Details of the Target

General Information of Target

Target ID LDTP11744
Target Name Beta-soluble NSF attachment protein (NAPB)
Gene Name NAPB
Gene ID 63908
Synonyms
SNAPB; Beta-soluble NSF attachment protein; SNAP-beta; N-ethylmaleimide-sensitive factor attachment protein beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMAEPWQALQLLLAILLTLMALPYQARKKTFLSVHEVMAVENYAKDSLQWITDQYNKESD
DKYHFRIFRVLKVQRQVTDHLEYHLNVEMQWTTCQKPETTNCVPQERELHKQVNCFFSVF
AVPWFEQYKILNKSCSSD
Target Bioclass
Other
Family
SNAP family
Subcellular location
Membrane
Function Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.
Uniprot ID
Q9H115
Ensemble ID
ENST00000377026.4
HGNC ID
HGNC:15751

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.N57IfsTer48 .
HT115 SNV: p.E40Ter .
JURKAT SNV: p.P196L .
RL952 Deletion: p.N57IfsTer48 .
SKHEP1 SNV: p.Q179L .
SUIT2 SNV: p.A64T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C164(0.99)  LDD1700  [1]
IA-alkyne
 Probe Info  		C42(0.49); C212(0.84)  LDD2182  [2]
DBIA
 Probe Info  		C42(0.99)  LDD0532  [3]
YN-1
 Probe Info  		N.A.  LDD0446  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C164(0.93)  LDD2130  [1]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C164(1.49)  LDD2132  [1]
 LDCM0214  AC1 HEK-293T C42(0.81); C66(1.16)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C42(0.99)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C66(1.10)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C66(0.99)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C66(1.04)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C66(1.11)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C66(0.94)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C66(0.96)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C66(0.90)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C66(1.01)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C66(0.95)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C66(0.98)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C42(1.10)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C66(1.31)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C66(1.49)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C66(1.43)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C66(1.00)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C66(1.00)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C66(0.99)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C66(1.00)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C66(1.10)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C66(1.17)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C66(1.15)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C42(0.89)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C66(1.03)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C66(1.13)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C66(1.26)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C66(1.30)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C66(1.10)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C66(1.28)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C66(1.44)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C66(1.60)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C66(1.10)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C66(1.16)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C66(1.01)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C66(0.97)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C66(0.97)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C66(1.18)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C66(1.22)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C66(1.03)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C66(1.08)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C66(1.31)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C66(1.56)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C66(1.27)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C42(0.95)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C66(1.17)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C66(1.24)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C66(1.20)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C42(0.90); C66(1.07)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C42(1.14); C66(1.36)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C42(1.10); C66(1.30)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C42(1.20); C66(1.27)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C42(1.24); C66(1.47)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C42(1.54); C66(1.36)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C42(1.25); C66(1.19)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C42(1.11)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C42(0.94); C66(1.19)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C42(0.97); C66(1.23)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C42(0.87); C66(1.18)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C42(1.02); C66(1.23)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C42(0.81); C66(1.10)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C42(0.81); C66(1.13)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C42(1.48); C66(1.36)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C42(1.10); C66(1.63)  LDD2165  [3]
 LDCM0276  AC17 HCT 116 C42(0.75)  LDD0593  [3]
 LDCM0277  AC18 HCT 116 C42(0.91)  LDD0594  [3]
 LDCM0278  AC19 HCT 116 C42(1.11)  LDD0595  [3]
 LDCM0279  AC2 HEK-293T C42(0.91); C66(1.04)  LDD0877  [3]
 LDCM0280  AC20 HCT 116 C42(0.78)  LDD0597  [3]
 LDCM0281  AC21 HCT 116 C42(0.98)  LDD0598  [3]
 LDCM0282  AC22 HCT 116 C42(0.82)  LDD0599  [3]
 LDCM0283  AC23 HCT 116 C42(0.80)  LDD0600  [3]
