Details of the Target

General Information of Target

Target ID	LDTP17387
Target Name	Kelch-like protein 35 (KLHL35)
Gene Name	KLHL35
Gene ID	283212
Synonyms	Kelch-like protein 35
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MAESGLAMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVDC DGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAF ESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQ LSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQT QLRELYLQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILHLGRNRIR QVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRL RALVLPHNHVAALGARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQL TRLPMGLPTGLRTLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLRVGDIGPGTWHELQA LQVRHRLVSHTVPRAPPSPCLPCHVPNILVSW
Target Bioclass	Other
Uniprot ID	Q6PF15
Ensemble ID	ENST00000539798.3
HGNC ID	HGNC:26597

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
A498	SNV: p.C265F	.
AN3CA	SNV: p.Q558Ter	.
CORL23	Substitution: p.Y353T	.
HT1080	SNV: p.T420P	.
Ishikawa (Heraklio) 02 ER	SNV: p.P86T	.
JURKAT	SNV: p.A277T	.
NCIH2286	SNV: p.G557W	.
PC3	SNV: p.H5R	.
PF382	SNV: p.A61V	.
SUPT1	SNV: p.R276H	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
YN-1 Probe Info			N.A.	LDD0446	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1)				Class-II pyridoxal-phosphate-dependent aminotransferase family	P13196
Ubiquitin domain-containing protein 2 (UBTD2)				.	Q8WUN7

Other

Click To Hide/Show 5 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2)	CALCOCO family	Q13137
Protein FAM25C (FAM25C)	FAM25 family	B3EWG5
Golgin subfamily A member 6-like protein 9 (GOLGA6L9)	GOLGA6 family	A6NEM1
Amyloid protein-binding protein 2 (APPBP2)	.	Q92624
Cytoplasmic protein NCK2 (NCK2)	.	O43639

References

1	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.