Details of the Target

General Information of Target

Target ID LDTP17314
Target Name Ankyrin repeat domain-containing protein 40 (ANKRD40)
Gene Name ANKRD40
Gene ID 91369
Synonyms
Ankyrin repeat domain-containing protein 40
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVQVVGSWPSVQPREAPREAIPERGNGFRLLSARLCALRPDDSSSARTEIHLLFDQLI
SENYSEGSGVAPEDVSALLVQACRLVPLNQNHLVSKVSQLIHHLLNRLQVIVDEQHLDFL
LAYTISAIHQCSSWTHREILQALAALVYCNGSKCQKYLPELLGNTGLLMKLSDLAQSDPE
VRRAAVHCMANLCLSVPGQPYLEEPYQNVCFQAFLTILQSPKSSDMDDITFCMLLQNALK
GIQSLLNGGRMKLTQTDELGALLAVLKKFMFHGLPGLNIEMPTVLYPTPLPQYDGRTPIK
PQQSESSASRPTLNKKKKSKVKPKKIQQGEEEEKESSGEIEAAPVTGTGRVNLHEGNTWC
PSSLGVQSLPLDGSGAAEKDGVSSSFSSSSWKRVSSSESDFSDAEGGMQSKMRSYQAKVR
QGALVCFLSTIKSIEKKVLYGYWSAFIPDTPELGSPQSVSLMTLTLKDPSPKTRACALQV
LSAILEGSKQFLSVAEDTSDHRRAFTPFSVMIACSIRELHRCLLLALVAESSSQTVTQII
KCLANLVSNAPYDRLKLSLLTKVWNQIKPYIRHKDVNVRVSSLTLLGAIVSTHAPLPEVQ
LLLQQPCSSGLGNSNSATPHLSPPDWWKKAPAGPSLEETSVSSPKGSSEPCWLIRLCISI
VVLPKEDSCSGSDAGSAAGSTYEPSPMRLEALQVLTLLARGYFSMTQAYLMELGEVICKC
MGEADPSIQLHGAKLLEELGTGLIQQYKPDSTAAPDQRAPVFLVVMFWTMMLNGPLPRAL
QNSEHPTLQASACDALSSILPEAFSNLPNDRQMLCITVLLGLNDSKNRLVKAATSRALGV
YVLFPCLRQDVIFVADAANAILMSLEDKSLNVRAKAAWSLGNLTDTLIVNMETPDPSFQE
EFSGLLLLKMLRSAIEASKDKDKVKSNAVRALGNLLHFLQPSHIEKPTFAEIIEESIQAL
ISTVLTEAAMKVRWNACYAMGNVFKNPALPLGTAPWTSQAYNALTSVVTSCKNFKVRIRS
AAALSVPGKREQYGSVDQYARIWNALVTALQKSEDTIDFLEFKYCVSLRTQICQALIHLL
SLASASDLPCMKETLELSGNMVQSYILQFLKSGAEGDDTGAPHSPQERDQMVRMALKHMG
SIQAPTGDTARRAIMGFLEEILAVCFDSSGSQGALPGLTNQ
Target Bioclass
Other
Uniprot ID
Q6AI12
Ensemble ID
ENST00000285243.7
HGNC ID
HGNC:28233

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C209(0.99)  LDD2090  [1]
AHL-Pu-1
 Probe Info  		C209(2.70)  LDD0171  [2]
DBIA
 Probe Info  		C209(1.32); C358(1.42)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [4]
NAIA_4
 Probe Info  		C209(0.00); C358(0.00)  LDD2226  [5]
WYneN
 Probe Info  		C209(0.00); C358(0.00)  LDD0021  [6]
IPM
 Probe Info  		N.A.  LDD0005  [6]
VSF
 Probe Info  		N.A.  LDD0007  [6]
YN-1
 Probe Info  		N.A.  LDD0446  [7]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [8]
W1
 Probe Info  		C358(0.00); C209(0.00); C298(0.00)  LDD0236  [9]
m-APA
 Probe Info  		N.A.  LDD0405  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C209(2.70)  LDD0171  [2]
 LDCM0214  AC1 HCT 116 C209(1.32); C358(1.42)  LDD0531  [3]
 LDCM0215  AC10 HCT 116 C296(1.03); C297(1.03); C358(0.93)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C209(0.89); C296(0.57); C297(0.57); C298(0.57)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C209(0.76); C296(0.48); C297(0.48); C298(0.48)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C209(0.68); C296(0.37); C297(0.37); C298(0.37)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C209(1.28); C296(0.28); C297(0.28); C298(0.28)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C209(20.00); C296(0.28); C297(0.28); C298(0.28)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C209(1.35); C296(0.33); C297(0.33); C298(0.33)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C209(1.18); C296(0.29); C297(0.29); C298(0.29)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C209(1.63); C296(0.31); C297(0.53); C298(0.31)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C209(0.84); C296(0.26); C297(0.23); C298(0.26)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C209(0.56); C296(0.43); C297(0.36); C298(0.43)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C296(1.24); C297(1.24); C358(1.17)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C209(0.64); C296(0.29); C297(0.36); C298(0.29)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C209(1.61); C296(0.37); C297(0.33); C298(0.37)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C209(0.81); C296(0.48); C297(0.39); C298(0.48)  LDD0546  [3]
 LDCM0230  AC113 HCT 116 C296(1.57); C297(1.57); C358(1.07)  LDD0547  [3]
 LDCM0231  AC114 HCT 116 C296(0.95); C297(0.95); C358(1.11)  LDD0548  [3]
 LDCM0232  AC115 HCT 116 C296(0.85); C297(0.85); C358(1.32)  LDD0549  [3]
 LDCM0233  AC116 HCT 116 C296(0.98); C297(0.98); C358(0.95)  LDD0550  [3]
 LDCM0234  AC117 HCT 116 C296(1.86); C297(1.86); C358(0.92)  LDD0551  [3]
 LDCM0235  AC118 HCT 116 C296(1.18); C297(1.18); C358(0.90)  LDD0552  [3]
 LDCM0236  AC119 HCT 116 C296(1.27); C297(1.27); C358(0.90)  LDD0553  [3]
 LDCM0237  AC12 HCT 116 C296(0.93); C297(0.93); C358(1.10)  LDD0554  [3]
 LDCM0238  AC120 HCT 116 C296(0.91); C297(0.91); C358(0.63)  LDD0555  [3]
 LDCM0239  AC121 HCT 116 C296(1.81); C297(1.81); C358(1.07)  LDD0556  [3]
 LDCM0240  AC122 HCT 116 C296(1.15); C297(1.15); C358(1.03)  LDD0557  [3]
 LDCM0241  AC123 HCT 116 C296(1.14); C297(1.14); C358(1.31)  LDD0558  [3]
 LDCM0242  AC124 HCT 116 C296(1.54); C297(1.54); C358(1.20)  LDD0559  [3]
 LDCM0243  AC125 HCT 116 C296(0.96); C297(0.96); C358(0.84)  LDD0560  [3]
 LDCM0244  AC126 HCT 116 C296(0.95); C297(0.95); C358(0.91)  LDD0561  [3]
 LDCM0245  AC127 HCT 116 C296(1.08); C297(1.08); C358(0.90)  LDD0562  [3]
