Details of the Target

General Information of Target

Target ID	LDTP01429
Target Name	Nucleolar protein 4 (NOL4)
Gene Name	NOL4
Gene ID	8715
Synonyms	NOLP; Nucleolar protein 4; Nucleolar-localized protein
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MESERDMYRQFQDWCLRTYGDSGKTKTVTRKKYERIVQLLNGSESSSTDNAKFKFWVKSK GFQLGQPDEVRGGGGGAKQVLYVPVKTTDGVGVDEKLSLRRVAVVEDFFDIIYSMHVETG PNGEQIRKHAGQKRTYKAISESYAFLPREAVTRFLMSCSECQKRMHLNPDGTDHKDNGKP PTLVTSMIDYNMPITMAYMKHMKLQLLNSQQDEDESSIESDEFDMSDSTRMSAVNSDLSS NLEERMQSPQNLHGQQDDDSAAESFNGNETLGHSSIASGGTHSREMGDSNSDGKTGLEQD EQPLNLSDSPLSAQLTSEYRIDDHNSNGKNKYKNLLISDLKMEREARENGSKSPAHSYSS YDSGKNESVDRGAEDLSLNRGDEDEDDHEDHDDSEKVNETDGVEAERLKAFNMFVRLFVD ENLDRMVPISKQPKEKIQAIIDSCRRQFPEYQERARKRIRTYLKSCRRMKRSGFEMSRPI PSHLTSAVAESILASACESESRNAAKRMRLERQQDESAPADKQCKPEATQATYSTSAVPG SQDVLYINGNGTYSYHSYRGLGGGLLNLNDASSSGPTDLSMKRQLATSSGSSSSSNSRPQ LSPTEINAVRQLVAGYRESAAFLLRSADELENLILQQN
Target Bioclass	Other
Subcellular location	Nucleus, nucleolus
Uniprot ID	O94818
Ensemble ID	ENST00000261592.10
HGNC ID	HGNC:7870

Target Site Mutations in Different Cell Lines

Cell line	Mutation details	Probe for labeling this protein in this cell
C4II	SNV: p.R371Q	.
CAL51	SNV: p.R101W	.
CHL1	SNV: p.R425Q	.
HCC15	SNV: p.D6N	.
HS936T	SNV: p.G549E	.
IGR1	SNV: p.R617Ter	.
LOXIMVI	SNV: p.E383K	.
NCIH1155	SNV: p.E34K	.
NCIH2172	Deletion: p.G280EfsTer25	.
NCIH2291	Insertion: p.E118GfsTer58	.
REH	SNV: p.D401N	.
RKO	SNV: p.S317W	.
SW1271	SNV: p.G381E	.

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 1 Probe Related to This Target

Probe name		Structure	Binding Site(Ratio)	Interaction ID	Ref
YN-1 Probe Info			Y143(0.00); S142(0.00); P147(0.00)	LDD0446	[1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 2 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
C-terminal-binding protein 2 (CTBP2)				D-isomer specific 2-hydroxyacid dehydrogenase family	P56545
Protein disulfide-isomerase (P4HB)				Protein disulfide isomerase family	P07237

Transcription factor

Click To Hide/Show 1 Protein(s) Interacting with This Target

Protein name				Family	Uniprot ID
Zinc finger protein 383 (ZNF383)				Krueppel C2H2-type zinc-finger protein family	Q8NA42

Other

Click To Hide/Show 6 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Protein FAM9B (FAM9B)	FAM9 family	Q8IZU0
Spindle and kinetochore-associated protein 3 (SKA3)	SKA3 family	Q8IX90
Complement C1q tumor necrosis factor-related protein 2 (C1QTNF2)	.	Q9BXJ5
Melanoma-associated antigen 11 (MAGEA11)	.	P43364
snRNA-activating protein complex subunit 5 (SNAPC5)	.	O75971
Testis-expressed protein 9 (TEX9)	.	Q8N6V9

References

1	Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.