 LDCM0284  AC24 HCT 116 C42(0.73)  LDD0601  [3]
 LDCM0285  AC25 HCT 116 C42(1.06)  LDD0602  [3]
 LDCM0286  AC26 HCT 116 C42(0.95)  LDD0603  [3]
 LDCM0287  AC27 HCT 116 C42(0.88)  LDD0604  [3]
 LDCM0288  AC28 HCT 116 C42(0.90)  LDD0605  [3]
 LDCM0289  AC29 HCT 116 C42(0.94)  LDD0606  [3]
 LDCM0290  AC3 HEK-293T C42(1.07); C66(1.10)  LDD0888  [3]
 LDCM0291  AC30 HCT 116 C42(0.84)  LDD0608  [3]
 LDCM0292  AC31 HCT 116 C42(0.78)  LDD0609  [3]
 LDCM0293  AC32 HCT 116 C42(1.05)  LDD0610  [3]
 LDCM0294  AC33 HCT 116 C42(1.01)  LDD0611  [3]
 LDCM0295  AC34 HCT 116 C42(1.08)  LDD0612  [3]
 LDCM0296  AC35 HCT 116 C42(1.55)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C42(1.05)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C42(1.23)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C42(0.91)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C42(1.06)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C42(1.04); C66(1.28)  LDD0899  [3]
 LDCM0302  AC40 HCT 116 C42(0.90)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C42(1.31)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C42(1.18)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C42(1.44)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C42(1.16)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C42(1.17)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C42(1.18)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C42(1.24)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C42(1.32)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C42(1.06)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C42(0.84); C66(1.47)  LDD0910  [3]
 LDCM0313  AC50 HCT 116 C42(0.91)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C42(1.41)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C42(1.20)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C42(1.16)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C42(1.25)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C42(1.06)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C42(1.21)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C42(1.12); C66(0.96)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C42(1.42); C66(0.90)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C42(1.49); C66(0.85)  LDD0920  [3]
 LDCM0323  AC6 HCT 116 C42(1.01)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C42(1.20); C66(0.77)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C42(1.27); C66(1.02)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C42(2.21); C66(0.94)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C42(1.56); C66(0.97)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C42(1.87); C66(0.93)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C42(1.64); C66(0.93)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C42(1.83); C66(0.82)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C42(1.48); C66(0.88)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C42(0.68); C66(1.14)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C42(0.66); C66(1.22)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C42(1.00)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C42(0.57); C66(1.25)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C42(0.53); C66(1.16)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C42(0.52); C66(1.26)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C42(0.56); C66(1.20)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C42(0.41); C66(1.52)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C42(0.42); C66(1.24)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C42(0.58); C66(1.25)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C42(0.62); C66(1.26)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C42(0.75); C66(1.22)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C42(0.59); C66(1.14)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C42(1.14)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C42(0.40); C66(1.23)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C42(0.44); C66(1.24)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C42(0.32); C66(1.47)  LDD0946  [3]
 LDCM0349  AC83 HCT 116 C42(1.59)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C42(1.71)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C42(1.06)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C42(2.15)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C42(1.14)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C42(1.39)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C42(1.75)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C42(3.87)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C42(0.96)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C42(1.59)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C42(2.02)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C42(0.98)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C42(1.32)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C42(1.47)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C42(1.47)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C66(1.00)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C66(0.91)  LDD0964  [3]
 LDCM0545  Acetamide MDA-MB-231 C164(0.39)  LDD2138  [1]
 LDCM0248  AKOS034007472 HCT 116 C42(0.78)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C42(0.91)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C42(0.70)  LDD0592  [3]
 LDCM0367  CL1 HEK-293T C42(0.61); C66(1.05)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C42(0.55); C66(1.74)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C42(0.87); C66(1.05)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C42(0.89)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C42(1.37)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C42(1.19)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C42(1.09)  LDD0690  [3]
