Details of the Target

General Information of Target

Target ID LDTP04593
Target Name IST1 homolog (IST1)
Gene Name IST1
Gene ID 9798
Synonyms
KIAA0174; IST1 homolog; hIST1; Charged multivesicular body protein 8; CHMP8; Putative MAPK-activating protein PM28
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLGSGFKAERLRVNLRLVINRLKLLEKKKTELAQKARKEIADYLAAGKDERARIRVEHII
REDYLVEAMEILELYCDLLLARFGLIQSMKELDSGLAESVSTLIWAAPRLQSEVAELKIV
ADQLCAKYSKEYGKLCRTNQIGTVNDRLMHKLSVEAPPKILVERYLIEIAKNYNVPYEPD
SVVMAEAPPGVETDLIDVGFTDDVKKGGPGRGGSGGFTAPVGGPDGTVPMPMPMPMPSAN
TPFSYPLPKGPSDFNGLPMGTYQAFPNIHPPQIPATPPSYESVDDINADKNISSAQIVGP
GPKPEASAKLPSRPADNYDNFVLPELPSVPDTLPTASAGASTSASEDIDFDDLSRRFEEL
KKKT
Target Bioclass
Other
Family
IST1 family
Subcellular location
Cytoplasmic vesicle
Function
ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation. Is required for efficient abscission during cytokinesis. Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells. During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing. Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2. Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST.
Uniprot ID
P53990
Ensemble ID
ENST00000329908.12
HGNC ID
HGNC:28977

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y43(7.18)  LDD0260  [1]
TH216
 Probe Info  		Y43(10.05)  LDD0259  [1]
STPyne
 Probe Info  		K127(0.55); K130(10.00); K134(4.38); K29(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y43(11.18)  LDD3495  [3]
DBIA
 Probe Info  		C138(2.22)  LDD3310  [4]
BTD
 Probe Info  		C125(0.33)  LDD2089  [5]
HHS-482
 Probe Info  		Y43(0.87)  LDD0285  [6]
HHS-475
 Probe Info  		Y43(1.04)  LDD0264  [7]
HHS-465
 Probe Info  		Y43(10.00)  LDD2237  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
IPM
 Probe Info  		N.A.  LDD0147  [11]
PF-06672131
 Probe Info  		N.A.  LDD0017  [13]
SF
 Probe Info  		N.A.  LDD0028  [14]
YN-1
 Probe Info  		E113(0.00); E116(0.00)  LDD0446  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [16]
W1
 Probe Info  		E131(0.00); Y132(0.00)  LDD0236  [17]
NAIA_5
 Probe Info  		C76(0.00); C125(0.00); C136(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C278
 Probe Info  		51.98  LDD1948  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C125(0.89)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C125(1.51); C136(0.89)  LDD2152  [5]
 LDCM0214  AC1 HEK-293T C125(0.94)  LDD1507  [20]
 LDCM0215  AC10 HEK-293T C125(0.96)  LDD1508  [20]
 LDCM0226  AC11 HEK-293T C125(0.95)  LDD1509  [20]
 LDCM0237  AC12 HEK-293T C125(0.94)  LDD1510  [20]
 LDCM0259  AC14 HEK-293T C125(0.94)  LDD1512  [20]
 LDCM0270  AC15 HEK-293T C125(0.97)  LDD1513  [20]
 LDCM0276  AC17 HEK-293T C125(0.85)  LDD1515  [20]
 LDCM0277  AC18 HEK-293T C125(0.97)  LDD1516  [20]
 LDCM0278  AC19 HEK-293T C125(0.85)  LDD1517  [20]
 LDCM0279  AC2 HEK-293T C125(1.06)  LDD1518  [20]