 LDCM0246  AC128 HCT 116 C296(0.71); C297(0.71); C298(0.70); C358(0.42)  LDD0563  [3]
 LDCM0247  AC129 HCT 116 C296(0.92); C297(0.92); C298(0.82); C358(0.44)  LDD0564  [3]
 LDCM0249  AC130 HCT 116 C296(0.94); C297(0.94); C298(0.94); C358(0.50)  LDD0566  [3]
 LDCM0250  AC131 HCT 116 C296(1.05); C297(1.05); C298(1.09); C358(0.55)  LDD0567  [3]
 LDCM0251  AC132 HCT 116 C296(1.11); C297(1.11); C298(0.87); C358(0.57)  LDD0568  [3]
 LDCM0252  AC133 HCT 116 C296(1.03); C297(1.03); C298(1.11); C358(0.50)  LDD0569  [3]
 LDCM0253  AC134 HCT 116 C296(0.72); C297(0.72); C298(0.65); C358(0.72)  LDD0570  [3]
 LDCM0254  AC135 HCT 116 C296(0.74); C297(0.74); C298(0.64); C358(0.68)  LDD0571  [3]
 LDCM0255  AC136 HCT 116 C296(0.98); C297(0.98); C298(0.96); C358(0.63)  LDD0572  [3]
 LDCM0256  AC137 HCT 116 C296(0.98); C297(0.98); C298(0.90); C358(0.47)  LDD0573  [3]
 LDCM0257  AC138 HCT 116 C296(0.95); C297(0.95); C298(0.98); C358(0.56)  LDD0574  [3]
 LDCM0258  AC139 HCT 116 C296(1.01); C297(1.01); C298(0.91); C358(0.59)  LDD0575  [3]
 LDCM0259  AC14 HCT 116 C296(1.40); C297(1.40); C358(1.05)  LDD0576  [3]
 LDCM0260  AC140 HCT 116 C296(0.87); C297(0.87); C298(0.79); C358(0.55)  LDD0577  [3]
 LDCM0261  AC141 HCT 116 C296(0.94); C297(0.94); C298(0.83); C358(0.61)  LDD0578  [3]
 LDCM0262  AC142 HCT 116 C296(1.45); C297(1.45); C298(1.27); C358(0.47)  LDD0579  [3]
 LDCM0263  AC143 HCT 116 C209(1.06); C296(0.83); C297(0.83); C358(1.10)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C296(0.39); C297(0.39); C209(0.87); C358(1.14)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C296(0.65); C297(0.65); C209(0.81); C358(0.93)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C296(0.59); C297(0.59); C209(1.05); C358(1.17)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C296(0.49); C297(0.49); C358(1.26); C209(1.76)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C296(0.38); C297(0.38); C209(0.64); C358(0.81)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C296(0.44); C297(0.44); C209(0.88); C358(1.22)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C296(0.96); C297(0.96); C358(0.98)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C296(0.68); C297(0.68); C358(0.95); C209(1.08)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C296(0.62); C297(0.62); C209(0.90); C358(1.02)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C296(0.38); C297(0.38); C209(0.91); C358(0.98)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C296(0.39); C297(0.39); C209(0.53); C358(0.71)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C209(1.18); C296(0.43); C297(0.43); C358(0.99)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C209(0.73); C296(0.44); C297(0.44); C358(0.81)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C209(0.92); C296(0.96); C297(0.96); C358(1.07)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C209(0.83); C296(0.72); C297(0.72); C358(0.94)  LDD2161  [3]
 LDCM0276  AC17 HCT 116 C358(0.64); C296(0.78); C297(0.78); C298(0.87)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C296(0.53); C297(0.53); C358(0.70); C298(0.78)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C358(0.69); C296(0.75); C297(0.75); C298(0.88)  LDD0595  [3]
 LDCM0279  AC2 HCT 116 C358(1.50); C209(1.68)  LDD0596  [3]
 LDCM0280  AC20 HCT 116 C358(0.64); C296(0.77); C297(0.77); C298(0.92)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C358(0.57); C296(0.78); C297(0.78); C298(1.00)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C358(0.54); C296(0.94); C297(0.94); C298(0.96)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C358(0.54); C296(0.81); C297(0.81); C298(0.89)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C358(0.54); C296(0.79); C297(0.79); C298(0.88)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C296(0.92); C297(0.92); C298(0.92)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C296(0.54); C297(0.54); C298(0.54)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C296(0.61); C297(0.61); C298(0.61)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C296(0.66); C297(0.66); C298(0.66)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C296(0.83); C297(0.83); C298(0.83)  LDD0606  [3]
 LDCM0290  AC3 HCT 116 C358(1.18); C209(1.99)  LDD0607  [3]
 LDCM0291  AC30 HCT 116 C296(0.66); C297(0.66); C298(0.66)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C296(0.62); C297(0.62); C298(0.62)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C296(0.56); C297(0.56); C298(0.56)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C296(0.65); C297(0.65); C298(0.65)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C296(0.45); C297(0.45); C298(0.45)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C296(1.03); C297(1.03); C298(1.11)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C296(1.19); C297(1.19); C298(1.21)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C296(1.10); C297(1.10); C298(1.17)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C298(1.01); C296(1.05); C297(1.05)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C298(1.07); C296(1.12); C297(1.12)  LDD0617  [3]
