDCM0308  AC46 HEK-293T C1255(0.97)  LDD0906  [4]
 LDCM0309  AC47 HEK-293T C1255(1.03)  LDD0907  [4]
 LDCM0310  AC48 HEK-293T C1255(1.17)  LDD0908  [4]
 LDCM0311  AC49 HEK-293T C1255(1.18)  LDD0909  [4]
 LDCM0312  AC5 HCT 116 C1252(1.02); C1255(1.02)  LDD0629  [4]
 LDCM0313  AC50 HEK-293T C1255(1.24)  LDD0911  [4]
 LDCM0314  AC51 HEK-293T C1255(1.26)  LDD0912  [4]
 LDCM0315  AC52 HEK-293T C1255(1.36)  LDD0913  [4]
 LDCM0316  AC53 HEK-293T C1255(1.05)  LDD0914  [4]
 LDCM0317  AC54 HEK-293T C1255(1.34)  LDD0915  [4]
 LDCM0318  AC55 HEK-293T C1255(1.25)  LDD0916  [4]
 LDCM0319  AC56 HEK-293T C1255(1.06)  LDD0917  [4]
 LDCM0320  AC57 PaTu 8988t C1252(0.81); C1255(0.81); C1273(1.08); C1276(1.08)  LDD1199  [4]
 LDCM0321  AC58 PaTu 8988t C1252(0.96); C1255(0.96); C1273(1.07); C1276(1.07)  LDD1200  [4]
 LDCM0322  AC59 PaTu 8988t C1252(0.75); C1255(0.75); C1273(1.05); C1276(1.05)  LDD1201  [4]
 LDCM0323  AC6 HCT 116 C330(1.08); C350(1.08)  LDD0640  [4]
 LDCM0324  AC60 PaTu 8988t C1252(0.81); C1255(0.81); C1273(1.15); C1276(1.15)  LDD1203  [4]
 LDCM0325  AC61 PaTu 8988t C1252(0.90); C1255(0.90); C1273(1.01); C1276(1.01)  LDD1204  [4]
 LDCM0326  AC62 PaTu 8988t C1252(0.89); C1255(0.89); C1273(1.09); C1276(1.09)  LDD1205  [4]
 LDCM0327  AC63 PaTu 8988t C1252(0.92); C1255(0.92); C1273(1.15); C1276(1.15)  LDD1206  [4]
 LDCM0328  AC64 PaTu 8988t C1252(0.89); C1255(0.89); C1273(1.11); C1276(1.11)  LDD1207  [4]
 LDCM0329  AC65 PaTu 8988t C1252(1.02); C1255(1.02); C1273(1.11); C1276(1.11)  LDD1208  [4]
 LDCM0330  AC66 PaTu 8988t C1252(0.90); C1255(0.90); C1273(1.24); C1276(1.24)  LDD1209  [4]
 LDCM0331  AC67 PaTu 8988t C1252(0.99); C1255(0.99); C1273(1.00); C1276(1.00)  LDD1210  [4]
 LDCM0332  AC68 HCT 116 C1252(1.02); C1255(1.02); C330(1.07); C350(1.07)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C1252(1.02); C1255(1.02); C330(1.11); C350(1.11)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C330(1.02); C350(1.02)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C330(0.83); C350(0.83); C1252(0.87); C1255(0.87)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C1252(0.93); C1255(0.93); C330(0.98); C350(0.98)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C1252(0.78); C1255(0.78); C330(0.96); C350(0.96)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C1252(0.86); C1255(0.86); C330(0.97); C350(0.97)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C1252(0.89); C1255(0.89); C330(1.00); C350(1.00)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C1252(0.90); C1255(0.90); C330(0.98); C350(0.98)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C1252(0.92); C1255(0.92); C330(1.09); C350(1.09)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C1252(0.95); C1255(0.95); C330(1.19); C350(1.19)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C1252(0.81); C1255(0.81); C330(1.20); C350(1.20)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C1252(0.94); C1255(0.94); C330(1.04); C350(1.04)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C330(0.80); C350(0.80)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C1252(0.79); C1255(0.79); C330(1.01); C350(1.01)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C330(0.85); C350(0.85); C1252(1.12); C1255(1.12)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C1252(1.01); C1255(1.01); C330(1.39); C350(1.39)  LDD0665  [4]
 LDCM0349  AC83 HEK-293T C1255(0.92)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C1255(1.30)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C1255(1.06)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C1255(1.04)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C1255(1.30)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C1255(1.29)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C1255(1.31)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C1255(1.28)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C1255(1.19)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C1255(1.35)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C1255(1.22)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C1255(1.29)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C1255(1.29)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C1255(1.22)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C1255(2.28)  LDD0962  [4]