 LDCM0280  AC20 HEK-293T C125(0.99)  LDD1519  [20]
 LDCM0281  AC21 HEK-293T C125(0.99)  LDD1520  [20]
 LDCM0282  AC22 HEK-293T C125(1.00)  LDD1521  [20]
 LDCM0283  AC23 HEK-293T C125(1.06)  LDD1522  [20]
 LDCM0284  AC24 HEK-293T C125(1.09)  LDD1523  [20]
 LDCM0285  AC25 HEK-293T C125(0.89)  LDD1524  [20]
 LDCM0286  AC26 HEK-293T C125(0.95)  LDD1525  [20]
 LDCM0287  AC27 HEK-293T C125(0.95)  LDD1526  [20]
 LDCM0288  AC28 HEK-293T C125(0.99)  LDD1527  [20]
 LDCM0289  AC29 HEK-293T C125(0.97)  LDD1528  [20]
 LDCM0290  AC3 HEK-293T C125(0.94)  LDD1529  [20]
 LDCM0291  AC30 HEK-293T C125(0.96)  LDD1530  [20]
 LDCM0292  AC31 HEK-293T C125(1.04)  LDD1531  [20]
 LDCM0293  AC32 HEK-293T C125(1.01)  LDD1532  [20]
 LDCM0294  AC33 HEK-293T C125(0.95)  LDD1533  [20]
 LDCM0295  AC34 HEK-293T C125(0.92)  LDD1534  [20]
 LDCM0296  AC35 HEK-293T C125(0.89)  LDD1535  [20]
 LDCM0297  AC36 HEK-293T C125(0.95)  LDD1536  [20]
 LDCM0298  AC37 HEK-293T C125(1.06)  LDD1537  [20]
 LDCM0299  AC38 HEK-293T C125(1.03)  LDD1538  [20]
 LDCM0300  AC39 HEK-293T C125(1.00)  LDD1539  [20]
 LDCM0301  AC4 HEK-293T C125(0.92)  LDD1540  [20]
 LDCM0302  AC40 HEK-293T C125(0.93)  LDD1541  [20]
 LDCM0303  AC41 HEK-293T C125(0.96)  LDD1542  [20]
 LDCM0304  AC42 HEK-293T C125(0.91)  LDD1543  [20]
 LDCM0305  AC43 HEK-293T C125(0.92)  LDD1544  [20]
 LDCM0306  AC44 HEK-293T C125(0.95)  LDD1545  [20]
 LDCM0307  AC45 HEK-293T C125(1.00)  LDD1546  [20]
 LDCM0308  AC46 HEK-293T C125(0.92)  LDD1547  [20]
 LDCM0309  AC47 HEK-293T C125(0.99)  LDD1548  [20]
 LDCM0310  AC48 HEK-293T C125(1.02)  LDD1549  [20]
 LDCM0311  AC49 HEK-293T C125(0.95)  LDD1550  [20]
 LDCM0312  AC5 HEK-293T C125(1.03)  LDD1551  [20]
 LDCM0313  AC50 HEK-293T C125(0.95)  LDD1552  [20]
 LDCM0314  AC51 HEK-293T C125(1.00)  LDD1553  [20]
 LDCM0315  AC52 HEK-293T C125(0.94)  LDD1554  [20]
 LDCM0316  AC53 HEK-293T C125(1.06)  LDD1555  [20]
 LDCM0317  AC54 HEK-293T C125(1.01)  LDD1556  [20]
 LDCM0318  AC55 HEK-293T C125(1.01)  LDD1557  [20]
 LDCM0319  AC56 HEK-293T C125(0.95)  LDD1558  [20]
 LDCM0320  AC57 HEK-293T C125(0.89)  LDD1559  [20]
 LDCM0321  AC58 HEK-293T C125(0.93)  LDD1560  [20]
 LDCM0322  AC59 HEK-293T C125(1.01)  LDD1561  [20]
 LDCM0323  AC6 HEK-293T C125(0.95)  LDD1562  [20]
 LDCM0324  AC60 HEK-293T C125(0.90)  LDD1563  [20]
 LDCM0325  AC61 HEK-293T C125(0.97)  LDD1564  [20]
 LDCM0326  AC62 HEK-293T C125(0.99)  LDD1565  [20]
 LDCM0327  AC63 HEK-293T C125(1.02)  LDD1566  [20]
 LDCM0328  AC64 HEK-293T C125(1.03)  LDD1567  [20]
 LDCM0334  AC7 HEK-293T C125(1.05)  LDD1568  [20]
 LDCM0345  AC8 HEK-293T C125(0.99)  LDD1569  [20]
 LDCM0520  AKOS000195272 MDA-MB-231 C125(0.83)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C125(1.00)  LDD1511  [20]
 LDCM0356  AKOS034007680 HEK-293T C125(0.95)  LDD1570  [20]
