Details of the Target

General Information of Target

Target ID LDTP04564
Target Name CCAAT/enhancer-binding protein gamma (CEBPG)
Gene Name CEBPG
Gene ID 1054
Synonyms
CCAAT/enhancer-binding protein gamma; C/EBP gamma
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSKISQQNSTPGVNGISVIHTQAHASGLQQVPQLVPAGPGGGGKAVAPSKQSKKSSPMDR
NSDEYRQRRERNNMAVKKSRLKSKQKAQDTLQRVNQLKEENERLEAKIKLLTKELSVLKD
LFLEHAHNLADNVQSISTENTTADGDNAGQ
Target Bioclass
Transcription factor
Family
BZIP family, C/EBP subfamily
Subcellular location
Nucleus
Function
Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.
Uniprot ID
P53567
Ensemble ID
ENST00000284000.9
HGNC ID
HGNC:1837

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		N.A.  LDD0446  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Basic leucine zipper transcriptional factor ATF-like (BATF) BZIP family Q16520
Basic leucine zipper transcriptional factor ATF-like 2 (BATF2) BZIP family Q8N1L9
Basic leucine zipper transcriptional factor ATF-like 3 (BATF3) BZIP family Q9NR55
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) BZIP family Q9Y2D1
DNA damage-inducible transcript 3 protein (DDIT3) BZIP family P35638
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) BZIP family P18847
CCAAT/enhancer-binding protein alpha (CEBPA) BZIP family P49715
CCAAT/enhancer-binding protein beta (CEBPB) BZIP family P17676
CCAAT/enhancer-binding protein delta (CEBPD) BZIP family P49716
CCAAT/enhancer-binding protein epsilon (CEBPE) BZIP family Q15744
Nuclear factor erythroid 2-related factor 2 (NFE2L2) BZIP family Q16236
Protein c-Fos (FOS) BZIP family P01100
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) BZIP family P15336
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Prefoldin subunit 6 (PFDN6) Prefoldin subunit beta family O15212

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.