Details of the Target

General Information of Target

Target ID LDTP05615
Target Name Cingulin-like protein 1 (CGNL1)
Gene Name CGNL1
Gene ID 84952
Synonyms
JACOP; KIAA1749; Cingulin-like protein 1; Junction-associated coiled-coil protein; Paracingulin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MELYFGEYQHVQQEYGVHLRLASDDTQKSRSSQNSKAGSYGVSIRVQGIDGHPYIVLNNT
ERCLAGTSFSENGPPFPPPVINNLPLHSSNGSVPKENSEELQLPENPYAQPSPIRNLKQP
LLHEGKNGVLDRKDGSVKPSHLLNFQRHPELLQPYDPEKNELNLQNHQPSESNWLKTLTE
EGINNKKPWTCFPKPSNSQPTSPSLEDPAKSGVTAIRLCSSVVIEDPKKQTSVCVNVQSC
TKERVGEEALFTSGRPLTAHSPHAHPETKKTRPDVLPFRRQDSAGPVLDGARSRRSSSSS
TTPTSANSLYRFLLDDQECAIHADNVNRHENRRYIPFLPGTGRDIDTGSIPGVDQLIEKF
DQKPGLQRRGRSGKRNRINTDDRKRSRSVDSAFPFGLQGNSEYLIEFSRNLGKSSEHLLR
PSQVCPQRPLSQERRGKQSVGRTFAKLQGAAHGASCAHSRPPQPNIDGKVLETEGSQEST
VIRAPSLGAQSKKEEEVKTATATLMLQNRATATSPDSGAKKISVKTFPSASNTQATPDLL
KGQQELTQQTNEETAKQILYNYLKEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNN
QACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNE
KVEENSTLQQRLEESEGELRKNLEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRS
EDREKGALIEELLQAKQDLQDLLIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDK
LKEQYDAELQALRESVEEATKNVEVLASRSNTSEQDQAGTEMRVKLLQEENEKLQGRSEE
LERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENE
LEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMADI
VEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEEE
LRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEEE
RNNSDLLSERISRSREQMEQLRNELLQERAARQDLECDKISLERQNKDLKSRIIHLEGSY
RSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNRRLERKVKELVMQVDDEHLSLTDQ
KDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLRLK
KLPSKVLDDMDDDDDLSTDGGSLYEAPVSYTFSKDSTVASQI
Target Bioclass
Other
Family
Cingulin family
Subcellular location
Cell junction, tight junction
Function May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons.
Uniprot ID
Q0VF96
Ensemble ID
ENST00000281282.6
HGNC ID
HGNC:25931