 LDCM0275  AKOS034007705 HEK-293T C125(0.95)  LDD1514  [20]
 LDCM0632  CL-Sc Hep-G2 C125(1.28)  LDD2227  [18]
 LDCM0367  CL1 HEK-293T C125(0.97); C136(1.03)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C125(0.89)  LDD1572  [20]
 LDCM0369  CL100 HEK-293T C125(0.96)  LDD1573  [20]
 LDCM0370  CL101 HEK-293T C125(0.94); C136(1.04)  LDD1574  [20]
 LDCM0371  CL102 HEK-293T C125(0.88)  LDD1575  [20]
 LDCM0372  CL103 HEK-293T C125(1.07)  LDD1576  [20]
 LDCM0373  CL104 HEK-293T C125(1.09)  LDD1577  [20]
 LDCM0374  CL105 HEK-293T C125(0.98); C136(0.99)  LDD1578  [20]
 LDCM0375  CL106 HEK-293T C125(0.96)  LDD1579  [20]
 LDCM0376  CL107 HEK-293T C125(1.05)  LDD1580  [20]
 LDCM0377  CL108 HEK-293T C125(0.95)  LDD1581  [20]
 LDCM0378  CL109 HEK-293T C125(0.94); C136(1.10)  LDD1582  [20]
 LDCM0379  CL11 HEK-293T C125(0.93)  LDD1583  [20]
 LDCM0380  CL110 HEK-293T C125(0.87)  LDD1584  [20]
 LDCM0381  CL111 HEK-293T C125(0.99)  LDD1585  [20]
 LDCM0382  CL112 HEK-293T C125(0.92)  LDD1586  [20]
 LDCM0383  CL113 HEK-293T C125(0.96); C136(1.04)  LDD1587  [20]
 LDCM0384  CL114 HEK-293T C125(0.85)  LDD1588  [20]
 LDCM0385  CL115 HEK-293T C125(1.02)  LDD1589  [20]
 LDCM0386  CL116 HEK-293T C125(1.02)  LDD1590  [20]
 LDCM0387  CL117 HEK-293T C125(0.93); C136(1.04)  LDD1591  [20]
 LDCM0388  CL118 HEK-293T C125(0.95)  LDD1592  [20]
 LDCM0389  CL119 HEK-293T C125(1.00)  LDD1593  [20]
 LDCM0390  CL12 HEK-293T C125(0.90)  LDD1594  [20]
 LDCM0391  CL120 HEK-293T C125(1.02)  LDD1595  [20]
 LDCM0392  CL121 HEK-293T C125(0.99); C136(1.05)  LDD1596  [20]
 LDCM0393  CL122 HEK-293T C125(0.94)  LDD1597  [20]
 LDCM0394  CL123 HEK-293T C125(0.93)  LDD1598  [20]
 LDCM0395  CL124 HEK-293T C125(1.01)  LDD1599  [20]
 LDCM0396  CL125 HEK-293T C125(0.98); C136(0.99)  LDD1600  [20]
 LDCM0397  CL126 HEK-293T C125(0.91)  LDD1601  [20]
 LDCM0398  CL127 HEK-293T C125(1.01)  LDD1602  [20]
 LDCM0399  CL128 HEK-293T C125(1.03)  LDD1603  [20]
 LDCM0400  CL13 HEK-293T C125(0.93); C136(0.98)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C125(1.01)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C125(0.98)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C125(1.12)  LDD1607  [20]
 LDCM0404  CL17 HEK-293T C125(0.86)  LDD1608  [20]
 LDCM0405  CL18 HEK-293T C125(0.97)  LDD1609  [20]
 LDCM0406  CL19 HEK-293T C125(0.89)  LDD1610  [20]
 LDCM0407  CL2 HEK-293T C125(0.94)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C125(0.85)  LDD1612  [20]
 LDCM0409  CL21 HEK-293T C125(0.92)  LDD1613  [20]
 LDCM0410  CL22 HEK-293T C125(0.99)  LDD1614  [20]
 LDCM0411  CL23 HEK-293T C125(0.97)  LDD1615  [20]
 LDCM0412  CL24 HEK-293T C125(0.91)  LDD1616  [20]
 LDCM0413  CL25 HEK-293T C125(0.93); C136(0.96)  LDD1617  [20]
 LDCM0414  CL26 HEK-293T C125(1.02)  LDD1618  [20]
 LDCM0415  CL27 HEK-293T C125(1.05)  LDD1619  [20]