 LDCM0301  AC4 HCT 116 C358(1.17); C209(2.05)  LDD0618  [3]
 LDCM0302  AC40 HCT 116 C296(0.79); C297(0.79); C298(0.80)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C298(0.99); C296(1.05); C297(1.05)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C298(0.80); C296(0.87); C297(0.87)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C296(0.93); C297(0.93); C298(0.94)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C298(0.86); C296(0.90); C297(0.90)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C298(0.82); C296(0.87); C297(0.87)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C296(1.26); C297(1.26); C298(1.38)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C296(1.06); C297(1.06); C298(1.18)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C296(1.63); C297(1.63); C298(1.73)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C298(0.76); C296(0.76); C297(0.76)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C358(1.21); C209(2.06)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C296(0.75); C297(0.75); C298(0.79)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C296(1.71); C297(1.71); C298(1.82)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C296(0.92); C297(0.92); C298(0.96)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C296(0.90); C297(0.90); C298(0.92)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C296(0.92); C297(0.92); C298(0.93)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C296(0.81); C297(0.81); C298(0.86)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C298(0.81); C296(0.82); C297(0.82)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C298(0.47); C296(0.47); C297(0.47)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C298(0.43); C296(0.45); C297(0.45)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C298(0.38); C296(0.39); C297(0.39)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C296(0.82); C297(0.82); C358(0.94)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C298(0.50); C296(0.53); C297(0.53)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C296(0.77); C297(0.77); C298(0.78)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C298(0.36); C296(0.37); C297(0.37)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C298(0.49); C296(0.51); C297(0.51)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C298(0.36); C296(0.39); C297(0.39)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C298(0.44); C296(0.46); C297(0.46)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C298(0.51); C296(0.52); C297(0.52)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C298(0.28); C296(0.30); C297(0.30)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C358(0.86); C296(0.90); C297(0.90); C209(1.34)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C358(0.69); C296(0.88); C297(0.88); C209(1.09)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C358(1.04); C296(1.27); C297(1.27)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C296(0.65); C297(0.65); C358(1.08); C209(1.75)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C358(0.83); C296(1.03); C297(1.03); C209(1.65)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C296(0.91); C297(0.91); C358(0.99); C209(1.91)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C296(0.71); C297(0.71); C358(1.10); C209(1.85)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C296(0.72); C297(0.72); C358(0.93); C209(1.78)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C296(0.68); C297(0.68); C358(0.93); C209(2.33)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C296(0.69); C297(0.69); C358(1.07); C209(1.69)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C296(0.71); C297(0.71); C358(0.98); C209(1.70)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C358(0.99); C209(1.23); C296(1.59); C297(1.59)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C358(0.82); C296(0.95); C297(0.95); C209(1.32)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C358(1.02); C296(1.29); C297(1.29)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C296(0.80); C297(0.80); C358(0.87); C209(1.49)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C358(0.88); C296(1.14); C297(1.14); C209(1.44)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C296(0.71); C297(0.71); C358(0.78); C209(2.36)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C297(0.30); C296(0.78); C298(0.78); C209(1.65)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C297(0.36); C296(0.79); C298(0.79); C209(1.70)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C297(0.59); C296(0.76); C298(0.76); C209(1.51)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C297(0.68); C296(0.92); C298(0.92); C209(1.61)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C297(1.07); C296(1.17); C298(1.17); C209(1.31)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C297(0.62); C296(1.00); C298(1.00); C209(1.10)