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R1026Ter .
COLO679 SNV: p.H1135Y .
HCT15 SNV: p.E61K .
HUPT4 SNV: p.R1167M .
IGR1 SNV: p.G66S .
Ishikawa (Heraklio) 02 ER SNV: p.T480A DBIA    Probe Info 
JURKAT SNV: p.R328H .
KMRC3 SNV: p.S1121C .
KMS11 SNV: p.A215T .
KYSE180 SNV: p.S221F; p.S388N .
KYSE30 SNV: p.R435H .
LOXIMVI SNV: p.G819E .
MDAMB157 SNV: p.G38C .
MDST8 SNV: p.R294W .
MEWO SNV: p.N185I; p.M778I .
NCIH2286 SNV: p.K228N .
NCIH661 SNV: p.L130P .
OVCAR8 SNV: p.T499I .
REH SNV: p.S514L .
SBC5 SNV: p.V235I DBIA    Probe Info 
SISO SNV: p.K577E .
SKMEL30 SNV: p.S1121F .
TE4 SNV: p.Q1200K DBIA    Probe Info 
TOV21G SNV: p.K1130N .
UACC257 SNV: p.G726E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C427(1.79)  LDD3313  [1]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [2]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
YN-1
 Probe Info  		N.A.  LDD0446  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C1117(1.15)  LDD1508  [5]
 LDCM0226  AC11 HEK-293T C1117(1.11)  LDD1509  [5]
 LDCM0237  AC12 HEK-293T C1117(0.98)  LDD1510  [5]
 LDCM0259  AC14 HEK-293T C1117(1.10)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C1117(1.03)  LDD1513  [5]
 LDCM0277  AC18 HEK-293T C1117(0.93)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C1117(1.01)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C1117(1.09)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C1117(0.97)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C1117(1.08)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C1117(0.95)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C1117(0.99)  LDD1522  [5]
 LDCM0286  AC26 HEK-293T C1117(0.95)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C1117(1.08)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C1117(0.96)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C1117(1.03)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C1117(1.12)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C1117(0.96)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C1117(1.08)  LDD1531  [5]
 LDCM0295  AC34 HEK-293T C1117(1.20)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C1117(1.14)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C1117(1.13)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C1117(1.07)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C1117(1.00)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C1117(1.12)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C1117(0.99)  LDD1540  [5]
 LDCM0304  AC42 HEK-293T C1117(1.04)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C1117(1.15)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C1117(1.01)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C1117(1.02)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C1117(1.09)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C1117(1.32)  LDD1548  [5]
 LDCM0312  AC5 HEK-293T C1117(1.02)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C1117(1.12)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C1117(1.27)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C1117(1.07)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C1117(1.06)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C1117(1.04)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C1117(1.13)  LDD1557  [5]
 LDCM0321  AC58 HEK-293T C1117(1.06)  LDD1560  [5]
 LDCM0322  AC59 HEK-293T C1117(1.13)  LDD1561  [5]
 LDCM0323  AC6 HEK-293T C1117(1.04)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C1117(0.98)  LDD1563  [5]
 LDCM0325  AC61 HEK-293T C1117(1.16)  LDD1564  [5]
 LDCM0326  AC62 HEK-293T C1117(1.07)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C1117(0.95)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C1117(1.18)  LDD1568  [5]
 LDCM0248  AKOS034007472 HEK-293T C1117(1.00)  LDD1511  [5]
 LDCM0368  CL10 HEK-293T C1117(1.03)  LDD1572  [5]
 LDCM0369  CL100 HEK-293T C1117(1.03)  LDD1573  [5]
 LDCM0373  CL104 HEK-293T C1117(0.99)  LDD1577  [5]
 LDCM0377  CL108 HEK-293T C1117(0.97)  LDD1581  [5]
 LDCM0379  CL11 HEK-293T C1117(1.29)  LDD1583  [5]
 LDCM0382  CL112 HEK-293T C1117(1.04)  LDD1586  [5]
 LDCM0386  CL116 HEK-293T C1117(1.10)  LDD1590  [5]
 LDCM0391  CL120 HEK-293T C1117(1.10)  LDD1595  [5]
 LDCM0395  CL124 HEK-293T C1117(1.11)  LDD1599  [5]
 LDCM0399  CL128 HEK-293T C1117(1.04)  LDD1603  [5]
 LDCM0403  CL16 HEK-293T C1117(1.07)  LDD1607  [5]
 LDCM0405  CL18 HEK-293T C1117(1.03)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C1117(1.16)  LDD1610  [5]
 LDCM0408  CL20 HEK-293T C1117(1.08)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C1117(0.99)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C1117(1.20)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C1117(1.23)  LDD1615  [5]
 LDCM0416  CL28 HEK-293T C1117(0.97)  LDD1620  [5]
 LDCM0419  CL30 HEK-293T C1117(1.13)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C1117(1.15)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C1117(1.01)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C1117(0.96)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C1117(1.12)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C1117(1.26)  LDD1628  [5]
 LDCM0429  CL4 HEK-293T C1117(0.98)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C1117(1.08)  LDD1634  [5]
 LDCM0432  CL42 HEK-293T C1117(1.15)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C1117(1.12)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C1117(0.99)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C1117(1.05)  LDD1639  [5]
 LDCM0436  CL46 HEK-293T C1117(1.08)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C1117(1.33)  LDD1641  [5]
 LDCM0443  CL52 HEK-293T C1117(1.11)  LDD1646  [5]
 LDCM0445  CL54 HEK-293T C1117(1.07)  LDD1648  [5]
 LDCM0446  CL55 HEK-293T C1117(1.22)  LDD1649  [5]
 LDCM0447  CL56 HEK-293T C1117(1.14)  LDD1650  [5]
 LDCM0448  CL57 HEK-293T C1117(1.16)  LDD1651  [5]
 LDCM0449  CL58 HEK-293T C1117(1.06)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C1117(1.26)  LDD1653  [5]
 LDCM0451  CL6 HEK-293T C1117(1.20)  LDD1654  [5]
 LDCM0456  CL64 HEK-293T C1117(0.99)  LDD1659  [5]
 LDCM0458  CL66 HEK-293T C1117(1.17)  LDD1661  [5]
 LDCM0459  CL67 HEK-293T C1117(1.13)  LDD1662  [5]
 LDCM0460  CL68 HEK-293T C1117(1.03)  LDD1663  [5]
 LDCM0461  CL69 HEK-293T C1117(1.07)  LDD1664  [5]
 LDCM0462  CL7 HEK-293T C1117(1.12)  LDD1665  [5]
 LDCM0463  CL70 HEK-293T C1117(1.15)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C1117(1.45)  LDD1667  [5]
 LDCM0469  CL76 HEK-293T C1117(1.06)  LDD1672  [5]
 LDCM0471  CL78 HEK-293T C1117(1.19)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C1117(1.19)  LDD1675  [5]
 LDCM0473  CL8 HEK-293T C1117(0.78)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C1117(1.11)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C1117(1.10)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C1117(1.10)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C1117(1.24)  LDD1680  [5]
 LDCM0482  CL88 HEK-293T C1117(1.08)  LDD1685  [5]
 LDCM0484  CL9 HEK-293T C1117(1.03)  LDD1687  [5]
 LDCM0485  CL90 HEK-293T C1117(1.06)  LDD1688  [5]
 LDCM0486  CL91 HEK-293T C1117(1.16)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C1117(0.96)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C1117(1.05)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C1117(1.10)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C1117(1.14)  LDD1693  [5]
 LDCM0022  KB02 769-P C603(1.66)  LDD2246  [1]
 LDCM0023  KB03 769-P C603(2.07)  LDD2663  [1]
 LDCM0024  KB05 Hs 936.T C427(1.79)  LDD3313  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402