 LDCM0416  CL28 HEK-293T C125(0.99)  LDD1620  [20]
 LDCM0417  CL29 HEK-293T C125(1.02)  LDD1621  [20]
 LDCM0418  CL3 HEK-293T C125(0.98)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C125(1.07)  LDD1623  [20]
 LDCM0420  CL31 HEK-293T C125(0.89)  LDD1624  [20]
 LDCM0421  CL32 HEK-293T C125(0.91)  LDD1625  [20]
 LDCM0422  CL33 HEK-293T C125(0.89)  LDD1626  [20]
 LDCM0423  CL34 HEK-293T C125(1.05)  LDD1627  [20]
 LDCM0424  CL35 HEK-293T C125(1.07)  LDD1628  [20]
 LDCM0425  CL36 HEK-293T C125(0.92)  LDD1629  [20]
 LDCM0426  CL37 HEK-293T C125(1.03); C136(0.97)  LDD1630  [20]
 LDCM0428  CL39 HEK-293T C125(1.02)  LDD1632  [20]
 LDCM0429  CL4 HEK-293T C125(1.07)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C125(1.11)  LDD1634  [20]
 LDCM0431  CL41 HEK-293T C125(0.89)  LDD1635  [20]
 LDCM0432  CL42 HEK-293T C125(1.04)  LDD1636  [20]
 LDCM0433  CL43 HEK-293T C125(1.05)  LDD1637  [20]
 LDCM0434  CL44 HEK-293T C125(0.93)  LDD1638  [20]
 LDCM0435  CL45 HEK-293T C125(0.87)  LDD1639  [20]
 LDCM0436  CL46 HEK-293T C125(0.99)  LDD1640  [20]
 LDCM0437  CL47 HEK-293T C125(1.01)  LDD1641  [20]
 LDCM0438  CL48 HEK-293T C125(0.92)  LDD1642  [20]
 LDCM0439  CL49 HEK-293T C125(0.98); C136(0.98)  LDD1643  [20]
 LDCM0440  CL5 HEK-293T C125(0.92)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C125(0.93)  LDD1645  [20]
 LDCM0443  CL52 HEK-293T C125(0.96)  LDD1646  [20]
 LDCM0444  CL53 HEK-293T C125(0.85)  LDD1647  [20]
 LDCM0445  CL54 HEK-293T C125(0.84)  LDD1648  [20]
 LDCM0446  CL55 HEK-293T C125(0.87)  LDD1649  [20]
 LDCM0447  CL56 HEK-293T C125(0.87)  LDD1650  [20]
 LDCM0448  CL57 HEK-293T C125(0.86)  LDD1651  [20]
 LDCM0449  CL58 HEK-293T C125(0.97)  LDD1652  [20]
 LDCM0450  CL59 HEK-293T C125(0.97)  LDD1653  [20]
 LDCM0451  CL6 HEK-293T C125(0.89)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C125(0.92)  LDD1655  [20]
 LDCM0453  CL61 HEK-293T C125(0.96); C136(0.93)  LDD1656  [20]
 LDCM0454  CL62 HEK-293T C125(0.99)  LDD1657  [20]
 LDCM0455  CL63 HEK-293T C125(1.12)  LDD1658  [20]
 LDCM0456  CL64 HEK-293T C125(0.90)  LDD1659  [20]
 LDCM0457  CL65 HEK-293T C125(0.94)  LDD1660  [20]
 LDCM0458  CL66 HEK-293T C125(0.93)  LDD1661  [20]
 LDCM0459  CL67 HEK-293T C125(0.89)  LDD1662  [20]
 LDCM0460  CL68 HEK-293T C125(0.94)  LDD1663  [20]
 LDCM0461  CL69 HEK-293T C125(0.97)  LDD1664  [20]
 LDCM0462  CL7 HEK-293T C125(0.87)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C125(0.97)  LDD1666  [20]
 LDCM0464  CL71 HEK-293T C125(0.97)  LDD1667  [20]
 LDCM0465  CL72 HEK-293T C125(0.94)  LDD1668  [20]
 LDCM0466  CL73 HEK-293T C125(0.95); C136(0.92)  LDD1669  [20]
 LDCM0467  CL74 HEK-293T C125(1.03)  LDD1670  [20]
 LDCM0469  CL76 HEK-293T C125(1.02)  LDD1672  [20]
 LDCM0470  CL77 HEK-293T C125(0.82)  LDD1673  [20]
 LDCM0471  CL78 HEK-293T C125(1.01)  LDD1674  [20]