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C297(0.36); C296(0.89); C298(0.89); C209(2.07)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C209(0.66); C297(1.07); C296(1.12); C298(1.12)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C297(0.32); C296(0.81); C298(0.81); C209(1.86)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C297(0.31); C296(0.77); C298(0.77); C209(1.53)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C297(0.53); C296(0.79); C298(0.79); C209(1.41)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C297(0.65); C296(0.94); C298(0.94); C209(1.18)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C297(1.00); C296(1.20); C298(1.20); C209(1.43)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C297(0.44); C296(1.15); C298(1.15); C209(1.35)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C297(0.30); C296(0.82); C298(0.82); C209(1.47)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C296(0.17); C297(0.17); C298(0.17); C358(1.02)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C296(0.48); C297(0.48); C298(0.48); C358(0.71)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C296(1.69); C297(1.69); C358(1.10)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C358(1.13); C296(1.50); C297(1.50)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C296(0.85); C297(0.85); C358(1.01)  LDD0592  [3]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [10]
 LDCM0020  ARS-1620 HCC44 C358(1.13)  LDD2171  [3]
 LDCM0367  CL1 HCT 116 C209(0.97); C358(1.34); C296(1.75); C297(1.75)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C209(0.89); C296(1.15); C297(1.15); C358(1.32)  LDD0685  [3]
 LDCM0369  CL100 HCT 116 C358(1.27); C209(1.72)  LDD0686  [3]
 LDCM0370  CL101 HCT 116 C358(0.81); C296(0.92); C297(0.92)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C358(1.04); C296(1.96); C297(1.96)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C358(0.90); C296(1.93); C297(1.93)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C358(0.80); C296(1.50); C297(1.50)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C358(0.52); C296(0.67); C297(0.67); C298(0.93)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C296(0.51); C297(0.51); C358(0.64); C298(0.90)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C296(0.48); C297(0.48); C358(0.63); C298(0.75)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C296(0.50); C297(0.50); C358(0.58); C298(0.78)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C296(0.61); C297(0.61); C358(0.65); C298(0.80)  LDD0695  [3]
 LDCM0379  CL11 HCT 116 C209(0.72); C296(1.04); C297(1.04); C358(1.12)  LDD0696  [3]
 LDCM0380  CL110 HCT 116 C358(0.52); C296(0.64); C297(0.64); C298(0.71)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C358(0.59); C296(0.66); C297(0.66); C298(0.71)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C296(0.75); C297(0.75); C298(0.75)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C296(0.57); C297(0.57); C298(0.57)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C296(1.19); C297(1.19); C298(1.19)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C296(0.71); C297(0.71); C298(0.71)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C296(0.57); C297(0.57); C298(0.57)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C298(0.65); C296(0.68); C297(0.68)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C298(0.97); C296(0.97); C297(0.97)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C298(0.82); C296(0.83); C297(0.83)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C209(0.60); C296(1.03); C297(1.03); C358(1.25)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C296(1.16); C297(1.16); C298(1.17)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C296(1.77); C297(1.77); C298(2.27)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C298(1.06); C296(1.11); C297(1.11)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C296(1.16); C297(1.16); C298(1.25)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C298(0.81); C296(0.86); C297(0.86)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C298(0.98); C296(1.07); C297(1.07)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C298(0.90); C296(1.01); C297(1.01)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C298(0.85); C296(0.88); C297(0.88)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C298(0.40); C296(0.42); C297(0.42)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C209(0.98); C358(1.12); C296(1.24); C297(1.24)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C209(0.73); C358(1.29); C296(1.41); C297(1.41)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C209(0.73); C296(1.27); C297(1.27); C358(1.51)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C296(0.86); C297(0.86); C358(0.87); C298(0.90)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C358(1.12); C296(1.15); C297(1.15); C298(1.29)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C358(0.81); C298(1.15); C296(1.25); C297(1.25)