Details of the Target

General Information of Target

Target ID LDTP07926
Target Name Kinase non-catalytic C-lobe domain-containing protein 1 (KNDC1)
Gene Name KNDC1
Gene ID 85442
Synonyms
C10orf23; KIAA1768; RASGEF2; VKIND; Kinase non-catalytic C-lobe domain-containing protein 1; KIND domain-containing protein 1; Cerebral protein 9; Protein very KIND; v-KIND; Ras-GEF domain-containing family member 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MQAMDPAAADLYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCL
ECSLSMRSVAHAAIFQSLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDVTGNTFE
AHIYSLGATLKAALEYVAEPTLEPRLSQDLEALLSRMQAEDPGDRPDLESIIALCEEKLQ
LTSSCRVCRSLSAVGRRVLSIESFGALQDVSESSWRERPAPGNAGPRRPPGDPSTDPEVL
PTPEGPESETSRGPRASPTKALLSTPVRNGESHSREGLAGLVLDAERTLGELDRDALRRS
RLRKVQTFPRLLSDSPEATLCLPLTRGKSQLPISELFSPDPRKAFLDRKNGLSSFQAQPK
CRLWPEQEPEHQLGRVPCAGRSTDRGPGVPGSPGQPETSHPSQGPAEAPADPRDASGEAQ
TPRDDERIPEGARQLESAAAEQWVSLQDLLSQLGRPFREYELWALCLACLRALQTRPEHP
AYLCLDSVLVAEDGAVLFQPPPANGSYDSFFLAPELAEERLVTEKASVYCVAAVLWTAAK
FSVPRNHKLALPRRLKTLLLDMARRSAPERPSAAEAIKVCGSYLLQRGMDSRKILAHLRA
SICQVYQEEETISLQNAFSVVELKPSVAPAPEPSPGFLPVNSDTGLVAVPGPVPGQHPCG
EEATQLPAAFTSEATHFKPIVLAQNASVARDQPALAQEESEERGGQREGEGEEKLSLEAH
AGSPSLKTPDGPVPGPGPQGAAPEPLGASVQRDSAQGRPCPPPQAPANQPEGASSAAPGS
PVPAPPTKASALPVEQGPAEPIPPGVASGGLRPDALGPTTAHHGPRHPPKPPRSKATERP
GQEPEGPGATPAGERDDQSPDSVPERPRPADRRLCLPCVDASPLPGRTACPSLQEATRLI
QEEFAFDGYLDNGLEALIMGEYIFALKDLTFATFCGAISEKFCDLYWDEKLLQNLFKVVN
GQASPSPSTAEEAGSQLEGSQSPRSPSSKRPSLHRLGKEKPAMARTSSRAPCSPTSVSDV
DSDALSRGNFEVGFRPQRSVKAERAQQPEAGEDRRPAGGASDVEAVTRLARSKGVGPALS
PGPAGFQSCSPGWCSAFYEADCFGADVHNYVKDLGRQQADGALPDAQSPELEQQLMMEKR
NYRKTLKFYQKLLQKEKRNKGSDVKTMLSKLKGQLEEMKSRVQFLSLVKKYLQVMYAERW
GLEPCTLPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGGRQKARILQAGTPLGLMA
YLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRINSTLTRAHQDPTSTFTKIYRRSL
CVLQAWVEDCYAVDFPRNSGLLGKLEDFISSKILPLDGSAKHLLGLLEVGMDRRAEGNPR
GTDLENPREAEEDARPFNALCKRLSEDGISRKSFPWRLPRGNGLVLPPHKERPYTIAAAL
PKPCFLEDFYGPCAKTSEKGPYFLTEYSTHQLFSQLTLLQQELFQKCHPVHFLNSRALGV
MDKSTAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKL
QVNLLSKFLLIAKSCYEQRNFATAMQILSGLEHLAVRQSPAWRILPAKIAEVMEELKAVE
VFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVVS
QVHAFQENPYTFSPDPKLQSYLKQRIARFSGADISTLAADSRANFHQVSSEKHSRKIQDK
LRRMKATFQ
Target Bioclass
Other
Subcellular location
Cell projection, dendrite
Function
RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2. May be involved in cellular senescence.
Uniprot ID
Q76NI1
Ensemble ID
ENST00000304613.8
HGNC ID
HGNC:29374

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DEL SNV: p.P801T .
DU145 SNV: p.A1215S .
HCT15 SNV: p.G886W .
HT115 SNV: p.S1180Y .
HT3 SNV: p.S1128N .
ICC4 SNV: p.S1319I .
IPC298 SNV: p.P783S .
Ishikawa (Heraklio) 02 ER SNV: p.D1372Y .
KMS27 SNV: p.D18E .
KYSE510 SNV: p.D1720Y .
LNCaP clone FGC SNV: p.E238D .
MELJUSO SNV: p.P832Q .
MEWO SNV: p.G886E .
MFE319 SNV: p.A905V .
MOLT4 SNV: p.L1717F .
NCIH1155 SNV: p.S211N .
NCIH1703 Substitution: p.Q367_E368delinsHTer .
NCIH1793 SNV: p.K1190N .
NCIH2170 SNV: p.R455L .
NCIH2172 SNV: p.E800Ter .
NCIH23 Deletion: p.A1004PfsTer37 .
OCIAML5 SNV: p.P6Q .
PF382 SNV: p.R1634W .
REH SNV: p.P818S .
RPMI8226 SNV: p.Q1536L .
SKMEL28 Substitution: p.T242P .
SKMEL3 SNV: p.A881V .
SKMEL5 SNV: p.M1178I .
SUPT1 SNV: p.P258S; p.P365S .
TCCSUP SNV: p.R703T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0230  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]
YN-1
 Probe Info  		D293(0.00); D295(0.00); E291(0.00)  LDD0446  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0230  [1]

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.