 LDCM0472  CL79 HEK-293T C125(0.97)  LDD1675  [20]
 LDCM0473  CL8 HEK-293T C125(0.69)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C125(0.98)  LDD1677  [20]
 LDCM0475  CL81 HEK-293T C125(1.02)  LDD1678  [20]
 LDCM0476  CL82 HEK-293T C125(1.03)  LDD1679  [20]
 LDCM0477  CL83 HEK-293T C125(0.96)  LDD1680  [20]
 LDCM0478  CL84 HEK-293T C125(0.87)  LDD1681  [20]
 LDCM0479  CL85 HEK-293T C125(1.01); C136(0.94)  LDD1682  [20]
 LDCM0480  CL86 HEK-293T C125(1.01)  LDD1683  [20]
 LDCM0481  CL87 HEK-293T C125(1.05)  LDD1684  [20]
 LDCM0482  CL88 HEK-293T C125(0.96)  LDD1685  [20]
 LDCM0483  CL89 HEK-293T C125(0.98)  LDD1686  [20]
 LDCM0484  CL9 HEK-293T C125(1.00)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C125(0.81)  LDD1688  [20]
 LDCM0486  CL91 HEK-293T C125(0.97)  LDD1689  [20]
 LDCM0487  CL92 HEK-293T C125(0.87)  LDD1690  [20]
 LDCM0488  CL93 HEK-293T C125(0.96)  LDD1691  [20]
 LDCM0489  CL94 HEK-293T C125(0.96)  LDD1692  [20]
 LDCM0490  CL95 HEK-293T C125(0.75)  LDD1693  [20]
 LDCM0491  CL96 HEK-293T C125(0.86)  LDD1694  [20]
 LDCM0492  CL97 HEK-293T C125(0.90); C136(0.95)  LDD1695  [20]
 LDCM0493  CL98 HEK-293T C125(0.92)  LDD1696  [20]
 LDCM0494  CL99 HEK-293T C125(0.96)  LDD1697  [20]
 LDCM0495  E2913 HEK-293T C125(1.06)  LDD1698  [20]
 LDCM0625  F8 Ramos C125(1.07)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C125(0.76)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C125(0.65)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C125(0.89)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C125(0.96)  LDD2192  [21]
 LDCM0576  Fragment14 Ramos C125(0.92)  LDD2193  [21]
 LDCM0579  Fragment20 Ramos C125(0.86)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C125(1.01)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C125(0.86)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C125(1.10)  LDD2197  [21]
 LDCM0586  Fragment28 Ramos C125(0.68)  LDD2198  [21]
 LDCM0588  Fragment30 Ramos C125(1.23)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C125(1.12)  LDD2200  [21]
 LDCM0590  Fragment32 Ramos C125(0.71)  LDD2201  [21]
 LDCM0468  Fragment33 HEK-293T C125(1.04)  LDD1671  [20]
 LDCM0596  Fragment38 Ramos C125(1.11)  LDD2203  [21]
 LDCM0566  Fragment4 Ramos C125(0.97)  LDD2184  [21]
 LDCM0427  Fragment51 HEK-293T C125(0.99)  LDD1631  [20]
 LDCM0610  Fragment52 Ramos C125(1.34)  LDD2204  [21]
 LDCM0614  Fragment56 Ramos C125(1.51)  LDD2205  [21]
 LDCM0569  Fragment7 Ramos C125(0.71)  LDD2186  [21]
 LDCM0571  Fragment9 Ramos C125(0.93)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y43(1.04)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y43(1.07)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y43(1.16)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y43(1.09)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y43(1.16)  LDD0268  [7]
