Details of the Target

General Information of Target

Target ID LDTP00419
Target Name Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)
Gene Name NHERF1
Gene ID 9368
Synonyms
NHERF; SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1; NHERF-1; Ezrin-radixin-moesin-binding phosphoprotein 50; EBP50; Regulatory cofactor of Na(+)/H(+) exchanger; Sodium-hydrogen exchanger regulatory factor 1; Solute carrier family 9 isoform A3 regulatory factor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV
EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA
EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR
SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK
KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ
DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm
Function
Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for recycling of internalized ADRB2. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3. May enhance Wnt signaling. May participate in HTR4 targeting to microvilli. Involved in the regulation of phosphate reabsorption in the renal proximal tubules. Involved in sperm capacitation. May participate in the regulation of the chloride and bicarbonate homeostasis in spermatozoa.
Uniprot ID
O14745
Ensemble ID
ENST00000262613.10
HGNC ID
HGNC:11075
ChEMBL ID
CHEMBL4523125

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HUH7 SNV: p.A140D DBIA    Probe Info 
L428 SNV: p.V86M DBIA    Probe Info 
OVK18 Deletion: p.K305NfsTer17 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K159(4.72); K34(7.70); K350(1.35); K351(1.54)  LDD0277  [2]
OPA-S-S-alkyne
 Probe Info  		K227(3.96)  LDD3494  [3]
Probe 1
 Probe Info  		Y38(7.03); Y164(40.18)  LDD3495  [4]
BTD
 Probe Info  		C206(1.05)  LDD2117  [5]
DBIA
 Probe Info  		C206(1.30)  LDD0531  [6]
5E-2FA
 Probe Info  		H72(0.00); H29(0.00); H169(0.00); H212(0.00)  LDD2235  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
Compound 10
 Probe Info  		N.A.  LDD2216  [9]
Compound 11
 Probe Info  		N.A.  LDD2213  [9]
IPM
 Probe Info  		N.A.  LDD0147  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [10]
VSF
 Probe Info  		N.A.  LDD0007  [11]
YN-1
 Probe Info  		N.A.  LDD0446  [12]
Acrolein
 Probe Info  		C206(0.00); C16(0.00); H72(0.00)  LDD0217  [13]
Methacrolein
 Probe Info  		C206(0.00); C16(0.00)  LDD0218  [13]
W1
 Probe Info  		N.A.  LDD0236  [14]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C206(1.05)  LDD2117  [5]
 LDCM0214  AC1 HCT 116 C206(1.30)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C206(1.56)  LDD0532  [6]
 LDCM0226  AC11 HCT 116 C206(1.03)  LDD0543  [6]
 LDCM0237  AC12 HCT 116 C206(1.22)  LDD0554  [6]
 LDCM0259  AC14 HCT 116 C206(1.82)  LDD0576  [6]
 LDCM0263  AC143 HCT 116 C206(0.96)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C206(1.05)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C206(1.28)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C206(1.25)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C206(1.27)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C206(1.66)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C206(1.42)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C206(1.50)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C206(1.06)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C206(1.15)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C206(1.49)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C206(1.75)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C206(1.29)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C206(1.35)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C206(1.10)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C206(0.92)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C206(0.82)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C206(0.80)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C206(0.48)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C206(1.32)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C206(0.91)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C206(0.86)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C206(0.96)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C206(0.79)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C206(0.92)  LDD0601  [6]
 LDCM0285  AC25 HEK-293T C206(0.97)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C206(0.97)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C206(0.92)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C206(1.00)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C206(0.97)  LDD1528  [17]
 LDCM0290  AC3 HCT 116 C206(1.40)  LDD0607  [6]
 LDCM0291  AC30 HEK-293T C206(0.96)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C206(0.95)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C206(0.95)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C206(0.92)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C206(0.93)  LDD1534  [17]
 LDCM0296  AC35 HCT 116 C206(0.63)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C206(0.77)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C206(0.76)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C206(1.00)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C206(1.12)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C206(1.44)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C206(1.15)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C206(0.97)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C206(0.88)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C206(1.07)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C206(0.63)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C206(1.01)  LDD0624  [6]
 LDCM0308  AC46 HEK-293T C206(0.92)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C206(0.93)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C206(0.99)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C206(0.89)  LDD1550  [17]
 LDCM0312  AC5 HCT 116 C206(1.47)  LDD0629  [6]
 LDCM0313  AC50 HEK-293T C206(1.01)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C206(1.00)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C206(1.02)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C206(1.06)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C206(0.95)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C206(0.94)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C206(0.90)  LDD1558  [17]
 LDCM0320  AC57 HCT 116 C206(1.16)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C206(1.20)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C206(1.14)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C206(2.05)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C206(1.04)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C206(1.05)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C206(1.04)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C206(0.96)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C206(1.14)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C206(1.35)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C206(1.13)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C206(1.10)  LDD0648  [6]
 LDCM0334  AC7 HCT 116 C206(1.34)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C206(1.86)  LDD0662  [6]
 LDCM0248  AKOS034007472 HCT 116 C206(2.03)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C206(1.92)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C206(3.21)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 11.71  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H72(0.00); C16(0.00); C206(0.00)  LDD0222  [13]
 LDCM0632  CL-Sc Hep-G2 C206(1.37); C206(0.62)  LDD2227  [15]
 LDCM0367  CL1 HCT 116 C206(0.77)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C206(1.12)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C206(1.18)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C206(1.46)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C206(1.33)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C206(1.11)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C206(1.92)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C206(0.87)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C206(0.56)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C206(0.94)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C206(0.86)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C206(0.78)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C206(1.35)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C206(0.85)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C206(0.54)  LDD0698  [6]
 LDCM0382  CL112 HEK-293T C206(0.97)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C206(0.99)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C206(0.88)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C206(0.98)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C206(0.93)  LDD1590  [17]
 LDCM0387  CL117 HCT 116 C206(1.09)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C206(1.03)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C206(1.14)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C206(1.61)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C206(0.80)  LDD0708  [6]
