Details of the Target

General Information of Target

Target ID LDTP11015
Target Name Tyrosine-protein phosphatase non-receptor type 18 (PTPN18)
Gene Name PTPN18
Gene ID 26469
Synonyms
BDP1; Tyrosine-protein phosphatase non-receptor type 18; EC 3.1.3.48; Brain-derived phosphatase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSEKSGLPDSVPHTSPPPYNAPQPPAEPPAPPPQAAPSSHHHHHHHYHQSGTATLPRLG
AGGLASSAATAQRGPSSSATLPRPPHHAPPGPAAGAPPPGCATLPRMPPDPYLQETRFEG
PLPPPPPAAAAPPPPAPAQTAQAPGFVVPTHAGTVGTLPLGGYVAPGYPLQLQPCTAYVP
VYPVGTPYAGGTPGGTGVTSTLPPPPQGPGLALLEPRRPPHDYMPIAVLTTICCFWPTGI
IAIFKAVQVRTALARGDMVSAEIASREARNFSFISLAVGIAAMVLCTILTVVIIIAAQHH
ENYWDP
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
Subcellular location
Nucleus
Function Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Uniprot ID
Q99952
Ensemble ID
ENST00000175756.10
HGNC ID
HGNC:9649
ChEMBL ID
CHEMBL3351197

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L108S; p.P411S .
CCK81 SNV: p.S184F .
DETROIT562 SNV: p.R140S .
ICC10 Substitution: p.M210_V211delinsIL .
ICC106 Substitution: p.M210_V211delinsIL .
ICC108 Substitution: p.M210_V211delinsIL .
NCIH716 Insertion: p.G432_A433insGR .
OVKATE SNV: p.Q358Ter .
SF295 SNV: p.E278Q .
SW403 SNV: p.S186Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C46(2.33)  LDD3408  [1]
YN-1
 Probe Info  		E133(0.00); E135(0.00)  LDD0446  [2]
AOyne
 Probe Info  		13.50  LDD0443  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 EoL-1 C46(1.31)  LDD2324  [1]
 LDCM0023  KB03 HEL C46(2.41)  LDD2768  [1]
 LDCM0024  KB05 RL C46(2.33)  LDD3408  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
F-box/WD repeat-containing protein 1A (BTRC) . Q9Y297
Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) . O43586

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.