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C358(0.55); C296(0.72); C297(0.72); C298(0.74)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C209(0.82); C358(1.29); C296(1.53); C297(1.53)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C298(0.52); C296(0.54); C297(0.54); C358(1.80)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C296(0.59); C297(0.59); C298(0.60); C358(1.06)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C296(0.49); C297(0.49); C298(0.51); C358(0.74)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C358(0.52); C296(0.56); C297(0.56); C298(0.59)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C296(0.53); C297(0.53); C298(0.55); C358(0.92)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C296(0.57); C297(0.57); C298(0.63); C358(0.86)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C296(0.70); C297(0.70); C298(0.64); C358(1.23)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C296(0.75); C297(0.75); C298(0.79); C358(1.01)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C296(0.72); C297(0.72); C298(0.79); C358(0.80)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C296(0.59); C297(0.59); C298(0.65); C358(0.89)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C209(0.80); C296(1.21); C297(1.21); C358(1.26)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C296(0.78); C297(0.78); C298(0.81); C358(0.79)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C296(0.84); C297(0.84)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C209(1.45); C296(1.47); C297(1.47); C358(1.14)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C209(1.00); C296(1.07); C297(1.07); C358(1.14)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C209(1.33); C296(0.64); C297(0.64); C358(1.07)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C209(1.64); C296(0.55); C297(0.55); C358(1.10)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C209(1.33); C296(0.56); C297(0.56); C358(0.91)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C209(1.49); C296(0.60); C297(0.60); C358(0.92)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C209(1.16); C296(0.54); C297(0.54); C358(1.11)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C209(1.14); C296(1.42); C297(1.42); C358(1.04)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C209(0.92); C296(0.66); C297(0.66); C358(0.95)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C209(1.17); C296(0.57); C297(0.57); C358(1.17)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C209(1.13); C296(0.54); C297(0.54); C358(0.84)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C209(1.26); C296(0.52); C297(0.52); C358(0.98)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C209(1.46); C296(0.80); C297(0.80); C358(1.01)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C209(1.38); C296(0.57); C297(0.57); C358(1.00)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C358(1.18)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C358(1.08)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C358(1.13)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C358(0.97)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C209(0.68); C296(1.18); C297(1.18); C358(1.01)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C358(0.97)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C358(1.13)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C358(1.23)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C358(1.35)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C358(1.40)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C358(0.85)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C358(0.76)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C358(0.87)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C358(1.42)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C358(1.11)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C209(0.77); C296(1.58); C297(1.58); C358(1.57)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C358(1.12)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C296(0.96); C297(0.96); C298(1.04); C358(0.81)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C296(0.97); C297(0.97); C298(1.09); C358(0.84)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C296(0.87); C297(0.87); C298(1.08); C358(0.73)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C296(0.69); C297(0.69); C298(0.73); C358(0.55)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C296(0.84); C297(0.84); C298(0.87); C358(1.14)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C296(0.61); C297(0.61); C298(0.73); C358(0.94)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C296(0.64); C297(0.64); C298(0.72); C358(0.88)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C296(0.87); C297(0.87); C298(0.97); C358(0.94)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C296(1.80); C297(1.80); C298(2.13); C358(1.32)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C209(1.00); C296(0.96); C297(0.96); C358(1.04)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