 LDCM0374  CL105 HCT 116 C42(0.67)  LDD0691  [3]
 LDCM0375  CL106 HCT 116 C42(0.73)  LDD0692  [3]
 LDCM0376  CL107 HCT 116 C42(0.67)  LDD0693  [3]
 LDCM0377  CL108 HCT 116 C42(0.53)  LDD0694  [3]
 LDCM0378  CL109 HCT 116 C42(0.67)  LDD0695  [3]
 LDCM0379  CL11 HEK-293T C42(0.56); C66(1.43)  LDD0977  [3]
 LDCM0380  CL110 HCT 116 C42(0.67)  LDD0697  [3]
 LDCM0381  CL111 HCT 116 C42(0.74)  LDD0698  [3]
 LDCM0382  CL112 HCT 116 C42(0.98)  LDD0699  [3]
 LDCM0383  CL113 HCT 116 C42(1.08)  LDD0700  [3]
 LDCM0384  CL114 HCT 116 C42(0.79)  LDD0701  [3]
 LDCM0385  CL115 HCT 116 C42(0.77)  LDD0702  [3]
 LDCM0386  CL116 HCT 116 C42(1.05)  LDD0703  [3]
 LDCM0387  CL117 HCT 116 C42(0.98)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C42(1.00)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C42(0.89)  LDD0706  [3]
 LDCM0390  CL12 HEK-293T C42(0.53); C66(1.02)  LDD0988  [3]
 LDCM0391  CL120 HCT 116 C42(1.15)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C42(1.25)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C42(1.14)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C42(1.03)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C42(1.13)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C42(1.13); C66(0.97)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C42(1.36); C66(1.04)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C42(1.30); C66(1.00)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C42(1.38); C66(0.84)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C42(0.49); C66(1.19)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C42(0.45); C66(1.04)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C42(0.46); C66(1.21)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C42(0.71)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C42(0.89)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C42(0.73)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C42(0.72)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C42(0.76); C66(1.14)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C42(0.52)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C42(0.60)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C42(0.67)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C42(0.54)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C42(0.61)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C42(0.70)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C42(0.74)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C42(0.75)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C42(0.59)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C42(0.79)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C42(0.52); C66(1.20)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C42(0.80)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C42(0.57); C66(1.11)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C42(0.59); C66(1.10)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C42(0.55); C66(1.12)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C42(0.79); C66(1.03)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C42(0.61); C66(1.13)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C42(0.73); C66(1.08)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C42(0.63); C66(1.10)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C42(0.70); C66(1.44)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C42(0.53); C66(1.10)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C42(0.79); C66(1.09)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C42(0.69); C66(1.31)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C42(0.70); C66(1.27)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C42(0.76); C66(1.30)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C42(0.70); C66(1.05)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C42(0.62); C66(1.24)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C42(0.82); C66(1.09)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C42(0.95); C66(0.99)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C42(0.97); C66(1.06)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C42(0.81); C66(1.04)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C42(0.51); C66(1.26)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C42(0.76); C66(1.20)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C42(0.84); C66(1.05)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C42(1.38); C66(0.90)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C42(0.92); C66(0.94)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C42(0.86); C66(1.02)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C42(0.81); C66(1.11)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C42(1.42); C66(0.94)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C42(0.72); C66(1.02)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C42(0.83); C66(0.99)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C42(0.79); C66(1.12)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C42(0.57); C66(1.09)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C42(0.75); C66(1.16)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C42(1.04)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C42(1.09)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C42(0.94)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C42(1.18)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C42(1.04)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C42(0.88)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C42(1.06)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C42(1.16)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C42(0.98)  LDD0778  [3]