 LDCM0365  AC98 PaTu 8988t C1252(0.88); C1255(0.88); C1273(1.18); C1276(1.18)  LDD1244  [4]
 LDCM0366  AC99 PaTu 8988t C1252(0.90); C1255(0.90); C1273(1.29); C1276(1.29)  LDD1245  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C1003(0.40)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C330(1.11); C350(1.11)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C330(1.61); C350(1.61)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C330(0.86); C350(0.86)  LDD0592  [4]
 LDCM0020  ARS-1620 HCC44 C330(1.05); C350(1.05)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C1252(0.89); C1255(0.89); C330(1.01); C350(1.01)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C330(0.60); C350(0.60); C1252(0.91); C1255(0.91)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C1252(0.95); C1255(0.95)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C330(1.12); C350(1.12)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C330(1.11); C350(1.11)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C330(1.02); C350(1.02)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C330(1.04); C350(1.04)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C330(0.54); C350(0.54)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C330(0.51); C350(0.51)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C330(0.51); C350(0.51)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C330(0.49); C350(0.49)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C330(0.68); C350(0.68)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C330(0.70); C350(0.70); C1252(0.91); C1255(0.91)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C330(0.49); C350(0.49)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C330(0.66); C350(0.66)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C1252(0.73); C1255(0.73)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C1252(0.79); C1255(0.79)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C1252(0.94); C1255(0.94)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C1252(0.84); C1255(0.84)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C1252(0.85); C1255(0.85)  LDD0703  [4]
 LDCM0387  CL117 PaTu 8988t C1252(0.88); C1255(0.88); C1273(0.95); C1276(0.95)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C1252(0.84); C1255(0.84); C1273(0.94); C1276(0.94)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C1252(0.91); C1255(0.91); C1273(0.95); C1276(0.95)  LDD1268  [4]
 LDCM0390  CL12 HCT 116 C330(0.62); C350(0.62); C1252(1.17); C1255(1.17)  LDD0707  [4]
 LDCM0391  CL120 PaTu 8988t C1252(0.96); C1255(0.96); C1273(0.92); C1276(0.92)  LDD1270  [4]
 LDCM0392  CL121 HEK-293T C1255(1.30)  LDD0990  [4]
 LDCM0393  CL122 HEK-293T C1255(1.06)  LDD0991  [4]
 LDCM0394  CL123 HEK-293T C1255(0.92)  LDD0992  [4]
 LDCM0395  CL124 HEK-293T C1255(1.08)  LDD0993  [4]
 LDCM0396  CL125 PaTu 8988t C1252(0.85); C1255(0.85); C1273(1.20); C1276(1.20)  LDD1275  [4]
 LDCM0397  CL126 PaTu 8988t C1252(0.94); C1255(0.94); C1273(1.12); C1276(1.12)  LDD1276  [4]
 LDCM0398  CL127 PaTu 8988t C1252(0.82); C1255(0.82); C1273(1.10); C1276(1.10)  LDD1277  [4]
 LDCM0399  CL128 PaTu 8988t C1252(0.86); C1255(0.86); C1273(1.06); C1276(1.06)  LDD1278  [4]
 LDCM0400  CL13 HCT 116 C330(0.52); C350(0.52); C1252(0.91); C1255(0.91)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C330(0.69); C350(0.69); C1252(0.78); C1255(0.78)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C330(0.61); C350(0.61); C1252(0.83); C1255(0.83)  LDD0719  [4]