 LDCM0392  CL121 HEK-293T C206(1.01)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C206(0.98)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C206(0.87)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C206(0.91)  LDD1599  [17]
 LDCM0396  CL125 HCT 116 C206(1.04)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C206(0.94)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C206(1.08)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C206(1.09)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C206(1.12)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C206(0.98)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C206(1.16)  LDD0719  [6]
 LDCM0403  CL16 HEK-293T C206(0.91)  LDD1607  [17]
 LDCM0404  CL17 HCT 116 C206(0.52)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C206(0.73)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C206(0.69)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C206(0.93)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C206(0.61)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C206(0.69)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C206(0.89)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C206(0.74)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C206(0.61)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C206(0.59)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C206(0.65)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C206(0.76)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C206(0.88)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C206(0.51)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C206(1.05)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C206(0.53)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C206(0.76)  LDD0737  [6]
 LDCM0421  CL32 HEK-293T C206(0.94)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C206(0.80)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C206(0.90)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C206(0.91)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C206(0.84)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C206(1.02)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C206(0.96)  LDD1632  [17]
 LDCM0429  CL4 HCT 116 C206(1.10)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C206(0.93)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C206(0.89)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C206(0.95)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C206(0.97)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C206(1.02)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C206(0.88)  LDD1639  [17]
 LDCM0436  CL46 HCT 116 C206(1.04)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C206(0.83)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C206(0.81)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C206(0.77)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C206(0.95)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C206(1.07)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C206(1.35)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C206(0.75)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C206(0.68)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C206(1.12)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C206(0.67)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C206(1.11)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C206(1.04)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C206(0.80)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C206(0.85)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C206(1.14)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C206(0.81)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C206(0.92)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C206(1.03)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C206(1.16)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C206(1.09)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C206(1.12)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C206(1.68)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C206(1.51)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C206(1.16)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C206(0.94)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C206(1.16)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C206(1.10)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C206(1.25)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C206(0.93)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C206(1.13)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C206(1.10)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C206(0.94)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C206(0.82)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C206(1.00)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C206(0.97)  LDD1675  [17]
 LDCM0473  CL8 HCT 116 C206(1.46)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C206(0.98)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C206(0.98)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C206(0.90)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C206(0.91)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C206(0.82)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C206(0.99)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C206(1.06)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C206(0.95)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C206(0.99)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C206(0.94)  LDD1686  [17]
 LDCM0484  CL9 HCT 116 C206(1.19)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C206(0.77)  LDD1688  [17]
 LDCM0486  CL91 HCT 116 C206(0.98)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C206(0.88)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C206(0.90)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C206(0.94)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C206(1.07)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C206(1.34)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C206(1.15)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C206(1.28)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C206(1.22)  LDD0811  [6]
 LDCM0634  CY-0357 Hep-G2 C206(0.96)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C206(0.96)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C206(1.06)  LDD1702  [5]
 LDCM0625  F8 Ramos C206(1.46)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C206(0.88)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C206(15.61)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C206(1.02)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C206(1.46)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C206(0.74)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C206(0.93)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C206(1.49)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C206(1.28)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C206(1.11)  LDD2197  [18]
 LDCM0586  Fragment28 Ramos C206(0.68)  LDD2198  [18]
 LDCM0588  Fragment30 Ramos C206(1.35)  LDD2199  [18]
 LDCM0590  Fragment32 Ramos C206(0.93)  LDD2201  [18]
 LDCM0468  Fragment33 HCT 116 C206(1.03)  LDD0785  [6]
 LDCM0596  Fragment38 Ramos C206(0.88)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C206(0.91)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C206(0.97)  LDD1631  [17]
 LDCM0610  Fragment52 Ramos C206(1.08)  LDD2204  [18]
 LDCM0614  Fragment56 Ramos C206(1.12)  LDD2205  [18]
 LDCM0569  Fragment7 Ramos C206(0.67)  LDD2186  [18]
 LDCM0571  Fragment9 Ramos C206(0.73)  LDD2188  [18]
 LDCM0107  IAA HeLa H72(0.00); C16(0.00)  LDD0221  [13]
 LDCM0022  KB02 HEK-293T C206(0.98)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C206(0.98)  LDD1497  [17]
 LDCM0024  KB05 HMCB C50(0.99)  LDD3312  [19]
 LDCM0109  NEM HeLa N.A.  LDD0223  [13]
 LDCM0131  RA190 MM1.R C206(1.07)  LDD0304  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cystic fibrosis transmembrane conductance regulator (CFTR) ABCC family P13569
Angiotensin-converting enzyme 2 (ACE2) Peptidase M2 family Q9BYF1
Platelet-derived growth factor receptor beta (PDGFRB) Tyr protein kinase family P09619
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) PTEN phosphatase protein family P60484
PH domain leucine-rich repeat-containing protein phosphatase 1 (PHLPP1) . O60346
PH domain leucine-rich repeat-containing protein phosphatase 2 (PHLPP2) . Q6ZVD8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) . O14745
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
P2Y purinoceptor 1 (P2RY1) G-protein coupled receptor 1 family P47900
Beta-2 adrenergic receptor (ADRB2) G-protein coupled receptor 1 family P07550
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular retinoic acid-binding protein 1 (CRABP1) Fatty-acid binding protein (FABP) family P29762
Amyloid protein-binding protein 2 (APPBP2) . Q92624
Ezrin (EZR) . P15311
Moesin (MSN) . P26038

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
13 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
14 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
20 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.