 LDCM0462  CL7 HEK-293T C42(0.56); C66(1.19)  LDD1060  [3]
 LDCM0463  CL70 HCT 116 C42(1.04)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C42(0.92)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C42(0.99)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C42(1.19)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C42(1.21)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C66(1.02)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C66(1.03)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C66(0.74)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C66(0.90)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C42(1.16); C212(0.62); C103(0.79); C66(0.73)  LDD1676  [8]
 LDCM0474  CL80 HEK-293T C66(0.93)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C66(1.01)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C66(1.24)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C66(1.25)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C66(0.82)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C66(0.90)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C66(0.76)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C66(0.96)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C66(1.03)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C66(0.91)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C42(1.26); C212(1.00); C103(0.95)  LDD1687  [8]
 LDCM0485  CL90 HEK-293T C66(1.01)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C42(0.86); C66(1.47)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C42(0.80); C66(0.94)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C42(1.11); C66(1.32)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C42(0.66); C66(1.34)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C42(0.79); C66(1.40)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C42(0.73); C66(1.11)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C42(0.76); C66(0.98)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C42(0.89); C66(1.64)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C42(0.78); C66(0.96)  LDD1092  [3]
 LDCM0495  E2913 HEK-293T C42(0.91); C212(1.12); C103(1.17); C66(1.06)  LDD1698  [8]
 LDCM0625  F8 Ramos C212(0.81)  LDD2187  [2]
 LDCM0572  Fragment10 Ramos C42(0.76)  LDD2189  [2]
 LDCM0573  Fragment11 Ramos C42(1.58); C212(2.70)  LDD2190  [2]
 LDCM0576  Fragment14 Ramos C42(1.99); C212(1.28)  LDD2193  [2]
 LDCM0579  Fragment20 Ramos C42(2.12)  LDD2194  [2]
 LDCM0586  Fragment28 Ramos C42(0.45); C212(0.91)  LDD2198  [2]
 LDCM0590  Fragment32 Ramos C42(2.49)  LDD2201  [2]
 LDCM0468  Fragment33 HCT 116 C42(0.99)  LDD0785  [3]
 LDCM0566  Fragment4 Ramos C42(0.64); C212(0.91)  LDD2184  [2]
 LDCM0427  Fragment51 HEK-293T C42(0.47); C66(1.15)  LDD1025  [3]
 LDCM0569  Fragment7 Ramos C42(0.24); C212(0.85)  LDD2186  [2]
 LDCM0022  KB02 HEK-293T C66(0.92)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C66(1.04)  LDD1497  [8]
 LDCM0024  KB05 NB1 C66(1.42)  LDD3340  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C164(0.41)  LDD2121  [1]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C164(1.00)  LDD2092  [1]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C164(1.05)  LDD2093  [1]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C164(0.75)  LDD2094  [1]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C164(1.20)  LDD2105  [1]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C164(0.90)  LDD2120  [1]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C164(1.33)  LDD2128  [1]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C164(0.78)  LDD2129  [1]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C164(0.68)  LDD2135  [1]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C164(0.99)  LDD1700  [1]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C164(1.09)  LDD2143  [1]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C164(3.89)  LDD2147  [1]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C164(0.52)  LDD2150  [1]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C164(1.19)  LDD2153  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) MAPEG family P20292
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Transporter and channel
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptosomal-associated protein 23 (SNAP23) SNAP-25 family O00161
Synaptotagmin-1 (SYT1) Synaptotagmin family P21579
Syntaxin-19 (STX19) Syntaxin family Q8N4C7
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-3 (STX3) Syntaxin family Q13277
Syntaxin-4 (STX4) Syntaxin family Q12846
Syntaxin-5 (STX5) Syntaxin family Q13190
Syntaxin-6 (STX6) Syntaxin family O43752
Syntenin-1 (SDCBP) . O00560
Transmembrane protein 139 (TMEM139) . Q8IV31
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Transcription factor EC (TFEC) MiT/TFE family O14948
Paired-like homeodomain transcription factor LEUTX (LEUTX) Paired homeobox family A8MZ59
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sialic acid-binding Ig-like lectin 5 (SIGLEC5) SIGLEC (sialic acid binding Ig-like lectin) family O15389
Other
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ADP-ribosylation factor-like protein 6-interacting protein 1 (ARL6IP1) ARL6ip family Q15041
BET1 homolog (BET1) BET1 family O15155
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Gap junction beta-5 protein (GJB5) Connexin family O95377
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Synaptosomal-associated protein 29 (SNAP29) SNAP-25 family O95721
Synaptotagmin-2 (SYT2) Synaptotagmin family Q8N9I0
Syntaxin-16 (STX16) Syntaxin family O14662
Syntaxin-1B (STX1B) Syntaxin family P61266
C-type lectin domain family 10 member A (CLEC10A) . Q8IUN9
Pleckstrin homology domain-containing family O member 1 (PLEKHO1) . Q53GL0

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840