 LDCM0403  CL16 PaTu 8988t C1252(0.86); C1255(0.86)  LDD1282  [4]
 LDCM0404  CL17 PaTu 8988t C1252(0.78); C1255(0.78)  LDD1283  [4]
 LDCM0405  CL18 PaTu 8988t C1252(0.81); C1255(0.81)  LDD1284  [4]
 LDCM0406  CL19 PaTu 8988t C1252(0.74); C1255(0.74)  LDD1285  [4]
 LDCM0407  CL2 HCT 116 C1252(0.78); C1255(0.78); C330(0.84); C350(0.84)  LDD0724  [4]
 LDCM0408  CL20 PaTu 8988t C1252(0.88); C1255(0.88)  LDD1287  [4]
 LDCM0409  CL21 PaTu 8988t C1252(0.81); C1255(0.81)  LDD1288  [4]
 LDCM0410  CL22 PaTu 8988t C1252(0.80); C1255(0.80)  LDD1289  [4]
 LDCM0411  CL23 PaTu 8988t C1252(0.83); C1255(0.83)  LDD1290  [4]
 LDCM0412  CL24 PaTu 8988t C1252(0.82); C1255(0.82)  LDD1291  [4]
 LDCM0413  CL25 PaTu 8988t C1252(0.81); C1255(0.81)  LDD1292  [4]
 LDCM0414  CL26 PaTu 8988t C1252(0.87); C1255(0.87)  LDD1293  [4]
 LDCM0415  CL27 PaTu 8988t C1252(0.84); C1255(0.84)  LDD1294  [4]
 LDCM0416  CL28 PaTu 8988t C1252(0.83); C1255(0.83)  LDD1295  [4]
 LDCM0417  CL29 PaTu 8988t C1252(0.85); C1255(0.85)  LDD1296  [4]
 LDCM0418  CL3 HCT 116 C1252(0.83); C1255(0.83); C330(0.76); C350(0.76)  LDD0735  [4]
 LDCM0419  CL30 PaTu 8988t C1252(0.79); C1255(0.79)  LDD1298  [4]
 LDCM0420  CL31 PaTu 8988t C1252(0.88); C1255(0.88); C1273(0.90); C1276(0.90)  LDD1299  [4]
 LDCM0421  CL32 PaTu 8988t C1252(0.86); C1255(0.86); C1273(0.95); C1276(0.95)  LDD1300  [4]
 LDCM0422  CL33 PaTu 8988t C1252(0.77); C1255(0.77); C1273(0.75); C1276(0.75)  LDD1301  [4]
 LDCM0423  CL34 PaTu 8988t C1252(0.93); C1255(0.93); C1273(0.82); C1276(0.82)  LDD1302  [4]
 LDCM0424  CL35 PaTu 8988t C1252(0.96); C1255(0.96); C1273(0.85); C1276(0.85)  LDD1303  [4]
 LDCM0425  CL36 PaTu 8988t C1252(0.28); C1255(0.28); C1273(0.78); C1276(0.78)  LDD1304  [4]
 LDCM0426  CL37 PaTu 8988t C1252(0.86); C1255(0.86); C1273(0.83); C1276(0.83)  LDD1305  [4]
 LDCM0428  CL39 PaTu 8988t C1252(0.86); C1255(0.86); C1273(0.85); C1276(0.85)  LDD1307  [4]
 LDCM0429  CL4 HCT 116 C1252(0.91); C1255(0.91); C330(0.92); C350(0.92)  LDD0746  [4]
 LDCM0430  CL40 PaTu 8988t C1252(0.85); C1255(0.85); C1273(0.91); C1276(0.91)  LDD1309  [4]
 LDCM0431  CL41 PaTu 8988t C1252(0.68); C1255(0.68); C1273(0.82); C1276(0.82)  LDD1310  [4]
 LDCM0432  CL42 PaTu 8988t C1252(0.76); C1255(0.76); C1273(0.90); C1276(0.90)  LDD1311  [4]
 LDCM0433  CL43 PaTu 8988t C1252(0.80); C1255(0.80); C1273(0.97); C1276(0.97)  LDD1312  [4]
 LDCM0434  CL44 PaTu 8988t C1252(0.82); C1255(0.82); C1273(0.93); C1276(0.93)  LDD1313  [4]
 LDCM0435  CL45 PaTu 8988t C1252(0.73); C1255(0.73); C1273(0.91); C1276(0.91)  LDD1314  [4]
 LDCM0436  CL46 HEK-293T C1255(1.19)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C1255(0.86)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C1255(1.81)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C1255(1.15)  LDD1037  [4]
 LDCM0440  CL5 HCT 116 C1252(0.83); C1255(0.83); C330(0.87); C350(0.87)  LDD0757  [4]
 LDCM0441  CL50 HEK-293T C1255(1.02)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C1255(0.76)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C1255(0.66)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C1255(0.79)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C1255(0.81)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C1255(1.25)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C1255(0.92)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C1255(0.65)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C1255(1.08)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C1255(1.01)  LDD1048  [4]
 LDCM0451  CL6 HCT 116 C1252(0.82); C1255(0.82); C330(0.86); C350(0.86)  LDD0768  [4]
 LDCM0452  CL60 HEK-293T C1255(0.88)  LDD1050  [4]