C296(0.83); C297(0.83); C298(0.90); C358(0.88)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C296(0.77); C297(0.77); C298(0.87); C358(0.73)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C296(1.21); C297(1.21); C298(1.59); C358(0.73)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C296(0.70); C297(0.70); C298(0.77); C358(0.84)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C296(0.74); C297(0.74); C298(0.82); C358(0.88)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C358(0.83)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C358(0.75)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C358(1.01)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C358(0.75)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C209(0.85); C296(0.94); C297(0.94); C358(1.50)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C358(0.84)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C358(0.72)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C358(0.98)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C358(0.95)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C358(0.79)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C358(0.84)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C358(0.92)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C358(0.89)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C358(0.81)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C358(0.89)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C209(0.75); C296(0.89); C297(0.89); C358(1.07)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C358(0.74)  LDD0802  [3]
 LDCM0486  CL91 HCT 116 C209(1.01); C358(0.89)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C209(0.76); C358(1.05)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C209(1.33); C358(0.91)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C209(1.54); C358(1.08)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C209(1.44); C358(0.94)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C209(1.64); C358(0.94)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C209(1.95); C358(1.07)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C209(1.22); C358(1.03)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C209(1.34); C358(1.02)  LDD0811  [3]
 LDCM0495  E2913 HEK-293T C209(1.09); C358(0.99)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C358(0.94)  LDD1702  [1]
 LDCM0625  F8 Ramos C209(1.37)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C209(1.47)  LDD2189  [12]
 LDCM0574  Fragment12 Ramos C209(1.05)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C209(1.63)  LDD2192  [12]
 LDCM0580  Fragment21 Ramos C209(0.76)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C209(1.61)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C209(1.33)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C209(0.58)  LDD2198  [12]
 LDCM0589  Fragment31 Ramos C209(1.29)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C209(3.33)  LDD2201  [12]
 LDCM0468  Fragment33 HCT 116 C296(0.88); C297(0.88); C298(1.00); C358(1.00)  LDD0785  [3]
 LDCM0596  Fragment38 Ramos C209(1.25)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C209(0.63)  LDD2184  [12]
 LDCM0427  Fragment51 HCT 116 C209(1.13); C296(0.52); C297(0.52); C358(1.22)  LDD0744  [3]
 LDCM0571  Fragment9 Ramos C209(0.84)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C358(1.01); C209(0.90)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C358(1.01); C209(0.95)  LDD1497  [11]
 LDCM0024  KB05 MEWO C209(1.96)  LDD3319  [13]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C209(1.28)  LDD2102  [1]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C209(0.99)  LDD2090  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C209(0.95)  LDD2092  [1]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C209(1.48)  LDD2096  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C209(1.26)  LDD2105  [1]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C358(0.99)  LDD2107  [1]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C209(1.07)  LDD2118  [1]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C358(2.40)  LDD2119  [1]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C209(1.29)  LDD2122  [1]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C358(0.74)  LDD2146  [1]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C209(1.79)  LDD2153  [1]
 LDCM0021  THZ1 HCT 116 C358(1.13)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Replication factor C subunit 3 (RFC3) Activator 1 small subunits family P40938
Adenosylhomocysteinase (AHCY) Adenosylhomocysteinase family P23526
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) . Q13526
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding protein FXR1 (FXR1) FMR1 family P51114
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
10 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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Mass spectrometry data entry: PXD047840