 LDCM0123  JWB131 DM93 Y43(0.87)  LDD0285  [6]
 LDCM0124  JWB142 DM93 Y43(0.67)  LDD0286  [6]
 LDCM0125  JWB146 DM93 Y43(0.93)  LDD0287  [6]
 LDCM0126  JWB150 DM93 Y43(4.15)  LDD0288  [6]
 LDCM0127  JWB152 DM93 Y43(2.27)  LDD0289  [6]
 LDCM0128  JWB198 DM93 Y43(1.80)  LDD0290  [6]
 LDCM0129  JWB202 DM93 Y43(0.59)  LDD0291  [6]
 LDCM0130  JWB211 DM93 Y43(1.17)  LDD0292  [6]
 LDCM0022  KB02 HEK-293T C125(1.02)  LDD1492  [20]
 LDCM0023  KB03 HEK-293T C125(1.03)  LDD1497  [20]
 LDCM0024  KB05 COLO792 C138(2.22)  LDD3310  [4]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C125(0.33)  LDD2089  [5]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C125(0.86)  LDD2097  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C136(0.86)  LDD2099  [5]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C125(1.01)  LDD2101  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C125(0.42)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C125(0.79)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C125(0.66)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C125(1.05)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C125(0.49)  LDD2115  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C136(1.04)  LDD2120  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C136(0.33)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C125(0.71)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C125(0.84)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C125(0.98)  LDD2127  [5]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C136(0.77)  LDD2128  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C125(1.06)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C125(0.61)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C125(0.46)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C125(1.15)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C125(1.12)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C136(0.72)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C125(0.54); C136(0.63)  LDD2140  [5]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C136(0.95)  LDD2143  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C136(0.76)  LDD2146  [5]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C125(0.55)  LDD2148  [5]
 LDCM0131  RA190 MM1.R C125(1.76)  LDD0304  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calpain-7 (CAPN7) Peptidase C2 family Q9Y6W3
Acylamino-acid-releasing enzyme (APEH) Peptidase S9C family P13798
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Charged multivesicular body protein 1a (CHMP1A) SNF7 family Q9HD42
Charged multivesicular body protein 1b (CHMP1B) SNF7 family Q7LBR1
BAG family molecular chaperone regulator 4 (BAG4) . O95429
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.