 LDCM0453  CL61 HCT 116 C1252(0.99); C1255(0.99); C330(0.70); C350(0.70)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C1252(1.13); C1255(1.13); C330(1.08); C350(1.08)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C1252(1.00); C1255(1.00); C330(0.63); C350(0.63)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C1252(1.11); C1255(1.11); C330(0.54); C350(0.54)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C1252(0.99); C1255(0.99); C330(0.62); C350(0.62)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C1252(1.07); C1255(1.07); C330(0.63); C350(0.63)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C1252(1.10); C1255(1.10); C330(0.68); C350(0.68)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C1252(1.05); C1255(1.05); C330(0.60); C350(0.60)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C1252(1.12); C1255(1.12); C330(0.79); C350(0.79)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C1252(1.00); C1255(1.00); C330(0.56); C350(0.56)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C1252(1.11); C1255(1.11); C330(0.56); C350(0.56)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C1252(0.93); C1255(0.93); C330(0.74); C350(0.74)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C1252(1.15); C1255(1.15); C330(0.89); C350(0.89)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C1252(1.04); C1255(1.04); C330(0.69); C350(0.69)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C1252(0.98); C1255(0.98); C330(0.63); C350(0.63)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C1252(0.92); C1255(0.92)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C1252(0.80); C1255(0.80)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C1252(0.94); C1255(0.94)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C1252(0.93); C1255(0.93)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C1252(0.66); C1255(0.66); C330(1.34); C350(1.34)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C1252(0.87); C1255(0.87)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C1252(0.88); C1255(0.88)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C1252(0.92); C1255(0.92)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C1252(1.12); C1255(1.12)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C1252(0.95); C1255(0.95)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C1252(0.92); C1255(0.92)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C1252(0.88); C1255(0.88)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C1252(0.90); C1255(0.90)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C1252(0.96); C1255(0.96)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C1252(0.87); C1255(0.87)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C1252(0.91); C1255(0.91); C330(0.74); C350(0.74)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C1252(0.85); C1255(0.85)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C1252(1.14); C1255(1.14)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C1252(0.94); C1255(0.94)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C1252(0.87); C1255(0.87)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C1252(0.95); C1255(0.95)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C1252(0.96); C1255(0.96)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C1252(1.23); C1255(1.23)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C1252(1.03); C1255(1.03)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C1252(0.96); C1255(0.96)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C1252(1.00); C1255(1.00)  LDD0811  [4]
 LDCM0468  Fragment33 HCT 116 C1252(1.09); C1255(1.09); C330(0.48); C350(0.48)  LDD0785  [4]
 LDCM0427  Fragment51 PaTu 8988t C1252(0.75); C1255(0.75); C1273(1.24); C1276(1.24)  LDD1306  [4]
 LDCM0022  KB02 786-O C638(2.38)  LDD2247  [9]
 LDCM0023  KB03 786-O C638(3.19)  LDD2664  [9]
 LDCM0024  KB05 SKMEL24 C744(2.10)  LDD3323  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1003(0.52)  LDD2114  [3]
 LDCM0021  THZ1 HCT 116 C330(1.21); C350(1.21)  LDD2173  [4]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840